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European Journal of Nuclear Medicine and Molecular Imaging

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01.02.2010 | Original Article

Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable ¹⁵O-O₂

verfasst von: Takashi Temma, Hidehiro Iida, Takuya Hayashi, Noboru Teramoto, Youichiro Ohta, Nobuyuki Kudomi, Hiroshi Watabe, Hideo Saji, Yasuhiro Magata

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 2/2010

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Abstract

Purpose

Although ¹⁵O-O₂ gas inhalation can provide a reliable and accurate myocardial metabolic rate for oxygen by PET, the spillover from gas volume in the lung distorts the images. Recently, we developed an injectable method in which blood takes up ¹⁵O-O₂ from an artificial lung, and this made it possible to estimate oxygen metabolism without the inhalation protocol. In the present study, we evaluated the effectiveness of the injectable ¹⁵O-O₂ system in porcine hearts.

Methods

PET scans were performed after bolus injection and continuous infusion of injectable ¹⁵O-O₂ via a shunt between the femoral artery and the vein in normal pigs. The injection method was compared to the inhalation method. The oxygen extraction fraction (OEF) in the lateral walls of the heart was calculated by a compartmental model in view of the spillover and partial volume effect.

Results

A significant decrease of lung radioactivity in PET images was observed compared to the continuous inhalation of ¹⁵O-O₂ gas. Furthermore, the injectable ¹⁵O-O₂ system provides a measurement of OEF in lateral walls of the heart that is similar to the continuous-inhalation method (0.71 ± 0.036 and 0.72 ± 0.020 for the bolus-injection and continuous-infusion methods, respectively).

Conclusion

These results indicate that injectable ¹⁵O-O₂ has the potential to evaluate myocardial oxygen metabolism.

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Titel: Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable 15O-O2
verfasst von: Takashi Temma
Hidehiro Iida
Takuya Hayashi
Noboru Teramoto
Youichiro Ohta
Nobuyuki Kudomi
Hiroshi Watabe
Hideo Saji
Yasuhiro Magata
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 2/2010
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1262-2

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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