Erschienen in:
01.04.2014 | Research Article
Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk
verfasst von:
Ming Shen, Yuan-Yuan Hu, Yu-Kun Hu, Long-Chuan Xie, Xiao-Ming Xu, Ming-Yue Wu, Yu-Ming Niu
Erschienen in:
Tumor Biology
|
Ausgabe 4/2014
Einloggen, um Zugang zu erhalten
Abstract
The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case–control studies were collected; odds ratios (ORs) with 95 % confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95 % CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95 % CI = 1.03–1.25, P = 0.014, P
heterogeneity = 0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95 % CI = 1.06–1.60, P = 0.013, P
heterogeneity = 0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95 % CI = 1.05–1.46, P = 0.013, P
heterogeneity = 0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.