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Erschienen in: World Journal of Urology 4/2010

01.08.2010 | Original Article

Radical cystectomy in the elderly patient: a contemporary comparison of perioperative complications in a single institution series

verfasst von: Derya Tilki, Dirk Zaak, Matthias Trottmann, Alexander Buchner, Yeliz Ekiz, Niklas Gerwens, Boris Schlenker, Alexander Karl, Sebastian Walther, Patrick J. Bastian, Christian Gratzke, Stefan Tritschler, Ruth Knüchel-Clarke, Süleyman Ergün, Christian G. Stief, Oliver Reich, Michael Seitz

Erschienen in: World Journal of Urology | Ausgabe 4/2010

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Abstract

Purpose

To report on our recent experience with peri- and postoperative morbidity of radical cystectomy in patients 75 years and older compared to younger patients.

Patients and methods

Medical records of 326 consecutive patients undergoing radical cystectomy from May 2004 through April 2008 were reviewed.

Results

Eighty-five of 326 patients (26%) were ≥75 years (75–95) old. ASA score was equal 3 or greater in 51% of patients ≥75 years and 32% of patients <75 years. Ileal conduit was performed in 83% of patients ≥75, 16% received an ileal neobladder compared to 46 and 51%, respectively, in patients <75. A total of 33 patients (39%) in the older patient group received blood transfusions intraoperatively compared to 76 patients (32%) in the younger age group. In 6 patients ≥75 years (7.1%) and 17 patients <75 (7.1%) open surgical revision was necessary, perioperative complication rate was 22 and 21%, respectively. The most common complications were wound dehiscence (5.9 vs. 7.5%), infections (4.7 vs. 4.6%), and pulmonary embolism (3.5 vs. 2.1%). Perioperative mortality was 1.2% (1 patient) in the elderly versus 0.4% (1 patient) in the younger age group.

Conclusion

Our data show that radical cystectomy can be offered to the elderly patient with acceptable morbidity. Because of higher comorbidity rate in the elderly, therapeutic decision for radical cystectomy in elderly patients should be made carefully and individually. Nevertheless our results demonstrate that age itself is not a main criterion which has to be considered strongly in decision making for radical cystectomy.
Literatur
1.
Zurück zum Zitat Hautmann RE, Gschwend JE, de Petriconi RC et al (2006) Cystectomy for transitional cell carcinoma of the bladder: results of a surgery only series in the neobladder era. J Urol 176:486–492CrossRefPubMed Hautmann RE, Gschwend JE, de Petriconi RC et al (2006) Cystectomy for transitional cell carcinoma of the bladder: results of a surgery only series in the neobladder era. J Urol 176:486–492CrossRefPubMed
2.
Zurück zum Zitat Madersbacher S, Hochreiter W, Burkhard F et al (2003) Radical cystectomy for bladder cancer today—a homogeneous series without neoadjuvant therapy. J Clin Oncol 21:690–696CrossRefPubMed Madersbacher S, Hochreiter W, Burkhard F et al (2003) Radical cystectomy for bladder cancer today—a homogeneous series without neoadjuvant therapy. J Clin Oncol 21:690–696CrossRefPubMed
3.
Zurück zum Zitat Shariat SF, Karakiewicz PI, Palapattu GS et al (2006) Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol 176:2414–2422CrossRefPubMed Shariat SF, Karakiewicz PI, Palapattu GS et al (2006) Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol 176:2414–2422CrossRefPubMed
4.
Zurück zum Zitat Ahmed A, Tollefsbol T (2001) Telomeres and telomerase: basic science implications for aging. J Am Geriatr Soc 49:1105–1109CrossRefPubMed Ahmed A, Tollefsbol T (2001) Telomeres and telomerase: basic science implications for aging. J Am Geriatr Soc 49:1105–1109CrossRefPubMed
5.
Zurück zum Zitat Kachnic LA, Kaufman DS, Heney NM et al (1997) Bladder preservation by combined modality therapy for invasive bladder cancer. J Clin Oncol 15:1022–1029PubMed Kachnic LA, Kaufman DS, Heney NM et al (1997) Bladder preservation by combined modality therapy for invasive bladder cancer. J Clin Oncol 15:1022–1029PubMed
6.
Zurück zum Zitat Lodde M, Palermo S, Comploj E et al (2005) Four years experience in bladder preserving management for muscle invasive bladder cancer. Eur Urol 47:773–778CrossRefPubMed Lodde M, Palermo S, Comploj E et al (2005) Four years experience in bladder preserving management for muscle invasive bladder cancer. Eur Urol 47:773–778CrossRefPubMed
7.
Zurück zum Zitat Shipley WU, Winter KA, Kaufman DS et al (1998) Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy: initial results of Radiation Therapy Oncology Group 89–03. J Clin Oncol 16:3576–3583PubMed Shipley WU, Winter KA, Kaufman DS et al (1998) Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy: initial results of Radiation Therapy Oncology Group 89–03. J Clin Oncol 16:3576–3583PubMed
8.
Zurück zum Zitat Zebic N, Weinknecht S, Kroepfl D (2005) Radical cystectomy in patients aged > or = 75 years: an updated review of patients treated with curative and palliative intent. BJU Int 95:1211–1214CrossRefPubMed Zebic N, Weinknecht S, Kroepfl D (2005) Radical cystectomy in patients aged > or = 75 years: an updated review of patients treated with curative and palliative intent. BJU Int 95:1211–1214CrossRefPubMed
9.
Zurück zum Zitat Figueroa AJ, Stein JP, Dickinson M et al (1998) Radical cystectomy for elderly patients with bladder carcinoma: an updated experience with 404 patients. Cancer 83:141–147CrossRefPubMed Figueroa AJ, Stein JP, Dickinson M et al (1998) Radical cystectomy for elderly patients with bladder carcinoma: an updated experience with 404 patients. Cancer 83:141–147CrossRefPubMed
10.
Zurück zum Zitat Koch MO, Smith JA Jr (1996) Influence of patient age and co-morbidity on outcome of a collaborative care pathway after radical prostatectomy and cystoprostatectomy. J Urol 155:1681–1684CrossRefPubMed Koch MO, Smith JA Jr (1996) Influence of patient age and co-morbidity on outcome of a collaborative care pathway after radical prostatectomy and cystoprostatectomy. J Urol 155:1681–1684CrossRefPubMed
11.
Zurück zum Zitat Leibovitch I, Avigad I, Ben-Chaim J et al (1993) Is it justified to avoid radical cystoprostatectomy in elderly patients with invasive transitional cell carcinoma of the bladder? Cancer 71:3098–3101CrossRefPubMed Leibovitch I, Avigad I, Ben-Chaim J et al (1993) Is it justified to avoid radical cystoprostatectomy in elderly patients with invasive transitional cell carcinoma of the bladder? Cancer 71:3098–3101CrossRefPubMed
12.
Zurück zum Zitat Lowrance WT, Rumohr JA, Chang SS et al (2008) Contemporary open radical cystectomy: analysis of perioperative outcomes. J Urol 179:1313–1318CrossRefPubMed Lowrance WT, Rumohr JA, Chang SS et al (2008) Contemporary open radical cystectomy: analysis of perioperative outcomes. J Urol 179:1313–1318CrossRefPubMed
13.
Zurück zum Zitat Keats AS (1978) The ASA classification of physical status—a recapitulation. Anesthesiology 49:233–236CrossRefPubMed Keats AS (1978) The ASA classification of physical status—a recapitulation. Anesthesiology 49:233–236CrossRefPubMed
14.
Zurück zum Zitat Hautmann RE, Schumacher M, Gschwend JE et al (2006) Long-term results of standard procedures in urology: the ileal neobladder. World J Urol Hautmann RE, Schumacher M, Gschwend JE et al (2006) Long-term results of standard procedures in urology: the ileal neobladder. World J Urol
15.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMed Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRefPubMed
16.
Zurück zum Zitat Stein JP, Skinner DG (2006) Radical cystectomy for invasive bladder cancer: long-term results of a standard procedure. World J Urol 24:296–304CrossRefPubMed Stein JP, Skinner DG (2006) Radical cystectomy for invasive bladder cancer: long-term results of a standard procedure. World J Urol 24:296–304CrossRefPubMed
17.
Zurück zum Zitat Frazier HA, Robertson JE, Paulson DF (1992) Complications of radical cystectomy and urinary diversion: a retrospective review of 675 cases in 2 decades. J Urol 148:1401–1405PubMed Frazier HA, Robertson JE, Paulson DF (1992) Complications of radical cystectomy and urinary diversion: a retrospective review of 675 cases in 2 decades. J Urol 148:1401–1405PubMed
18.
Zurück zum Zitat Parekh DJ, Gilbert WB, Koch MO et al (2000) Continent urinary reconstruction versus ileal conduit: a contemporary single-institution comparison of perioperative morbidity and mortality. Urology 55:852–855CrossRefPubMed Parekh DJ, Gilbert WB, Koch MO et al (2000) Continent urinary reconstruction versus ileal conduit: a contemporary single-institution comparison of perioperative morbidity and mortality. Urology 55:852–855CrossRefPubMed
19.
Zurück zum Zitat Novotny V, Hakenberg OW, Wiessner D et al (2007) Perioperative complications of radical cystectomy in a contemporary series. Eur Urol 51:397–401CrossRefPubMed Novotny V, Hakenberg OW, Wiessner D et al (2007) Perioperative complications of radical cystectomy in a contemporary series. Eur Urol 51:397–401CrossRefPubMed
20.
Zurück zum Zitat Stroumbakis N, Herr HW, Cookson MS et al (1997) Radical cystectomy in the octogenarian. J Urol 158:2113–2117CrossRefPubMed Stroumbakis N, Herr HW, Cookson MS et al (1997) Radical cystectomy in the octogenarian. J Urol 158:2113–2117CrossRefPubMed
21.
Zurück zum Zitat Malavaud B, Vaessen C, Mouzin M et al (2001) Complications for radical cystectomy. Impact of the American Society of Anesthesiologists score. Eur Urol 39:79–84CrossRefPubMed Malavaud B, Vaessen C, Mouzin M et al (2001) Complications for radical cystectomy. Impact of the American Society of Anesthesiologists score. Eur Urol 39:79–84CrossRefPubMed
Metadaten
Titel
Radical cystectomy in the elderly patient: a contemporary comparison of perioperative complications in a single institution series
verfasst von
Derya Tilki
Dirk Zaak
Matthias Trottmann
Alexander Buchner
Yeliz Ekiz
Niklas Gerwens
Boris Schlenker
Alexander Karl
Sebastian Walther
Patrick J. Bastian
Christian Gratzke
Stefan Tritschler
Ruth Knüchel-Clarke
Süleyman Ergün
Christian G. Stief
Oliver Reich
Michael Seitz
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
World Journal of Urology / Ausgabe 4/2010
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-009-0482-1

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