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01.10.2014

Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils

verfasst von: Takahiro Kataoka, Reo Etani, Yuji Takata, Yuichi Nishiyama, Atsushi Kawabe, Masayuki Kumashiro, Takehito Taguchi, Kiyonori Yamaoka

Erschienen in: Inflammation | Ausgabe 5/2014

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Abstract

Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m³ for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

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Titel: Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils
verfasst von: Takahiro Kataoka
Reo Etani
Yuji Takata
Yuichi Nishiyama
Atsushi Kawabe
Masayuki Kumashiro
Takehito Taguchi
Kiyonori Yamaoka
Publikationsdatum: 01.10.2014
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 5/2014
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-014-9896-z

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Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils

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