Skip to main content
Erschienen in: Journal of Medical Systems 10/2015

01.10.2015 | Mobile Systems

Real-Time Statistical Modeling of Blood Sugar

verfasst von: Mwaffaq Otoom, Hussam Alshraideh, Hisham M. Almasaeid, Diego López-de-Ipiña, José Bravo

Erschienen in: Journal of Medical Systems | Ausgabe 10/2015

Einloggen, um Zugang zu erhalten

Abstract

Diabetes is considered a chronic disease that incurs various types of cost to the world. One major challenge in the control of Diabetes is the real time determination of the proper insulin dose. In this paper, we develop a prototype for real time blood sugar control, integrated with the cloud. Our system controls blood sugar by observing the blood sugar level and accordingly determining the appropriate insulin dose based on patient’s historical data, all in real time and automatically. To determine the appropriate insulin dose, we propose two statistical models for modeling blood sugar profiles, namely ARIMA and Markov-based model. Our experiment used to evaluate the performance of the two models shows that the ARIMA model outperforms the Markov-based model in terms of prediction accuracy.
Literatur
1.
Zurück zum Zitat Andreassen, S., Benn, J.J., Hovorka, R., Olesen, K.G., Carson, E.R., A probabilistic approach to glucose prediction and insulin dose adjustment: description of metabolic model and pilot evaluation study. Comput. Methods Prog. Biomed. 41(3):153–165, 1994.CrossRef Andreassen, S., Benn, J.J., Hovorka, R., Olesen, K.G., Carson, E.R., A probabilistic approach to glucose prediction and insulin dose adjustment: description of metabolic model and pilot evaluation study. Comput. Methods Prog. Biomed. 41(3):153–165, 1994.CrossRef
2.
Zurück zum Zitat Akematsu, Y., and Tsuji, M., Economic effect of eHealth: Focusing on the reduction of days spent for treatment. In: 11th International Conference on e-Health Networking, Applications and Services, Healthcom, 2009. Akematsu, Y., and Tsuji, M., Economic effect of eHealth: Focusing on the reduction of days spent for treatment. In: 11th International Conference on e-Health Networking, Applications and Services, Healthcom, 2009.
3.
Zurück zum Zitat Alasaarela, E., Nemana, R., DeMello, S., Drivers and challenges of wireless solutions in future healthcare. In: International Conference on eHealth, Telemedicine, and Social Medicine. Alasaarela, E., Nemana, R., DeMello, S., Drivers and challenges of wireless solutions in future healthcare. In: International Conference on eHealth, Telemedicine, and Social Medicine.
4.
Zurück zum Zitat Andrianasy, F., and Milgram, M., Applying neural networks to adjust insulin-pump doses. In: Proceedings of the 1997 IEEE Workshop Neural Networks for Signal Processing VII. Andrianasy, F., and Milgram, M., Applying neural networks to adjust insulin-pump doses. In: Proceedings of the 1997 IEEE Workshop Neural Networks for Signal Processing VII.
5.
Zurück zum Zitat Alshraideh H., and Runger G., Process Monitoring Using Hidden Markov Models. Qual. Reliab. Eng. Int. 30:13791387, 2014. Alshraideh H., and Runger G., Process Monitoring Using Hidden Markov Models. Qual. Reliab. Eng. Int. 30:13791387, 2014.
6.
Zurück zum Zitat Alshraideh, H., and Khatatbeh, E., A Gaussian Process Control Chart for Monitoring Autocorrelated Process Data. J. Qual. Technol. 46(4):317–322, 2014. Alshraideh, H., and Khatatbeh, E., A Gaussian Process Control Chart for Monitoring Autocorrelated Process Data. J. Qual. Technol. 46(4):317–322, 2014.
7.
Zurück zum Zitat Campos-Cornejo, F., and Campos-DelgadoD, U., Self-Tuning Insulin Dosing Algorithm for Glucose Regulation in Type 1 Diabetic Patients. Health Care Exchanges. PAHCE. Pan American (2009) Campos-Cornejo, F., and Campos-DelgadoD, U., Self-Tuning Insulin Dosing Algorithm for Glucose Regulation in Type 1 Diabetic Patients. Health Care Exchanges. PAHCE. Pan American (2009)
8.
Zurück zum Zitat Jordanova M.M., eHealth: from space medicine to civil healthcare. In: Proceedings of 2nd International Conference on Recent Advances in Space Technologies, 2005 Jordanova M.M., eHealth: from space medicine to civil healthcare. In: Proceedings of 2nd International Conference on Recent Advances in Space Technologies, 2005
9.
Zurück zum Zitat King, A.B., Clark, D., Wolfe, G.S., How much do I give? Dose estimation formulas for once-nightly insulin glargine and premeal insulin lispro in type 1 diabetes mellitus. Endocr. Pract. 18(3):382–386, 2012.CrossRefPubMed King, A.B., Clark, D., Wolfe, G.S., How much do I give? Dose estimation formulas for once-nightly insulin glargine and premeal insulin lispro in type 1 diabetes mellitus. Endocr. Pract. 18(3):382–386, 2012.CrossRefPubMed
10.
Zurück zum Zitat Klonoff, D.C., Buse, J.B., Nielsen, L.L., Guan, X., Bowlus, C.L., Holcombe, J.H., Maggs, D.G., Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr. Med. Res. Opin. 24(1):275–286, 2007.CrossRef Klonoff, D.C., Buse, J.B., Nielsen, L.L., Guan, X., Bowlus, C.L., Holcombe, J.H., Maggs, D.G., Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr. Med. Res. Opin. 24(1):275–286, 2007.CrossRef
11.
Zurück zum Zitat Otoom, M., Alshraideh, H., Almasaeid, H., López-de-Ipiña, Diego, Bravo, J., A Real-Time Insulin Injection System. In: Proceedings of the Ambient Assisted Living and Active Aging - 5th International Work-Conference, IWAAL, pp. 120–127, 2013. Otoom, M., Alshraideh, H., Almasaeid, H., López-de-Ipiña, Diego, Bravo, J., A Real-Time Insulin Injection System. In: Proceedings of the Ambient Assisted Living and Active Aging - 5th International Work-Conference, IWAAL, pp. 120–127, 2013.
12.
Zurück zum Zitat Rizza, R. A., Mandarino, L.J., Gerich, J.E., Dose-response characteristics for effects of insulin on production and utilization of glucose in man. American Journal of Physiology-Endocrinology And Metabolism 240(6):E630–E639, 1981. Rizza, R. A., Mandarino, L.J., Gerich, J.E., Dose-response characteristics for effects of insulin on production and utilization of glucose in man. American Journal of Physiology-Endocrinology And Metabolism 240(6):E630–E639, 1981.
13.
Zurück zum Zitat Ross, S.M., Introduction to Probability Models. Tenth Edition: Elsevier AP, 2010. Ross, S.M., Introduction to Probability Models. Tenth Edition: Elsevier AP, 2010.
14.
Zurück zum Zitat Shimauchi, T., Kugai, N., Nagata, N., Takatani, O., Microcomputer-aided insulin dose determination in intensified conventional insulin therapy. IEEE Transactions on Biomedical Engineering. 2013. Shimauchi, T., Kugai, N., Nagata, N., Takatani, O., Microcomputer-aided insulin dose determination in intensified conventional insulin therapy. IEEE Transactions on Biomedical Engineering. 2013.
15.
Zurück zum Zitat Stein, O.S., Eirik, A., Ragnar, M.J., Fred, G., Statistical Modeling of Aggregated Lifestyle and Blood Glucose Data in Type 1 Diabetes Patients. In: Second International Conference on eHealth, Telemedicine, and Social Medicine, 2010. Stein, O.S., Eirik, A., Ragnar, M.J., Fred, G., Statistical Modeling of Aggregated Lifestyle and Blood Glucose Data in Type 1 Diabetes Patients. In: Second International Conference on eHealth, Telemedicine, and Social Medicine, 2010.
16.
Zurück zum Zitat Taha, H.A., Operations Research: An Introduction. Ninth Edition. New Jersey: Prentice Hall, 2010. Taha, H.A., Operations Research: An Introduction. Ninth Edition. New Jersey: Prentice Hall, 2010.
17.
Zurück zum Zitat Pickup, J.C., Insulin-pump therapy for type 1 diabetes mellitus. N. Engl. J. Med. 366(17):1616–1624, 2012.CrossRefPubMed Pickup, J.C., Insulin-pump therapy for type 1 diabetes mellitus. N. Engl. J. Med. 366(17):1616–1624, 2012.CrossRefPubMed
18.
Zurück zum Zitat Vasilyeva, E., Pechenizkiy, M., Puuronen, S., Towards the framework of adaptive user interfaces for eHealth. In: 18th IEEE Symposium on Computer-Based Medical Systems, 2005. Vasilyeva, E., Pechenizkiy, M., Puuronen, S., Towards the framework of adaptive user interfaces for eHealth. In: 18th IEEE Symposium on Computer-Based Medical Systems, 2005.
19.
Zurück zum Zitat Wallace, T.M., and Matthews, D.R., The assessment of insulin resistance in man. Diabet. Med. 19(7): 527–534, 2002.CrossRefPubMed Wallace, T.M., and Matthews, D.R., The assessment of insulin resistance in man. Diabet. Med. 19(7): 527–534, 2002.CrossRefPubMed
20.
Zurück zum Zitat Wang, N., and Kang, G.A., Monitoring system for type 2 diabetes mellitus. In: IEEE 14th International Conference on e-Health Networking, Applications and Service (Healthcom), pp. 62–67, 2012. Wang, N., and Kang, G.A., Monitoring system for type 2 diabetes mellitus. In: IEEE 14th International Conference on e-Health Networking, Applications and Service (Healthcom), pp. 62–67, 2012.
Metadaten
Titel
Real-Time Statistical Modeling of Blood Sugar
verfasst von
Mwaffaq Otoom
Hussam Alshraideh
Hisham M. Almasaeid
Diego López-de-Ipiña
José Bravo
Publikationsdatum
01.10.2015
Verlag
Springer US
Erschienen in
Journal of Medical Systems / Ausgabe 10/2015
Print ISSN: 0148-5598
Elektronische ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-015-0301-8

Weitere Artikel der Ausgabe 10/2015

Journal of Medical Systems 10/2015 Zur Ausgabe