Real-world costs of autosomal dominant polycystic kidney disease in the Nordics

This was a cross-sectional study of patients with ADPKD based on data collected from medical charts and patient self-administered questionnaires. Nine nephrology clinics participated; four in Denmark, one in Finland, two in Norway and two in Sweden. Between April and December 2014, we screened and enrolled convenience samples of subjects from each clinic. Patients were recruited by phone or in-person during routine clinical care.

Ethics approvals for the study were granted by the Helsinki University Hospital Ethical Review Board, the Regional Committee of Medical and Health Research Ethics in Oslo (REC South East) and the Regional Ethical Review Board in Stockholm. While the study was reported to the Danish Health and Medicines Authority, formal ethics approval was not required due to the non-interventional design. The study protocol and consent procedures were also reviewed and approved by the participating clinics.

Subjects were enrolled into four mutually exclusive strata using a hierarchical approach:

Disease severity among ADPKD patients was determined using the estimated GFR (eGFR), as calculated by each respective laboratory; eGFR <30 ml/min/1.73m² for CKD stages 4–5 and eGFR ≥30 ml/min/1.73m² for CKD stages 1–3. The most recent laboratory value was used to establish disease severity at enrolment date. Enrolment of patients was tracked in order to achieve a balanced recruitment across the four groups.

Subjects were eligible for enrolment in the study if they were 18 years of age or older and had been managed for ADPKD at the clinic during the past 12 months. Furthermore, participants were required to have had an eGFR value recorded in the past 12 months (not applicable if on dialysis). Subjects were excluded if they had been involved in a clinical trial in the past 12 months that resulted in a change in the standard of care received. Patients on maintenance dialysis were required to have had initiated dialysis at least six months prior to enrolment. Similarly, patients with a working kidney transplant were required to have had undergone the transplant procedure at least six months prior to enrolment. Finally, informed written consent was required for participation in the study.

Data were extracted from medical charts using a standardised case report form (CRF) and complemented with a self-administered questionnaire [see Additional files 1 and 2]. The CRF and questionnaire were matched for each subject using anonymised subject identifiers.

The standardised CRF allowed for uniform collection of demographic data, disease history and annual ADPKD-related resource utilisation. The CRF covered the 12-month period prior to patient enrolment (enrolment date).

The questionnaire, completed by patients, included complementary questions on ADPKD-related healthcare services received in the past four weeks outside of the primary nephrology clinic, including informal care. Indirect morbidity measures in terms of time missed from work and impairment of work productivity were obtained using the Work Productivity and Activity Impairment (WPAI:GH) questionnaire [11].

A societal perspective was used to estimate total costs. We summarised both direct and indirect annual costs related to ADPKD. Resources used in the past 12 months were quantified for each patient and multiplied by unit costs to derive total annual costs. Unit costs for healthcare services (e.g. primary care visit or blood transfusion) were obtained from local and national pricelists as presented in Table 1. Additional costs were derived from public reports and national statistics offices (e.g. daily cost of peritoneal dialysis or gross earnings/employment rates).

Medical resource utilisation was analysed in terms of hospitalisation, outpatient visits, primary care visits, transportation, surgical procedures, diagnostic tests and pharmacotherapy. Pharmacotherapy costs were estimated using conservative dosage estimates as per the drug label [12] for the following classes: antihypertensives, phosphate binders, erythropoiesis-stimulating agents (ESAs), analgesics for kidney pain, vitamin D analogues and immunosuppressive agents.

Indirect costs included informal care and productivity loss. Cost of informal care was based on hours of help from family and friends in the patient’s home and calculated using data on average national gross earnings. Productivity loss was estimated using the human capital approach, taking the patient’s perspective and counting every lost hour of work as lost production and income [42]. Age- and sex-dependent gross earnings and employment rates were obtained from official statistics offices in each country, with employment overheads and benefits added on top. It was assumed that ADPKD patients would have had the same employment rate as the general population had they not been ill.

Annual cost estimates were derived using national cost data and expressed in the local currency of each respective country (2014 values).

Summary statistics were calculated, including means and standard deviations (SDs) for continuous variables and frequency distributions for categorical variables. We presented costs as means and used non-parametric bootstrapping procedures to derive 95% confidence intervals. Differences across strata were evaluated using the Kruskal–Wallis and χ²/Fisher’s exact tests as appropriate. Resource utilisation in the past four weeks, as captured in the self-administered questionnaire, was extrapolated to one year. Data management and analysis were performed using Stata 12.1 (StataCorp LP, College Station, TX, USA).

A total of 266 patients were contacted. Of these 243 (91%) provided consent to participate and were enrolled into the four disease strata: CKD stages 1–3 (n = 64), CKD stages 4–5 (n = 55), transplant (n = 61), and dialysis (n = 63). Overall, 241 (99%) of participants completed the questionnaire.

Dialysis and transplant patients tended to be older than patients in earlier stages of the disease; those younger than 65 years were 80% in patients with CKD stages 1–3, 76% in CKD stages 4–5, 54% in dialysis patients and 70% in transplant recipients. Mean age for initiation of dialysis was 59 years in the dialysis stratum and the average age at the time of kidney transplantation was 52 years. Among those on dialysis, only two patients (3%) had received both haemodialysis and peritoneal dialysis in the past 12 months. No differences between disease strata were seen in sex and BMI (Table 2). Employment rates were lowest in the dialysis stratum (21%), with corresponding rates of 44% in transplant recipients, 49% in CKD stages 4–5 and 63% in CKD stages 1–3.

Medical resource utilisation differed substantially between disease strata (Table 3). In general, dialysis patients had the highest number of hospitalisations and outpatient visits, followed by transplant recipients and other dialysis-independent patients. This difference, however, was not observed for primary care visits, as reported in the self-administered questionnaire.

Only 8% of CKD stages 1–3 patients had a surgery related to ADPKD in the past year, compared to 18% of CKD stages 4–5 patients, 29% of transplant recipients and 49% of dialysis patients. Consequently, there was a significant difference in the mean number of surgical procedures in the past year between the disease strata, ranging from 0.1 in patients with CKD stages 1–3 to 1.6 in dialysis patients. Among transplant recipients, 10% had received the transplant in the past year. Similarly, 25% of dialysis patients had initiated treatment in the past year.

Dialysis patients were generally prescribed more drugs compared to the other disease states; 95% of dialysis patients used phosphate binders, 80% used erythropoiesis-stimulating agents (ESAs) and 97% were prescribed vitamin D analogues (Table 4). Analgesics for kidney pain were, however, most common in CKD stages 4–5, used by 27% compared to 16–23% in the other disease strata. Almost all patients with CKD stages 4–5 (98%) were prescribed antihypertensives.

Among dialysis patients 59% travelled by taxi to receive their treatment, while 35% drove and 6% used public transport. Forty-three percent travelled for at least 30 min one-way to receive treatment.

The levels of general daily activity impairment and productivity impairment due to health problems differed with disease severity. Activity impairment was highest among dialysis patients with 53% but also substantial at 30% in both patients with CKD stages 4–5 and among transplant recipients (Table 5). Among those employed, an average of 4–26% of work time was missed due to health problems, while patients estimated 7–26% of time lost while at work, depending on disease severity. Taken together, overall work impairment due to health was significantly different between disease strata. Work impairment was highest among dialysis patients (42%), followed by CKD stages 4–5 (23%), transplant recipients (16%) and CKD stages 1–3 (9%).

Costs are presented by disease severity and expressed in each respective local currency (Tables 6, 7, 8 and 9). Average total annual costs were highest for dialysis patients, followed by transplant recipients, patients in CKD stages 4–5 and CKD stages 1–3 (P < 0.0001, for all countries). Compared to CKD stages 1–3, annual costs were almost twice as high in CKD stages 4–5, two to three times higher in transplant recipients, and seven to nine times higher in dialysis patients. Differences between disease strata were even more pronounced when looking at direct costs alone (P < 0.0001, for all countries). Direct costs were almost twice as high in patients with CKD stages 4–5 compared to stages 1–3, but around six times higher among transplant recipients and 21 times higher among dialysis patients. Direct medical costs were substantial among dialysis patients, with routine dialysis care alone accounting over half of total costs. Productivity loss was a driver of costs across all stages of ADPKD, and especially substantial at around two-thirds of total costs in patients with CKD stages 1–3 and 4–5.