Introduction
Methods
Experimental Procedures
Analytical Procedures
Data analysis
Results
t-statistic and p-value for comparison on demographic variables | ||||||||
---|---|---|---|---|---|---|---|---|
N (%) | Cigs | CO | d(TgpA) | d(PfpA) | dGh | |||
Gender | Male | 10 (52%) |
t
| 1.187 |
2.205
| -0.409 | -0.318 | -0.580 |
Female | 9 (48%) |
p
| 0.251 |
0.041
| 0.688 | 0.755 | 0.569 | |
Race | White | 15 (79%) |
t
| 1.259 | 0.434 | -0.849 | -0.647 | 1.145 |
Black | 4 (21%) |
p
| 0.225 | 0.670 | 0.408 | 0.526 | 0.268 | |
Treatment Group | Active | 13 (68%) |
t
| -0.577 | 0.109 | -0.163 | 0.845 | 1.688 |
Placebo | 6 (32%) |
p
| 0.571 | 0.914 | 0.873 | 0.410 | 0.110 | |
Mean (SD) | Pearson correlation and p-value between biomarkers and smoking variables | |||||||
Age (years) | 50.2 (10.1) |
r
| -0.12 | 0.31 | -0.03 | -0.10 | -0.35 | |
p | 0.630 | 0.199 | 0.889 | 0.680 | 0.146 | |||
Years Smoked | 28.8 (9.6) |
r
| 0.22 | 0.40 | 0.04 | 0.01 | -0.14 | |
p
| 0.358 | 0.090 | 0.861 | 0.972 | 0.573 | |||
Cigarettes per Week | 126 (33) |
r
| 1.00 |
0.56
| -0.09 | -0.18 | 0.04 | |
p
| -- |
0.013
| 0.706 | 0.474 | 0.881 | |||
Carbon Monoxide (ppm) | 40.9 (3.7) |
r
|
0.56
| 1.00 | -0.29 | -0.22 | -0.05 | |
p
|
0.013
| -- | 0.225 | 0.357 | 0.848 |
Sample (N) | % abstinent | Cigarette per week (SEM) | d(TgpA) fmol/μg (SEM) | d(PfpA) fmol/μg (SEM) | dGhfmol/μg (SEM) | |||
---|---|---|---|---|---|---|---|---|
Unadj | Adj | Unadj | Adj | Unadj | Adj | |||
TQD - 4 weeks [baseline] (N = 19) | 0 | 126 (7.5) | 0.89 (1.15) | 1.06 (0.15) | 1.77 (1.13) | 1.93 (0.20) | 31.70 (1.12) | 33.15 (2.49) |
TQD [week 0] (N = 19) | 68.4 | 85 (8.7) | 0.55 (1.19) | 0.71 (0.10) | 1.51 (1.09) | 1.55 (0.12) | 21.97 (1.07) | 21.48 (1.68) |
TQD + 4 weeks [week 4] (N = 13) | 100 | 0 | 0.57 (1.17) | 0.64 (0.09) | 1.07 (1.14) | 1.12 (0.17) | 16.40 (1.11) | 15.76 (1.65) |
TQD +11 [week 11] (N = 10) | 100 | 0 | 0.81 (1.18) | 0.91 (0.13) | 1.25 (1.13) | 1.23 (0.14) | 15.56 (1.15) | 15.43 (2.60) |
d(TgpA) | d(PfpA) | dGh | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B | SE | Wald χ2(df = 1) | p | B | SE | Wald χ2(df = 1) | p | B | SE | Wald χ2(df = 1) | p | |
Intercept | 0.015 | 0.52 | 0.001 | 0.078 | 0.486 | 0.487 | 0.993 | 0.319 | 3.815 | 0.208 | 336.884 | <0.001 |
Active Tx | REF | REF | REF | |||||||||
Placebo | 0.044 | 0.11 | 0.020 | 0.185 | -0.193 | 0.132 | 2.139 | 0.085 |
-0.244
|
0.110
|
4.910
|
0.027
|
Female | REF | REF | REF | |||||||||
Male | 0.145 | 0.11 | 1.758 | 0.185 | 0.120 | 0.141 | 0.730 | 0.393 | 0.083 | 0.097 | 0.733 | 0.392 |
TQD - 4 weeks [baseline] | REF | REF | REF | |||||||||
TQD [week 0] | -0.398 | 0.22 | 3.170 | 0.075 | -0.221 | 0.129 | 2.958 | 0.085 |
-0.434
|
0.094
|
21.303
|
<0.001
|
TQD + 4 weeks [week 4] |
-0.496
|
0.17
|
8.454
|
0.004
|
-0.546
|
0.191
|
8.196
|
0.004
|
-0.744
|
0.124
|
36.068
|
<0.001
|
TQD +11 [week 11] | -0.147 | 0.24 | 0.387 | 0.534 |
-0.447
|
0.187
|
5.704
|
0.017
|
-0.765
|
0.202
|
14.299
|
<0.001
|
Age | -0.001 | 0.008 | 0.020 | 0.889 | 0.004 | 0.009 | 0.229 | 0.632 | -0.005 | 0.004 | 1.549 | 0.213 |