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Erschienen in: Breast Cancer Research 1/2002

01.02.2002 | Review

Regulation of BRCA1 expression and its relationship to sporadic breast cancer

verfasst von: Christopher R Mueller, Calvin D Roskelley

Erschienen in: Breast Cancer Research | Ausgabe 1/2002

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Abstract

Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has been shown to be common in sporadic tumours, and the magnitude of the decrease correlates with disease progression. BRCA1 expression is also tightly regulated during normal breast development. Determining how these developmental regulators of BRCA1 expression are co-opted during breast tumourigenesis could lead to a better understanding of sporadic breast cancer aetiology and the generation of novel therapeutic strategies aimed at preventing sporadic breast tumour progression.
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Metadaten
Titel
Regulation of BRCA1 expression and its relationship to sporadic breast cancer
verfasst von
Christopher R Mueller
Calvin D Roskelley
Publikationsdatum
01.02.2002
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2002
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr557

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