Background
Methods
Patients
Determination of GNAS1 T393C genotypes
Statistical analysis
Results
GNAS1 T393C genotype and clinical characteristics
All |
GNAS1 T393C genotype |
p value | |||
---|---|---|---|---|---|
TT | TC | CC | |||
Primary THA | |||||
n (%) | 231 | 52 (22.5) | 122 (52.8) | 57 (24.7) | |
Age at implantation (years) | 64.54 ± 10.9 | 62.12 ± 11.3 | 65.77 ± 10.0 | 64.12 ± 12.0 | 0.136 |
Gender | |||||
Female (%) | 151 (65.4) | 39 (25.8) | 80 (53.0) | 32 (21.2) | 0.118 |
Male (%) | 80 (34.6) | 13 (16.3) | 42 (52.5) | 25 (31.3) | |
BMI (kg/m2) | 27.31 ± 4.5 | 26.95 ± 4.6 | 27.64 ± 4.3 | 27.00 ± 4.9 | 0.556 |
Aseptic loosening | |||||
n (%) | 234 | 44 (18.8) | 126 (53.8) | 64 (27.4) | |
Age at implantation (years) | 52.80 ± 12.8 | 51.44 ± 13.6 | 53.08 ± 13.1 | 53.22 ± 11.6 | 0.735 |
Age at replantation (years) | 65.34 ± 12.4 | 63.20 ± 12.6 | 65.53 ± 12.7 | 66.46 ± 11.9 | 0.399 |
Gender | |||||
Female (%) | 165 (70.5) | 31 (18.8) | 87 (52.7) | 47 (28.5) | 0.821 |
Male (%) | 69 (29.5) | 13 (18.8) | 39 (56.5) | 17 (24.6) | |
BMI (kg/m2) | 26.94 ± 5.9 | 27.15 ± 4.8 | 27.13 ± 7.0 | 26.45 ± 3.9 | 0.734 |
First cup with cement (n = 212) | |||||
No | 73 (34.4) | 15 (20.5) | 37 (50.7) | 21 (28.8) | 0.749 |
Yes | 139 (65.6) | 26 (18.7) | 78 (56.1) | 35 (25.2) | |
First stem with cement (n = 213) | |||||
No | 75 (35.2) | 14 (18.7) | 42 (56.0) | 19 (25.3) | 0.946 |
Yes | 138 (64.8) | 27 (19.6) | 74 (53.6) | 37 (26.8) |
GNAS1 T393C genotype and time to aseptic loosening
All | Gender |
p value | ||
---|---|---|---|---|
Female | Male | |||
n (%) | 234 | 165 (70.5) | 69 (29.5) | |
MTAL, months (range) | 142 (1–431) | 152 (1–431) | 132 (3–396) | 0.576 |
All |
GNAS1 T393C genotype |
p value | |||
---|---|---|---|---|---|
TT | TC | CC | |||
n (%) | 234 | 44 (18.8) | 126 (53.8) | 64 (27.4) | |
MTAL, months (range) | 142 (1–431) | 134.5 (1–405) | 144 (1–431) | 141.5 (2–397) | 0.667 |
Female | |||||
n (%) | 165 | 31 (18.8) | 87 (52.7) | 47 (28.5) | |
MTAL, months (range) | 152 (1–431) | 137 (1–405) | 159 (1–431) | 173 (2–397) | 0.353* |
Male | |||||
n (%) | 69 | 13 (18.8) | 39 (56.5) | 17 (24.6) | |
MTAL, months (range) | 132 (3–396) | 128 (27–354) | 144 (3–396) | 108 (12–304) | 0.868 |
Variable | Multivariate analysis | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All | Female | Male | ||||||||||
p* |
p
| HR | 95% CI |
p* |
p
| HR | 95% CI |
p* |
p
| HR | 95% CI | |
T393C | ||||||||||||
TT | 1a
| 1a
| 1a
| |||||||||
TC | 0.648 | 0.427 | 0.868 | 0.61–1.23 | 0.166 | 0.079 | 0.685 | 0.45–1.05 | 0.354 | 0.329 | 1.407 | 0.71–2.79 |
CC | 0.564 | 0.342 | 0.828 | 0.56–1.22 | 0.172 | 0.124 | 0.695 | 0.44–1.11 | 0.344 | 0.572 | 1.245 | 0.58–2.66 |
Age | <0.001 | <0.001 | 1.037 | 1.02–1.05 | <0.001 | <0.001 | 1.036 | 1.02–1.05 | 0.003 | 0.002 | 1.039 | 1.01–1.06 |
BMI | 0.158 | 0.030 | 1.020 | 1.00–1.04 | 0.286 | 0.068 | 1.018 | 0.99–1.04 | 0.192 | 0.176 | 1.051 | 0.98–1.13 |