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29.08.2019 | Original Paper

Relationship between West African ancestry with lung cancer risk and survival in African Americans

verfasst von: Khadijah A. Mitchell, Ebony Shah, Elise D. Bowman, Adriana Zingone, Noah Nichols, Sharon R. Pine, Rick A. Kittles, Bríd M. Ryan

Erschienen in: Cancer Causes & Control | Ausgabe 11/2019

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Abstract

Purpose

African Americans, especially men, have a higher incidence of lung cancer compared with all other racial and ethnic groups in the US. Self-reported race is frequently used in genomic research studies to capture an individual’s race or ethnicity. However, it is clear from studies of genetic admixture that human genetic variation does not segregate into the same biologically discrete categories as socially defined categories of race. Previous studies have suggested that the degree of West African ancestry among African Americans can contribute to cancer risk in this population, though few studies have addressed this question in lung cancer.

Methods

Using a genetic ancestry panel of 100 SNPs, we estimated West African, European, and Native American ancestry in 1,407 self-described African Americans and 2,413 European Americans.

Results

We found that increasing West African ancestry was associated with increased risk of lung cancer among African American men (OR_{Q5 vs Q1} = 2.55 (1.45–4.48), p = 0.001), while no association was observed in African American women (OR_{Q5 vs Q1} = 0.90 (0.51–1.59), p = 0.56). This relationship diminished following adjustment for income and education.

Conclusions

Genetic ancestry is not a major contributor to lung cancer risk or survival disparities.

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Titel: Relationship between West African ancestry with lung cancer risk and survival in African Americans
verfasst von: Khadijah A. Mitchell
Ebony Shah
Elise D. Bowman
Adriana Zingone
Noah Nichols
Sharon R. Pine
Rick A. Kittles
Bríd M. Ryan
Publikationsdatum: 29.08.2019
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 11/2019
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-019-01212-z

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Relationship between West African ancestry with lung cancer risk and survival in African Americans