17.02.2017 | Author's reply
Reply to the Letter to the Editor of Y. Zhao, et al. concerning “Association between IGF1 gene single nucleotide polymorphism (rs5742612) and adolescent idiopathic scoliosis: a meta-analysis” by Ming Guan, Huan Wang et al. Eur Spine J (2016). doi:10.1007/s00586-016-4742-7
Erschienen in: European Spine Journal | Ausgabe 4/2017
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First of all, I would like to thank the authors for their thoughtful and critical remarks on our article entitled “Association between IGF1 gene single nucleotide polymorphism (rs5742612) and adolescent idiopathic scoliosis: a meta-analysis” [1]. We are very grateful for the kind comments and the opportunity to respond to the Letter to the Editor. Our responses are as follows:
Study
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Nikolova et al. [3]
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Moon et al. [4]
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Yang et al. [5]
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Yeung et al. [2]
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Selection
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Adequacy of case definition
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Multiple processes to ascertain case status, including reference to primary record source (a)a
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Multiple processes to ascertain case status, including reference to primary record source (a)a
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Multiple processes to ascertain case status, including reference to primary record source (a)a
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Multiple processes to ascertain case status, including reference to primary record source (a)a
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Representativeness of the cases
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All cases in defined hospitals and with outcome of the interest over a defined period of time (a)a
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All cases in a defined hospital and with outcome of the interest over a defined period of time (a)a
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All cases in a defined hospital and with outcome of the interest over a defined period of time (a)a
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All cases with outcome of the interest over a defined period of time (a)a
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Selection of controls
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Hospital controls and community controls; genetic polymorphism of interest not in HWE (b)
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Hospital controls and community controls; genetic polymorphism of interest in HWE (b)
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Hospital controls and community controls; genetic polymorphism of interest in HWE (b)
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No description of source; genetic polymorphism of interest in HWE (d)
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Definition of controls
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No history of AIS (a)a
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No history of AIS (a)a
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No history of AIS (a)a
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No history of AIS (a)a
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Comparability
|
||||
Cases and controls of homogeneous ethnic descent
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Homogeneous ethnic descent (a)a
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Homogeneous ethnic descent (a)a
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Homogeneous ethnic descent (a)a
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Homogeneous ethnic descent (a)a
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Population stratification
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No description (c)
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No description (c)
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No description (c)
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No description (c)
|
Exposure
|
||||
Ascertainment of exposure
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Not reported (c)
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Not reported (c)
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Not reported (c)
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Not reported (c)
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Same method of ascertainment for cases and controls
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Yes (a)a
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Yes (a)a
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Yes (a)a
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Yes (a)a
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Genotyping call rate
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Not reported (b)
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Not reported (b)
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Not reported (b)
|
Not reported (b)
|
Total
|
n = 5b
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n = 5b
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n = 5b
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n = 5b
|