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Journal of the Association for Research in Otolaryngology

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Open Access 01.08.2011

Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays

verfasst von: Marcel van der Heijden, Dries H. G. Louage, Philip X. Joris

Erschienen in: Journal of the Association for Research in Otolaryngology | Ausgabe 4/2011

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Abstract

The quality of temporal coding of sound waveforms in the monaural afferents that converge on binaural neurons in the brainstem limits the sensitivity to temporal differences at the two ears. The anteroventral cochlear nucleus (AVCN) houses the cells that project to the binaural nuclei, which are known to have enhanced temporal coding of low-frequency sounds relative to auditory nerve (AN) fibers. We applied a coincidence analysis within the framework of detection theory to investigate the extent to which AVCN processing affects interaural time delay (ITD) sensitivity. Using monaural spike trains to a 1-s broadband or narrowband noise token, we emulated the binaural task of ITD discrimination and calculated just noticeable differences (jnds). The ITD jnds derived from AVCN neurons were lower than those derived from AN fibers, showing that the enhanced temporal coding in the AVCN improves binaural sensitivity to ITDs. AVCN processing also increased the dynamic range of ITD sensitivity and changed the shape of the frequency dependence of ITD sensitivity. Bandwidth dependence of ITD jnds from AN as well as AVCN fibers agreed with psychophysical data. These findings demonstrate that monaural preprocessing in the AVCN improves the temporal code in a way that is beneficial for binaural processing and may be crucial in achieving the exquisite sensitivity to ITDs observed in binaural pathways.

Batra R, Kuwada S, Fitzpatrick DC (1997) Sensitivity to interaural temporal disparities of low- and high-frequency neurons in the superior olivary complex. I. Heterogeneity of responses. J Neurophysiol 78:1222–1236PubMed

Bernstein LR (2001) Auditory processing of interaural timing information: new insights. J Neurosci Res 66:1035–1046PubMedCrossRef

Bernstein LR, Trahiotis C (1994) Detection of interaural delay in high-frequency sinusoidally amplitude-modulated tones, two-tone complexes, and bands of noise. J Acoust Soc Am 95:3561–3567PubMedCrossRef

Bernstein LR, Trahiotis C (2003) Enhancing interaural-delay-based extends of laterality at high frequencies by using “transposed stimuli”. J Acoust Soc Am 113:3335–3347PubMedCrossRef

Blackburn CC, Sachs MB (1989) Classification of unit types in the anteroventral cochlear nucleus: PST histograms and regularity analysis. J Neurophysiol 62:1303–1329PubMed

Blauert J (1983) Spatial hearing. MIT, Cambridge

Brand A, Behrend O, Marquardt T, McAlpine D, Grothe B (2002) Precise inhibition is essential for microsecond interaural time difference coding. Nature 417:543–547PubMedCrossRef

Cant NB, Hyson RL (1992) Projections from the lateral nucleus of the trapezoid body to the medial superior olivary nucleus in the gerbil. Hear Res 58:26–34PubMedCrossRef

Carney LHC (1990) Sensitivities of cells in anteroventral cochlear nucleus of cat to spatiotemporal discharge patterns across primary afferents. J Neurophysiol 64:437–456PubMed

Colburn HS (1973) Theory of binaural interaction based on auditory-nerve data. I. General strategy and preliminary results on interaural discrimination. J Acoust Soc Am 54:1458–1470PubMedCrossRef

Colburn HS (1977) Theory of binaural interaction based on auditory-nerve data. II. Detection of tones in noise. J Acoust Soc Am 61:525–533PubMedCrossRef

Colburn HS, Kulkarni A (2005) Models of sound localization. In: Popper A, Fay R (eds) Sound source localization. Springer, New York, pp 272–316CrossRef

Colburn HS, Latimer JS (1978) Theory of binaural interaction based on auditory-nerve data. III. Joint dependence on interaural time and amplitude differences in discrimination and detection. J Acoust Soc Am 64:95–106PubMedCrossRef

Durlach NI, Colburn HS (1978) Binaural phenomena. In: Carterette EC, Friedman MP (eds) Handbook of Perception. Academic, New York, pp 365–466

Finlayson PG, Caspary DM (1991) Low-frequency neurons in the lateral superior olive exhibit phase-sensitive binaural inhibition. J Neurophysiol 65:598–605PubMed

Frisina RD, Smith RL, Chamberlain SC (1990) Encoding of amplitude modulation in the gerbil cochlear nucleus: I. A hierarchy of enhancement. Hear Res 44:99–122PubMedCrossRef

Goldberg JM, Brown PB (1969) Response of binaural neurons of dog superior olivary complex to dichotic tonal stimuli: some physiological mechanisms of sound localization. J Neurophysiol 32:613–636PubMed

Green DM, Swets JA (1966) Signal detection theory and psychophysics. Wiley, New York

Grothe B, Sanes DH (1994) Synaptic inhibition influences the temporal coding properties of medial superior olivary neurons: an in vitro study. J Neurosci 14:1701–1709PubMed

Hancock KE, Delgutte B (2004a) A physiologically based model of interaural time difference discrimination. J Neurosc 24:7110–7117CrossRef

Hancock KE, Delgutte B (2004b) A physiologically based model of interaural time difference discrimination. J Neurosci 24:7110–7117PubMedCrossRef

Harper NS, McAlpine D (2004) Optimal neural population coding of an auditory spatial cue. Nature 430:682–686PubMedCrossRef

Jeffress LA (2004) A place theory of sound localization. J Comp Psychol 44(35–39):1948

Joris PX (2003) Interaural time sensitivity dominated by cochlea-induced envelope patterns. J Neurosci 23:6345–6350PubMed

Joris PX, Smith PH (1998) Temporal and binaural properties in dorsal cochlear nucleus and its output tract. J Neurosci 18:10157–10170PubMed

Joris PX, Smith PH (2008) The volley theory and the spherical cell puzzle. Neuroscience 154:65–76PubMedCrossRef

Joris PX, Yin TCT (1990) Time sensitivity of cells in the lateral superior olive (LSO) to monaural and binaural amplitude-modulated complexes. Assoc Res Otolaryngol Abstr 13:267–268

Joris PX, Yin TCT (1998) Envelope coding in the lateral superior olive. III. Comparison with afferent pathways. J Neurophysiol 79:253–269PubMed

Joris P, Yin TC (2007) A matter of time: internal delays in binaural processing. Trends Neurosci 30:70–78PubMedCrossRef

Joris PX, Carney LHC, Smith PH, Yin TCT (1994) Enhancement of synchronization in the anteroventral cochlear nucleus. I. Responses to tonebursts at characteristic frequency. J Neurophysiol 71:1022–1036PubMed

Joris PX, Schreiner CE, Rees A (2004) Neural processing of amplitude-modulated sounds. Physiol Rev 84:541–577PubMedCrossRef

Joris PX, van de Sande B, Louage DH, van der Heijden M (2006a) Binaural and cochlear disparities. Proc Natl Acad Sci USA 103:12917–12922CrossRef

Joris PX, Louage DH, Cardoen L, van der Heijden M (2006b) Correlation Index: a new metric to quantify temporal coding. Hear Res 216–217:19–30

Klumpp RG, Eady HR (1956) Some measurements of interaural time difference thresholds. J Acoust Soc Am 28:859–860CrossRef

Louage DHG, van der Heijden M, Joris PX (2004) Temporal properties of responses to broadband noise in the auditory nerve. J Neurophysiol 91:2051–2065PubMedCrossRef

Louage DHG, van der Heijden M, Joris PX (2005) Enhanced temporal response properties of anteroventral cochlear nucleus neurons to broadband noise. J Neurosci 25:1560–1570PubMedCrossRef

Louage DHG, Joris PX, van der Heijden M (2006) Decorrelation sensitvity of Auditory Nerve and Anteroventral Cochlear nucleus fibers to broadband and narrowband noise. J Neurosc 26:96–108CrossRef

Macpherson EA, Middlebrooks JC (2002) Listener weighting of cues for lateral angle: the duplex theory of sound localization revisited. J Acoust Soc Am 111:2219–2236PubMedCrossRef

Marquardt T, McAlpine D (2007) A pi-limit for coding ITDs: implications for binaural models. In: Kollmeier B, Hohmann V, Mauermann M, Verhey J, Klump G, Langemann U, Uppenkamp S (eds) Hearing—from sensory processing to perception. Springer, Berlin, pp 407–416CrossRef

Mc Laughlin M, Van de Sande B, van der Heijden M, Joris PX (2007) Comparison of bandwidths in the inferior colliculus and the auditory nerve. I. Measurement using a spectrally manipulated stimulus. J Neurophysiol 98:2566–2579PubMedCrossRef

Mc Laughlin M, Chabwine JN, van der Heijden M, Joris PX (2008) Comparison of bandwidths in the inferior colliculus and the auditory nerve. II: Measurement using a temporally manipulated stimulus. J Neurophysiol 100:2312–2327PubMedCrossRef

McAlpine D, Jiang D, Palmer AR (2001) A neural code for low frequency sound localization in mammals. Nat Neurosci 4:396–401PubMedCrossRef

Paolini AG, FitzGerald JV, Burkitt AN, Clark GM (2001) Temporal processing from the auditory nerve to the medial nucleus of the trapezoid body in the rat. Hear Res 159:101–116PubMedCrossRef

Pecka M, Brand A, Behrend O, Grothe B (2008) Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition. J Neurosci 28:6914–6925PubMedCrossRef

Pfeiffer RR (1966) Classification of response patterns of spike discharges for units in the cochlear nucleus: tone-burst stimulation. Exp Brain Res 1:220–235PubMedCrossRef

Rhode WS, Greenberg S (1994) Encoding of amplitude modulation in the cochlear nucleus of the cat. J Neurophysiol 71:1797–1825PubMed

Rhode WS, Smith PH (1986) Encoding timing and intensity in the ventral cochlear nucleus of the cat. J Neurophysiol 56:261–286PubMed

Schiano JL, Trahiotis C, Bernstein LR (1986) Lateralization of low-frequency tones and narrow bands of noise. J Acoust Soc Am 79:1563–1570PubMedCrossRef

Shackleton TM, Skottun BC, Arnott RH, Palmer AR (2003) Interaural time difference discrimination thresholds for single neurons in the inferior colliculus of Guinea pigs. J Neurosci 23:716–724PubMed

Shackleton TM, Palmer AR (2006) Contributions of intrinsic neural and stimulus variance to binaural sensitivity. J Assoc Res Otolaryngol 7:425–442

Simon HJ, Collins CC, Jampolsky A, Morledge DE, Yu J (1994) The measurement of the lateralization of narrow bands of noise using an acoustic pointing paradigm: the effect of sound-pressure level. J Acoust Soc Am 95:1534–1547PubMedCrossRef

Siveke I, Pecka M, Seidl AH, Baudoux S, Grothe B (2006) Binaural response properties of low-frequency neurons in the Gerbil dorsal nucleus of the lateral lemniscus. J Neurophysiol 96:1425–1440PubMedCrossRef

Skottun BC, Shackleton TM, Arnott RH, Palmer AR (2001) The ability of inferior colliculus neurons to signal differences in interaural delay. Proc Natl Acad Sci USA 98:14050–14054PubMedCrossRef

Smith PH, Joris PX, Carney LHC, Yin TCT (1991) Projections of physiologically characterized globular bushy cell axons from the cochlear nucleus of the cat. J Comp Neurol 304:387–407PubMedCrossRef

Smith PH, Joris PX, Yin TC (1993) Projections of physiologically characterized spherical bushy cell axons from the cochlear nucleus of the cat: evidence for delay lines to the medial superior olive. J Comp Neurol 331:245–260PubMedCrossRef

Smith PH, Joris PX, Yin TCT (1998) Anatomy and physiology of principal cells of the medial nucleus of the trapezoid body (MNTB) of the cat. J Neurophysiol 79:3127–3142PubMed

Spirou GA, Brownell WE, Zidanic M (1990) Recordings from cat trapezoid body and HRP labeling of globular bushy cell axons. J Neurophysiol 63:1169–1190PubMed

Spitzer MW, Semple MN (1995) Neurons sensitive to interaural phase disparity in gerbil superior olive: diverse monaural and temporal response properties. J Neurophysiol 73:1668–1690PubMed

Tollin DJ, Yin TC (2005) Interaural phase and level difference sensitivity in low-frequency neurons in the lateral superior olive. J Neurosci 25:10648–10657PubMedCrossRef

Trahiotis C, Bernstein L, Stern R, Buell T (2005) Interaural correlation as the basis of a working model of binaural processing: an introduction. In: Popper A, Fay R (eds) Sound source localization. Springer, New York, pp 238–271CrossRef

van de Par S, Trahiotis C, Bernstein L (2001) A consideration of the normalization that is typically included in correlation-based models of binaural detection. J Acoust Soc Am 109:830–833PubMedCrossRef

Wang X, Sachs MB (1994) Neural encoding of single-formant stimuli in the cat. II. Responses of anteroventral cochlear nucleus units. J Neurophysiol 71:59–78PubMed

Wightman FL, Kistler DJ (1992) The dominant role of low-frequency interaural time differences in sound localization. J Acoust Soc Am 91:1648–1661PubMedCrossRef

Yin TCT, Chan JCK (1990) Interaural time sensitivity in medial superior olive of cat. J Neurophysiol 64:465–488PubMed

Yin TCT, Kuwada S (1983) Binaural interaction in low-frequency neurons in inferior colliculus of the cat. III. Effects of changing frequency. J Neurophysiol 50:1020–1042PubMed

Titel: Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays
verfasst von: Marcel van der Heijden
Dries H. G. Louage
Philip X. Joris
Publikationsdatum: 01.08.2011
Verlag: Springer-Verlag
Erschienen in: Journal of the Association for Research in Otolaryngology / Ausgabe 4/2011
Print ISSN: 1525-3961
Elektronische ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-011-0268-1

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Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays

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