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Clinical Orthopaedics and Related Research®

Erschienen in:

01.04.2014 | Symposium: Thumb Carpometacarpal Arthritis

Review of the Molecular Development of the Thumb: Digit Primera

verfasst von: Kerby C. Oberg, MD, PhD

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 4/2014

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Abstract

Background

The thumb, or digit 1, is not a typical digit. In addition to its unusual mobility and function, its formation is also unusual. It is the last digit to form and the most commonly targeted when limb development is disrupted. The thumb domain is defined by the overlapping expression of HOXA13, TBX5, GLI3R, and HOXD13 and, importantly, by an absence of other distal HOXD transcription factors. This brief review, combining developmental biology and clinical genetics, discusses the current understanding of how the thumb domain is established.

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Titel: Review of the Molecular Development of the Thumb: Digit Primera
verfasst von: Kerby C. Oberg, MD, PhD
Publikationsdatum: 01.04.2014
Verlag: Springer US
Erschienen in: Clinical Orthopaedics and Related Research® / Ausgabe 4/2014
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-013-3008-5

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