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Translational Stroke Research
Erschienen in: Translational Stroke Research 6/2023

12.11.2022 | Review Article

Revisiting Transcranial Light Stimulation as a Stroke Therapeutic—Hurdles and Opportunities

verfasst von: Wuwei Feng, Alexis Domeracki, Christine Park, Shreyansh Shah, Pratik Y. Chhatbar, Swaroop Pawar, Cherylee Chang, Po-Chun Hsu, Eric Richardson, David Hasan, Estate Sokhadze, Quanguang Zhang, Hanli Liu

Erschienen in: Translational Stroke Research | Ausgabe 6/2023

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Abstract

Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the end, we propose potential future opportunities with transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.
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Metadaten
Titel
Revisiting Transcranial Light Stimulation as a Stroke Therapeutic—Hurdles and Opportunities
verfasst von
Wuwei Feng
Alexis Domeracki
Christine Park
Shreyansh Shah
Pratik Y. Chhatbar
Swaroop Pawar
Cherylee Chang
Po-Chun Hsu
Eric Richardson
David Hasan
Estate Sokhadze
Quanguang Zhang
Hanli Liu
Publikationsdatum
12.11.2022
Verlag
Springer US
Erschienen in
Translational Stroke Research / Ausgabe 6/2023
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-022-01103-7

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