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Current Oral Health Reports
Erschienen in: Current Oral Health Reports 1/2015

01.03.2015 | Systemic Diseases (M Bartold, Section Editor)

Rheumatoid Arthritis and Periodontal Disease: A Rheumatologist's Perspective

verfasst von: Elliot D. Rosenstein, Laura J. Kushner, Neil Kramer

Erschienen in: Current Oral Health Reports | Ausgabe 1/2015

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Abstract

Despite advances in our understanding of the inflammatory events that underlie rheumatoid arthritis (RA), which have led to targeted therapies that more effectively control the condition, the etiology of RA is not fully understood. With the discovery that serum antibodies to citrullinated peptides (ACPA) are highly specific for RA and that Porphyromonas gingivalis, the major pathogen responsible for periodontitis (PD), contains the enzyme responsible for the citrullination of peptides, a plausible explanation for observations of increased incidence and severity of PD in RA patients and an appreciation of pathogenic similarities between the two conditions has emerged. Studies of the effect of RA treatment on the severity of PD have been limited and conflicting, especially with respect to anti-TNF agents, but indicate the potential for IL-6 as a therapeutic target for both conditions. PD treatment appears to improve clinical and laboratory evidence of RA disease activity, and the response of RA to anti-TNF therapy is abrogated by the presence of PD. Thus, evaluation and treatment of PD can be recommended for all RA patients.
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Metadaten
Titel
Rheumatoid Arthritis and Periodontal Disease: A Rheumatologist's Perspective
verfasst von
Elliot D. Rosenstein
Laura J. Kushner
Neil Kramer
Publikationsdatum
01.03.2015
Verlag
Springer International Publishing
Erschienen in
Current Oral Health Reports / Ausgabe 1/2015
Elektronische ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-014-0038-3

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