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Erschienen in: International Orthopaedics 1/2010

01.01.2010 | Original Paper

Risk factors for accelerated polyethylene wear and osteolysis in ABG I total hip arthroplasty

verfasst von: Jiri Gallo, Vitezslav Havranek, Jana Zapletalova

Erschienen in: International Orthopaedics | Ausgabe 1/2010

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Abstract

We analysed data from 155 revisions of identical cementless hip prostheses to determine the influence of patient-, implant- and surgery-related factors on the polyethylene wear rate and size of periprosthetic osteolysis (OL). This was calculated by logistic regression analysis. Factors associated with an increased/decreased wear rate included position of the cup relative to Kohler’s line, increase in abduction angle of the cup, traumatic and inflammatory arthritis as a primary diagnosis, and patient height. Severe acetabular bone defects were predicted by an increased wear rate (odds ratio, OR = 5.782 for wear rate above 200 mm3/y), and increased height of the patient (OR = 0.905 per each centimetre). Predictors of severe bone defects in the femur were the increased wear rate (OR = 3.479 for wear rate above 200 mm3/y) and placement of the cup outside of the true acetabulum (OR = 3.292). Variables related to surgical technique were the most predictive of polyethylene wear rate.
Literatur
1.
Zurück zum Zitat Pearle AD, Crow MK, Rakshit DS, Wohlgemuth J, Nestor BJ (2007) Distinct inflammatory gene pathways induced by particles. Clin Orthop Relat Res 458:194–201PubMed Pearle AD, Crow MK, Rakshit DS, Wohlgemuth J, Nestor BJ (2007) Distinct inflammatory gene pathways induced by particles. Clin Orthop Relat Res 458:194–201PubMed
2.
Zurück zum Zitat Drees P, Eckardt A, Gay RE, Gay S, Huber LC (2007) Mechanisms of disease: molecular insights into aseptic loosening of orthopedic implants. Nat Clin Pract Rheumatol 3:165–171CrossRefPubMed Drees P, Eckardt A, Gay RE, Gay S, Huber LC (2007) Mechanisms of disease: molecular insights into aseptic loosening of orthopedic implants. Nat Clin Pract Rheumatol 3:165–171CrossRefPubMed
3.
Zurück zum Zitat McKellop HA (2007) The lexicon of polyethylene wear in artificial joints. Biomaterials 28:5049–5057CrossRefPubMed McKellop HA (2007) The lexicon of polyethylene wear in artificial joints. Biomaterials 28:5049–5057CrossRefPubMed
4.
Zurück zum Zitat Hopper RH Jr, Engh CA Jr, Fowlkes LB, Engh CA (2004) The pros and cons of polyethylene sterilization with gamma irradiation. Clin Orthop Relat Res 429:54–62CrossRefPubMed Hopper RH Jr, Engh CA Jr, Fowlkes LB, Engh CA (2004) The pros and cons of polyethylene sterilization with gamma irradiation. Clin Orthop Relat Res 429:54–62CrossRefPubMed
5.
Zurück zum Zitat Schmalzried TP, Dorey FJ, McKellop H (1998) The multifactorial nature of polyethylene wear in vivo. J Bone Joint Surg Am 80:1234–1242PubMed Schmalzried TP, Dorey FJ, McKellop H (1998) The multifactorial nature of polyethylene wear in vivo. J Bone Joint Surg Am 80:1234–1242PubMed
6.
Zurück zum Zitat Schmalzried TP, Shepherd EF, Dorey FJ, Jackson WO, dela Rosa M et al (2000) The John Charnley Award. Wear is a function of use, not time. Clin Orthop Relat Res 381:36–46CrossRefPubMed Schmalzried TP, Shepherd EF, Dorey FJ, Jackson WO, dela Rosa M et al (2000) The John Charnley Award. Wear is a function of use, not time. Clin Orthop Relat Res 381:36–46CrossRefPubMed
7.
Zurück zum Zitat Wroblewski BM, Siney PD, Fleming PA (2004) Wear of the cup in the Charnley LFA in the young patient. J Bone Joint Surg Br 86:498–503PubMed Wroblewski BM, Siney PD, Fleming PA (2004) Wear of the cup in the Charnley LFA in the young patient. J Bone Joint Surg Br 86:498–503PubMed
8.
Zurück zum Zitat Wan Z, Boutary M, Dorr LD (2008) The influence of acetabular component position on wear in total hip arthroplasty. J Arthroplasty 23:51–56CrossRefPubMed Wan Z, Boutary M, Dorr LD (2008) The influence of acetabular component position on wear in total hip arthroplasty. J Arthroplasty 23:51–56CrossRefPubMed
9.
Zurück zum Zitat Gallo J, Havranek V, Cechova I, Zapletalova J (2006) Influence of demographic, surgical and implant variables on wear rate and osteolysis in ABG I hip arthroplasty. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:135–141PubMed Gallo J, Havranek V, Cechova I, Zapletalova J (2006) Influence of demographic, surgical and implant variables on wear rate and osteolysis in ABG I hip arthroplasty. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150:135–141PubMed
10.
Zurück zum Zitat Gallo J, Langova K, Havranek V, Cechova I (2008) Poor survival of ABG I hip prosthesis in younger patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 152:163–168PubMed Gallo J, Langova K, Havranek V, Cechova I (2008) Poor survival of ABG I hip prosthesis in younger patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 152:163–168PubMed
11.
Zurück zum Zitat Oosterbos CJ, Rahmy AI, Tonino AJ, Witpeerd W (2004) High survival rate of hydroxyapatite-coated hip prostheses: 100 consecutive hips followed for 10 years. Acta Orthop Scand 75:127–133PubMedCrossRef Oosterbos CJ, Rahmy AI, Tonino AJ, Witpeerd W (2004) High survival rate of hydroxyapatite-coated hip prostheses: 100 consecutive hips followed for 10 years. Acta Orthop Scand 75:127–133PubMedCrossRef
12.
Zurück zum Zitat Garcia Araujo C, Fernandez Gonzalez J, Tonino A (1998) Rheumatoid arthritis and hydroxyapatite-coated hip prostheses: five-year results. International ABG Study Group. J Arthroplasty 13:660–667CrossRefPubMed Garcia Araujo C, Fernandez Gonzalez J, Tonino A (1998) Rheumatoid arthritis and hydroxyapatite-coated hip prostheses: five-year results. International ABG Study Group. J Arthroplasty 13:660–667CrossRefPubMed
13.
Zurück zum Zitat Rossi P, Sibelli P, Fumero S, Crua E (1995) Short-term results of hydroxyapatite-coated primary total hip arthroplasty. Clin Orthop Relat Res 310:98–102PubMed Rossi P, Sibelli P, Fumero S, Crua E (1995) Short-term results of hydroxyapatite-coated primary total hip arthroplasty. Clin Orthop Relat Res 310:98–102PubMed
14.
Zurück zum Zitat Gallo J, Havranek V, Hrabovsky M (2003) Measurement of retrieved polyethylene cup by universal microscope. Fine Mech Opt 48:333–338 (in Czech) Gallo J, Havranek V, Hrabovsky M (2003) Measurement of retrieved polyethylene cup by universal microscope. Fine Mech Opt 48:333–338 (in Czech)
15.
Zurück zum Zitat Gallo J, Havranek V, Zapletalova J, Mandat D (2006) Measurement of acetabular polyethylene wear of total hip replacement, using a universal measuring microscope. Characteristics of measurements. Acta Chir Orthop Traumatol Cech 73:28–33 (in Czech)PubMed Gallo J, Havranek V, Zapletalova J, Mandat D (2006) Measurement of acetabular polyethylene wear of total hip replacement, using a universal measuring microscope. Characteristics of measurements. Acta Chir Orthop Traumatol Cech 73:28–33 (in Czech)PubMed
16.
Zurück zum Zitat Charnley J (1972) The long-term results of low-friction arthroplasty of the hip performed as a primary intervention. J Bone Joint Surg Br 54:61–76PubMed Charnley J (1972) The long-term results of low-friction arthroplasty of the hip performed as a primary intervention. J Bone Joint Surg Br 54:61–76PubMed
17.
Zurück zum Zitat Pagnano W, Hanssen AD, Lewallen DG, Shaughnessy WJ (1996) The effect of superior placement of the acetabular component on the rate of loosening after total hip arthroplasty. J Bone Joint Surg Am 78:1004–1014PubMed Pagnano W, Hanssen AD, Lewallen DG, Shaughnessy WJ (1996) The effect of superior placement of the acetabular component on the rate of loosening after total hip arthroplasty. J Bone Joint Surg Am 78:1004–1014PubMed
18.
Zurück zum Zitat Saleh KJ, Holtzman J, Gafni A, Saleh L, Davis A et al (2001) Reliability and intraoperative validity of preoperative assessment of standardized plain radiographs in predicting bone loss at revision hip surgery. J Bone Joint Surg Am 83:1040–1046PubMed Saleh KJ, Holtzman J, Gafni A, Saleh L, Davis A et al (2001) Reliability and intraoperative validity of preoperative assessment of standardized plain radiographs in predicting bone loss at revision hip surgery. J Bone Joint Surg Am 83:1040–1046PubMed
19.
Zurück zum Zitat Wang D, Zhang W, Bakhai A (2004) Comparison of Bayesian model averaging and stepwise methods for model selection in logistic regression. Stat Med 23:3451–3467CrossRefPubMed Wang D, Zhang W, Bakhai A (2004) Comparison of Bayesian model averaging and stepwise methods for model selection in logistic regression. Stat Med 23:3451–3467CrossRefPubMed
20.
Zurück zum Zitat Karachalios T, Hartofilakidis G, Zacharakis N, Tsekoura M (1993) A 12- to 18-year radiographic follow-up study of Charnley low-friction arthroplasty. The role of the center of rotation. Clin Orthop Relat Res 296:140–147PubMed Karachalios T, Hartofilakidis G, Zacharakis N, Tsekoura M (1993) A 12- to 18-year radiographic follow-up study of Charnley low-friction arthroplasty. The role of the center of rotation. Clin Orthop Relat Res 296:140–147PubMed
21.
Zurück zum Zitat Wilkinson JM, Hamer AJ, Stockley I, Eastell R (2005) Polyethylene wear rate and osteolysis: critical threshold versus continuous dose-response relationship. J Orthop Res 23:520–525CrossRefPubMed Wilkinson JM, Hamer AJ, Stockley I, Eastell R (2005) Polyethylene wear rate and osteolysis: critical threshold versus continuous dose-response relationship. J Orthop Res 23:520–525CrossRefPubMed
22.
Zurück zum Zitat Orishimo KF, Sychterz CJ, Hopper RH Jr, Engh CA (2003) Can component and patient factors account for the variance in wear rates among bilateral total hip arthroplasty patients? J Arthroplasty 18:154–160CrossRefPubMed Orishimo KF, Sychterz CJ, Hopper RH Jr, Engh CA (2003) Can component and patient factors account for the variance in wear rates among bilateral total hip arthroplasty patients? J Arthroplasty 18:154–160CrossRefPubMed
23.
Zurück zum Zitat Johnston RC, Brand RA, Crowninshield RD (1979) Reconstruction of the hip. A mathematical approach to determine optimum geometric relationships. J Bone Joint Surg Am 61:639–652PubMed Johnston RC, Brand RA, Crowninshield RD (1979) Reconstruction of the hip. A mathematical approach to determine optimum geometric relationships. J Bone Joint Surg Am 61:639–652PubMed
24.
Zurück zum Zitat Hirakawa K, Mitsugi N, Koshino T, Saito T, Hirasawa Y et al (2001) Effect of acetabular cup position and orientation in cemented total hip arthroplasty. Clin Orthop Relat Res 388:135–142CrossRefPubMed Hirakawa K, Mitsugi N, Koshino T, Saito T, Hirasawa Y et al (2001) Effect of acetabular cup position and orientation in cemented total hip arthroplasty. Clin Orthop Relat Res 388:135–142CrossRefPubMed
25.
Zurück zum Zitat Patil S, Bergula A, Chen PC, Colwell CW Jr, D’Lima DD (2003) Polyethylene wear and acetabular component orientation. J Bone Joint Surg Am 85(Suppl 4):56–63PubMed Patil S, Bergula A, Chen PC, Colwell CW Jr, D’Lima DD (2003) Polyethylene wear and acetabular component orientation. J Bone Joint Surg Am 85(Suppl 4):56–63PubMed
26.
Zurück zum Zitat Del Schutte H Jr, Lipman AJ, Bannar SM, Livermore JT, Ilstrup D et al (1998) Effects of acetabular abduction on cup wear rates in total hip arthroplasty. J Arthroplasty 13:621–626CrossRefPubMed Del Schutte H Jr, Lipman AJ, Bannar SM, Livermore JT, Ilstrup D et al (1998) Effects of acetabular abduction on cup wear rates in total hip arthroplasty. J Arthroplasty 13:621–626CrossRefPubMed
27.
Zurück zum Zitat Nevelos JE, Ingham E, Doyle C, Nevelos AB, Fisher J (2001) The influence of acetabular cup angle on the wear of "BIOLOX Forte" alumina ceramic bearing couples in a hip joint simulator. J Mater Sci Mater Med 12:141–144CrossRefPubMed Nevelos JE, Ingham E, Doyle C, Nevelos AB, Fisher J (2001) The influence of acetabular cup angle on the wear of "BIOLOX Forte" alumina ceramic bearing couples in a hip joint simulator. J Mater Sci Mater Med 12:141–144CrossRefPubMed
28.
Zurück zum Zitat Kligman M, Michael H, Roffman M (2002) The effect of abduction differences between cup and contralateral acetabular angle on polyethylene component wear. Orthopedics 25:65–67PubMed Kligman M, Michael H, Roffman M (2002) The effect of abduction differences between cup and contralateral acetabular angle on polyethylene component wear. Orthopedics 25:65–67PubMed
29.
Zurück zum Zitat Digas G, Karrholm J, Thanner J, Malchau H, Herberts P (2003) Highly cross-linked polyethylene in cemented THA: randomized study of 61 hips. Clin Orthop Relat Res 417:126–138PubMed Digas G, Karrholm J, Thanner J, Malchau H, Herberts P (2003) Highly cross-linked polyethylene in cemented THA: randomized study of 61 hips. Clin Orthop Relat Res 417:126–138PubMed
30.
Zurück zum Zitat Chuter GS, Cloke DJ, Mahomed A, Partington PF, Green SM (2007) Wear analysis of failed acetabular polyethylene: a comparison of analytical methods. J Bone Joint Surg Br 89:273–279CrossRefPubMed Chuter GS, Cloke DJ, Mahomed A, Partington PF, Green SM (2007) Wear analysis of failed acetabular polyethylene: a comparison of analytical methods. J Bone Joint Surg Br 89:273–279CrossRefPubMed
31.
Zurück zum Zitat Pierrynowski MR, Galea V (2001) Enhancing the ability of gait analyses to differentiate between groups: scaling gait data to body size. Gait Posture 13:193–201CrossRefPubMed Pierrynowski MR, Galea V (2001) Enhancing the ability of gait analyses to differentiate between groups: scaling gait data to body size. Gait Posture 13:193–201CrossRefPubMed
32.
Zurück zum Zitat Vassiliou K, Unsworth A (2004) Is the wear factor in total joint replacements dependent on the nominal contact stress in ultra-high molecular weight polyethylene contacts? Proc Inst Mech Eng Part H-J Eng Med 218:101–107CrossRef Vassiliou K, Unsworth A (2004) Is the wear factor in total joint replacements dependent on the nominal contact stress in ultra-high molecular weight polyethylene contacts? Proc Inst Mech Eng Part H-J Eng Med 218:101–107CrossRef
33.
Zurück zum Zitat Jin ZM, Stone M, Ingham E, Fisher J (2006) Biotribology. Curr Orthop 20:32–40CrossRef Jin ZM, Stone M, Ingham E, Fisher J (2006) Biotribology. Curr Orthop 20:32–40CrossRef
34.
Zurück zum Zitat Charles MN, Bourne RB, Davey JR, Greenwald AS, Morrey BF et al (2005) Soft-tissue balancing of the hip: the role of femoral offset restoration. Instr Course Lect 54:131–141PubMed Charles MN, Bourne RB, Davey JR, Greenwald AS, Morrey BF et al (2005) Soft-tissue balancing of the hip: the role of femoral offset restoration. Instr Course Lect 54:131–141PubMed
35.
Zurück zum Zitat Bicanic G, Delimar D, Delimar M, Pecina M (2008) Influence of the acetabular cup position on hip load during arthroplasty in hip dysplasia. Int Orthop (in press). doi:10.1007/s00264-008-0683-z Bicanic G, Delimar D, Delimar M, Pecina M (2008) Influence of the acetabular cup position on hip load during arthroplasty in hip dysplasia. Int Orthop (in press). doi:10.​1007/​s00264-008-0683-z
36.
Zurück zum Zitat Sakalkale DP, Sharkey PF, Eng K, Hozack WJ, Rothman RH (2001) Effect of femoral component offset on polyethylene wear in total hip arthroplasty. Clin Orthop Relat Res 388:125–134CrossRefPubMed Sakalkale DP, Sharkey PF, Eng K, Hozack WJ, Rothman RH (2001) Effect of femoral component offset on polyethylene wear in total hip arthroplasty. Clin Orthop Relat Res 388:125–134CrossRefPubMed
37.
Zurück zum Zitat Roder C, Staub LP, Eichler P, Widmer M, Dietrich D et al (2006) Avoiding misclassification bias with the traditional Charnley classification: rationale for a fourth Charnley class BB. J Orthop Res 24:1803–1808CrossRefPubMed Roder C, Staub LP, Eichler P, Widmer M, Dietrich D et al (2006) Avoiding misclassification bias with the traditional Charnley classification: rationale for a fourth Charnley class BB. J Orthop Res 24:1803–1808CrossRefPubMed
38.
Zurück zum Zitat Dumbleton JH, Manley MT, Edidin AA (2002) A literature review of the association between wear rate and osteolysis in total hip arthroplasty. J Arthroplasty 17:649–661CrossRefPubMed Dumbleton JH, Manley MT, Edidin AA (2002) A literature review of the association between wear rate and osteolysis in total hip arthroplasty. J Arthroplasty 17:649–661CrossRefPubMed
39.
Zurück zum Zitat Kim WY, Muddu BN (2006) Eleven-year results of the ABG I hip replacement. Int Orthop 30:182–184CrossRefPubMed Kim WY, Muddu BN (2006) Eleven-year results of the ABG I hip replacement. Int Orthop 30:182–184CrossRefPubMed
40.
Zurück zum Zitat Blacha J (2004) High osteolysis and revision rate with the hydroxyapatite-coated ABG hip prostheses: 65 hips in 56 young patients followed for 5–9 years. Acta Orthop Scand 75:276–282PubMedCrossRef Blacha J (2004) High osteolysis and revision rate with the hydroxyapatite-coated ABG hip prostheses: 65 hips in 56 young patients followed for 5–9 years. Acta Orthop Scand 75:276–282PubMedCrossRef
41.
Zurück zum Zitat Delank KS, Drees P, Menzel N, Hansen T, Duschner H et al (2006) Increased polyethylene wear after cementless ABG I total hip arthroplasty. Arch Orthop Trauma Surg 126:509–516CrossRefPubMed Delank KS, Drees P, Menzel N, Hansen T, Duschner H et al (2006) Increased polyethylene wear after cementless ABG I total hip arthroplasty. Arch Orthop Trauma Surg 126:509–516CrossRefPubMed
42.
Zurück zum Zitat Badhe S, Livesley P (2006) Early polyethylene wear and osteolysis with ABG acetabular cups (7- to 12-year follow-up). Int Orthop 30:31–34CrossRefPubMed Badhe S, Livesley P (2006) Early polyethylene wear and osteolysis with ABG acetabular cups (7- to 12-year follow-up). Int Orthop 30:31–34CrossRefPubMed
43.
Zurück zum Zitat Castoldi F, Rossi R, La Russa M, Sibelli P, Rossi P et al (2007) Ten-year survivorship of the Anatomique Benoist Girard I total hip arthroplasty. J Arthroplasty 22:363–368CrossRefPubMed Castoldi F, Rossi R, La Russa M, Sibelli P, Rossi P et al (2007) Ten-year survivorship of the Anatomique Benoist Girard I total hip arthroplasty. J Arthroplasty 22:363–368CrossRefPubMed
44.
Zurück zum Zitat Canales Cortes V, Panisello Sebastia JJ, Herrera Rodriguez A, Peguero Bona A, Martinez Martin A et al (2006) Ten-year follow-up of an anatomical hydroxyapatite-coated total hip prosthesis. Int Orthop 30:84–90CrossRefPubMed Canales Cortes V, Panisello Sebastia JJ, Herrera Rodriguez A, Peguero Bona A, Martinez Martin A et al (2006) Ten-year follow-up of an anatomical hydroxyapatite-coated total hip prosthesis. Int Orthop 30:84–90CrossRefPubMed
45.
Zurück zum Zitat Ingram J, Matthews JB, Tipper J, Stone M, Fisher J et al (2002) Comparison of the biological activity of grade GUR 1120 and GUR 415HP UHMWPE wear debris. Bio-Med Mater Eng 12:177–188 Ingram J, Matthews JB, Tipper J, Stone M, Fisher J et al (2002) Comparison of the biological activity of grade GUR 1120 and GUR 415HP UHMWPE wear debris. Bio-Med Mater Eng 12:177–188
46.
Zurück zum Zitat Kurtz SM, Rimnac CM, Hozack WJ, Turner J, Marcolongo M et al (2005) In vivo degradation of polyethylene liners after gamma sterilization in air. J Bone Joint Surg Am 87:815–823CrossRefPubMed Kurtz SM, Rimnac CM, Hozack WJ, Turner J, Marcolongo M et al (2005) In vivo degradation of polyethylene liners after gamma sterilization in air. J Bone Joint Surg Am 87:815–823CrossRefPubMed
47.
Zurück zum Zitat Kurtz SM, Harrigan TP, Herr M, Manley MT (2005) An in vitro model for fluid pressurization of screw holes in metal-backed total joint components. J Arthroplasty 20:932–938CrossRefPubMed Kurtz SM, Harrigan TP, Herr M, Manley MT (2005) An in vitro model for fluid pressurization of screw holes in metal-backed total joint components. J Arthroplasty 20:932–938CrossRefPubMed
Metadaten
Titel
Risk factors for accelerated polyethylene wear and osteolysis in ABG I total hip arthroplasty
verfasst von
Jiri Gallo
Vitezslav Havranek
Jana Zapletalova
Publikationsdatum
01.01.2010
Verlag
Springer-Verlag
Erschienen in
International Orthopaedics / Ausgabe 1/2010
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-009-0731-3

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