Risk of imminent fracture following a previous fracture in a Swedish database study

Fragility fractures due to osteoporosis are common. More than nine million fragility fractures have been estimated worldwide based on the year 2000 [1], and in Europe, 3.5 million fragility fractures were reported to occur annually [2]. In a study of patient records in Malmö, Sweden, for women aged 50 years, the lifetime probability of a fragility fracture was 23% for hip fracture and 15% for clinical vertebral fracture [3]. Moreover, the number of fragility fractures is expected to rise as the population ages, and in Europe, a 28% increase in the number of fragility fractures has been estimated by 2025 [4].

Fragility fractures cause substantial individual burden related to the significant reduction in a patient’s mobility, function, and quality of life [5, 6]. The increase in morbidities associated with fragility fractures is greater than can be attributed to aging alone and represents a major clinical problem [7]. Fragility fractures also lead to an increase in mortality [8‐12]. Consequently, an understanding of the variables leading to fracture is an important area of research, to enable treatment strategies to focus on those most at risk and effectively reduce the clinical burden of disease.

Multiple factors are known to increase the risk of sustaining a fragility fracture [13]. Among them, prior fragility fracture is a well-documented major risk factor for future fragility fracture [13‐17]. On average, the risk of future fracture is doubled in the presence of a prior fracture [18‐20]. In the Reykjavik study of 30,795 men and women, the risk of a second major osteoporotic fracture (MOF) within the year following the first fracture was 2.7-fold higher than the risk seen in the whole of the study population [21]. In addition, a significant number of patients who sustain a hip or wrist fracture have a history of up to three previous fractures [22].

The risk of a subsequent fracture changes over time, and the time elapsed since sustaining a prior fracture is now recognized as an important factor influencing subsequent fracture risk. The concept of “imminent risk” for fracture, defined as a markedly elevated risk of fracture within the next 12–24 months, has been emphasized [19, 23, 24]. In a study of postmenopausal women in The Netherlands, the risk of subsequent fracture was highest within the first year following the initial fracture [25]. This risk decreased over time, but remained higher compared with the whole of the study population during the follow-up period. Age is also an independent predictor of future fracture [21, 26]. In a study of women in the USA, the incidence of any clinical fracture at 1 and 2 years following the initial fracture was 10% and 18%, respectively [26], but the corresponding figures for women ≥ 75 years of age were higher, with a 2-year fracture risk of 25%. All-cause mortality is also highest in the year following a hip fracture [5, 10, 23, 27, 28].

Tools to assess the risk of fragility fracture are extensively used to make clinical decisions [29‐31]. FRAX®, University of Sheffield, in particular allows the identification of patients at high risk for fracture more effectively than bone mineral density (BMD) measures alone [32]. Accordingly, FRAX has proved useful in identifying individuals at risk of fracture over 10 years and assisting therapeutic decisions, but at present does not take into account the time since fracture or fracture location and was not primarily designed to identify patients at imminent risk of fracture. However, a recent publication suggests that FRAX could be adapted to predict fracture over a shorter period [33]. The need for research to identify the determinants of imminent fracture risk was recently reported in a consensus meeting for the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) [24].

Currently, many patients do not receive treatment for their osteoporosis after a fragility fracture, despite the recognition that sustaining a fracture increases the risk of a subsequent fracture [2, 13, 21, 34, 35]. Therefore, a more robust approach to the identification of patients at imminent risk of fracture is important and could prove relevant to determine the best treatment strategies for patients at increased fracture risk. This approach should also include other independent factors that may increase the risk of imminent fracture and may provide insights into a select group of patients in whom rapid intervention to decrease fracture risk is essential.

The aim of the current study was to determine the incidence of subsequent fractures within 1 and 2 years following a first fracture in a population-based study of women in Sweden, and to assess independent factors associated with subsequent fracture. This large-scale Swedish study was designed to strengthen the knowledge around the driving factors for imminent fracture risk.

In this study, we report the incidence of a subsequent fracture within 1 and 2 years following initial fracture in women ≥ 50 years of age in Sweden by index fracture type. The highest risk of subsequent fractures was observed following a clinical vertebral fracture. In addition, we show that even when taking into account the competing risk of death, advancing age and comorbidities remain strong independent risk factors for imminent fracture. We also observed a high frequency of usage of medications known to increase fall risk in the year before the index fracture.

In the current study, the incidence of subsequent fractures within 12 months was 7.1%, increasing to 12.0% at 24 months. This is similar to a previous study of 4140 postmenopausal women performed in The Netherlands, where the absolute risk of any subsequent fracture in the year following first fracture was 6.1% [25]. Unlike the current study, the study undertaken in The Netherlands was a questionnaire study and relied on the proportion of patients who responded to the request to complete the questionnaire; this is likely to introduce bias, as patients who had suffered a new fracture could have been overrepresented in the responding group. In the current study, all women in Sweden ≥ 50 years of age with a fracture during the period of study were included, thus limiting sources of possible bias.

Our data are comparable with a US study of 377,561 women, which also employed a retrospective database design [26] and where the incidence of any subsequent fracture was 10% within 1 year of initial fracture. In our study, at 12 months, the incidence of subsequent fracture was highest following index clinical vertebral fracture (16.2%). This is also consistent with the US database study, where the subsequent fracture rate following index vertebral fracture was approximately 14% at 12 months [26]. In an earlier study of women with an index hip fracture, conducted in Sweden, 15% of women re-fractured within 1 year [42]. The proportion was lower in our study; 7.4% of women with index hip fracture went on to have a fracture within the following year. This difference in finding may be due to differences in sample size, patient demographic, and analysis methods. For example, the earlier Swedish study [42] comprised 766 adult women aged > 20 years compared with the 51,904 women (≥ 50 years) with index hip fracture in the current study. Further, in the study by von Friesendorff et al., a Kaplan-Meier estimate was used to quantify fracture risk, while in our study, a cumulative incidence function was used. As we took the competing risk of death into account, the cumulative incidence function will give a lower estimate than the Kaplan-Meier method if competing events are present.

In addition to the well-known elevated risk of fracture that follows a fragility fracture, we identified several independent risk factors for imminent fracture in this study. Age was an important factor; the HRs of age > 80 years compared with age 50–59 years were greater than 3.0. Age was also identified in other studies of risk factors for imminent fracture [23, 26, 43‐46]. The risk of imminent fracture was doubled for every additional decade after age 50 years in a study of patients with no recent fracture [23]. A further study showed that incidence of subsequent fracture was higher with increasing age, with a HR of 1.2 per decade [44].

The risk factors identified in the current study are generally consistent with the risk factors included in the FRAX algorithm, i.e., age, rheumatic disease, and glucocorticoid use. However, we also identified other significant risk factors not included in FRAX, such as the use of a multi-dose drug dispensing service in the last 12 months, drugs that are associated with an increase in risk of falls, and specific comorbidities. Our data are consistent with the findings of the US Study of Osteoporotic Fractures (SOF), where independent predictors of any non-vertebral fracture within 1 year of follow-up included age, prior fracture, Parkinson’s disease or cerebrovascular disease, total hip T-score, prior falls, walking speed, and smoking [28]. However, in SOF, the 1-year follow-up period was not anchored to an index fragility fracture as in our study. Unlike the SOF study, in the current study, we did not capture data on falls, walking speed, or smoking status. In our study, the use of assisted drug dispensing was used as a broad proxy for dependency, frailty, medication burden, and functional and cognitive impairment, which we hypothesized would be associated with increased risk of fracture. Our findings were consistent with this hypothesis, as use of the ApoDos system was associated with a significantly increased risk of fracture.

We acknowledge that our study has some limitations. Diagnosis of fracture in this study was based on medical records, and we were not able to verify that all sustained fractures were associated with a low-trauma event. Therefore, it was not possible to make an absolute diagnosis of fragility fracture in all cases. Only ICD-10-coded clinical vertebral fractures were identified. Clinical vertebral fractures are a subset of all vertebral fractures; therefore, our numbers likely represent an underestimate of the true incidence and prevalence of vertebral fractures. While we acknowledge the limitations in the accuracy of fracture diagnoses, the diagnosis of hip fracture is expected to be more accurate than for vertebral fractures. Hip fractures were based on the ICD-10 code S72.x. Unlike previous studies [47, 48], we did not base the identification of hip fracture on the surgical procedure code as this would exclude women who (1) died shortly after hip fracture before undergoing surgery, (2) were too frail to undergo such a procedure and/or terminally ill, and (3) patients who were transferred elsewhere for the procedure. Still, our data are likely to underestimate the incidence of subsequent fractures. We observed a higher risk of subsequent fracture in patients using osteoporosis medications, which may be explained by a potential channeling bias; this has also been observed in previous studies [49]. A history of falls is a known strong predictor of imminent future fracture [23, 28]; data on falls were not available in our study. In addition, we examine data from a single country, and findings may not be transferable to other countries or populations. However, our study also has some major strengths. It is a large inclusive sample providing data on every diagnosed fracture in Sweden during the period of investigation. The Swedish social security number, which is unique for each citizen, allows for following patients over time and allows data to be linked to other registers, i.e., the PDR and the Cause of Death Register. In addition, minimal exclusion criteria were applied; therefore, it arguably provides a more representative depiction of events in a real-world clinical setting than that reported in smaller, more selective studies. Our study provides a comprehensive account of the incidence of subsequent fractures in women with a previous fracture and the risk factors associated with subsequent fractures; it does not, however, provide an estimate of the level of fracture risk compared with a control population.

In summary, there has been extensive research estimating fracture risk over a patient’s lifetime, but there is less evidence describing imminent fracture risk (within 12 and 24 months). Imminent risk of fragility fracture has been identified as an important area for further research [19, 24], provides an opportunity for rapid interventions to reduce future fracture events, and is key to the appropriate treatment of those patients at the highest risk of fracture. In such patients, to positively impact osteoporosis management, it is necessary to intervene with therapies proven to rapidly decrease fracture risk. Identifying individuals at imminent risk for fracture can be achieved through the recognition of associated risk factors, such as a recent fragility fracture and older age. In view of the current under treatment of patients at increased risk for fracture and in particular of those who have already suffered a fragility fracture, our findings highlight the need and the opportunity to put in place healthcare systems to intervene rapidly after a fracture, such as Fracture Liaison Services, or other forms of organized care intervention, linking orthopedic and emergency departments with doctors providing the longer term care of patients with fragility fractures. Indeed, the occurrence of a fragility fracture provides physicians and medical systems with a unique opportunity to act to reduce the risk of subsequent fractures.