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European Journal of Epidemiology

Erschienen in:

01.10.2018 | CANCER

Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study

verfasst von: Kristin Benjaminsen Borch, Elisabete Weiderpass, Tonje Braaten, Merethe Selnes Hansen, Idlir Licaj

Erschienen in: European Journal of Epidemiology | Ausgabe 5/2019

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Abstract

We aimed to investigate physical activity (PA) and risk of different histological subtypes of lung cancer according to smoking status and body mass index using repeated measurements in a large cohort of women in Norway. The study sample for the multiple imputation analyses consisted of 86,499 and for the complete-case analysis 80,802 women. Repeated measurements of PA level, smoking habits, weight, and height were available for 54,691 women (63.2%), who were included in repeated measurement analyses combined with multiple imputation to address attrition. Cox proportional hazards regression models were used to calculate hazard ratios with 95% confidence intervals. During a median follow-up of 12.9 years, 866 cases of primary lung cancer were identified. We found an inverse association between PA and lung cancer overall. The results were consistent from multiple imputed data analysis to complete-case analysis of PA and possible confounders. We observed a similar trend for adenocarcinoma, but not for squamous cell or small cell carcinomas. Our findings suggest a more pronounced association between lung cancer overall and PA levels in current and former smokers, and in normal-weight and overweight participants with increasing PA levels. The potential of a modifiable lifestyle factor as PA to reduce the risk of lung cancer independently of smoking status is important in public health.

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Titel: Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study
verfasst von: Kristin Benjaminsen Borch
Elisabete Weiderpass
Tonje Braaten
Merethe Selnes Hansen
Idlir Licaj
Publikationsdatum: 01.10.2018
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 5/2019
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-018-0446-0

Springer Medizin

Abstract

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