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International Archives of Occupational and Environmental Health

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15.04.2019 | Original Article

Risk of mesothelioma after cessation of asbestos exposure: a systematic review and meta-regression

verfasst von: Paolo Boffetta, Francesca Donato, Enrico Pira, Hung N. Luu, Carlo La Vecchia

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 7/2019

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Abstract

Purpose

A ‘risk reversal’ has been observed for several human carcinogens following cessation of exposure, but it is unclear whether it also exists for asbestos-related mesothelioma.

Methods

We conducted a systematic review of the literature and identified nine studies that reported information on risk of mesothelioma after cessation of asbestos exposure, and performed a meta-regression based on random effects models. As comparison we analyzed results on lung cancer risk from four of these studies.

Results

A total of six risk estimates from five studies were included in the meta-analysis. The summary relative risk (RR) of mesothelioma for 10-year interval since cessation of exposure was 1.02 [95% confidence interval (CI) 0.87–1.19; p-heterogeneity 0.01]. The corresponding RR of lung cancer was 0.91 (95% CI 0.84–0.98).

Conclusions

This analysis provides evidence that the risk of mesothelioma does not decrease after cessation of asbestos exposure, while lung cancer risk does.

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Titel: Risk of mesothelioma after cessation of asbestos exposure: a systematic review and meta-regression
verfasst von: Paolo Boffetta
Francesca Donato
Enrico Pira
Hung N. Luu
Carlo La Vecchia
Publikationsdatum: 15.04.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 7/2019
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-019-01433-4

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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