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European Journal of Nuclear Medicine and Molecular Imaging

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01.05.2014 | Original Article

Role of ⁶⁸Ga-DOTATOC PET/CT in initial evaluation of patients with suspected bronchopulmonary carcinoid

verfasst von: Balasubramanian Venkitaraman, Sellam Karunanithi, Arvind Kumar, G. C. Khilnani, Rakesh Kumar

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 5/2014

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Abstract

Purpose

The objective of this study was to evaluate the role of ⁶⁸Ga-DOTATOC positron emission tomography (PET)/CT scan in patients with suspected pulmonary carcinoid tumour and to compare its results with ¹⁸F-fluorodeoxyglucose (FDG) PET/CT scan.

Methods

In this prospective study, 32 patients (age 34.22 ± 12.03 years; 53.1 % female) with clinical suspicion of bronchopulmonary carcinoid were evaluated with ⁶⁸Ga-DOTATOC PET/CT and ¹⁸F-FDG PET/CT. The two imaging modalities were compared, considering the tissue diagnosis as the reference standard.

Results

Based on the reference standard 26 cases were carcinoid tumours [21 typical carcinoids (TC) and 5 atypical carcinoids (AC)] and 6 cases were non-carcinoid tumours. The sensitivity, specificity and accuracy of ⁶⁸Ga-DOTATOC PET/CT in the diagnosis of pulmonary carcinoid tumour were 96.15, 100 and 96.87 % respectively, whereas those of ¹⁸F-FDG PET/CT were 78.26, 11.1 and 59.37 % respectively. The maximum standardised uptake value (SUV_max) of TC on ⁶⁸Ga-DOTATOC PET/CT scan ranged from 3.58 to 55, while that of AC ranged from 1.1 to 32.5. ¹⁸F-FDG PET/CT was true-positive in all cases of AC and false-negative in eight cases of TC (sensitivity for TC 61.9 % and for AC 100 %).

Conclusion

⁶⁸Ga-DOTATOC PET/CT is a useful imaging investigation for the evaluation of pulmonary carcinoids. ¹⁸F-FDG PET/CT scan suffers from low sensitivity and specificity in differentiating the pulmonary carcinoids from other tumours.

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Titel: Role of 68Ga-DOTATOC PET/CT in initial evaluation of patients with suspected bronchopulmonary carcinoid
verfasst von: Balasubramanian Venkitaraman
Sellam Karunanithi
Arvind Kumar
G. C. Khilnani
Rakesh Kumar
Publikationsdatum: 01.05.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 5/2014
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2659-5

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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