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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 8/2016

22.01.2016 | Original Article

Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw

verfasst von: Jin-Woo Kim, Maria Erika A. Landayan, Ju-Young Lee, Jacquiline Czar I. Tatad, Sun-Jong Kim, Myung-Rae Kim, In-Ho Cha

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2016

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Abstract

Objectives

The aim of this study was to investigate the potential role of microcrack accumulation in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (ONJ) through an animal model.

Materials and methods

Twenty-four ovariectomized rats were randomly divided into a bisphosphonate group (n = 19) and control group (n = 5) and weekly injected with zoledronic acid and normal saline, respectively. After 6 weeks, surgical intervention was performed, and the injections were continued for eight additional weeks. Then, the animals were sacrificed, and ONJ lesions were inspected for the presence of microcracks using scanning electron microscopy. Measurements included bone dimension, number of cracks, crack length, and normalized indices; crack density (Cr.Dn) and crack surface density (Cr.S.Dn) were used for group comparison.

Results

Both number of cracks and crack length in the bisphosphonate group were greater than those in the control group (P < 0.05). Of the 19 rats injected with bisphosphonates, 13 rats (68.4 %) were classified into the ONJ group. Cr.Dn and Cr.S.Dn were significantly greater in the ONJ group than in the non-ONJ group, indicating accumulation of unrepaired microcracks (P < 0.05). Seventy-two percent of microcracks in the ONJ group conformed to the defined length that was considered significant according to a previous literature (30–80 μm); whereas 12 % of microcracks in the non-ONJ group were considered significant (P < 0.05).

Conclusion

Accumulation of unrepaired microcracks was significantly associated with the development of bisphosphonate-related ONJ. Further research is required to determine the role of microcracks in the pathogenesis of bisphosphonate-related ONJ.

Clinical Relevance

Long-term bisphosphonates use may deteriorate the biomechanical and physiological bone integrity, contributing to the pathogenesis of bisphosphonate-related ONJ.
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Metadaten
Titel
Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw
verfasst von
Jin-Woo Kim
Maria Erika A. Landayan
Ju-Young Lee
Jacquiline Czar I. Tatad
Sun-Jong Kim
Myung-Rae Kim
In-Ho Cha
Publikationsdatum
22.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 8/2016
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-016-1718-2

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