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Current Treatment Options in Oncology

Erschienen in:

01.08.2020 | Sarcoma (SH Okuno, Section Editor)

Role of TKI for Metastatic Osteogenic Sarcoma

verfasst von: Florence Duffaud, MD, PhD

Erschienen in: Current Treatment Options in Oncology | Ausgabe 8/2020

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Opinion statement

Osteosarcomas (OS) belong to a large family of mesenchymal tumor entities which exhibit heterogenous histological, genetic, and molecular features. Current OS treatment regimen consists of the combination of surgery and intensive multi-agent chemotherapy. Ever since the introduction of chemotherapy, 5-year survival rate among OS patients has improved to 60–75%. However, 30–35% of OS patients are associated with pulmonary metastasis and relapse, which have significantly poor prognosis, with an overall 5-year survival rate of about 20%. The fact that OS are both rare forms of cancer and highly heterogeneous may explain why patients’ survival has not improved in the past three decades, especially for metastatic/relapsed and unresectable osteosarcomas. Patients who experience relapse with metastatic disease have limited therapeutic options, often receiving additional cytotoxic therapy such as ifosfamide and etoposide and/or carboplatin or gemcitabine plus docetaxel. Novel precise OS-targeted thrapies are being developed with the hope of improving metastatic/relapsed OS prognosis. This review provides an overview of the most updated targeted therapies in relapsed/metastatic osteosarcoma and dicusses some clinical options in order to improve progression-free survival.

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Titel: Role of TKI for Metastatic Osteogenic Sarcoma
verfasst von: Florence Duffaud, MD, PhD
Publikationsdatum: 01.08.2020
Verlag: Springer US
Erschienen in: Current Treatment Options in Oncology / Ausgabe 8/2020
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI: https://doi.org/10.1007/s11864-020-00760-w

Springer Medizin

Role of TKI for Metastatic Osteogenic Sarcoma

Opinion statement

Neu im Fachgebiet Onkologie

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Springer Medizin

Opinion statement

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