Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Archives of Virology
Erschienen in: Archives of Virology 3/2017

15.11.2016 | Review

Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

verfasst von: Zhenguang Li, Xiaoqin Xu, Xue Leng, Minghui He, Jiangke Wang, Shipeng Cheng, Hua Wu

Erschienen in: Archives of Virology | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Several biological processes as well as infectious agents, physiological or environmental stress, and perturbed antioxidant response can promote oxidative stress. Oxidative stress usually happens when cells are exposed to more electrically charged reactive oxygen species (ROS) such as H2O2 or O2 −. ROS are well known for being both beneficial and deleterious. Recent studies have indicated that ROS are deleterious to cells, leading to programmed cell death (PCD) at high concentrations. At low concentrations, however, ROS can act as signaling molecules in a variety of cellular processes. In this review, we present an update of our current understanding of the role and regulation of reactive oxygen species in various viral infections, cellular signaling pathways and immune responses. We then discuss how the antioxidant defense system acts as an antiviral effector to limit cell damage.
Literatur
1.
Alandijany T, Kammouni W, Roy Chowdhury SK, Fernyhough P, Jackson AC (2013) Mitochondrial dysfunction in rabies virus infection of neurons. J Neurovirol 19:537–549CrossRefPubMed
2.
3.
Bir SC, Shen X, Kavanagh TJ, Kevil CG, Pattillo CB (2013) Control of angiogenesis dictated by picomolar superoxide levels. Free Radic Biol Med 63:135–142CrossRefPubMedPubMedCentral
4.
Cadenas E, Davies KJ (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29:222–230CrossRefPubMed
5.
Cruz CM, Rinna A, Forman HJ, Ventura AL, Persechini PM, Ojcius DM (2007) ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 282:2871–2879CrossRefPubMed
6.
Dhalla NS, Temsah RM, Netticadan T (2000) Role of oxidative stress in cardiovascular diseases. J Hypertens 18:655–673CrossRefPubMed
7.
Dhingra S, Sharma AK, Singla DK, Singal PK (2007) p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 293:H3524–H3531CrossRefPubMed
8.
9.
Flory E, Kunz M, Scheller C, Jassoy C, Stauber R, Rapp UR, Ludwig S (2000) Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase. J Biol Chem 275:8307–8314CrossRefPubMed
10.
11.
Gong G, Waris G, Tanveer R, Siddiqui A (2001) Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci USA 98:9599–9604CrossRefPubMedPubMedCentral
12.
13.
Holgado-Madruga M, Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23:4471–4484CrossRefPubMedPubMedCentral
14.
Holmstrom KM, Finkel T (2014) Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 15:411–421CrossRefPubMed
15.
Hottz ED, Lopes JF, Freitas C, Valls-de-Souza R, Oliveira MF, Bozza MT, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza FA, Bozza PT (2013) Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood 122:3405–3414CrossRefPubMedPubMedCentral
16.
Hu S, Sheng WS, Schachtele SJ, Lokensgard JR (2011) Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia. J Neuroinflamm 8:123CrossRef
17.
Huang SY, Fang CY, Wu CC, Tsai CH, Lin SF, Chen JY (2013) Reactive oxygen species mediate Epstein–Barr virus reactivation by N-methyl-N′-nitro-N-nitrosoguanidine. PLoS One 8:e84919CrossRefPubMedPubMedCentral
18.
Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90–94CrossRefPubMed
19.
Israel N, Gougerot-Pocidalo MA (1997) Oxidative stress in human immunodeficiency virus infection. Cell Mol Life Sci 53:864–870CrossRefPubMed
20.
21.
Jakovljevic A, Andric M, Miletic M, Beljic-Ivanovic K, Knezevic A, Mojsilovic S, Milasin J (2016) Epstein–Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. Med Hypotheses 94:40–42CrossRefPubMed
22.
Jenner P (2003) Oxidative stress in Parkinson’s disease. Ann Neurol 53(Suppl 3):S26–36 (discussion S36–28) CrossRefPubMed
23.
Kaminski M, Kiessling M, Suss D, Krammer PH, Gulow K (2007) Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol 27:3625–3639CrossRefPubMedPubMedCentral
24.
Kaminski MM, Roth D, Krammer PH, Gulow K (2013) Mitochondria as oxidative signaling organelles in T-cell activation: physiological role and pathological implications. Arch Immunol Therap Exp 61:367–384CrossRef
25.
Kammouni W, Wood H, Saleh A, Appolinario CM, Fernyhough P, Jackson AC (2015) Rabies virus phosphoprotein interacts with mitochondrial Complex I and induces mitochondrial dysfunction and oxidative stress. J Neurovirol 21:370–382CrossRefPubMed
26.
Lander HM (1997) An essential role for free radicals and derived species in signal transduction. FASEB J 11:118–124PubMed
27.
Landis GN, Tower J (2005) Superoxide dismutase evolution and life span regulation. Mech Ageing Dev 126:365–379CrossRefPubMed
28.
Laniewski NG, Grayson JM (2004) Antioxidant treatment reduces expansion and contraction of antigen-specific CD8+ T cells during primary but not secondary viral infection. J Virol 78:11246–11257CrossRefPubMedPubMedCentral
29.
Lee SM, Kleiboeker SB (2007) Porcine reproductive and respiratory syndrome virus induces apoptosis through a mitochondria-mediated pathway. Virology 365:419–434CrossRefPubMed
30.
Lee YJ, Cho HN, Soh JW, Jhon GJ, Cho CK, Chung HY, Bae S, Lee SJ, Lee YS (2003) Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation. Exp Cell Res 291:251–266CrossRefPubMed
31.
Lin RJ, Liao CL, Lin YL (2004) Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system. J Gen Virol 85:521–533CrossRefPubMed
32.
Macip S, Igarashi M, Berggren P, Yu J, Lee SW, Aaronson SA (2003) Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 23:8576–8585CrossRefPubMedPubMedCentral
33.
Maraldi T, Prata C, Caliceti C, Vieceli Dalla Sega F, Zambonin L, Fiorentini D, Hakim G (2010) VEGF-induced ROS generation from NAD(P)H oxidases protects human leukemic cells from apoptosis. Int J Oncol 36:1581–1589PubMed
34.
Marcaccini A, Lopez-Pena M, Bermudez R, Quiroga MI, Guerrero FH, Nieto JM, Aleman N (2007) Pseudorabies virus induces a rapid up-regulation of nitric oxide synthases in the nervous system of swine. Vet Microbiol 125:232–243CrossRefPubMed
35.
Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB (2014) Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal 20:1126–1167CrossRefPubMedPubMedCentral
36.
Panieri E, Santoro MM (2015) ROS signaling and redox biology in endothelial cells. CMLS, Cell Mol Life Sci
37.
Paracha UZ, Fatima K, Alqahtani M, Chaudhary A, Abuzenadah A, Damanhouri G, Qadri I (2013) Oxidative stress and hepatitis C virus. Virol J 10:251CrossRefPubMedPubMedCentral
38.
Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY (2013) ROS and ERK1/2-mediated caspase-9 activation increases XAF1 expression in dexamethasone-induced apoptosis of EBV-transformed B cells. Int J Oncol 43:29–38PubMedPubMedCentral
39.
Peterhans E (1997) Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. J Nutr 127:962S–965SPubMed
40.
41.
Reczek CR, Chandel NS (2015) ROS-dependent signal transduction. Curr Opin Cell Biol 33:8–13CrossRefPubMed
42.
43.
Salminen A, Kaarniranta K, Kauppinen A (2013) Crosstalk between oxidative stress and SIRT1: impact on the aging process. Int J Mol Sci 14:3834–3859CrossRefPubMedPubMedCentral
44.
Schachtele SJ, Hu S, Little MR, Lokensgard JR (2010) Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2. J Neuroinflamm 7:35CrossRef
45.
Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26:1749–1760CrossRefPubMedPubMedCentral
46.
Scherz-Shouval R, Elazar Z (2011) Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 36:30–38CrossRefPubMed
47.
48.
Schwarz KB (1996) Oxidative stress during viral infection: a review. Free Radic Biol Med 21:641–649CrossRefPubMed
49.
Segovia J, Sabbah A, Mgbemena V, Tsai SY, Chang TH, Berton MT, Morris IR, Allen IC, Ting JP, Bose S (2012) TLR2/MyD88/NF-kappaB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One 7:e29695CrossRefPubMedPubMedCentral
50.
Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS (2013) Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 38:225–236CrossRefPubMedPubMedCentral
51.
Sharoni Y, Danilenko M, Dubi N, Ben-Dor A, Levy J (2004) Carotenoids and transcription. Arch Biochem Biophys 430:89–96CrossRefPubMed
52.
Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG (2004) Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24:5914–5922CrossRefPubMedPubMedCentral
53.
Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M (2012) Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36:401–414CrossRefPubMedPubMedCentral
54.
Sies H, Cadenas E (1985) Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci 311:617–631CrossRefPubMed
55.
56.
Simon HU, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K (1997) Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 158:3902–3908PubMed
57.
Staal FJ, Roederer M, Herzenberg LA, Herzenberg LA (1990) Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 87:9943–9947CrossRefPubMedPubMedCentral
58.
Stout AK, Raphael HM, Kanterewicz BI, Klann E, Reynolds IJ (1998) Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci 1:366–373CrossRefPubMed
59.
Wang T, Arifoglu P, Ronai Z, Tew KD (2001) Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 276:20999–21003CrossRefPubMed
60.
61.
Wheeler ML, Defranco AL (2012) Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol 189:4405–4416CrossRefPubMedPubMedCentral
62.
Zhao L, Xie F, Wang TT, Liu MY, Li JL, Shang L, Deng ZX, Zhao PX, Ma XM (2015) Chlorpyrifos induces the expression of the Epstein–Barr virus lytic cycle activator BZLF-1 via reactive oxygen species. Oxid Med Cell Longev 2015:309125PubMedPubMedCentral
63.
Zhao Z, Tang X, Zhao X, Zhang M, Zhang W, Hou S, Yuan W, Zhang H, Shi L, Jia H, Liang L, Lai Z, Gao J, Zhang K, Fu L, Chen W (2014) Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-kappaB activation. Biochem Pharmacol 90:73–87CrossRefPubMed
Metadaten
Titel
Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections
verfasst von
Zhenguang Li
Xiaoqin Xu
Xue Leng
Minghui He
Jiangke Wang
Shipeng Cheng
Hua Wu
Publikationsdatum
15.11.2016
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 3/2017
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3130-2

Weitere Artikel der Ausgabe 3/2017

Archives of Virology 3/2017 Zur Ausgabe

Annotated Sequence Record

Nucleotide sequences of Japanese isolates of citrus vein enation virus

Annotated Sequence Record

Complete sequence and variability of a new subgroup B nepovirus infecting potato in central Peru

Erratum

Erratum to: Preliminary characterization of Tasmanian aquareovirus (TSRV) isolates

Original Article

Development of a fluorescence resonance energy transfer–based intracellular assay to identify novel enterovirus 71 antivirals

Erratum

Erratum to: Complete nucleotide sequences of seven soybean mosaic viruses (SMV), isolated from wild soybeans (Glycine soja) in China

Original Article

Genomic characterization of a wild-bird-origin pigeon paramyxovirus type 1 (PPMV-1) first isolated in the northwest region of China

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 | Hypertonie | Nachrichten

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 | Parkinson-Krankheit | Nachrichten

Viel Bewegung in der Parkinsonforschung

25.04.2024 | Nierenkarzinom | Nachrichten

Adjuvante Immuntherapie verlängert Leben bei RCC
weitere anzeigen

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise