Skip to main content
Erschienen in: Journal of Thrombosis and Thrombolysis 1/2021

26.05.2020

Safety and efficacy of rt-PA treatment for acute stroke in pseudoxanthoma elasticum: the first report

verfasst von: Silvia Lanfranconi, Isabella Ghione, Gloria Valcamonica, Stefania Paola Corti, Sara Bonato, Nereo Bresolin

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 1/2021

Einloggen, um Zugang zu erhalten

Abstract

Pseudoxanthoma elasticum is a rare cause for ischaemic stroke. Little is known about acute and secondary prevention strategies in these subjects given the increased risk of gastrointestinal and urinary bleedings. Here we present the case of a 62 years old man affected by pseudoxanthoma elasticum who presented with acute ischaemic stroke and was successfully treated with intravenous thrombolysis. Neurological signs improved after intravenous thrombolysis without bleeding complication. To our knowledge, this is the first case of pseudoxanthoma elasticum—related stroke undergoing intravenous thrombolysis.
Literatur
1.
Zurück zum Zitat Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Varadi A, Plomp A, Bergen AA, Oude Elferink RP, Borst P, van de Wetering K (2014) ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report. Arterioscler Thromb Vasc Biol 34(9):1985–1989CrossRef Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Varadi A, Plomp A, Bergen AA, Oude Elferink RP, Borst P, van de Wetering K (2014) ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report. Arterioscler Thromb Vasc Biol 34(9):1985–1989CrossRef
2.
Zurück zum Zitat Jansen RS, Kucukosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K (2013) ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci USA 110(50):20206–20211CrossRef Jansen RS, Kucukosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K (2013) ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci USA 110(50):20206–20211CrossRef
3.
Zurück zum Zitat Boraldi F, Annovi G, Bartolomeo A, Quaglino D (2014) Fibroblasts from patients affected by pseudoxanthoma elasticum exhibit an altered PPi metabolism and are more responsive to pro-calcifying stimuli. J Dermatol Sci 74(1):72–80CrossRef Boraldi F, Annovi G, Bartolomeo A, Quaglino D (2014) Fibroblasts from patients affected by pseudoxanthoma elasticum exhibit an altered PPi metabolism and are more responsive to pro-calcifying stimuli. J Dermatol Sci 74(1):72–80CrossRef
4.
Zurück zum Zitat Lomashvili KA, Narisawa S, Millan JL, O'Neill WC (2014) Vascular calcification is dependent on plasma levels of pyrophosphate. Kidney Int 85(6):1351–1356CrossRef Lomashvili KA, Narisawa S, Millan JL, O'Neill WC (2014) Vascular calcification is dependent on plasma levels of pyrophosphate. Kidney Int 85(6):1351–1356CrossRef
5.
Zurück zum Zitat Neldner KH (1988) Pseudoxanthoma elasticum. Clin Dermatol 6(1):1–159CrossRef Neldner KH (1988) Pseudoxanthoma elasticum. Clin Dermatol 6(1):1–159CrossRef
6.
Zurück zum Zitat Pfendner EG, Vanakker OM, Terry SF, Vourthis S, McAndrew PE, McClain MR, Fratta S, Marais AS, Hariri S, Coucke PJ, Ramsay M, Viljoen D, Terry PF, De Paepe A, Uitto J, Bercovitch LG (2007) Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. J Med Genet 44(10):621–628CrossRef Pfendner EG, Vanakker OM, Terry SF, Vourthis S, McAndrew PE, McClain MR, Fratta S, Marais AS, Hariri S, Coucke PJ, Ramsay M, Viljoen D, Terry PF, De Paepe A, Uitto J, Bercovitch LG (2007) Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. J Med Genet 44(10):621–628CrossRef
7.
Zurück zum Zitat Schulz V, Hendig D, Henjakovic M, Szliska C, Kleesiek K, Götting C (2006) Mutational analysis of the ABCC6 gene and the proximal ABCC6 gene promoter in German patients with pseudoxanthoma elasticum (PXE). Hum Mutat 27(8):831CrossRef Schulz V, Hendig D, Henjakovic M, Szliska C, Kleesiek K, Götting C (2006) Mutational analysis of the ABCC6 gene and the proximal ABCC6 gene promoter in German patients with pseudoxanthoma elasticum (PXE). Hum Mutat 27(8):831CrossRef
8.
Zurück zum Zitat Germain DP (2017) Pseudoxanthoma elasticum. Orphanet J Rare Dis 12(1):85CrossRef Germain DP (2017) Pseudoxanthoma elasticum. Orphanet J Rare Dis 12(1):85CrossRef
9.
Zurück zum Zitat National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587CrossRef National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587CrossRef
10.
Zurück zum Zitat van den Berg JS, Hennekam RC, Cruysberg JR, Steijlen PM, Swart J, Tijmes N et al (2000) Prevalence of symptomatic intracranial aneurysm and ischaemic stroke in pseudoxanthoma elasticum. Cerebrovasc Dis 10:315–319CrossRef van den Berg JS, Hennekam RC, Cruysberg JR, Steijlen PM, Swart J, Tijmes N et al (2000) Prevalence of symptomatic intracranial aneurysm and ischaemic stroke in pseudoxanthoma elasticum. Cerebrovasc Dis 10:315–319CrossRef
Metadaten
Titel
Safety and efficacy of rt-PA treatment for acute stroke in pseudoxanthoma elasticum: the first report
verfasst von
Silvia Lanfranconi
Isabella Ghione
Gloria Valcamonica
Stefania Paola Corti
Sara Bonato
Nereo Bresolin
Publikationsdatum
26.05.2020
Verlag
Springer US
Erschienen in
Journal of Thrombosis and Thrombolysis / Ausgabe 1/2021
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-020-02150-3

Weitere Artikel der Ausgabe 1/2021

Journal of Thrombosis and Thrombolysis 1/2021 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.