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Archives of Virology

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01.05.2008 | Rapid Communication

Search for cellular partners of human papillomavirus type 16 E2 protein

verfasst von: Agnieszka K. Olejnik-Schmidt, Marcin T. Schmidt, Witold Kędzia, Anna Goździcka-Józefiak

Erschienen in: Archives of Virology | Ausgabe 5/2008

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Abstract

Human papillomaviruses (HPVs) are small, double-stranded DNA viruses that infect cutaneous and mucosal epithelia. Type 16 (HPV16) displays tropism to genital epithelia, giving rise to genital warts and cervical intraepithelial neoplasia (CIN), which is a precursor lesion to invasive carcinoma of the cervix. The great majority of human cervical cancers contain integrated HPV DNA where the E2 gene is usually disrupted, suggesting that the loss of the E2 protein is an important step in HPV-induced carcinogenesis. The HPV16 E2 protein is a regulatory protein that seems to be essential for creating favourable conditions for establishment of infection and proper completion of the viral life cycle. Recently, diverse activities of the E2 proteins have been described, but the molecular basis of these processes has not beenfully elucidated. Using a yeast two-hybrid system, we have identified epithelial cellular proteins that bind to the E2 protein of HPV16.

Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (2000) A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet 9:1533–1542PubMedCrossRef

Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, Elomaa O, Moser M, de Cid R, Ripatti S, Vorechovsky I, Marcusson JA, Nakagawa H, Lazaro C, Estivill X, Capon F, Novelli G, Saarialho-Kere U, Barker J, Trembath R, Kere J (2002) Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. Hum Mol Genet 11:589–597PubMedCrossRef

Ballabeni A, Melixetian M, Zamponi R, Masiero L, Marinoni F, Helin K (2004) Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J 23:3122–3132PubMedCrossRef

Bastien N, McBride AA (2000) Interaction of the papillomavirus E2 protein with mitotic chromosomes. Virology 270:124–134PubMedCrossRef

Benson JD, Lawande R, Howley PM (1997) Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins. J Virol 71:8041–8047PubMed

Boner W, Morgan IM (2002) Novel cellular interacting partners of the human papillomavirus 16 transcription/replication factor E2. Virus Res 90:113–118PubMedCrossRef

Boner W, Taylor ER, Tsirimonaki E, Yamane K, Campo MS, Morgan IM (2002) A functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1. J Biol Chem 277:22297–22303PubMedCrossRef

Bouvard V, Storey A, Pim D, Banks L (1994) Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. EMBO J 13:5451–5459PubMed

Breiding DE, Sverdrup F, Grossel MJ, Moscufo N, Boonchai W, Androphy EJ (1997) Functional interaction of a novel cellular protein with the papillomavirus E2 transactivation domain. Mol Cell Biol 17:7208–7219PubMed

10.

Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (2001) Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. Gene 262:275–281PubMedCrossRef

11.

Cheng LE, Chan FK, Cado D, Winoto A (1997) Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J 16:1865–1875PubMedCrossRef

12.

Collins T, Stone JR, Williams AJ (2001) All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol Cell Biol 21:3609–3615PubMedCrossRef

13.

Cripe TP, Haugen TH, Turk JP, Tabatabai F, Schmid PG, Durst M, Gissmann L, Roman A, Turek LP (1987) Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans- activator and repressor gene products: implications for cervical carcinogenesis. EMBO J 6:3745–3753PubMed

14.

Defrancesco L, Wilkinson D (1999) The two body problem. Scientist 13:21–23

15.

Demeret C, Yaniv M, Thierry F (1994) The E2 transcriptional repressor can compensate for Sp1 activation of the human papillomavirus type 18 early promoter. J Virol 68:7075–7082PubMed

16.

Demeret C, Garcia-Carranca A, Thierry F (2003) Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein. Oncogene 22:168–175PubMedCrossRef

17.

Desaintes C, Demeret C, Goyat S, Yaniv M, Thierry F (1997) Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J 16:504–514PubMedCrossRef

18.

Desaintes C, Goyat S, Garbay S, Yaniv M, Thierry F (1999) Papillomavirus E2 induces p53-independent apoptosis in HeLa cells. Oncogene 18:4538–4545PubMedCrossRef

19.

Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K (2000) A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G2-to-M transition. Mol Cell Biol 20:6537–6549PubMedCrossRef

20.

Dowhanick JJ, McBride AA, Howley PM (1995) Suppression of cellular proliferation by the papillomavirus E2 protein. J Virol 69:7791–7799PubMed

21.

Dunphy EL, Johnson T, Auerbach SS, Wang EH (2000) Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression. Mol Cell Biol 20:1134–1139PubMedCrossRef

22.

Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H (2003) Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. Leuk Res 27:687–694PubMedCrossRef

23.

Fujii T, Brandsma JL, Peng X, Srimatkandada S, Li L, Canaan A, Deisseroth AB (2001) High and low levels of cottontail rabbit papillomavirus E2 protein generate opposite effects on gene expression. J Biol Chem 276:867–874PubMedCrossRef

24.

Fournier N, Raj K, Saudan P, Utzig S, Sahli R, Simanis V, Beard P (1999) Expression of human papillomavirus 16 E2 protein in Schizosaccharomyces pombe delays the initiation of mitosis. Oncogene 18:4015–4021PubMedCrossRef

25.

Futcher AB, Cox BS (1984) Copy number and the stability of 2-micron circle-based artificial plasmids of Saccharomyces cerevisiae. J Bacteriol 57:283–290

26.

Gandhi TK, Zhong J, Mathivanan S, Karthick L, Chandrika KN, Mohan SS, Sharma S, Pinkert S, Nagaraju S, Periaswamy B, Mishra G, Nandakumar K, Shen B, Deshpande N, Nayak R, Sarker M, Boeke JD, Parmigiani G, Schultz J, Bader JS, Pandey A (2006) Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet 38:285–293PubMedCrossRef

27.

Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (1992) Cloning and chromosomal mapping of a human immunodeficiency virus 1 “TATA” element modulatory factor. Proc Natl Acad Sci USA 89:9372–9376PubMedCrossRef

28.

Giri I, Yaniv M (1988) Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains. EMBO J 7:2823–2829PubMed

29.

Gish W, States DJ (1993) Identification of protein coding regions by database similarity search. Nat Genet 3:266–272PubMedCrossRef

30.

Goodwin EC, Naeger LK, Breiding DE, Androphy EJ, DiMaio D (1998) Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J Virol 72:3925–3934PubMed

32.

Ham J, Steger G, Yaniv M (1994) Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure. EMBO J 13:147–157PubMed

32.

Ham J, Dostatni N, Gauthier JM, Yaniv M (1991) The papillomavirus E2 protein: a factor with many talents. Trends Biochem Sci 16:440–444PubMedCrossRef

33.

Howley PM (1996) Papillomavirinae the viruses and their replication. In: Fields BN, Knipe DM, Howley PM (eds) Virology, 2nd edn. Lippincott-Raven Publishers, Philadelphia, pp 2045–2076

34.

Hwang ES, Riese DJ, Settleman J, Nilson LA, Honig J, Flynn S, DiMaio D (1993) Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol 67:3720–3729PubMed

35.

Hwang ES, Naeger LK, DiMaio D (1996) Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene. Oncogene 12:795–803PubMed

36.

Klucevsek K, Wertz M, Lucchi J, Leszczynski A, Moroianu J (2007) Characterization of the nuclear localization signal of high risk HPV16 E2 protein. Virology 360:191–198PubMedCrossRef

37.

Kovelman R, Bilter GK, Glezer E, Tsou AY, Barbosa MS (1996) Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomaviruses. J Virol 70:7549–7560PubMed

38.

Lambert PF, Dostatni N, McBride AA, Yaniv M, Howley PM, Arcangioli B (1989) Functional analysis of the papilloma virus E2 trans-activator in Saccharomyces cerevisiae. Genes Dev 3:38–48PubMedCrossRef

39.

Lee D, Lee B, Kim J, Kim DW, Choe J (2000) cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription. J Biol Chem 275:7045–7051PubMedCrossRef

40.

Lee KY, Broker TR, Chow LT (1998) Transcription factor YY1 represses cell-free replication from human papillomavirus origins. J Virol 72:4911–4917PubMed

41.

Lee JM, Lee K, Weidner M, Osborne BA, Hayward SD (2002) Epstein-Barr virus EBNA2 blocks Nur77-mediated apoptosis. Proc Natl Acad Sci USA 99:11878–11883PubMedCrossRef

42.

Lehman CW, King DS, Botchan MR (1997) A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention. J Virol 71:3652–3665PubMed

43.

Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, Zhang X (2000) Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 289:1159–1164PubMedCrossRef

44.

Lopez R, Garrido E, Vazquez G, Pina P, Perez C, Alvarado I, Salcedo M (2006) A subgroup of HOX Abd-B gene is differentially expressed in cervical cancer. Int J Gynecol Cancer 16:1289–1296PubMedCrossRef

45.

Lu JZ, Sun YN, Rose RC, Bonnez W, McCance DJ (1993) Two E2 binding sites (E2BS) alone or one E2BS plus an A/T-rich region are minimal requirements for the replication of the human papillomavirus type 11 origin. J Virol 67:7131–7139PubMed

46.

Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002) A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol 22:6509–6520PubMedCrossRef

47.

Massimi P, Pim D, Bertoli C, Bouvard V, Banks L (1999) Interaction between the HPV-16 E2 transcriptional activator and p53. Oncogene 18:7748–7754PubMedCrossRef

48.

McPhillips MG, Oliveira JG, Spindler JE, Mitra R, McBride AA (2006) Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J Virol 80:9530–9543PubMedCrossRef

49.

Montanari M, Boninsegn A, Faraglia B, Coco C, Giordano A, Cittadini A, Sgambato A (2005) Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors. J Cell Physiol 202:215–222PubMedCrossRef

50.

Morrissey LC, Barsoum J, Androphy EJ (1989) Trans activation by the bovine papillomavirus E2 protein in Saccharomyces cerevisiae. J Virol 63:4422–4425PubMed

51.

O’Brien T, Tjian R (1998) Functional analysis of the human TAFII250 N-terminal kinase domain. Mol Cell 1:905–911PubMedCrossRef

52.

Okabe T, Takayanagi R, Adachi M, Imasaki K, Nawata H (1998) Nur77, a member of the steroid receptor superfamily, antagonizes negative feedback of ACTH synthesis and secretion by glucocorticoid in pituitary corticotrope cells. J Endocrinol 156:169–175PubMedCrossRef

53.

Olejnik-Schmidt AK, Schmidt MT, Gozdzicka-Jozefiak A (2006) Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein. Cell Mol Biol Lett 11:102–108PubMedCrossRef

54.

Pham AD, Sauer F (2000) Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila. Science 289:2357–2360PubMedCrossRef

55.

Rank NM, Lambert PF (1995) Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB. J Virol 69:6323–6334PubMed

56.

Remm M, Brain R, Jenkins JR (1992) The E2 binding sites determine the efficiency of replication for the origin of human papillomavirus type 18. Nucleic Acids Res 20:6015–6021PubMedCrossRef

57.

Romanczuk H, Thierry F, Howley PM (1990) Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J Virol 64:2849–2859PubMed

58.

Sakai H, Yasugi T, Benson JD, Dowhanick JJ, Howley PM (1996) Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. J Virol 70:1602–1611PubMed

59.

Sax JK, El-Deiry WS (2003) Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene. J Biol Chem 278:36435–36444PubMedCrossRef

60.

Schweiger MR, You J, Howley PM (2006) Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol 80:4276–4285PubMedCrossRef

61.

Sedman J, Stenlund A (1995) Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro. EMBO J 14:6218–6228PubMed

62.

Sedman J, Stenlund A (1996) The initiator protein E1 binds to the bovine papillomavirus origin of replication as a trimeric ring-like structure. EMBO J 15:5085–5092PubMed

63.

Sedman T, Sedman J, Stenlund A (1997) Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus. J Virol 71:2887–2896PubMed

64.

Skiadopoulos MH, McBride AA (1998) Bovine papillomavirus type 1 genomes and the E2 transactivator protein are closely associated with mitotic chromatin. J Virol 72:2079–2088PubMed

65.

Steger G, Corbach S (1997) Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein. J Virol 71:50–58PubMed

66.

Steger G, Ham J, Lefebvre O, Yaniv M (1995) The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding. EMBO J 14:329–340PubMed

67.

Steger G, Schnabel C, Schmidt HM (2002) The hinge region of the human papillomavirus type 8 E2 protein activates the human p21(WAF1/CIP1) promoter via interaction with Sp1. J Gen Virol 83:503–510PubMed

68.

Strasswimmer J, Lorson CL, Breiding DE, Chen JJ, Le T, Burghes AH, Androphy EJ, (1999) Identification of survival motor neuron as a transcriptional activator- binding protein. Hum Mol Genet 8:1219–1226PubMedCrossRef

69.

Tan SH, Gloss B, Bernard HU (1992) During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element. Nucleic Acids Res 20:251–256PubMedCrossRef

70.

Tan SH, Leong LE, Walker PA, Bernard HU (1994) The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID. J Virol 68:6411–6420PubMed

71.

Tanackovic G, Kramer A (2005) Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo. Mol Biol Cell 16:1366–1377PubMedCrossRef

72.

Utley RT, K Ikeda, Grant PA, Cote J, Steger DJ, Eberharter A, John S, Workman JL (1998) Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature 394:498–502PubMedCrossRef

73.

Voitenleitner C, Botchan M (2002) E1 protein of bovine papillomavirus type 1 interferes with E2 protein- mediated tethering of the viral DNA to mitotic chromosomes. J Virol 76:3440–3451PubMedCrossRef

74.

Wang JC (2002) Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol 3:430–440PubMedCrossRef

75.

Wassarman DA, Sauer F (2001) TAF(II)250: a transcription toolbox. J Cell Sci 114:2895–2902PubMed

76.

Webster K, Parish J, Pandya M, Stern PL, Clarke AR, Gaston K (2000) The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J Biol Chem 275:87–94PubMedCrossRef

77.

Wu SY, Lee AY, Hou SY, Kemper JK, Erdjument-Bromage H, Tempst P, Chiang CM (2006) Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev 20:2383–2396PubMedCrossRef

78.

Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D’Arpa P (2002) Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I. BMC Genomics 3:1PubMedCrossRef

79.

Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002) Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem 277:28051–28057PubMedCrossRef

80.

Yao JM, Breiding DE, Androphy EJ (1998) Functional interaction of the bovine papillomavirus E2 transactivation domain with TFIIB. J Virol 72:1013–1019PubMed

81.

You J, Croyle JL, Nishimura A, Ozato K, Howley PM (2004) Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 117:349–360PubMedCrossRef

82.

Zhang D, Paley AJ, Childs G (1998) The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. J Biol Chem 273:18086–18091PubMedCrossRef

Titel: Search for cellular partners of human papillomavirus type 16 E2 protein
verfasst von: Agnieszka K. Olejnik-Schmidt
Marcin T. Schmidt
Witold Kędzia
Anna Goździcka-Józefiak
Publikationsdatum: 01.05.2008
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 5/2008
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-008-0061-6

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