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01.10.2014 | Original paper

Sedentary behavior is associated with colorectal adenoma recurrence in men

verfasst von: Christine L. Sardo Molmenti, Elizabeth A. Hibler, Erin L. Ashbeck, Cynthia A. Thomson, David O. Garcia, Denise Roe, Robin B. Harris, Peter Lance, Martin Cisneroz, Maria Elena Martinez, Patricia A. Thompson, Elizabeth T. Jacobs

Erschienen in: Cancer Causes & Control | Ausgabe 10/2014

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Abstract

Purpose

The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.

Methods

Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.

Results

No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.

Conclusions

This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.

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Titel: Sedentary behavior is associated with colorectal adenoma recurrence in men
verfasst von: Christine L. Sardo Molmenti
Elizabeth A. Hibler
Erin L. Ashbeck
Cynthia A. Thomson
David O. Garcia
Denise Roe
Robin B. Harris
Peter Lance
Martin Cisneroz
Maria Elena Martinez
Patricia A. Thompson
Elizabeth T. Jacobs
Publikationsdatum: 01.10.2014
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 10/2014
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-014-0444-9

Springer Medizin

Sedentary behavior is associated with colorectal adenoma recurrence in men