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Archives of Women's Mental Health

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01.12.2018 | Short Communication

Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

verfasst von: Jodi L. Pawluski, Ursula Brain, Geoffrey L. Hammond, Tim F. Oberlander

Erschienen in: Archives of Women's Mental Health | Ausgabe 3/2019

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Abstract

The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.

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Titel: Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression
verfasst von: Jodi L. Pawluski
Ursula Brain
Geoffrey L. Hammond
Tim F. Oberlander
Publikationsdatum: 01.12.2018
Verlag: Springer Vienna
Erschienen in: Archives of Women's Mental Health / Ausgabe 3/2019
Print ISSN: 1434-1816
Elektronische ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-018-0931-1

Springer Medizin

Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

Abstract

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Springer Medizin

Abstract

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