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Journal of Neurology

Erschienen in:

05.12.2019 | Original Communication

Serial position effects rapidly distinguish Alzheimer’s from frontotemporal dementia

verfasst von: Nadine Kloth, Jolene Lemke, Heinz Wiendl, Sven G. Meuth, Thomas Duning, Andreas Johnen

Erschienen in: Journal of Neurology | Ausgabe 4/2020

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Abstract

Objective

A significant proportion of patients with behavioural variant frontotemporal dementia (bvFTD) show memory impairments similar to patients with Alzheimer’s disease (AD), making them prone to misdiagnosis in early disease stages. Our objective was to establish a rapid and efficient memory measure that enhances discrimination between patients with dementia due to Alzheimer’s disease and amnestic presentations of behavioural variant frontotemporal dementia.

Method

Word list learning data of patients with diagnoses of AD and both amnestic and non-amnestic presentations of bvFTD were analysed. The overall recall rate and the relative contributions of the first two (primacy items) and last two words (recency items) to recall performance were compared between groups.

Results

Overall recall rate was indistinguishable between patients with AD and amnestic bvFTD. However, AD patients’ recall was mostly driven by recency items, whereas amnestic bvFTD patients’ performance was mostly driven by primacy items.

Conclusion

We conclude that obtaining a simple recency dominance index from a single, 15-item word list memory trial can help discriminate patients with AD from patients with bvFTD, even if they present with similarly severe memory impairment.

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Titel: Serial position effects rapidly distinguish Alzheimer’s from frontotemporal dementia
verfasst von: Nadine Kloth
Jolene Lemke
Heinz Wiendl
Sven G. Meuth
Thomas Duning
Andreas Johnen
Publikationsdatum: 05.12.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 4/2020
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-019-09662-w

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Abstract

Objective

Method

Results

Conclusion

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