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01.05.2008 | Article

Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus

verfasst von: L. Uusitalo, J. Nevalainen, S. Niinistö, G. Alfthan, J. Sundvall, T. Korhonen, M. G. Kenward, H. Oja, R. Veijola, O. Simell, J. Ilonen, M. Knip, S. M. Virtanen

Erschienen in: Diabetologia | Ausgabe 5/2008

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Abstract

Aims/hypothesis

The aim of our study was to assess the associations of serum α- and γ-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus.

Methods

A case–control study with 108 cases with advanced beta cell autoimmunity and 216 matched control participants nested within the birth cohort of the Type 1 Diabetes Prediction and Prevention Project. A serum sample for vitamin E analyses was collected from all the children in the cohort at the age of 1 year and thereafter at 12 month intervals. For each case–control group, all the repeated serum samples up to the age of seroconversion to autoantibody positivity in the case were analysed. A conditional logistic regression model was used to determine potential associations between seroconversion and serum tocopherol concentrations.

Results

Serum α- or γ-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for μmol/l increase in serum concentration of the first-year sample was 0.97 (0.92–1.03) for α-tocopherol and 1.10 (0.70–1.74) for γ-tocopherol. However, there was an interaction between high values of γ-tocopherol at the age of 1 year and the time of seroconversion (p = 0.024).

Conclusions/interpretation

It seems unlikely that high concentrations of α- or γ-tocopherol protect against advanced beta cell autoimmunity in young children.

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Titel: Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus
verfasst von: L. Uusitalo
J. Nevalainen
S. Niinistö
G. Alfthan
J. Sundvall
T. Korhonen
M. G. Kenward
H. Oja
R. Veijola
O. Simell
J. Ilonen
M. Knip
S. M. Virtanen
Publikationsdatum: 01.05.2008
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 5/2008
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-008-0959-2

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