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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Severe propylthiouracil-induced hepatotoxicity in pregnancy managed successfully by liver transplantation: A case report

Zeitschrift:
Journal of Medical Case Reports > Ausgabe 1/2011
Autoren:
Evan Sequeira, Sikolia Wanyonyi, Raj Dodia
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

ES managed this patient during pregnancy, provided his professional opinion throughout the management of the patient, obtained consent from the patient for publication of this case report, is the custodian of the patient's records and contributed to the writing of the final manuscript. SW summarized the case, did the literature search, and was a major contributor to the writing of the manuscript. RD also did the case summary by compiling all the medical reports and contributed extensively to the writing of the manuscript and interpretation of the results. All authors read and approved the final manuscript.

Abstract

Introduction

Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the fetus.

Case presentation

We report a rare case of fulminant hepatic failure in a 36-year-old gravida 2 black woman of African descent that occurred at 17 weeks gestation following propylthiouracil treatment for Graves' disease. Her liver failure was managed by liver transplantation and thyroidectomy. Her pregnancy was continued to term, though with not so favorable early childhood sequelae.

Conclusion

This case illustrates a very rare complication of treatment with a presumed safe drug during pregnancy followed by adverse neonatal outcomes due to the extensive treatment.

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