Introduction
Methods
Tehran heart center
Coronary angiography data bank
Design and participants
Definitions and protocols
Statistical analysis
Result
Population
Year | Age | Sex (%) | Coronary artery disease risk factors | ||||||
---|---|---|---|---|---|---|---|---|---|
HTN | DLP | DM | Cigarette smoking | Obesity | Opium addiction | Family History | |||
2007–2010 | 60.7 ± 9.46 | Male 73.2 | 5210 (51.90%) | 6201 (61.70%) | 3491 (34.70%) | 1645 (16.40%) | 2361 (23.6%) | 1122 (11.40%) | 4278 (42.60%) |
Female 26.8 | |||||||||
2011–2013 | 60.81 ± 9.53 | Male 73.3 | 2945 (48.30%) | 3003 (49.20%) | 2483 (40.70%) | 961 (15.80%) | 1366 (22.4%) | 629 (10.80%) | 2594 (42.50%) |
Female 26.7 | |||||||||
2014–2017 | 61.7 ± 9.5 | Male 74.3 | 4760 (58.40%) | 4387 (53.90%) | 3363 (41.20%) | 1656 (20.40%) | 2017 (24.9%) | 1509 (18.60%) | 2449 (30.00%) |
Female 25.7 | |||||||||
Total | 60.8 ± 9.52 | Male 73.6 | 12,915 (53.10%) | 13,591 (56.00%) | 9337 (38.40%) | 4262 (17.60%) | 5744 (23.7%) | 3260 (13.70%) | 9321 (38.30%) |
Female 26.4 |
Risk factor distribution
Total population
Premature population, men versus women
Age-sex category | Coronary artery disease risk factors | ||||||
---|---|---|---|---|---|---|---|
Hypertension | Dyslipidemia | Diabetes mellitus | Cigarette smoking | Obesity | Opium addiction | Family History | |
Men ≤ 50 | 1023 (35.50%) | 1620 (56.30%) | 708 (24.60%) | 998 (34.60%) | 775 (27.0%) | 734 (25.90%) | 1517 (52.60%) |
Men > 50 | 7269 (48.50%) | 7513 (50.10%) | 5081 (33.90%) | 3080 (20.60%) | 2562 (17.1%) | 2394 (16.40%) | 4986 (33.20%) |
Women ≤ 55 | 930 (64.30%) | 1008 (69.70%) | 844 (58.30%) | 56 (3.90%) | 646 (44.7%) | 44 (3.00%) | 803 (55.50%) |
Women > 55 | 3693 (74.30%) | 3450 (69.50%) | 2704 (54.40%) | 128 (2.60%) | 1761 (35.6%) | 88 (1.80%) | 2015 (40.50%) |
Men | 8292 (46.4%) | 9133 (51.1%) | 5789 (32.3%) | 4078 (22.8%) | 3337 (18.7%) | 3128 (17.8%) | 6503 (36.3%) |
Women | 4623 (72.0%) | 4458 (69.5%) | 3548 (55.2%) | 184 (2.8%) | 2407 (37.6%) | 132 (2.0%) | 2818 (43.8%) |
P value* | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Long term outcome
Men versus women
Age-sex category | Overall survival | MACE-free survival | |||
---|---|---|---|---|---|
Men | Men ≤ 50 | 86.2% | 93.6% | 75.4% | 79.2% |
Men > 50 | 84.80% | 74.70% | |||
Women | Women ≤ 55 | 84.9% | 90.5% | 70.3% | 73.6% |
Women > 55 | 83.4% | 69.4% |
Sex | Outcome | Model | HR | CI 95% | P value* | |
---|---|---|---|---|---|---|
Lower | Higher | |||||
Men versus women | Mortality | Model 1 | 0.91 | 0.84 | 0.98 | 0.01 |
Model 2 | 0.85 | 0.78 | 0.93 | < 0.001 | ||
Model 3 | 1.00 | 0.79 | 1.28 | 0.98 | ||
MACE | Model 1 | 0.81 | 0.77 | 0.85 | < 0.001 | |
Model 2 | 0.82 | 0.77 | 0.87 | < 0.001 | ||
Model 3 | 0.72 | 0.57 | 0.91 | 0.01 |
CADRF
CADRFs | Death | MACE | ||||||
---|---|---|---|---|---|---|---|---|
HR | 95% CI | P value* | HR | 95% CI | P value* | |||
Lower | Higher | Lower | Higher | |||||
All patients | ||||||||
Diabetes mellitus | 1.49 | 1.39 | 1.60 | < 0.001 | 1.38 | 1.31 | 1.46 | < 0.001 |
Hypertension | 1.46 | 1.36 | 1.58 | < 0.001 | 1.31 | 1.24 | 1.38 | < 0.001 |
Dyslipidemia | 0.75 | 0.70 | 0.81 | < 0.001 | 0.88 | 0.84 | 0.93 | < 0.001 |
Obesity | 0.90 | 0.82 | 0.98 | 0.011 | 1.02 | 0.96 | 1.08 | 0.567 |
Positive Family History | 0.70 | 0.65 | 0.76 | < 0.001 | 0.87 | 0.83 | 0.92 | < 0.001 |
Cigarette smoking | 1.03 | 0.93 | 1.13 | 0.613 | 1.08 | 1.00 | 1.16 | 0.041 |
Opium addiction | 1.21 | 1.09 | 1.34 | < 0.001 | 1.13 | 1.05 | 1.22 | 0.002 |
Women | ||||||||
Diabetes mellitus | 1.58 | 1.38 | 1.82 | < 0.001 | 1.38 | 1.25 | 1.51 | < 0.001 |
Hypertension | 1.59 | 1.35 | 1.86 | < 0.001 | 1.26 | 1.13 | 1.40 | < 0.001 |
Dyslipidemia | 0.77 | 0.67 | 0.89 | < 0.001 | 0.87 | 0.78 | 0.96 | 0.006 |
Obesity | 0.92 | 0.81 | 1.06 | 0.253 | 1.02 | 0.93 | 1.12 | 0.653 |
Positive Family History | 0.67 | 0.59 | 0.77 | < 0.001 | 0.86 | 0.78 | 0.94 | 0.001 |
Cigarette smoking | 1.04 | 0.70 | 1.54 | 0.853 | 1.31 | 1.01 | 1.70 | 0.043 |
Opium addiction | 1.44 | 0.97 | 2.15 | 0.069 | 1.18 | 0.87 | 1.59 | 0.29 |
Men | ||||||||
Diabetes mellitus | 1.44 | 1.32 | 1.57 | < 0.001 | 1.34 | 1.26 | 1.43 | < 0.001 |
Hypertension | 1.42 | 1.31 | 1.55 | < 0.001 | 1.29 | 1.22 | 1.38 | < 0.001 |
Dyslipidemia | 0.74 | 0.68 | 0.80 | < 0.001 | 0.88 | 0.82 | 0.93 | < 0.001 |
Obesity | 0.87 | 0.78 | 0.97 | 0.013 | 0.97 | 0.90 | 1.05 | 0.434 |
Positive Family History | 0.71 | 0.65 | 0.78 | < 0.001 | 0.87 | 0.82 | 0.93 | < 0.001 |
Cigarette smoking | 1.03 | 0.93 | 1.15 | 0.544 | 1.10 | 1.02 | 1.18 | 0.017 |
Opium addiction | 1.21 | 1.08 | 1.35 | 0.001 | 1.17 | 1.08 | 1.27 | < 0.001 |