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Sports Medicine
Erschienen in: Sports Medicine 12/2019

07.09.2019 | Systematic Review

Sex Dimorphism of VO2max Trainability: A Systematic Review and Meta-analysis

verfasst von: Candela Diaz-Canestro, David Montero

Erschienen in: Sports Medicine | Ausgabe 12/2019

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Abstract

Background

Increases in maximal oxygen uptake (VO2max) are strongly associated with improved cardiovascular health.

Objective

The aim was to perform a systematic review and meta-analysis to determine whether VO2max responses to endurance training (ET), the most effective intervention to improve VO2max, are influenced by sex.

Methods

We conducted a systematic search of MEDLINE and Web of Science since their inceptions until February 2019 for articles assessing the VO2max response to a given sex-matched dose of ET in healthy age-matched men and women. Meta-analyses were performed to determine the mean difference between VO2max responses in men versus women. Subgroup and meta-regression analyses were used to assess potential moderating factors.

Results

After systematic review, eight studies met the inclusion criteria. All studies implemented common modalities of ET in healthy untrained individuals, comprising a total of 175 men and women (90 ♂, 85 ♀). ET duration and intensity were sex-matched in all studies. After data pooling, ET induced substantially larger increases in absolute VO2max in men compared with women (mean difference = + 191 ml·min−1, 95% CI 99, 283; P < 0.001). A greater effect of ET on relative VO2max was also observed in men versus women (mean difference = + 1.95 ml·min−1·kg−1, 95% CI 0.76, 3.15; P = 0.001). No heterogeneity was detected among studies (I2 = 0%, P ≥ 0.59); the meta-analytical results were robust to potential moderating factors.

Conclusion

Pooled evidence demonstrates greater improvements in VO2max in healthy men compared with women in response to a given dose of ET, suggesting the presence of sexual dimorphism in the trainability of aerobic capacity.
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Literatur
1.
Lundby C, Robach P. Performance enhancement: what are the physiological limits? Physiology (Bethesda). 2015;30(4):282–92.PubMed
2.
Montero D, Diaz-Canestro C. Endurance training and maximal oxygen consumption with ageing: role of maximal cardiac output and oxygen extraction. Eur J Prev Cardiol. 2016;23(7):733–43.PubMed
3.
Montero D, Diaz-Canestro C, Lundby C. Endurance training and VO2max: role of maximal cardiac output and oxygen extraction. Med Sci Sports Exerc. 2015;47(10):2024–33.PubMed
4.
Lee DC, Artero EG, Sui X, Blair SN. Mortality trends in the general population: the importance of cardiorespiratory fitness. J Psychopharmacol. 2010;24(4 Suppl):27–35.PubMedPubMedCentral
5.
Mandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W. Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing. JAMA Netw Open. 2018;1(6):e183605.PubMedPubMedCentral
6.
Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA. 2009;301(19):2024–35.PubMed
7.
Montero D, Lundby C. Refuting the myth of non-response to exercise training: ‘non-responders’ do respond to higher dose of training. J Physiol. 2017;595(11):3377–87.PubMedPubMedCentral
8.
Ross R, de Lannoy L, Stotz PJ. Separate effects of intensity and amount of exercise on interindividual cardiorespiratory fitness response. Mayo Clin Proc. 2015;90(11):1506–14.PubMed
9.
Sisson SB, Katzmarzyk PT, Earnest CP, Bouchard C, Blair SN, Church TS. Volume of exercise and fitness nonresponse in sedentary, postmenopausal women. Med Sci Sports Exerc. 2009;41(3):539–45.PubMedPubMedCentral
10.
Rusko HK. Development of aerobic power in relation to age and training in cross-country skiers. Med Sci Sports Exerc. 1992;24(9):1040–7.PubMed
11.
Howden EJ, Perhonen M, Peshock RM, Zhang R, Arbab-Zadeh A, Adams-Huet B, et al. Females have a blunted cardiovascular response to 1 year of intensive supervised endurance training. J Appl Physiol (Bethesda, Md: 1985). 2015;119(1):37–46.
12.
Montero D, Madsen K, Meinild-Lundby AK, Edin F, Lundby C. Sexual dimorphism of substrate utilization: differences in skeletal muscle mitochondrial volume density and function. Exp Physiol. 2018;103(6):851–9.PubMed
13.
Kohrt WM, Malley MT, Coggan AR, Spina RJ, Ogawa T, Ehsani AA, et al. Effects of gender, age, and fitness level on response of VO2max to training in 60–71 year olds. J Appl Physiol (Bethesda, Md: 1985). 1991;71(5):2004–11.
14.
Carter SL, Rennie C, Tarnopolsky MA. Substrate utilization during endurance exercise in men and women after endurance training. Am J Physiol Endocrinol Metab. 2001;280(6):E898–907.PubMed
15.
McKenzie S, Phillips SM, Carter SL, Lowther S, Gibala MJ, Tarnopolsky MA. Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans. Am J Physiol Endocrinol Metab. 2000;278(4):E580–7.PubMed
16.
Montero D, Breenfeldt-Andersen A, Oberholzer L, Haider T, Goetze JP, Meinild-Lundby AK, et al. Erythropoiesis with endurance training: dynamics and mechanisms. Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R894–902.PubMed
17.
Seip RL, Moulin P, Cocke T, Tall A, Kohrt WM, Mankowitz K, et al. Exercise training decreases plasma cholesteryl ester transfer protein. Arterioscler Thromb J Vasc Biol. 1993;13(9):1359–67.
18.
Tarnopolsky MA, Rennie CD, Robertshaw HA, Fedak-Tarnopolsky SN, Devries MC, Hamadeh MJ. Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity. Am J Physiol Regul Integr Comp Physiol. 2007;292(3):R1271–8.PubMed
19.
Weber CL, Schneider DA. Increases in maximal accumulated oxygen deficit after high-intensity interval training are not gender dependent. Journal of Appl Physiol (Bethesda, Md: 1985). 2002;92(5):1795–801.
20.
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–12.
21.
Ross LE, Grigoriadis S, Mamisashvili L, Koren G, Steiner M, Dennis CL, et al. Quality assessment of observational studies in psychiatry: an example from perinatal psychiatric research. Int J Methods Psychiatr Res. 2011;20(4):224–34.PubMedPubMedCentral
22.
23.
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88.PubMed
24.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.PubMedPubMedCentral
25.
Roepstorff C, Steffensen CH, Madsen M, Stallknecht B, Kanstrup IL, Richter EA, et al. Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects. Am J Physiol Endocrinol Metab. 2002;282(2):E435–47.PubMed
26.
Roepstorff C, Thiele M, Hillig T, Pilegaard H, Richter EA, Wojtaszewski JF, et al. Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise. J Physiol. 2006;574(Pt 1):125–38.PubMedPubMedCentral
27.
Carrick-Ranson G, Hastings JL, Bhella PS, Shibata S, Fujimoto N, Palmer D, et al. The effect of age-related differences in body size and composition on cardiovascular determinants of VO2max. J Gerontol A Biol Sci Med Sci. 2013;68(5):608–16.PubMed
28.
Glucksmann A. Sexual dimorphism in mammals. Biol Rev Camb Philos Soc. 1974;49(4):423–75.PubMed
29.
Lindenfors P, Revell LJ, Nunn CL. Sexual dimorphism in primate aerobic capacity: a phylogenetic test. J Evol Biol. 2010;23(6):1183–94.PubMedPubMedCentral
30.
Lundby C, Montero D, Joyner M. Biology of VO2max: looking under the physiology lamp. Acta Physiol (Oxf). 2017;220(2):218–28.PubMed
31.
Rankinen T, Wolfarth B, Simoneau JA, Maier-Lenz D, Rauramaa R, Rivera MA, et al. No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J Appl Physiol (Bethesda, Md: 1985). 2000;88(5):1571–5.
32.
Montero D, Cathomen A, Jacobs RA, Fluck D, de Leur J, Keiser S, et al. Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol. 2015;593(20):4677–88.PubMedPubMedCentral
33.
Montero D, Lundby C. Regulation of red blood cell volume with exercise training. Compr Physiol. 2018;9(1):149–64.PubMed
34.
Sawka MN, Convertino VA, Eichner ER, Schnieder SM, Young AJ. Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sci Sports Exerc. 2000;32(2):332–48.PubMed
35.
Bonne TC, Doucende G, Fluck D, Jacobs RA, Nordsborg NB, Robach P, et al. Phlebotomy eliminates the maximal cardiac output response to six weeks of exercise training. Am J Physiol Regul Integr Comp Physiol. 2014;306(10):R752–60.PubMed
36.
Falz R, Fikenzer S, Hoppe S, Busse M. Normal values of hemoglobin mass and blood volume in young, active women and men. Int J Sports Med. 2019;40(4):236–44.PubMed
37.
Baekkerud FH, Solberg F, Leinan IM, Wisloff U, Karlsen T, Rognmo O. Comparison of three popular exercise modalities on VO2max in overweight and obese. Med Sci Sports Exerc. 2016;48(3):491–8.PubMed
38.
Cornelis J, Beckers P, Taeymans J, Vrints C, Vissers D. Comparing exercise training modalities in heart failure: a systematic review and meta-analysis. Int J Cardiol. 2016;15(221):867–76.
39.
Daussin FN, Ponsot E, Dufour SP, Lonsdorfer-Wolf E, Doutreleau S, Geny B, et al. Improvement of VO2max by cardiac output and oxygen extraction adaptation during intermittent versus continuous endurance training. Eur J Appl Physiol. 2007;101(3):377–83.PubMed
40.
Ray CA, Cureton KJ, Ouzts HG. Postural specificity of cardiovascular adaptations to exercise training. J Appl Physiol (Bethesda, Md: 1985). 1990;69(6):2202–8.
41.
Weston M, Taylor KL, Batterham AM, Hopkins WG. Effects of low-volume high-intensity interval training (HIT) on fitness in adults: a meta-analysis of controlled and non-controlled trials. Sports Med. 2014;44(7):1005–17.PubMedPubMedCentral
42.
Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115(24):3086–94.PubMed
43.
Obert P, Mandigouts S, Nottin S, Vinet A, N’Guyen LD, Lecoq AM. Cardiovascular responses to endurance training in children: effect of gender. Eur J Clin Investig. 2003;33(3):199–208.
44.
Whyte GP, George K, Sharma S, Firoozi S, Stephens N, Senior R, et al. The upper limit of physiological cardiac hypertrophy in elite male and female athletes: the British experience. Eur J Appl Physiol. 2004;92(4–5):592–7.PubMed
45.
de Simone G, Devereux RB, Daniels SR, Meyer RA. Gender differences in left ventricular growth. Hypertension. 1995;26(6 Pt 1):979–83.PubMed
46.
Mendes LA, Davidoff R, Cupples LA, Ryan TJ, Jacobs AK. Congestive heart failure in patients with coronary artery disease: the gender paradox. Am Heart J. 1997;134(2 Pt 1):207–12.PubMed
47.
Regitz-Zagrosek V, Kararigas G. Mechanistic pathways of sex differences in cardiovascular disease. Physiol Rev. 2017;97(1):1–37.PubMed
48.
Lundby C, Sander M, van Hall G, Saltin B, Calbet JA. Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives. J Physiol. 2006;573(Pt 2):535–47.PubMedPubMedCentral
49.
Rud B, Foss O, Krustrup P, Secher NH, Hallen J. One-legged endurance training: leg blood flow and oxygen extraction during cycling exercise. Acta Physiol (Oxf). 2012;205(1):177–85.PubMed
Metadaten
Titel
Sex Dimorphism of VO2max Trainability: A Systematic Review and Meta-analysis
verfasst von
Candela Diaz-Canestro
David Montero
Publikationsdatum
07.09.2019
Verlag
Springer International Publishing
Erschienen in
Sports Medicine / Ausgabe 12/2019
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-019-01180-z

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