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Supportive Care in Cancer

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25.09.2018 | Review Article

Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review

verfasst von: Vesile Yildiz Kabak, Patrick Calders, Tulin Duger, Jibril Mohammed, Eric van Breda

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2019

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Abstract

Purpose

To describe the impairments in physical fitness in individuals who were previously diagnosed and treated for childhood cancer.

Methods

Using the PRISMA-guidelines, a systematic search was performed in PubMed, Web of Science, and Embase using a combination of the following predefined keywords: “exercise capacity” OR “aerobic capacity” OR “fitness” OR “cardiorespiratory fitness” OR “cardiopulmonary fitness” OR “physical fitness” OR “exercise testing” OR “exercise tolerance” OR “exercise” OR “oxygen consumption” AND “leukemia” OR “childhood cancer” OR “childhood cancer survivors (CCS)”. Studies that met our inclusion criteria were reviewed on methodological quality, while the Newcastle-Ottawa Scale was used for evidence synthesis.

Results

A total of 2644 articles were identified from the database search. After screening based on the eligibility (abstracts) and inclusion (full texts) criteria, 49 articles remained. Even though the risk-of-bias scores in the studies were generally low, yet the results from those with high-quality studies revealed that poor fitness levels were prevalent in individuals with acute lymphoblastic leukemia, brain tumor, and mixed cancer histories, compared to healthy controls.

Conclusions

A global glance at CCS shows poor levels of fitness that is continuous and life-long even after active cancer treatment has ended. Nevertheless, the results presented in this review were based on a limited number of high-quality studies suggesting the need to for additional clinical trials in the topic area.

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Titel: Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review
verfasst von: Vesile Yildiz Kabak
Patrick Calders
Tulin Duger
Jibril Mohammed
Eric van Breda
Publikationsdatum: 25.09.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 1/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4483-8

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Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review

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