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Current Rheumatology Reports

Erschienen in:

01.04.2018 | Scleroderma (J Varga, Section Editor)

Sirtuins and Accelerated Aging in Scleroderma

verfasst von: Anne E. Wyman, Sergei P. Atamas

Erschienen in: Current Rheumatology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung fibrosis. The goal of this article is to review recent studies on the involvement of SIRTs in scleroderma from the perspective of aging-related molecular mechanisms.

Recent Findings

Despite a degree of controversy in this rapidly developing field, the majority of data suggest that SIRT levels are decreased in tissues from patients with scleroderma compared to healthy controls as well as in animal models of scleroderma. Molecular studies reveal several mechanisms through which declining SIRT levels contribute to fibrosis, with the most attention given to modulation of the TGF-β signaling pathway. Activation of SIRTs in cell culture and in animal models elicits antifibrotic effects.

Summary

Declining SIRT levels and activity are emerging as pathophysiological contributors to scleroderma. Restoration of SIRTs may be therapeutic in patients with scleroderma.

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Titel: Sirtuins and Accelerated Aging in Scleroderma
verfasst von: Anne E. Wyman
Sergei P. Atamas
Publikationsdatum: 01.04.2018
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 4/2018
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-018-0724-6

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