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Erschienen in:

27.03.2023 | Original Article

Skin sympathetic nerve activity as a potential biomarker for overactive bladder

verfasst von: Yu-Chen Chen, Hao-Wei Chen, Tien-Chi Huang, Ting-Yin Chu, Yung-Shun Juan, Cheng-Yu Long, Hsiang-Ying Lee, Shu-Pin Huang, Yu-Peng Liu, Chao-Ju Chen, Meng-Ni Wu, Kuang-Shun Chueh, Ching-Chia Li, Chien-Hung Lee, Wei-Chung Tsai, Wen-Jeng Wu

Erschienen in: World Journal of Urology | Ausgabe 5/2023

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Abstract

Purpose

Abnormalities in autonomic function are associated with an overactive bladder (OAB). Heart rate variability is generally used as the sole assessment of autonomic activity; however, we utilized neuECG, a novel method of recording skin electrical signals, to assess autonomic nervous function in healthy controls and patients with OAB before and after treatment.

Methods

The prospective sample included 52 participants: 23 patients newly diagnosed with OAB and 29 controls. Autonomic function was assessed in all participants in the morning using neuECG, which analyzed the average skin sympathetic nerve activity (aSKNA) and electrocardiogram simultaneously. All patients with OAB were administered antimuscarinics; urodynamic parameters were assessed before treatments; autonomic and bladder functions using validated questionnaires for OAB symptoms were evaluated before and after OAB treatment.

Results

Patients with OAB had significantly higher baseline aSKNA (p = 0.003), lower standard deviation of the normal-to-normal beat intervals, lower root mean square of the successive differences, lower high-frequency, and higher low-frequency than did controls. Baseline aSKNA had the highest value in predicting OAB (AUROC = 0.783, p < 0.001). The aSKNA was negatively correlated with first desire and normal desire in urodynamic studies (both p = 0.025) and was significantly decreased after treatment at rest, stress, and recovery phases, as compared to those before treatment (p = 0.046, 0.017, and 0.017, respectively).

Conclusion

Sympathetic activity increased significantly in patients with OAB compared to that in healthy controls, and decreased significantly post-treatment. Higher aSKNA is associated with decreased bladder volume at which voiding is desired. SKNA may be a potential biomarker for diagnosing OAB.

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Titel: Skin sympathetic nerve activity as a potential biomarker for overactive bladder
verfasst von: Yu-Chen Chen
Hao-Wei Chen
Tien-Chi Huang
Ting-Yin Chu
Yung-Shun Juan
Cheng-Yu Long
Hsiang-Ying Lee
Shu-Pin Huang
Yu-Peng Liu
Chao-Ju Chen
Meng-Ni Wu
Kuang-Shun Chueh
Ching-Chia Li
Chien-Hung Lee
Wei-Chung Tsai
Wen-Jeng Wu
Publikationsdatum: 27.03.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 5/2023
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-023-04376-1

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Skin sympathetic nerve activity as a potential biomarker for overactive bladder