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Journal of Neurology
Erschienen in: Journal of Neurology 12/2021

11.11.2020 | Review

Spinocerebellar ataxia type 23 (SCA23): a review

verfasst von: Fan Wu, Xu Wang, Xiaohan Li, Huidi Teng, Tao Tian, Jing Bai

Erschienen in: Journal of Neurology | Ausgabe 12/2021

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Abstract

Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant cerebellar ataxias (ADCAs), are a group of hereditary heterogeneous neurodegenerative diseases. Gait, progressive ataxia, dysarthria, and eye movement disorder are common symptoms of spinocerebellar ataxias. Other symptoms include peripheral neuropathy, cognitive impairment, psychosis, and seizures. Patients may lose their lives due to out of coordinated respiration and/or swallowing. Neurological signs cover pyramidal or extrapyramidal signs, spasm, ophthalmoplegia, hyperactive deep tendon reflexes, and so on. Different subtypes of SCAs present various clinical features. Spinocerebellar ataxia type 23 (SCA23), one subtype of the SCA family, is characterized by mutant prodynorphin (PDYN) gene. Based on literatures, this review details a series of SCA23, to improve a whole understanding of clinicians and point out the potential research direction of this dysfunction, including a history, pathophysiological mechanism, diagnosis and differential diagnosis, epigenetics, penetrance and prevalence, genetic counseling, treatment and prognosis.
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Metadaten
Titel
Spinocerebellar ataxia type 23 (SCA23): a review
verfasst von
Fan Wu
Xu Wang
Xiaohan Li
Huidi Teng
Tao Tian
Jing Bai
Publikationsdatum
11.11.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 12/2021
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-020-10297-5

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