Ausgabe 1/2012
Inhalt (246 Artikel)
Improved clinical outcome after invasive management of patients with recent myocardial infarction and proven myocardial viability: primary results of a randomized controlled trial (VIAMI-trial)
Ramon B van Loon, Gerrit Veen, Leo H B Baur, Otto Kamp, Jean G F Bronzwaer, Jos W R Twisk, Freek W A Verheugt, Albert C van Rossum
Managing co-morbid depression and anxiety in primary care patients with asthma and/or chronic obstructive pulmonary disease: study protocol for a randomized controlled trial
Antoinette M Pommer, François Pouwer, Johan Denollet, Victor J M Pop
Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience
Stephanie M Zielinski, Helena Viveiros, Martin J Heetveld, Marc F Swiontkowski, Mohit Bhandari, Peter Patka, Esther MM Van Lieshout
Acute cholecystitis in high risk surgical patients: percutaneous cholecystostomy versus laparoscopic cholecystectomy (CHOCOLATE trial): Study protocol for a randomized controlled trial
Kirsten Kortram, Bert van Ramshorst, Thomas L Bollen, Marc G H Besselink, Dirk J Gouma, Tom Karsten, Philip M Kruyt, Grard A P Nieuwenhuijzen, Johannes C Kelder, Ellen Tromp, Djamila Boerma
A GO intervention program for enhancing elementary school children's cognitive functions and control abilities of emotion and behavior: study protocol for a randomized controlled trial
Yoshiyuki Tachibana, Jiro Yoshida, Masahito Ichinomiya, Rui Nouchi, Carlos Miyauchi, Hikaru Takeuchi, Naoki Tomita, Hiroyuki Arai, Ryuta Kawashima
MAVIDOS Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial. The MAVIDOS Study Group
Nicholas C Harvey, Kassim Javaid, Nicholas Bishop, Stephen Kennedy, Aris T Papageorghiou, Robert Fraser, Saurabh V Gandhi, Inez Schoenmakers, Ann Prentice, Cyrus Cooper
Hand washing with soap and water together with behavioural recommendations prevents infections in common work environment: an open cluster-randomized trial
Carita Savolainen-Kopra, Jaason Haapakoski, Piia A Peltola, Thedi Ziegler, Terttu Korpela, Pirjo Anttila, Ali Amiryousefi, Pentti Huovinen, Markku Huvinen, Heikki Noronen, Pia Riikkala, Merja Roivainen, Petri Ruutu, Juha Teirilä, Erkki Vartiainen, Tapani Hovi
Effectiveness of cricoid pressure in preventing gastric aspiration during rapid sequence intubation in the emergency department: study protocol for a randomised controlled trial
Christopher E Trethewy, Julie M Burrows, Don Clausen, Steven R Doherty
Efficacy of Vitamin D Supplementation in Multiple Sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial
Jan Dörr, Stephanie Ohlraun, Horst Skarabis, Friedemann Paul
Feasibility study of a clinically-integrated randomized trial of modifications to radical prostatectomy
Andrew J Vickers, Caroline Bennette, Karim Touijer, Jonathan Coleman, Vincent Laudone, Brett Carver, James A Eastham, Peter T Scardino
Development of a clinical trial to determine whether watchful waiting is an acceptable alternative to surgical repair for patients with oligosymptomatic incisional hernia: study protocol for a randomized controlled trial
Johannes C Lauscher, Peter Martus, Andrea Stroux, Jens Neudecker, Uwe Behrens, Ralf Hammerich, Heinz J Buhr, Jörg-Peter Ritz
Tailored internet-administered treatment of anxiety disorders for primary care patients: study protocol for a randomised controlled trial
Lise Bergman Nordgren, Gerhard Andersson, Åsa Kadowaki, Per Carlbring
Evaluating the effectiveness of GP endorsement on increasing participation in the NHS Bowel Cancer Screening Programme in England: study protocol for a randomized controlled trial
Sarah Damery, Steve Smith, Alison Clements, Roger Holder, Linda Nichols, Heather Draper, Sue Clifford, Laura Parker, Richard Hobbs, Sue Wilson
Assertive Community Treatment for alcohol dependence (ACTAD): study protocol for a randomised controlled trial
Helen Gilburt, Tom Burns, Alex Copello, Simon Coulton, Michael Crawford, Ed Day, Paolo Deluca, Christine Godfrey, Steve Parrott, Abigail K Rose, Julia M A Sinclair, Christine Wright, Colin Drummond
A cost-effectiveness analysis of provider interventions to improve health worker practice in providing treatment for uncomplicated malaria in Cameroon: a study protocol for a randomized controlled trial
Virginia Wiseman, Lindsay J Mangham, Bonnie Cundill, Olivia A Achonduh, Akindeh Mbuh Nji, Abanda Ngu Njei, Clare Chandler, Wilfred F Mbacham
Effect of TENS on pain in relation to central sensitization in patients with osteoarthritis of the knee: study protocol of a randomized controlled trial
David Beckwée, Willem De Hertogh, Pierre Lievens, Ivan Bautmans, Peter Vaes
Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial
Romain Eschalier, Frédéric Jean, Bruno Pereira, Séverine Monzy, Charles Vorilhon, Valérie Mactoux, Bernard Citron, Vincent Sapin, Pascal Motreff, Jean R Lusson
Clustering in surgical trials - database of intracluster correlations
Jonathan A Cook, Thomas Bruckner, Graeme S MacLennan, Christoph M Seiler
Comparison of embedded and added motor imagery training in patients after stroke: results of a randomised controlled pilot trial
Corina Schuster, Jenny Butler, Brian Andrews, Udo Kischka, Thierry Ettlin
Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: study protocol for a randomized controlled trial
Martin Dennis, Peter Sandercock, John Reid, Catriona Graham, John Forbes
Erratum to: The International Stroke Trial database
Peter A G Sandercock, Maciej Niewada, Anna Członkowska
Involvement of consumers in studies run by the Medical Research Council Clinical Trials Unit: Results of a survey
Claire L Vale, Lindsay C Thompson, Claire Murphy, Silvia Forcat, Bec Hanley
Efficacy of early neonatal vitamin A supplementation in reducing mortality during infancy in Ghana, India and Tanzania: study protocol for a randomized controlled trial
Rajiv Bahl, Nita Bhandari, Brinda Dube, Karen Edmond, Wafaie Fawzi, Olivier Fontaine, Jasmine Kaur, Betty R Kirkwood, Jose Martines, Honorati Masanja, Sarmila Mazumder, Salum Msham, Sam Newton, Maureen Oleary, Julia Ruben, Caitlin Shannon, Emily Smith, Sunita Taneja, Sachiyo Yoshida
Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN) countries
Christian Gluud, Christine Kubiak, Kate Whitfield, Jane Byrne, Karl-Heinz Huemer, Steffen Thirstrup, Christian Libersa, Béatrice Barraud, Xina Grählert, Gabriele Dreier, Sebastian Geismann, Wolfgang Kuchinke, Zsuza Temesvari, Gyorgy Blasko, Gabriella Kardos, Timothy O'Brien, Margaret Cooney, Siobhan Gaynor, Arrigo Schieppati, Fernando de Andres, Nuria Sanz, German Kreis, Charlotte Asker-Hagelberg, Hanna Johansson, Sue Bourne, Adeeba Asghar, Jean-Marc Husson, Jacques Demotes-Mainard
The 'Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & antiplatelet REgimen' (HOST-ASSURE) trial: study protocol for a randomized controlled trial
Kyung Woo Park, Byoung-Eun Park, Si-Hyuck Kang, Jin-Joo Park, Seung-Pyo Lee, Kwang Soo Cha, Jay Young Rhew, Hui-Kyoung Jeon, Eun Seok Shin, Ju Hyeon Oh, Myung-Ho Jeong, Sanghyun Kim, Kyung-Kuk Hwang, Jung-Han Yoon, Sung Yun Lee, Tae-Ho Park, Keon Woong Moon, Hyuck-Moon Kwon, In-Ho Chae, Hyo-Soo Kim
Motivations for participating in a clinical trial on an avian influenza vaccine
Laura Costas, José M Bayas, Beatriz Serrano, Sarah Lafuente, M-Amparo Muñoz
Surgical treatment of zygomatic bone fracture using two points fixation versus three point fixation-a randomised prospective clinical trial
Majeed Rana, Riaz Warraich, Salman Tahir, Asifa Iqbal, Constantin von See, André M Eckardt, Nils-Claudius Gellrich
Home medicines reviews following acute coronary syndrome: study protocol for a randomized controlled trial
Daniel D L Bernal, Leanne Stafford, Luke R E Bereznicki, Ronald L Castelino, Patricia M Davidson, Gregory M Peterson
Beneficial effects of reading aloud and solving simple arithmetic calculations (learning therapy) on a wide range of cognitive functions in the healthy elderly: study protocol for a randomized controlled trial
Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi, Ryuta Kawashima
Effectiveness of Physio Acoustic Sound (PAS) therapy in demented nursing home residents with nocturnal restlessness: study protocol for a randomized controlled trial
Arnoldien J van Os, Leelie Aziz, Dorus Schalkwijk, Jos MGA Schols, Rob A de Bie
Health-related quality of life in cancer patients at the end of life, translation, validation, and longitudinal analysis of specific tools: study protocol for a randomized controlled trial
Anne-Lise Poirier, Fabrice Kwiatkowski, Jean-Marie Commer, Bénédicte D'Aillières, Virginie Berger, Mariette Mercier, Franck Bonnetain
Effects of Gyejibongnyeong-hwan on dysmenorrhea caused by blood stagnation: study protocol for a randomized controlled trial
Jeong-Su Park, Sunju Park, Chun-Hoo Cheon, Ho-Yeon Go, Seung-Ho Sun, Yong-Cheol Shin, Bo-Hyoung Jang, Seong-Gyu Ko
The Anticoagulation of Calf Thrombosis (ACT) project: study protocol for a randomized controlled trial
Daniel Horner, Kerstin Hogg, Richard Body, Michael J Nash, Kevin Mackway-Jones
Clinical effect of pricking blood at neiyingxiang (ExHN 9) on non-allergic rhinopathy: study protocol for a randomized controlled trial
Kyu Seok Kim, Sang Gyu Go, Yoon-Bum Kim
Effect of sequential treatment with syndrome differentiation on acute exacerbation of chronic obstructive pulmonary disease and "AECOPD Risk-Window": study protocol for a randomized placebo-controlled trial
Wang Haifeng, Li Jiansheng, Li Suyun, Yu Xueqing, Zhang Hailong, Wang Zhiwan, Wu Qiyi, Zhang Pankui, Wang Zhongchao, Li Fenglei, Yan Haihong
Intravenous magnesium prevents atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 7 double-blind, placebo-controlled, randomized clinical trials
Wan-Jie Gu, Zhen-Jie Wu, Peng-Fei Wang, Lynn Htet Htet Aung, Rui-Xing Yin
A pilot study to evaluate the effect of Taeumjowi-tang on obesity in Korean adults: study protocol for a randomised, double-blind, placebo-controlled, multicentre trial
Sunju Park, Jeong-Su Park, ChunHoo Cheon, Yong Joon Yang, Changsuk An, Bo-Hyoung Jang, Yun-Kyung Song, Hoyeon Go, Ju Ah Lee, Yongcheol Shin, Seong-Gyu Ko
Forty-five years of schizophrenia trials in Italy: a survey
Marianna Purgato, Clive Adams, Corrado Barbui
The effectiveness of a trauma-focused psycho-educational secondary prevention program for children exposed to interparental violence: study protocol for a randomized controlled trial
Mathilde M Overbeek, J Clasien de Schipper, Francien Lamers-Winkelman, Carlo Schuengel
Temporary epicardial cardiac resynchronisation versus conventional right ventricular pacing after cardiac surgery: study protocol for a randomised control trial
Stuart J Russell, Christine Tan, Peter O'Keefe, Saeed Ashraf, Afzal Zaidi, Alan G Fraser, Zaheer R Yousef
Alcohol email assessment and feedback study dismantling effectiveness for university students (AMADEUS-1): study protocol for a randomized controlled trial
Jim McCambridge, Preben Bendtsen, Marcus Bendtsen, Per Nilsen
The effect of telephone-based interpersonal psychotherapy for the treatment of postpartum depression: study protocol for a randomized controlled trial
Cindy-Lee Dennis, Paula Ravitz, Sophie Grigoriadis, Melissa Jovellanos, Ellen Hodnett, Lori Ross, John Zupancic
Factors contributing to therapeutic effects evaluated in acupuncture clinical trials
Guang-Xia Shi, Xiao-Min Yang, Cun-Zhi Liu, Lin-Peng Wang
Should we reconsider the routine use of placebo controls in clinical research?
Andrew L Avins, Daniel C Cherkin, Karen J Sherman, Harley Goldberg, Alice Pressman
A study of the effect of the FertilMate™ scrotum cooling patch on male fertility. SCOP trial (scrotal cooling patch) - study protocol for a randomised controlled trial
M Waseem Osman, llias Nikolopoulos, Zeina Haoula, Jayaprakasan Kannamannadiar, William Atiomo
Assessing the effectiveness of ‘pulse radiofrequency treatment of dorsal root ganglion’ in patients with chronic lumbar radicular pain: study protocol for a randomized control trial
Harsha Shanthanna, Philip Chan, James McChesney, James Paul, Lehana Thabane
INtimal hyPerplasia evAluated by oCT in de novo COROnary lesions treated by drug-eluting balloon and bare-metal stent (IN-PACT CORO): study protocol for a randomized controlled trial
Francesco Burzotta, Marta Francesca Brancati, Carlo Trani, Italo Porto, Antonella Tommasino, Gianluigi De Maria, Giampaolo Niccoli, Antonio Maria Leone, Valentina Coluccia, Giovanni Schiavoni, Filippo Crea
Acupuncture to improve live birth rates for women undergoing in vitro fertilization: a protocol for a randomized controlled trial
Caroline A Smith, Sheryl de Lacey, Michael Chapman, Julie Ratcliffe, Robert J Norman, Neil Johnson, Gavin Sacks, Jane Lyttleton, Clare Boothroyd
Behavioral activation-based guided self-help treatment administered through a smartphone application: study protocol for a randomized controlled trial
Kien Hoa Ly, Per Carlbring, Gerhard Andersson
Efficacy of two educational interventions about inhalation techniques in patients with chronic obstructive pulmonary disease (COPD). TECEPOC: study protocol for a partially randomized controlled trial (preference trial)
Francisca Leiva-Fernández, José Leiva-Fernández, Fernando Zubeldia-Santoyo, Antonio García-Ruiz, Daniel Prados-Torres, Pilar Barnestein-Fonseca
Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain: study protocol for a randomized controlled trial
Li Yuxiang, Tang Lu, Yu Jianqiang, Dai Xiuying, Zhou Wanfang, Zhang Wannian, Hu Xiaoyan, Xiao Shichu, Ni Wen, Ma Xiuqiang, Wu Yinsheng, Yao Ming, Mu Guoxia, Wang Guangyi, Han Wenjun, Xia Zhaofan, Tang Hongtai, Zhao Jijun
Small incision lenticule extraction (SMILE) versus laser in-situ keratomileusis (LASIK): study protocol for a randomized, non-inferiority trial
Marcus Ang, Donald Tan, Jodhbir S Mehta
The effect of ultrapro or prolene mesh on postoperative pain and well-being following endoscopic Totally Extraperitoneal (TEP) hernia repair (TULP): study protocol for a randomized controlled trial
Nelleke Schouten, Thijs van Dalen, Niels Smakman, Sjoerd G Elias, Geert Jan Clevers, Egbert-Jan M M Verleisdonk, Paul H P Davids, Ine PJ Burgmans
The effectiveness of a web-based brief alcohol intervention in reducing heavy drinking among adolescents aged 15 to 20 years with a low educational background: study protocol for a randomized controlled trial
Carmen V Voogt, Evelien A P Poelen, Lex A C J Lemmers, Rutger C M E Engels
Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II – Trial): study protocol for a randomised controlled trial
Ronald M van Dam, Edgar M Wong-Lun-Hing, Gerard JP van Breukelen, Jan HMB Stoot, Joost R van der Vorst, Marc HA Bemelmans, Steven WM Olde Damink, Kristoffer Lassen, Cornelis HC Dejong
The first 100 patients in the SUN(^_^)D trial (strategic use of new generation antidepressants for depression): examination of feasibility and adherence during the pilot phase
Shinji Shimodera, Tadashi Kato, Hirotoshi Sato, Kazuhira Miki, Yoshihiro Shinagawa, Masaki Kondo, Hirokazu Fujita, Ippei Morokuma, Yoshio Ikeda, Tatsuo Akechi, Norio Watanabe, Mitsuhiko Yamada, Masatoshi Inagaki, Naohiro Yonemoto, Toshi A Furukawa
Efficacy of vision restoration therapy after optic neuritis (VISION study): study protocol for a randomized controlled trial
Johann Schinzel, Lina Schwarzlose, Holger Dietze, Karolina Bartusch, Susanne Weiss, Stephanie Ohlraun, Friedemann Paul, Jan Dörr
Stimulation of the autonomic nervous system in colorectal surgery: a study protocol for a randomized controlled trial
Tim MP Berghmans, Karel WE Hulsewé, Wim A Buurman, Misha DP Luyer
A benefit-finding intervention for family caregivers of persons with Alzheimer disease: study protocol of a randomized controlled trial
Sheung-Tak Cheng, Rosanna WL Lau, Emily PM Mak, Natalie SS Ng, Linda CW Lam, Helene H Fung, Julian CL Lai, Timothy Kwok, Diana TF Lee
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: Study protocol for a randomised controlled trial
Michael Joseph Barrett, John Cronin, Adrian Murphy, Siobhan McCoy, John Hayden, SinéadNic an Fhailí, Tim Grant, Abel Wakai, Corrina McMahon, Sean Walsh, Ronan O’Sullivan
Use acupuncture to treat functional constipation: study protocol for a randomized controlled trial
Ying Li, Hui Zheng, Fang Zeng, Si-yuan Zhou, Feng Zhong, Hua-bing Zheng, Min Chen, Xiang-hong Jing, Yu-ying Cai, Bao-hui Jia, Bing Zhu, Zhi-shun Liu
Resuscitation of very preterm infants with 30% vs. 65% oxygen at birth: study protocol for a randomized controlled trial
Denise Rook, Henk Schierbeek, Anne C van der Eijk, Mariangela Longini, Giuseppe Buonocore, Maximo Vento, Johannes B van Goudoever, Marijn J Vermeulen
Maintenance Cognitive Stimulation Therapy (CST) in practice: study protocol for a randomized controlled trial
Amy Streater, Aimee Spector, Elisa Aguirre, Juanita Hoe, Zoe Hoare, Robert Woods, Ian Russell, Martin Orrell
Lack of proportionality. Seven specifications of public interest that override post-approval commercial interests on limited access to clinical data
Daniel Strech, Jasper Littmann
Effects of a manualized short-term treatment of internet and computer game addiction (STICA): study protocol for a randomized controlled trial
Susanne Jäger, Kai W Müller, Christian Ruckes, Tobias Wittig, Anil Batra, Michael Musalek, Karl Mann, Klaus Wölfling, Manfred E Beutel
Validating intramyocardial bone marrow stem cell therapy in combination with coronary artery bypass grafting, the PERFECT Phase III randomized multicenter trial: study protocol for a randomized controlled trial
Peter Donndorf, Alexander Kaminski, Gudrun Tiedemann, Guenther Kundt, Gustav Steinhoff
Examining the impact of genetic testing for type 2 diabetes on health behaviors: study protocol for a randomized controlled trial
Corrine I Voils, Cynthia J Coffman, David Edelman, Matthew L Maciejewski, Janet M Grubber, Azita Sadeghpour, Alex Cho, Jamiyla McKenzie, Francoise Blanpain, Maren Scheuner, Margarete Sandelowski, M Patrick Gallagher, Geoffrey S Ginsburg, William S Yancy Jr
The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study
Daniel J Bratton, Andrew J Nunn, Fenella Wojnarowska, Gudula Kirtschig, Anna Sandell, Hywel C Williams
UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial
Fiona F Craig, Kim S Thomas, Eleanor J Mitchell, Hywel C Williams, John Norrie, James M Mason, Anthony D Ormerod
Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people
Ian P Sinha, Ruairi Gallagher, Paula R Williamson, Rosalind L Smyth
The AgeWell study of behavior change to promote health and wellbeing in later life: study protocol for a randomized controlled trial
Linda Clare, John V Hindle, Ian R Jones, Jeanette M Thom, Sharon M Nelis, Barry Hounsome, Christopher J Whitaker
The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial
Anne Juul Wikkelsoe, Arash Afshari, Jakob Stensballe, Jens Langhoff-Roos, Charlotte Albrechtsen, Kim Ekelund, Gabriele Hanke, Heidi Fosgrau Sharif, Anja U Mitchell, Jens Svare, Ane Troelstrup, Lars Møller Pedersen, Jeannet Lauenborg, Mette Gøttge Madsen, Birgit Bødker, Ann M Møller
Thermotherapy. An alternative for the treatment of American cutaneous leishmaniasis.
Liliana López, Martha Robayo, Margarita Vargas, Iván D Vélez
A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial
Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann, Anna Meneghelli, Carla Cremonese, Paolo Scocco, Emanuela Leuci, Fausto Mazzi, Massimo Gennarelli, Paolo Brambilla, Sarah Bissoli, Maria Elena Bertani, Sarah Tosato, Katia De Santi, Sara Poli, Doriana Cristofalo, Michele Tansella
The Well London program - a cluster randomized trial of community engagement for improving health behaviors and mental wellbeing: baseline survey results
Gemma Phillips, Adrian Renton, Derek G Moore, Christian Bottomley, Elena Schmidt, Shahana Lais, Ge Yu, Martin Wall, Patrick Tobi, Caroline Frostick, Angela Clow, Karen Lock, Mark Petticrew, Richard Hayes
Oral nutrition or water loading before hip replacement surgery; a randomized clinical trial
Stefan Ljunggren, Robert G Hahn
Assessing the effect of high-repetitive single limb exercises (HRSLE) on exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD): study protocol for randomized controlled trial
Andre Nyberg, Britta Lindström, Karin Wadell
What is the role and authority of gatekeepers in cluster randomized trials in health research?
Antonio Gallo, Charles Weijer, Angela White, Jeremy M Grimshaw, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Andrew D McRae, Raphael Saginur, Merrick Zwarenstein, Monica Taljaard
Implementation of a publication strategy in the context of reporting biases. A case study based on new documents from Neurontin® litigation
S Swaroop Vedula, Palko S Goldman, Ilyas J Rona, Thomas M Greene, Kay Dickersin
Long-term dietary intervention trials: critical issues and challenges
Georgina E Crichton, Peter RC Howe, Jonathan D Buckley, Alison M Coates, Karen J Murphy, Janet Bryan
Nicotine patches and quitline counseling to help hospitalized smokers stay quit: study protocol for a randomized controlled trial
Sharon Cummins, Shu-Hong Zhu, Anthony Gamst, Carrie Kirby, Kendra Brandstein, Hillary Klonoff-Cohen, Edward Chaplin, Timothy Morris, Gregory Seymann, Joshua Lee
The optimized acupuncture treatment for neck pain caused by cervical spondylosis: a study protocol of a multicentre randomized controlled trial
Zhao-Hui Liang, Zhong Di, Shuo Jiang, Shu-Jun Xu, Xiao-Ping Zhu, Wen-Bin Fu, Ai-Ping Lu
Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial
Matthew R Sydes, Mahesh KB Parmar, Malcolm D Mason, Noel W Clarke, Claire Amos, John Anderson, Johann de Bono, David P Dearnaley, John Dwyer, Charlene Green, Gordana Jovic, Alastair WS Ritchie, J Martin Russell, Karen Sanders, George Thalmann, Nicholas D James
Assessment of adherence to the CONSORT statement for quality of reports on randomized controlled trial abstracts from four high-impact general medical journals
Saurav Ghimire, Eunjung Kyung, Wonku Kang, Eunyoung Kim
Developing core outcome sets for clinical trials: issues to consider
Paula R Williamson, Douglas G Altman, Jane M Blazeby, Mike Clarke, Declan Devane, Elizabeth Gargon, Peter Tugwell
Efficacy of single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial
Fadhili M Lyimo, Anthony N Massinde, Benson R Kidenya, Evelyne Konje, Stephen E Mshana
Intervention description is not enough: evidence from an in-depth multiple case study on the untold role and impact of context in randomised controlled trials of seven complex interventions
Mary Wells, Brian Williams, Shaun Treweek, Joanne Coyle, Julie Taylor
HElmet therapy Assessment in infants with Deformed Skulls (HEADS): protocol for a randomised controlled trial
Renske M van Wijk, Magda M Boere-Boonekamp, Catharina GM Groothuis-Oudshoorn, Leo A van Vlimmeren, Maarten J IJzerman
Effect of traditional Chinese medicine on outcomes in patients with mild/moderate chronic obstructive pulmonary disease: study protocol for a randomized placebo-controlled trial
Wang Minghang, Li Jiansheng, Li Suyun, Wang Haifeng, Yu Xueqing, Zhang Hailong
Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial
Sergio Bergese, Adolfo Viloria, Alberto Uribe, Alejandra Antor, Soledad Fernandez
Pancreatogastrostomy versus pancreatojejunostomy for RECOnstruction after partial PANCreatoduodenectomy (RECOPANC): study protocol of a randomized controlled trial UTN U1111-1117-9588
Ulrich Friedrich Wellner, Sabine Brett, Thomas Bruckner, Ronald Limprecht, Inga Rossion, Christoph Seiler, Olivia Sick, Inga Wegener, Ulrich Theodor Hopt, Tobias Keck
Influence of macrolide maintenance therapy and bacterial colonisation on exacerbation frequency and progression of COPD (COLUMBUS): Study protocol for a randomised controlled trial
Sevim Uzun, Remco S Djamin, JanAJW Kluytmans, Nils E Van’t Veer, Anton A M Ermens, Aline J Pelle, Paul Mulder, Menno M van der Eerden, JoachimGJV Aerts
The effects of exercise during pregnancy on the newborn’s brain: study protocol for a randomized controlled trial
Elise L LeMoyne, Daniel Curnier, Samuel St-Jacques, Dave Ellemberg
Self-help materials for the prevention of smoking relapse: study protocol for a randomized controlled trial
Fujian Song, Richard Holland, Garry R Barton, Max Bachmann, Annie Blyth, Viv Maskrey, Paul Aveyard, Stephen Sutton, Jo Leonardi-Bee, Thomas H Brandon
More Active Mums in Stirling (MAMMiS): a physical activity intervention for postnatal women. Study protocol for a randomized controlled trial
Alyssa S Gilinsky, Adrienne R Hughes, Rhona J McInnes
Psychoanalytic and cognitive-behavior therapy of chronic depression: study protocol for a randomized controlled trial
Manfred E Beutel, Marianne Leuzinger-Bohleber, Bernhard Rüger, Ulrich Bahrke, Alexa Negele, Antje Haselbacher, Georg Fiedler, Wolfram Keller, Martin Hautzinger
Overview of the consortium of hospitals advancing research on tobacco (chart)
William T Riley, Victor J Stevens, Shu-Hong Zhu, Glen Morgan, Debra Grossman
Life- and person-centred help in Mecklenburg-Western Pomerania, Germany (DelpHi): study protocol for a randomised controlled trial
Jochen René Thyrian, Thomas Fiß, Adina Dreier, Georgia Böwing, Aniela Angelow, Sven Lueke, Stefan Teipel, Steffen Fleßa, Hans Jörgen Grabe, Harald Jürgen Freyberger, Wolfgang Hoffmann
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial
Yashbir Dewan, Edward O Komolafe, Jorge H Mejía-Mantilla, Pablo Perel, Ian Roberts, Haleema Shakur
The Cessation in Pregnancy Incentives Trial (CPIT): study protocol for a randomized controlled trial
David M Tappin, Linda Bauld, Carol Tannahill, Linda de Caestecker, Andrew Radley, Alex McConnachie, Kathleen Boyd, Andrew Briggs, Liz Grant, Alan Cameron, Susan MacAskill, Lesley Sinclair, Brenda Friel, Tim Coleman
Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial
Rahil Sanatinia, Barbara Barrett, Sarah Byford, Madeleine Dean, John Green, Rachel Jones, Baptiste Leurent, Anne Lingford-Hughes, Michael Sweeting, Robin Touquet, Peter Tyrer, Helen Ward, Mike J Crawford
Transfer of manualized CBT for social phobia into clinical practice (SOPHO-PRAX): a study protocol for a cluster-randomized controlled trial
Stephen Crawcour, Eric Leibing, Denise Ginzburg, Ulrich Stangier, Jörg Wiltink, Jürgen Hoyer
The effects of continuous prostacyclin infusion on regional blood flow and cerebral vasospasm following subarachnoid haemorrhage: study protocol for a randomised controlled trial
Rune Rasmussen, Jørn Wetterslev, Trine Stavngaard, Jane Skjøth-Rasmussen, Per Olof Grände, Niels Vidiendal Olsen, Bertil Romner
The management of dental caries in primary teeth - involving service providers and users in the design of a trial
Zoe Marshman, Nicola Innes, Chris Deery, Melanie Hall, Chris Speed, Gail Douglas, Jan Clarkson, Helen Rodd
Assessment of blinding to treatment allocation in studies of a cannabis-based medicine (Sativex®) in people with multiple sclerosis: a new approach
Stephen Wright, Paul Duncombe, Douglas G Altman
Motivational Interviewing with computer assistance as an intervention to empower women to make contraceptive choices while incarcerated: study protocol for randomized controlled trial
Jennifer Clarke, Melanie A Gold, Rachel E Simon, Mary B Roberts, LAR Stein
Comparative effectiveness of post-discharge interventions for hospitalized smokers: study protocol for a randomized controlled trial
Sandra J Japuntich, Susan Regan, Joseph Viana, Justyna Tymoszczuk, Michele Reyen, Douglas E Levy, Daniel E Singer, Elyse R Park, Yuchiao Chang, Nancy A Rigotti
Registration of noncommercial randomised clinical trials: the feasibility of using trial registries to monitor the number of trials
James Raftery, Eleanor Fairbank, Lisa Douet, Louise Dent, Alison Price, Ruairidh Milne, Tom Walley
Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial
Anne B Chang, Keith Grimwood, Colin F Robertson, Andrew C Wilson, Peter P van Asperen, Kerry-Ann F O’Grady, Theo P Sloots, Paul J Torzillo, Emily J Bailey, Gabrielle B McCallum, Ian B Masters, Catherine A Byrnes, Mark D Chatfield, Helen M Buntain, Ian M Mackay, Peter S Morris
The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery
Mark Coburn, Robert D Sanders, Mervyn Maze, Rolf Rossaint
Surgical trial in traumatic intracerebral hemorrhage (STITCH(Trauma)): study protocol for a randomized controlled trial
Barbara A Gregson, Elise N Rowan, Patrick M Mitchell, Andy Unterberg, Elaine M McColl, Iain R Chambers, Paul McNamee, A David Mendelow
Improving patient-centeredness of fertility care using a multifaceted approach: study protocol for a randomized controlled trial
Aleida G Huppelschoten, Noortje TL van Duijnhoven, Rosella PMG Hermens, Chris Verhaak, Jan AM Kremer, Willianne LDM Nelen
Aerobic endurance training versus relaxation training in patients with migraine (ARMIG): study protocol for a randomized controlled trial
Andreas Totzeck, Susanne Unverzagt, Maja Bak, Pierre Augst, Hans-Christoph Diener, Charly Gaul
Nonadherence to treatment protocol in published randomised controlled trials: a review
Susanna Dodd, Ian R White, Paula Williamson
Psychosocial group intervention to enhance self-management skills of people with dementia and their caregivers: study protocol for a randomized controlled trial
Marja-Liisa Laakkonen, Eeva H Hölttä, Niina Savikko, Timo E Strandberg, Merja Suominen, Kaisu H Pitkälä
Developing an educational intervention on dementia diagnosis and management in primary care for the EVIDEM-ED trial
Steve Iliffe, Tamar Koch, Priya Jain, Frances Lefford, Geoffrey Wong, Alex Warner, Jane Wilcock
RETRACTED ARTICLE: WELL.ME - Wellbeing therapy based on real-time personalized mobile architecture, vs. cognitive therapy, to reduce psychological distress and promote healthy lifestyle in cardiovascular disease patients: study protocol for a randomized controlled trial
Angelo Compare, Vassilis Kouloulias, Vontas Apostolos, Wendy Moreno Peña, Enrico Molinari, Enzo Grossi, Efstathopoulos Efstathios, Michele Carenini
Comparing the effectiveness of copper intrauterine devices available in Canada. Is FlexiT non-inferior to NovaT when inserted immediately after first-trimester abortion? Study protocol for a randomized controlled trial
Wendy V Norman, Jessica L Chiles, Caroline A Turner, Rollin Brant, Andra Aslan, Janusz Kaczorowski
Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial
Manfred Hecking, Marlies Antlanger, Wolfgang Winnicki, Thomas Reiter, Johannes Werzowa, Michael Haidinger, Thomas Weichhart, Hans-Dietrich Polaschegg, Peter Josten, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Walter H Hörl, Gere Sunder-Plassmann, Marcus D Säemann
Single dose oral dexamethasone versus multi-dose prednisolone in the treatment of acute exacerbations of asthma in children who attend the emergency department: study protocol for a randomized controlled trial
John Cronin, Una Kennedy, Siobhan McCoy, Sinéad Nic an Fhailí, Gloria Crispino-O’Connell, John Hayden, Abel Wakai, Sean Walsh, Ronan O’Sullivan
Transarterial RAdioembolization versus ChemoEmbolization for the treatment of hepatocellular carcinoma (TRACE): study protocol for a randomized controlled trial
Beatrijs A Seinstra, Luc Defreyne, Bieke Lambert, Marnix GEHH Lam, Helena M Verkooijen, Karel J van Erpecum, Bart van Hoek, Arian R van Erkel, Minneke J Coenraad, Imad Al Younis, Hans van Vlierberghe, Maurice AAJ van den Bosch
Effect of electroacupuncture on opioid consumption in patients with chronic musculoskeletal pain: protocol of a randomised controlled trial
Charlie CL Xue, Robert D Helme, Stephen Gibson, Malcolm Hogg, Carolyn Arnold, Andrew A Somogyi, Cliff Da Costa, Yanyi Wang, Shao-chen Lu, Zhen Zheng
Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial
Aimee Spector, Martin Orrell, Miles Lattimer, Juanita Hoe, Michael King, Kate Harwood, Afifa Qazi, Georgina Charlesworth
Beneficial effects of short-term combination exercise training on diverse cognitive functions in healthy older people: study protocol for a randomized controlled trial
Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi, Ryuta Kawashima
Lovastatin for adult patients with dengue: protocol for a randomised controlled trial
James Whitehorn, Nguyen Van Vinh Chau, Nguyen Thanh Truong, Luong Thi Hue Tai, Nguyen Van Hao, Tran Tinh Hien, Marcel Wolbers, Laura Merson, Nguyen Thi Phuong Dung, Rosanna Peeling, Cameron Simmons, Bridget Wills, Jeremy Farrar
Using “warm handoffs” to link hospitalized smokers with tobacco treatment after discharge: study protocol of a randomized controlled trial
Kimber P Richter, Babalola Faseru, Laura M Mussulman, Edward F Ellerbeck, Theresa I Shireman, Jamie J Hunt, Beatriz H Carlini, Kristopher J Preacher, Candace L Ayars, David J Cook
Diagnostic randomized controlled trials: the final frontier
Marc Rodger, Tim Ramsay, Dean Fergusson
Computerised therapy for depression with clinician vs. assistant and brief vs. extended phone support: study protocol for a randomised controlled trial
Lina Gega, Louise Swift, Garry Barton, Gillian Todd, Nesta Reeve, Kelly Bird, Richard Holland, Amanda Howe, Jon Wilson, Jo Molle
Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial
Madlen Uhlemann, Volker Adams, Karsten Lenk, Axel Linke, Sandra Erbs, Jennifer Adam, Holger Thiele, Thomas Hilberg, Matthias Gutberlet, Martin Grunze, Gerhard C Schuler, Sven Möbius-Winkler
Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study protocol for a randomized controlled trial
Sulman Rafiq, Pär Ingemar Johansson, Mette Zacho, Trine Stissing, Klaus Kofoed, Nikolaj Bang Lilleør, Daniel Andreas Steinbrüchel
Rapid, easy, and cheap randomization: prospective evaluation in a study cohort
Melissa J Parker, Asmaa Manan, Mark Duffett
Progress report on the first sub-Saharan Africa trial of newer versus older antihypertensive drugs in native black patients
Augustine N Odili, Birinus Ezeala-Adikaibe, Mouhamadou B Ndiaye, Benedict C Anisiuba, Marius M Kamdem, Chinwuba K Ijoma, Joseph Kaptue, Hilaire J Boombhi, Philip M Kolo, Elvis N Shu, Lutgarde Thijs, Jan A Staessen, Babatunde A Omotoso, Samuel Kingue, Serigne A Ba, Daniel Lemogoum, Jean-René M’Buyamba-Kabangu, Ifeoma I Ulasi
Effectiveness of smoking-cessation interventions for urban hospital patients: study protocol for a randomized controlled trial
Ellie Grossman, Donna Shelley, R Scott Braithwaite, Iryna Lobach, Ana Goffin, Erin Rogers, Scott Sherman
Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial
Daniele S Pereira, Bárbara Z Queiroz, Elvis CC Mateo, Alexandra M Assumpção, Diogo C Felício, Aline S Miranda, Daniela MC Anjos, Fabianna Jesus-Moraleida, Rosângela C Dias, Danielle AG Pereira, Antônio L Teixeira, Leani SM Pereira
Efficiency and safety of inhalative sedation with sevoflurane in comparison to an intravenous sedation concept with propofol in intensive care patients: study protocol for a randomized controlled trial
Jens Soukup, Antje Selle, Andreas Wienke, Jörg Steighardt, Nana-Maria Wagner, Patrick Kellner
Drug safety assessment in clinical trials: methodological challenges and opportunities
Sonal Singh, Yoon K Loke
Sponsors’ participation in conduct and reporting of industry trials: a descriptive study
Andreas Lundh, Lasse T Krogsbøll, Peter C Gøtzsche
Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial [NCT01159639]
Hrvoje Gasparovic, Mate Petricevic, Tomislav Kopjar, Zeljko Djuric, Lucija Svetina, Bojan Biocina
Using novel Canadian resources to improve medication reconciliation at discharge: study protocol for a randomized controlled trial
Robyn Tamblyn, Allen R Huang, Ari N Meguerditchian, Nancy E Winslade, Christian Rochefort, Alan Forster, Tewodros Eguale, David Buckeridge, André Jacques, Kiyuri Naicker, Kristen E Reidel
Scaling-up from an implementation trial to state-wide coverage: results from the preliminary Melbourne Diabetes Prevention Study
Edward D Janus, James D Best, Nathalie Davis-Lameloise, Benjamin Philpot, Andrea Hernan, Catherine M Bennett, Sharleen O’Reilly, Rob Carter, Erkki Vartiainen, James A Dunbar
Study protocol of a mixed-methods evaluation of a cluster randomized trial to improve the safety of NSAID and antiplatelet prescribing: data-driven quality improvement in primary care
Aileen Grant, Tobias Dreischulte, Shaun Treweek, Bruce Guthrie
A comparison of three induction regimens using succinylcholine, vecuronium, or no muscle relaxant: impact on the intraoperative monitoring of the lateral spread response in hemifacial spasm surgery: study protocol for a randomised controlled trial
Yuan Fang, Heng Zhang, Wenke Liu, Yu Li
Clinical efficacy of antazoline in rapid cardioversion of paroxysmal atrial fibrillation -- a protocol of a single center, randomized, double-blind, placebo-controlled study (the AnPAF Study)
Michal M Farkowski, Aleksander Maciag, Rafal Dabrowski, Mariusz Pytkowski, Ilona Kowalik, Hanna Szwed
Inadequate description of educational interventions in ongoing randomized controlled trials
Cécile Pino, Isabelle Boutron, Philippe Ravaud
An embedded longitudinal multi-faceted qualitative evaluation of a complex cluster randomized controlled trial aiming to reduce clinically important errors in medicines management in general practice
Kathrin M Cresswell, Stacey Sadler, Sarah Rodgers, Anthony Avery, Judith Cantrill, Scott A Murray, Aziz Sheikh
A community mobilisation intervention to prevent violence against women and reduce HIV/AIDS risk in Kampala, Uganda (the SASA! Study): study protocol for a cluster randomised controlled trial
Tanya Abramsky, Karen Devries, Ligia Kiss, Leilani Francisco, Janet Nakuti, Tina Musuya, Nambusi Kyegombe, Elizabeth Starmann, Dan Kaye, Lori Michau, Charlotte Watts
Allocation techniques for balance at baseline in cluster randomized trials: a methodological review
Noah M Ivers, Ilana J Halperin, Jan Barnsley, Jeremy M Grimshaw, Baiju R Shah, Karen Tu, Ross Upshur, Merrick Zwarenstein
Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial
Yuelong Cao, Graeme Jones, Flavia Cicuttini, Tania Winzenberg, Anita Wluka, James Sharman, Kay Nguo, Changhai Ding
Cognitive behavioural therapy versus multidisciplinary rehabilitation treatment for patients with chronic fatigue syndrome: study protocol for a randomised controlled trial (FatiGo)
Desirée CWM Vos-Vromans, Rob JEM Smeets, Leonie JM Rijnders, René RM Gorrissen, Menno Pont, Albère JA Köke, Minou WMGC Hitters, Silvia MAA Evers, André J Knottnerus
A cluster randomized controlled trial of the effectiveness and cost-effectiveness of Intermediate Care Clinics for Diabetes (ICCD): study protocol for a randomized controlled trial
Natalie Armstrong, Darrin Baines, Richard Baker, Richard Crossman, Melanie Davies, Ainsley Hardy, Kamlesh Khunti, Sudhesh Kumar, Joseph Paul O’Hare, Neil Raymond, Ponnusamy Saravanan, Nigel Stallard, Ala Szczepura, Andrew Wilson
Nutritional treatment of aged individuals with Alzheimer disease living at home with their spouses: study protocol for a randomized controlled trial
Satu K Jyvakorpi, Taija Puranen, Kaisu H Pitkala, Merja H Suominen
Health and economic effects from linking bedside and outpatient tobacco cessation services for hospitalized smokers in two large hospitals: study protocol for a randomized controlled trial
Jeffrey L Fellows, Richard Mularski, Lisa Waiwaiole, Kim Funkhouser, Julie Mitchell, Kathleen Arnold, Sabrina Luke
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial
Mayur B Patel, John W McKenna, JoAnn M Alvarez, Ayaka Sugiura, Judith M Jenkins, Oscar D Guillamondegui, Pratik P Pandharipande
Permissive underfeeding versus target enteral feeding in adult critically ill patients (PermiT Trial): a study protocol of a multicenter randomized controlled trial
Yaseen M Arabi, Samir H Haddad, Abdulaziz S Aldawood, Hasan M Al-Dorzi, Hani M Tamim, Maram Sakkijha, Gwynne Jones, Lauralyn McIntyre, Sangeeta Mehta, Othman Solaiman, Musharaf Sadat, Lara Afesh, Bushra Sami
Patient directed self management of pain (PaDSMaP) compared to treatment as usual following total knee replacement: study protocol for a randomized controlled trial
Simon Donell, Katherine Deane, Louise Swift, Garry Barton, Paula Balls, Clare Darrah, Richard Gray
A cost-effectiveness analysis of provider and community interventions to improve the treatment of uncomplicated malaria in Nigeria: study protocol for a randomized controlled trial
Virginia Wiseman, Ezeoke Ogochukwu, Nwala Emmanuel, Mangham Lindsay J, Cundill Bonnie, Enemuo Jane, Uchegbu Eloka, Uzochukwu Benjamin, Onwujekwe Obinna
Pancreatitis of biliary origin, optimal timing of cholecystectomy (PONCHO trial): study protocol for a randomized controlled trial
Stefan A Bouwense, Marc G Besselink, Sandra van Brunschot, Olaf J Bakker, Hjalmar C van Santvoort, Nicolien J Schepers, Marja A Boermeester, Thomas L Bollen, Koop Bosscha, Menno A Brink, Marco J Bruno, Esther C Consten, Cornelis H Dejong, Peter van Duijvendijk, Casper H van Eijck, Jos J Gerritsen, Harry van Goor, Joos Heisterkamp, Ignace H de Hingh, Philip M Kruyt, I Quintus Molenaar, Vincent B Nieuwenhuijs, Camiel Rosman, Alexander F Schaapherder, Joris J Scheepers, Marcel BW Spanier, Robin Timmer, Bas L Weusten, Ben J Witteman, Bert van Ramshorst, Hein G Gooszen, Djamila Boerma
Alzheimer’s disease multiple intervention trial (ADMIT): study protocol for a randomized controlled clinical trial
Christopher M Callahan, Malaz A Boustani, Arlene A Schmid, Mary G Austrom, Douglas K Miller, Sujuan Gao, Carrie S Morris, Mickey Vogel, Hugh C Hendrie
Development of a manualized protocol of massage therapy for clinical trials in osteoarthritis
Ather Ali, Janet Kahn, Lisa Rosenberger, Adam I Perlman
Physical activity as an aid to smoking cessation during pregnancy (LEAP) trial: study protocol for a randomized controlled trial
Michael Ussher, Paul Aveyard, Isaac Manyonda, Sarah Lewis, Robert West, Beth Lewis, Bess Marcus, Adrian H Taylor, Pelham Barton, Tim Coleman
Evaluation of a real-time virtual intervention to empower persons living with HIV to use therapy self-management: study protocol for an online randomized controlled trial
José Côté, Gaston Godin, Yann-Gaël Guéhéneuc, Geneviève Rouleau, Pilar Ramirez-Garcìa, Joanne Otis, Cécile Tremblay, Ghayas Fadel
The impact of insecticide-treated school uniforms on dengue infections in school-aged children: study protocol for a randomised controlled trial in Thailand
Annelies Wilder-Smith, Peter Byass, Phanthip Olanratmanee, Pongsri Maskhao, Luechai Sringernyuang, James G Logan, Steve W Lindsay, Sarah Banks, Duane Gubler, Valérie R Louis, Yesim Tozan, Pattamaporn Kittayapong
Collaborative Interventions for Circulation and Depression (COINCIDE): study protocol for a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease
Peter A Coventry, Karina Lovell, Chris Dickens, Peter Bower, Carolyn Chew-Graham, Andrea Cherrington, Charlotte Garrett, Chris J Gibbons, Clare Baguley, Kate Roughley, Isabel Adeyemi, Chris Keyworth, Waquas Waheed, Mark Hann, Linda Davies, Farheen Jeeva, Chris Roberts, Sarah Knowles, Linda Gask
Adaptive trial designs: a review of barriers and opportunities
John A Kairalla, Christopher S Coffey, Mitchell A Thomann, Keith E Muller
Effect of oriental medicine music therapy on patients with Hwa-byung: a study protocol for a randomized controlled trial
Jeong-Su Park, Sunju Park, Chun-Hoo Cheon, Bo-Hyoung Jang, Song-Hee Lee, Seung-Hyun Lee, Sun-Yong Chung, Jong-Woo Kim, Chan-Yong Jeon, Jong-Hyeong Park, Yong-Cheol Shin, Seong-Gyu Ko
Will Mobile Diabetes Education Teams (MDETs) in primary care improve patient care processes and health outcomes? Study protocol for a randomized controlled trial
Enza Gucciardi, Mariella Fortugno, Stacey Horodezny, Wendy Lou, Souraya Sidani, Sherry Espin, Fiona Webster, Baiju R Shah
Surgery versus Active Monitoring in Intermittent Exotropia (SamExo): study protocol for a pilot randomised controlled trial
Deborah Buck, Elaine McColl, Christine J Powell, Jing Shen, John Sloper, Nick Steen, Robert Taylor, Peter Tiffin, Luke Vale, Michael P Clarke
Advancing the evidence base in cancer: psychosocial multicenter trials
Robert Sanson-Fisher, Lisa Mackenzie, Phyllis Butow, Nicole Rankin, Christine Paul
Individual Cognitive Stimulation Therapy for dementia (iCST): study protocol for a randomized controlled trial
Martin Orrell, Lauren A Yates, Alistair Burns, Ian Russell, Robert T Woods, Zoe Hoare, Esme Moniz-Cook, Catherine Henderson, Martin Knapp, Aimee Spector, Vasiliki Orgeta
Use of randomisation in clinical trials: a survey of UK practice
Gladys C McPherson, Marion K Campbell, Diana R Elbourne
The efficacy of vigorous-intensity exercise as an aid to smoking cessation in adults with elevated anxiety sensitivity: study protocol for a randomized controlled trial
Jasper AJ Smits, Michael J Zvolensky, David Rosenfield, Bess H Marcus, Timothy S Church, Georita M Frierson, Mark B Powers, Michael W Otto, Michelle L Davis, Lindsey B DeBoer, Nicole F Briceno
A qualitative study evaluating experiences of a lifestyle intervention in men with prostate cancer undergoing androgen suppression therapy
Liam Bourke, Ratna Sohanpal, Veronica Nanton, Helen Crank, Derek J Rosario, John M Saxton
Information on blinding in registered records of clinical trials
Roderik F Viergever, Davina Ghersi
Financial incentives for smoking cessation in low-income smokers: study protocol for a randomized controlled trial
Jean-François Etter
DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy
Simone Rothenhoefer, Florian Herrle, Alexander Herold, Andreas Joos, Dieter Bussen, Meinhard Kieser, Petra Schiller, Christina Klose, Christoph M Seiler, Peter Kienle, Stefan Post
Rationale and design of the RIACT–study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a randomized controlled trial
Lena Schiffer, Mario Schiffer, Saskia Merkel, Anke Schwarz, Michael Mengel, Christopher Jürgens, Christoph Schroeder, Alexander A Zoerner, Kerstin Püllmann, Verena Bröcker, Jan U Becker, Maximilian E Dämmrich, Jana Träder, Anika Großhennig, Frank Biertz, Hermann Haller, Armin Koch, Wilfried Gwinner
A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project
Corinne SC Merle, Charalambos Sismanidis, Oumou Bah Sow, Martin Gninafon, John Horton, Olivier Lapujade, Mame Bocar Lo, Denis A Mitchinson, Christian Perronne, Francoise Portaels, Joseph Odhiambo, Piero Olliaro, Roxana Rustomjee, Christian Lienhardt, Katherine Fielding
Standard abdominal wound edge protection with surgical dressings vs coverage with a sterile circular polyethylene drape for prevention of surgical site infections (BaFO): study protocol for a randomized controlled trial
André L Mihaljevic, Christoph W Michalski, Mert Erkan, Carolin Reiser-Erkan, Carsten Jäger, Tibor Schuster, Christoph Schuhmacher, Jörg Kleeff, Helmut Friess
A multi-centre randomised controlled trial of rehabilitation aimed at improving outdoor mobility for people after stroke: Study protocol for a randomised controlled trial
Pip A Logan, Mat P Leighton, Marion F Walker, Sarah Armstrong, John R F Gladman, Tracey H Sach, Shirley Smith, Ossie Newell, Tony Avery, Hywel Williams, James Scott, Kathleen O’Neil, Annie McCluskey, Simon Leach, David Barer, Claire Ritchie, Ailie Turton, Jane Bisiker, David Smithard, Tess Baird, Paul Guyler, Therese Jackson, Ingrid Watmough, Maggie Webster, Janet Ivey
A pilot randomised controlled trial of negative pressure wound therapy to treat grade III/IV pressure ulcers [ISRCTN69032034]
Rebecca L Ashby, Jo C Dumville, Marta O Soares, Elizabeth McGinnis, Nikki Stubbs, David J Torgerson, Nicky Cullum
Web-based smoking cessation intervention that transitions from inpatient to outpatient: study protocol for a randomized controlled trial
Kathleen F Harrington, Julie A McDougal, Maria Pisu, Bin Zhang, Rajani S Sadasivam, Thomas K Houston, William C Bailey
Dissemination of the nurse-administered Tobacco Tactics intervention versus usual care in six Trinity community hospitals: study protocol for a comparative effectiveness trial
Sonia A Duffy, David L Ronis, Marita G Titler, Frederic C Blow, Neil Jordan, Patricia L Thomas, Gay L Landstrom, Lee A Ewing, Andrea H Waltje
Reducing salt intake for prevention of cardiovascular diseases in high-risk patients by advanced health education intervention (RESIP-CVD study), Northern Thailand: study protocol for a cluster randomized trial
Myo Nyein Aung, Motoyuki Yuasa, Saiyud Moolphate, Supalert Nedsuwan, Hidehiro Yokokawa, Tsutomu Kitajima, Kazuo Minematsu, Susumu Tanimura, Hiroshi Fukuda, Yoshimune Hiratsuka, Koichi Ono, Sachio Kawai, Eiji Marui
Developing a guideline for clinical trial protocol content: Delphi consensus survey
Jennifer Marie Tetzlaff, David Moher, An-Wen Chan
The efficacy of a brief intervention to reduce alcohol misuse in patients with HIV in South Africa: study protocol for a randomized controlled trial
Diana Huis in ’t Veld, Linda Skaal, Karl Peltzer, Robert Colebunders, John V Ndimande, Supa Pengpid
Design and current status of CONTINT: continuous versus interrupted abdominal wall closure after emergency midline laparotomy - a randomized controlled multicenter trial [NCT00544583]
Nuh N Rahbari, Phillip Knebel, Meinhard Kieser, Thomas Bruckner, Detlef K Bartsch, Helmut Friess, Andre L Mihaljevic, Josef Stern, Markus K Diener, Sabine Voss, Inga Rossion, Markus W Büchler, Christoph M Seiler
Impact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial
Pascale Boissonnat, Ségolène Gaillard, Catherine Mercier, Michel Redonnet, Bernard Lelong, Marie-Françoise Mattei, Annick Mouly-Bandini, Sabine Pattier, Agnès Sirinelli, Eric Epailly, Shaida Varnous, Marc-Alain Billes, Laurent Sebbag, René Ecochard, Catherine Cornu, François Gueyffier
Duration of luteal support (DOLS) with progesterone pessaries to improve the success rates in assisted conception: study protocol for a randomized controlled trial
Rafet Gazvani, Richard Russell, Yasmin Sajjad, Zarko Alfirevic
Brief intervention to reduce risky drinking in pregnancy: study protocol for a randomized controlled trial
Graeme B Wilson, Ruth McGovern, Grace Antony, Paul Cassidy, Mark Deverill, Erin Graybill, Eilish Gilvarry, Moira Hodgson, Eileen FS Kaner, Kirsty Laing, Elaine McColl, Dorothy Newbury-Birch, Judith Rankin
Continuous controllable balloon dilation: a novel approach for cervix dilation
Slobodan Arsenijevic, Gordana Vukcevic-Globarevic, Vladislav Volarevic, Ivan Macuzic, Petar Todorovic, Irena Tanaskovic, Milan Mijailovic, Sasa Raicevic, Branislav Jeremic
Eight-step method to build the clinical content of an evidence-based care pathway: the case for COPD exacerbation
Cathy Lodewijckx, Marc Decramer, Walter Sermeus, Massimiliano Panella, Svin Deneckere, Kris Vanhaecht
Therapeutic efficacy of traditional Chinese medicine, Shen-Mai San, in cancer patients undergoing chemotherapy or radiotherapy: study protocol for a randomized, double-blind, placebo-controlled trial
Lun-Chien Lo, Chia-Yun Chen, Shou-Tung Chen, Hung-Chang Chen, Tsung-Chieh Lee, Cheng-Shyong Chang
Total versus near-total thyroidectomy in Graves’ disease and their outcome on postoperative transient hypoparathyroidism: study protocol for a randomized controlled trial?
Katja Maschuw, Katja Schlosser, Dirk Lubbe, Christoph Nies, Detlef Klaus Bartsch
Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
Boadie W Dunlop, Elisabeth B Binder, Joseph F Cubells, Mark M Goodman, Mary E Kelley, Becky Kinkead, Michael Kutner, Charles B Nemeroff, D Jeffrey Newport, Michael J Owens, Thaddeus W W Pace, James C Ritchie, Vivianne Aponte Rivera, Drew Westen, W Edward Craighead, Helen S Mayberg
Augmented visual feedback of movement performance to enhance walking recovery after stroke: study protocol for a pilot randomised controlled trial
Heather Thikey, Madeleine Grealy, Frederike van Wijck, Mark Barber, Philip Rowe
Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial
Daniel F McAuley, John G Laffey, Cecilia M O’Kane, Mark Cross, Gavin D Perkins, Lynn Murphy, Christine McNally, Grainne Crealey, Michael Stevenson
DiAlert: a prevention program for overweight first degree relatives of type 2 diabetes patients: results of a pilot study to test feasibility and acceptability
Wieke H Heideman, Maartje de Wit, Barend JC Middelkoop, Vera Nierkens, Karien Stronks, Arnoud P Verhoeff, Frank J Snoek
Open-access clinical trial registries: the Italian scenario
Paola Mosconi, Anna Roberto
Internet treatment for social anxiety disorder in Romania: study protocol for a randomized controlled trial
Bogdan Tudor Tulbure, Kristoffer NT Månsson, Gerhard Andersson
General practice-based clinical trials in Germany - a problem analysis
Eva Hummers-Pradier, Jutta Bleidorn, Guido Schmiemann, Stefanie Joos, Annette Becker, Attila Altiner, Jean-François Chenot, Martin Scherer
Treatment-emergent adverse events after infusion of adherent stem cells: the MiSOT-I score for solid organ transplantation
Johannes Dillmann, Felix C Popp, Barbara Fillenberg, Florian Zeman, Elke Eggenhofer, Stefan Farkas, Marcus N Scherer, Michael Koller, Edward K Geissler, Robert Deans, Deborah Ladenheim, Martin Loss, Hans J Schlitt, Marc H Dahlke
Practice effects in a longitudinal, multi-center Alzheimer’s disease prevention clinical trial
Erin L Abner, Brandon C Dennis, Melissa J Mathews, Marta S Mendiondo, Allison Caban-Holt, Richard J Kryscio, Frederick A Schmitt, John J Crowley
Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): statistical analysis plan
Barbara A Gregson, Gordon D Murray, Patrick M Mitchell, Elise N Rowan, Anil R Gholkar, A David Mendelow
School-based intervention to reduce anxiety in children: study protocol for a randomized controlled trial (PACES)
Paul Stallard, Gordon Taylor, Rob Anderson, Harry Daniels, Neil Simpson, Rhiannon Phillips, Elena Skryabina
Telerehabilitation to improve outcomes for people with stroke: study protocol for a randomised controlled trial
Nicola Saywell, Alain C Vandal, Paul Brown, H Carl Hanger, Leigh Hale, Suzie Mudge, Stephan Milosavljevic, Valery Feigin, Denise Taylor
Efficacy of a children’s procedural preparation and distraction device on healing in acute burn wound care procedures: study protocol for a randomized controlled trial
Nadia J Brown, Sylvia Rodger, Robert S Ware, Roy M Kimble, Leila Cuttle
Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial
Antonio J Carcas, Alberto M Borobia, Marta Velasco, Francisco Abad-Santos, Manuel Quintana Díaz, Carmen Fernández-Capitán, Nuria Ruiz-Giménez, Olga Madridano, Pilar Llamas Sillero
A randomized multicenter comparison of hybrid sirolimus-eluting stents with bioresorbable polymer versus everolimus-eluting stents with durable polymer in total coronary occlusion: rationale and design of the Primary Stenting of Occluded Native Coronary Arteries IV study
Koen Teeuwen, Tom Adriaenssens, Ben JL Van den Branden, José PS Henriques, Rene J Van der Schaaf, Jacques J Koolen, Paul HMJ Vermeersch, Mike AR Bosschaert, Jan GP Tijssen, Maarten J Suttorp
Immigrant family skills-building to prevent tobacco use in Latino youth: study protocol for a community-based participatory randomized controlled trial
Michele L Allen, Diego Garcia-Huidobro, G Ali Hurtado, Rose Allen, Cynthia S Davey, Jean L Forster, Monica Hurtado, Katia Lopez-Petrovich, Mary Marczak, Ursula Reynoso, Laura Trebs, María Veronica Svetaz
Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure: randomized clinical trial
Gilberto M Sperandio da Silva, Mayara C Chambela, Andrea S Sousa, Luiz Henrique C Sangenis, Sergio S Xavier, Andréa R Costa, Pedro Emmanuel AA Brasil, Alejandro M Hasslocher-Moreno, Roberto M Saraiva
Reducing inappropriate, anticholinergic and psychotropic drugs among older residents in assisted living facilities: study protocol for a randomized controlled trial
Kaisu H Pitkala, Anna-Liisa Juola, Helena Soini, Marja-Liisa Laakkonen, Hannu Kautiainen, Mariko Teramura-Gronblad, Harriet Finne-Soveri, Mikko Bjorkman
Treatment of adolescents with depression: the effect of transference interventions in a randomized controlled study of dynamic psychotherapy
Randi Ulberg, Anne Grete Hersoug, Per Høglend
Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy - a randomised controlled trial
Momin Malik, Kirsty McCormack, Zygmunt H Krukowski, Alison McDonald, Gladys McPherson, Jonathan A Cook, Irfan Ahmed
Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia: study protocol for a double-blinded randomized controlled trial
Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior, Ana Carolina Araruna Alves, Caroline Sobral de Melo Rambo, Luciana Maria Malosa Sampaio, Claudia Santos Oliveira, Regiane Albertini, Luis Vicente Franco de Oliveira
A theoretical framework for early human studies: uncertainty, intervention ensembles, and boundaries
Jonathan Kimmelman
Individual differences in the efficacy of a short theory of mind intervention for children with autism spectrum disorder: a randomized controlled trial
Elske Hoddenbach, Hans M Koot, Pamela Clifford, Carolien Gevers, Cassandra Clauser, Frits Boer, Sander Begeer
The effects of reducing worry in patients with persecutory delusions: study protocol for a randomized controlled trial
Daniel Freeman, Graham Dunn, Helen Startup, David Kingdon
Effects of conventional versus multimodal vestibular rehabilitation on functional capacity and balance control in older people with chronic dizziness from vestibular disorders: design of a randomized clinical trial
Natalia Aquaroni Ricci, Mayra Cristina Aratani, Heloisa Helena Caovilla, Fernando Freitas Ganança
The Patient Deficit Model Overturned: a qualitative study of patients' perceptions of invitation to participate in a randomized controlled trial comparing selective bladder preservation against surgery in muscle invasive bladder cancer (SPARE, CRUK/07/011)
Clare Moynihan, Rebecca Lewis, Emma Hall, Emma Jones, Alison Birtle, Robert Huddart
Removing barriers to participation in clinical trials, a conceptual framework and retrospective chart review study
Norma F Kanarek, Marty S Kanarek, Dare Olatoye, Michael A Carducci
Protecting intellectual property associated with Canadian academic clinical trials - approaches and impact
Sue Ross, Laura Magee, Mark Walker, Stephen Wood
The InterHerz project - a web-based psychological treatment for cardiac patients with depression: study protocol of a randomized controlled trial
Nadine Messerli-Bürgy, Jürgen Barth, Thomas Berger
Quality of reporting of clinical non-inferiority and equivalence randomised trials - update and extension
Petra Schiller, Nicole Burchardi, Michael Niestroj, Meinhard Kieser
Mindfulness-based cognitive therapy for multiple chemical sensitivity: a study protocol for a randomized controlled trial
Christian Riise Hauge, Peter Jensa E Bonde, Alice Rasmussen, Sine Skovbjerg
The efficacy of a health-related quality-of-life intervention during 48 weeks of biologic treatment of patients with moderate to severe psoriasis: study protocol for a multicenter randomized controlled trial
Cecilia AC Prinsen, Phyllis I Spuls, Mirjam AG Sprangers, Menno A de Rie, Catharina M Legierse, John de Korte
Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial
Guy Thwaites, Cressida Auckland, Gavin Barlow, Richard Cunningham, Gerry Davies, Jonathan Edgeworth, Julia Greig, Susan Hopkins, Dakshika Jeyaratnam, Neil Jenkins, Martin Llewelyn, Sarah Meisner, Emmanuel Nsutebu, Tim Planche, Robert C Read, Matthew Scarborough, Marta Soares, Robert Tilley, M Estée Török, John Williams, Peter Wilson, Sarah Wyllie, A Sarah Walker
Efficacy of moxibustion for pre- or stage I hypertension: study protocol for a pilot randomized controlled trial
Kyung-Min Shin, Ji-Eun Park, Yan Liu, Hee-Jung Jung, So-Young Jung, Min-Hee Lee, Kyung-Won Kang, Tae-Han Yook, Sun-Mi Choi
Developing novel evidence-based interventions to promote asthma action plan use: a cross-study synthesis of evidence from randomised controlled trials and qualitative studies
Nicola Ring, Ruth Jepson, Hilary Pinnock, Caroline Wilson, Gaylor Hoskins, Sally Wyke, Aziz Sheikh
The effect of a patient-oriented treatment decision aid for risk factor management in patients with diabetes (PORTDA-diab): study protocol for a randomised controlled trial
Petra Denig, Mathijs Dun, Jan Schuling, Flora M Haaijer-Ruskamp, Jaco Voorham
Evaluating the effectiveness of using personal tailored risk information and taster sessions to increase the uptake of smoking cessation services: study protocol for a randomised controlled trial
Hazel Gilbert, Stephen Sutton, Richard Morris, Steve Parrot, Simon Galton, Irwin Nazareth
Developing a survey of barriers and facilitators to recruitment in randomized controlled trials
Geetinder Kaur, Rosalind L Smyth, Paula Williamson
Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT trial)
Pieter C van der Sluis, Jelle P Ruurda, Sylvia van der Horst, Roy JJ Verhage, Marc GH Besselink, Margriet JD Prins, Leonie Haverkamp, Carlo Schippers, Inne HM Borel Rinkes, Hans CA Joore, Fiebo JW ten Kate, Hendrik Koffijberg, Christiaan C Kroese, Maarten S van Leeuwen, Martijn PJK Lolkema, Onne Reerink, Marguerite EI Schipper, Elles Steenhagen, Frank P Vleggaar, Emile E Voest, Peter D Siersema, Richard van Hillegersberg
Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial
Paolo Zamboni, Antonio Bertolotto, Paolo Boldrini, Patrizia Cenni, Roberto D’Alessandro, Roberto D’Amico, Massimo Del Sette, Roberto Galeotti, Stefania Galimberti, Alessandro Liberati, Luca Massacesi, Donato Papini, Fabrizio Salvi, Silvana Simi, Andrea Stella, Luigi Tesio, Maria Grazia Valsecchi, Graziella Filippini
Cluster randomized trial in the general practice research database: 2. Secondary prevention after first stroke (eCRT study): study protocol for a randomized controlled trial
Alex Dregan, Tjeerd van Staa, Lisa Mcdermott, Gerard McCann, Mark Ashworth, Judith Charlton, Charles Wolfe, Anthony Rudd, Lucy Yardley, Martin Gulliford
INTERBED: internet-based guided self-help for overweight and obese patients with full or subsyndromal binge eating disorder. A multicenter randomized controlled trial
Martina de Zwaan, Stephan Herpertz, Stephan Zipfel, Brunna Tuschen-Caffier, Hans-Christoph Friederich, Frauke Schmidt, Olaf Gefeller, Andreas Mayr, Tony Lam, Carmen Schade-Brittinger, Anja Hilbert
Genetic test feedback with weight control advice: study protocol for a randomized controlled trial
Susanne F Meisel, Rebecca J Beeken, Cornelia HM van Jaarsveld, Jane Wardle
DISCOVER: Dutch Iliac Stent trial: COVERed balloon-expandable versus uncovered balloon-expandable stents in the common iliac artery: study protocol for a randomized controlled trial
Joost A Bekken, Jan Albert Vos, Ruud A Aarts, Jean-Paul PM de Vries, Bram Fioole
PREVENTion of a parastomal hernia with a prosthetic mesh in patients undergoing permanent end-colostomy; the PREVENT-trial: study protocol for a multicenter randomized controlled trial
Henk-Thijs Brandsma, Birgitta ME Hansson, Hilde V-Haaren-de Haan, Theo J Aufenacker, Camiel Rosman, Rob P Bleichrodt
Acupuncture at local and distant points for tinnitus: study protocol for a randomized controlled trial
Guang-Xia Shi, Li-Li Han, Li-Ying Liu, Qian-Qian Li, Cun-Zhi Liu, Lin-Peng Wang
Diarrhea and dengue control in rural primary schools in Colombia: study protocol for a randomized controlled trial
Hans J Overgaard, Neal Alexander, Maria Ines Mátiz, Juan Felipe Jaramillo, Victor Alberto Olano, Sandra Vargas, Diana Sarmiento, Audrey Lenhart, Razak Seidu, Thor Axel Stenström
Acupuncture, Counseling, and Usual care for Depression (ACUDep): study protocol for a randomized controlled trial
Hugh MacPherson, Stewart Richmond, J Martin Bland, Harriet Lansdown, Ann Hopton, Arthur Kang’ombe, Stephen Morley, Sara Perren, Eldon Spackman, Karen Spilsbury, David Torgerson, Ian Watt
The Uganda Newborn Study (UNEST): an effectiveness study on improving newborn health and survival in rural Uganda through a community-based intervention linked to health facilities - study protocol for a cluster randomized controlled trial
Peter Waiswa, Stefan S Peterson, Gertrude Namazzi, Elizabeth Kiracho Ekirapa, Sarah Naikoba, Romano Byaruhanga, Juliet Kiguli, Karin Kallander, Abner Tagoola, Margaret Nakakeeto, George Pariyo
Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial
David E Newby, Michelle C Williams, Andrew D Flapan, John F Forbes, Allister D Hargreaves, Stephen J Leslie, Steff C Lewis, Graham McKillop, Scott McLean, John H Reid, James C Sprat, Neal G Uren, Edwin J van Beek, Nicholas A Boon, Liz Clark, Peter Craig, Marcus D Flather, Chiara McCormack, Giles Roditi, Adam D Timmis, Ashma Krishan, Gillian Donaldson, Marlene Fotheringham, Fiona J Hall, Paul Neary, Louisa Cram, Sarah Perkins, Fiona Taylor, Hany Eteiba, Alan P Rae, Kate Robb, Dawn Barrie, Kim Bissett, Adelle Dawson, Scot Dundas, Yvonne Fogarty, Prasad Guntur Ramkumar, Graeme J Houston, Deborah Letham, Linda O’Neill, Stuart D Pringle, Valerie Ritchie, Thiru Sudarshan, Jonathan Weir-McCall, Alistair Cormack, Iain N Findlay, Stuart Hood, Clare Murphy, Eileen Peat, Barbara Allen, Andrew Baird, Danielle Bertram, David Brian, Amy Cowan, Nicholas L Cruden, Marc R Dweck, Laura Flint, Samantha Fyfe, Collette Keanie, Tom J MacGillivray, David S Maclachlan, Margaret MacLeod, Saeed Mirsadraee, Avril Morrison, Nicholas L Mills, Fiona C Minns, Alyson Phillips, Laura J Queripel, Nicholas W Weir, Fiona Bett, Frances Divers, Katie Fairley, Ashok J Jacob, Edith Keegan, Tricia White, John Gemmill, Margo Henry, James McGowan, Lorraine Dinnel, C Mark Francis, Dennis Sandeman, Ajay Yerramasu, Colin Berry, Heather Boylan, Ammani Brown, Karen Duffy, Alison Frood, Janet Johnstone, Kirsten Lanaghan, Ross MacDuff, Martin MacLeod, Deborah McGlynn, Nigel McMillan, Laura Murdoch, Colin Noble, Victoria Paterson, Tracey Steedman, Nikolaos Tzemos
Brief intervention to prevent hazardous drinking in young people aged 14–15 in a high school setting (SIPS JR-HIGH): study protocol for a randomized controlled trial
Stephanie O’Neil, Simon Coulton, Paolo Deluca, Mark Deverill, Colin Drummond, Eilish Gilvarry, Erin Graybill, Christine Harle, Denise Howel, Eileen Kaner, Paul McArdle, Elaine McColl, Ruth McGovern, Chris Speed, Elaine Stamp, Les Tate, Dorothy Newbury-Birch