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Supportive Care in Cancer
Erschienen in: Supportive Care in Cancer 12/2005

01.12.2005 | Review Article

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

verfasst von: Carl J. Hochhauser, Michael Lewis, Barton A. Kamen, Peter D. Cole

Erschienen in: Supportive Care in Cancer | Ausgabe 12/2005

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Abstract

Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.
Literatur
1.
Ahmad M, Rasul FM (1999) Steroid-induced psychosis treated with haloperidol in a patient with active chronic obstructive pulmonary disease. Am J Emerg Med 17:735CrossRef
2.
Alderson AL, Novack TA (2002) Neurophysiological and clinical aspects of glucocorticoids and memory: a review. J Clin Exp Neuropsychol 24:335–355
3.
Armanini MP, Hutchins C, Stein BA, Sapolsky RM (1990) Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent. Brain Res 532:7–12CrossRefPubMed
4.
Bellamy MF, McDowell IF (1997) Putative mechanisms for vascular damage by homocysteine. J Inherit Metab Dis 20:307–315CrossRefPubMed
5.
Bender BG, Ikle DN, DuHamel T, Tinkelman D (1998) Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline. Pediatrics 101:355–360CrossRefPubMed
6.
Bender BG, Lerner JA, Kollasch E (1988) Mood and memory changes in asthmatic children receiving corticosteroids. J Am Acad Child Adolesc Psych 27:720–725
7.
Bertolino A, Frye M, Callicott JH, Mattay VS, Rakow R, Shelton-Repella J, Post R, Weinberger DR (2003) Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol Psychiatry 53:906–913CrossRefPubMed
8.
Beshay H, Pumariega AJ (1998) Sertraline treatment of mood disorder associated with prednisone: a case report. J Child Adolesc Psychopharmacol 8:187–193PubMed
9.
Bijlsma JWJ, Boers M, Saag KG, Furst DE (2003) Glucocorticoids in the treatment of early and late RA. Ann Rheum Dis 62:1033–1037CrossRefPubMed
10.
Bloch M, Gur E, Shalev A (1994) Chlorpromazine prophylaxis of steroid-induced psychosis. Gen Hosp Psych 16:42CrossRef
11.
Boon LM, MacDonald DM, Mulliken JB (1999) Complications of systemic corticosteroid therapy for problematic hemangioma. Plast Reconstr Surg 104:1616–1623PubMed
12.
Bostrom BC, Sensel MR, Sather HN, Gaynon PS, La MK, Johnston K, Erdmann GR, Gold S, Heerema NA, Hutchinson RJ et al (2003) Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children’s Cancer Group. Blood 101:3809–3817CrossRefPubMed
13.
14.
Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Mazure C, Capelli S, McCarthy G, Innis RB, Charney DS (1997) Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: a preliminary report. Biol Psychiatry 41:23–32CrossRefPubMed
15.
Bridges RJ, Hatalski CG, Shim SN, Cummings BJ, Vijayan V, Kundi A, Cotman CW (1992) Gliotoxic actions of excitatory amino acids. Neuropharmacology 31:899–907CrossRefPubMed
16.
Brown ES, Chamberlain W, Dhanani N, Paranjpe P, Carmody TJ, Sargeant M (2004) An open-label trial of olanzapine for corticosteroid-induced mood symptoms. J Affect Disord 83:277–281CrossRefPubMed
17.
Brown ES, Frol A, Bobadila BA, Nejtek VA, Perantie BS, Dhillon H (2003) Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids. Psychosomatics 44:204–208CrossRefPubMed
18.
Brown ES, Khan D, Nejtek VA (1999) The psychiatric side effects of corticosteroids. Ann Allergy Asthma Immun 83:495–504
19.
Brown ES, Rush AJ, McEwen BS (1999) Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology 21:474–484
20.
Brown ES, Woolston DJ, Frol A, Bobadilla L, Khan DA, Hanczyc M, Rush AJ, Fleckenstein J, Babcock E, Cullum CM (2004) Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. Biol Psychiatry 55:538–545CrossRefPubMed
21.
Cameron HA, Tanapat P, Gould E (1998) Adrenal steroids and N-methyl-d-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience 82:349–354CrossRefPubMed
22.
Charbonneau Y, Ravindran AV (1997) Successful treatment of steroid-induced panic disorder with fluvoxamine. J Psychiatry Neurosci 22:346–347PubMed
23.
Chen J, Adachi N, Tsubota S, Nagaro T, Arai T (1998) Dexamethasone augments ischemia-induced extracellular accumulation of glutamate in gerbil hippocampus. Eur J Pharmacol 347:67–70CrossRefPubMed
24.
Cuenod M, Grandes P, Zangerle L, Streit P, Do KQ (1993) Sulphur-containing excitatory amino acids in intercellular communication. Biochem Soc Trans 21:72–77PubMed
25.
Dawson KL, Carter ER (1998) A steroid-induced acute psychosis in a child with asthma. Pediatr Pulmonol 26:362–364CrossRefPubMed
26.
DeSilva CC, Vokey K (2002) Steroid-induced psychosis treated with risperidone. Can J Psychiatry 47:388–389
27.
Do KQ, Herrling PL, Streit P, Cuenod M (1988) Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor. J Neural Transm (General Section) 72:185–190CrossRef
28.
Drigan R, Spirito A, Gelber RD (1992) Behavioral effects of corticosteroids in children with acute lymphoblastic leukemia. Med Pediatr Oncol 20:13–21PubMed
29.
Escher JC, European Collaborative Research Group on Budesonide in Paediatric IBD (2004) Budesonide versus prednisolone for the treatment of active Crohn’s disease in children: a randomized, double-blind, controlled, multicentre trial. Eur J Gastroenterol Hepatol 16:47–54CrossRefPubMed
30.
Escher JC, Taminiau JA, Nieuwenhuis EE, Buller HA, Grand RJ (2003) Treatment of inflammatory bowel disease in childhood: best available evidence. Inflamm Bowel Dis 9:34–58CrossRefPubMed
31.
Estrada de la Riva G (1958) Psychic and somatic changes observed in allergic children after prolonged steroid therapy. South Med J 51:865–868PubMed
32.
Falk WE, Mahnke MW, Poskanzer DC (1979) Lithium prophylaxis of corticotropin-induced psychosis. JAMA 241:1011–1012CrossRefPubMed
33.
Ferris RL, Eisele DW (2003) Steroid psychosis after head and neck surgery: case report and review of the literature. Otolaryngol Head Neck Surg 129:591CrossRefPubMed
34.
Fishman SM, Catarau EM, Sachs G, Stojanovic M, Borsook D (1996) Corticosteroid-induced mania after single regional application at the celiac plexus. Anesthesiology 85:1194–1196CrossRefPubMed
35.
Ginsberg DL, Sussman N (2001) Gabapentin as prophylaxis against steroid-induced mania. Can J Psychiatry 46:455–456
36.
Goggans FC, Weisberg LJ, Koran LM (1983) Lithium prophylaxis of prednisone psychosis: a case report. J Clin Psychiatry 44:111–112PubMed
37.
Goldman LS, Goveas J (2002) Olanzapine treatment of corticosteroid-induced mood disorders. Psychosomatics 43:495–497CrossRefPubMed
38.
Griffiths R (1990) Cysteine sulphinate (CSA) as an excitatory amino acid transmitter candidate in the mammalian central nervous system. Prog Neurobiol 35:313–323CrossRefPubMed
39.
Griffiths R (1993) The biochemistry and pharmacology of excitatory sulphur-containing amino acids. Biochem Soc Trans 21:66–72PubMed
40.
Hall AS, Thorley G, Houtman PN (2003) The effects of corticosteroids on behavior in children with nephrotic syndrome. Pediatr Nephrol 18:1220–1223
41.
Hall RCW, Popkin MK, Kirkpatrick B (1978) Tricyclic exacerbation of steroid psychosis. J Nerv Ment Dis 166:738–742PubMed
42.
Harris JC, Carel CA, Rosenberg LA, Joshi P, Leventhal BG (1986) Intermittent high dose corticosteroid treatment in childhood cancer: behavioral and emotional consequences. J Am Acad Child Psych 25:120–124
43.
Haynes LE, Barber D, Mitchell IJ (2004) Chronic antidepressant medication attenuates dexamethasone-induced neuronal death and sublethal neuronal damage in the hippocampus and striatum. Brain Res 1026:157–167CrossRefPubMed
44.
Himelhoch S, Haller E (1996) Extreme mood lability associated with systemic lupus erythematosus and stroke successfully treated with valproic acid. J Clin Psychopharmacol 16:469–470
45.
Ingram DG, Hagemann TM (2003) Promethazine treatment of steroid-induced psychosis in a child. Ann Pharmacother 37:1036–1039
46.
Ito M, Onose M, Yamada T, Onishi H, Fujisawa S, Kanamori H (2003) Successful lithium carbonate treatment for steroid-induced depression following bone marrow transplantation: a case report. Jpn J Clin Oncol 33:538–540CrossRefPubMed
47.
Juengling FD, Schmahl C, Hesslinger B, Ebert D, Bremner JD, Gostomzyk J, Bohus M, Lieb K (2003) Positron emission tomography in female patients with borderline personality disorder. J Psychiatr Res 37:109–115CrossRefPubMed
48.
Kayani S, Shannon DC (2002) Adverse behavioral effects of treatment for acute exacerbation of asthma in children: a comparison of two doses of oral steroids. Chest 122:624–628CrossRefPubMed
49.
Kempermann G, Kronenberg G (2003) Depressed new neurons? Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 54:499–503CrossRefPubMed
50.
Kempermann G, Kuhn HG, Gage FH (1997) Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A 94:10409–10414CrossRefPubMed
51.
Klein-Gitelman MS, Pachman LM (1998) Intravenous corticosteroids: adverse reactions are more variable than expected in children. J Rheumatol 25:1995–2002PubMed
52.
Kramer TM, Cottingham EM (1999) Risperidone in the treatment of steroid-induced psychosis. J Child Adolesc Psychopharmacol 9:315–316PubMed
53.
Langmeier M, Folbergrova J, Haugvicova R, Pokorny J, Mares P (2003) Neuronal cell death in hippocampus induced by homocysteic acid in immature rats. Epilepsia 44:299–304CrossRefPubMed
54.
Lee KM, Lin YZ, Huang FY (2001) Steroid-induced acute psychosis in a child with asthma: report of one case. Acta Paediatr Taiwan 42:169–171PubMed
55.
Lewis DA, Smith RE (1983) Steroid-induced psychiatric syndromes—a report of 14 cases and a review of the literature. J Affect Disord 5:319–332CrossRefPubMed
56.
Lipton SA, Kim WK, Choi YB, Kumar S, D’Emilia DM, Rayudu PV, Arnelle DR, Stamler JS (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proc Natl Acad Sci U S A 94:5923–5928CrossRefPubMed
57.
Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613–622PubMed
58.
Lowy MT, Gault L, Yamamoto BK (1993) Adrenalectomy attenuates stress-induced elevations in extracellular glutamate concentrations in the hippocampus. J Neurochem 61:1957–1960PubMed
59.
Magarinos AM, McEwen BS, Flugge G, Fuchs E (1996) Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 16:3534–3540PubMed
60.
Magarinos AM, Verdugo JM, McEwen BS (1997) Chronic stress alters synaptic terminal structure in hippocampus. Proc Natl Acad Sci U S A 94:14002–14008CrossRefPubMed
61.
Mazumdar P, Najib M, Varma S (1995) Steroid induced rare bipolar mood disorder. Eur Psychiatry 10:264–265CrossRef
62.
McGrath P, Pitcher L (2002) ‘Enough is enough’: qualitative findings on the impact of dexamethasone during reinduction/consolidation for paediatric acute lymphoblastic leukaemia. Support Care Cancer 10:146–155CrossRefPubMed
63.
McKay LI, Cidlowski JA (2003) Corticosteroids. In: Kufe DW, Frei E, Holland JF, Weichselbaum RR, Pollack RE, Bast RC, Gansler TS (eds) Holland-Frei cancer medicine, 6th edn. BC Decker Inc., Philadelphia
64.
McNaughton N (1997) Cognitive dysfunction resulting from hippocampal hyperactivity—a possible cause of anxiety disorder? Pharmacol Biochem Behav 56:603–611CrossRefPubMed
65.
Miller WL, Tyrell JB (1995) The adrenal cortex. In: Felig P, Baxter JD, Frohman LA (eds) Endocrinology and metabolism, 3rd edn. McGraw-Hill, New York, pp 555–712
66.
Moghaddam B, Bolinao ML, Stein-Behrens B, Sapolsky R (1994) Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res 655:251–254CrossRefPubMed
67.
Mulholland PJ, Self RL, Harris BR, Littleton JM, Prendergast MA (2004) (−)-Nicotine ameliorates corticosterone’s potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity. Neuroscience 125:671–682CrossRefPubMed
68.
Patten SB, Neutel CI (2000) Corticosteroid-induced adverse psychiatric effects: incidence, diagnosis and management. Drug Safety 22:111–122PubMed
69.
Quinn CT, Griener JC, Bottiglieri T, Hyland K, Farrow A, Kamen BA (1997) Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol 15:2800–2806
70.
Ramos-Remus C, Gonzalez-Castaneda RE, Gonzalez-Perez O, Luquin S, Garcia-Estrada J (2002) Prednisone induces cognitive dysfunction, neuronal degeneration, and reactive gliosis in rats. J Investig Med 50:458–464PubMed
71.
Reagan LP, McEwen BS (1997) Controversies surrounding glucocorticoid-mediated cell death in the hippocampus. J Chem Neuroanat 13:149–167CrossRefPubMed
72.
Refsum H, Helland S, Ueland PM (1989) Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment. Clin Pharmacol Ther 46:510–520
73.
Sabet-Sharghi F, Hutzler JC (1990) Prophylaxis of steroid-induced psychiatric syndromes. Psychosomatics 31:113–114PubMed
74.
Sapolsky RM (2000) The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biol Psychiatry 48:755–765CrossRefPubMed
75.
Sheline YI (2000) 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry 48:791–800CrossRefPubMed
76.
Sheline YI, Gado MH, Kraemer HC (2003) Untreated depression and hippocampal volume loss. Am J Psychiatry 160:1516–1518CrossRefPubMed
77.
Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y, Gould E (2002) Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12:578–584CrossRefPubMed
78.
Siegel FP (1978) Lithium for steroid-induced psychosis. N Engl J Med 299:155–156
79.
Sirois F (2003) Steroid psychosis: a review. Gen Hosp Psych 25:27–33CrossRef
80.
Starkman MN, Gebarski SS, Berent S, Schteingart DE (1992) Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing’s syndrome. Biol Psychiatry 32:756–765CrossRefPubMed
81.
Starkman MN, Giordani B, Gebarski SS, Schteingart DE (2003) Improvement in learning associated with increase in hippocampal formation volume. Biol Psychiatry 53:233–238CrossRefPubMed
82.
Streck EL, Matte C, Vieira PS, Calcagnotto T, Wannmacher CM, Wajner M, Wyse AT (2003) Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia. Biochim Biophys Acta 1637:187–192PubMed
83.
Surtees R, Clelland J, Hann I (1998) Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies. J Clin Oncol 16:1505–1511PubMed
84.
Sutor B, Wells LA, Rummans T (1996) Steroid-induced depressive psychosis responsive to electroconvulsive therapy. Convuls Ther 12:104–107
85.
Tamminga CA, Lahti AC, Medoff DR, Gao X-M, Holcomb HH (2003) Evaluating glutamatergic transmission in schizophrenia. Annals of the New York Academy of Sciences: glutamate and disorders of cognition and motivation. Ann NY Acad Sci 1003:113–118
86.
Terao T, Yoshimura R, Shiratuchi T, Abe K (1997) Effects of lithium on steroid-induced depression. Biol Psychiatry 41:1225–1226CrossRefPubMed
87.
Turski WA (1989) Homocysteic acid: convulsant action of stereoisomers in mice. Brain Res 479:371–373CrossRefPubMed
88.
Wada K, Suzuki H, Taira T, Akiyama K, Kuroda S (2004) Successful use of intravenous clomipramine in depressive-catatonic state associated with corticosteroid treatment. Int J Psychiatry Clin Pract 8:131–133CrossRef
89.
Wada K, Yamada N, Yamauchi Y, Kuroda S (2001) Carbamazepine treatment of corticosteroid-induced mood disorder. J Affect Disord 65:315–317CrossRefPubMed
90.
Weiland NG, Orchinik M, Tanapat P (1997) Chronic corticosterone treatment induces parallel changes in N-methyl-d-aspartate receptor subunit messenger RNA levels and antagonist binding sites in the hippocampus. Neuroscience 78:653–662CrossRefPubMed
91.
Yoshimura R, Ueda N, Nakamura J (2001) Successful treatment of steroid-induced depression with low dosage of fluvoxamine. Aust N Z J Psychiatry 35:855–856PubMed
92.
Zarate CA, Jr, Du J, Quiroz J, Gray NA, Denicoff KD, Singh J, Charney DS, Manji HK (2003) Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Ann N Y Acad Sci 1003:273–291CrossRefPubMed
Metadaten
Titel
Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia
verfasst von
Carl J. Hochhauser
Michael Lewis
Barton A. Kamen
Peter D. Cole
Publikationsdatum
01.12.2005
Erschienen in
Supportive Care in Cancer / Ausgabe 12/2005
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-005-0882-8

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