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Erschienen in: BMC Pregnancy and Childbirth 1/2013

Open Access 01.12.2013 | Research article

Stillbirth classification in population-based data and role of fetal growth restriction: the example of RECODE

verfasst von: Anne Ego, Jennifer Zeitlin, Pierre Batailler, Séverine Cornec, Anne Fondeur, Marion Baran-Marszak, Pierre-Simon Jouk, Thierry Debillon, Christine Cans

Erschienen in: BMC Pregnancy and Childbirth | Ausgabe 1/2013

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Abstract

Background

Stillbirth classifications use various strategies to synthesise information associated with fetal demise with the aim of identifying key causes for the death. RECODE is a hierarchical classification of death-related conditions, which grants a major place to fetal growth restriction (FGR). Our objective was to explore how placement of FGR in the hierarchy affected results from the classification.

Methods

In the Rhône-Alpes region, all stillbirths were recorded in a local registry from 2000 to 2010 in three districts (N = 969). Small for gestational age (SGA) was defined as a birthweight below the 10th percentile. We applied RECODE and then modified the hierarchy, including FGR as the penultimate category (RECODE-R).

Results

49.0% of stillbirths were SGA. From RECODE to RECODE-R, stillbirths attributable to FGR decreased from 38% to 14%, in favour of other related conditions. Nearly half of SGA stillbirths (49%) were reclassified. There was a non-significant tendency toward moderate SGA, singletons and full-term stillbirths to older mothers being reclassified.

Conclusions

The position of FGR in hierarchical stillbirth classification has a major impact on the first condition associated with stillbirth. RECODE-R calls less attention to monitoring SGA fetuses but illustrates the diversity of death-related conditions for small fetuses.
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Literatur
1.
Zurück zum Zitat Gordijn SJ, Korteweg FJ, Erwich JJ, Holm JP, van Diem MT, Bergman KA, Timmer A: A multilayered approach for the analysis of perinatal mortality using different classification systems. Eur J Obstet Gynecol Reprod Biol. 2009, 144 (2): 99-104. 10.1016/j.ejogrb.2009.01.012.CrossRefPubMed Gordijn SJ, Korteweg FJ, Erwich JJ, Holm JP, van Diem MT, Bergman KA, Timmer A: A multilayered approach for the analysis of perinatal mortality using different classification systems. Eur J Obstet Gynecol Reprod Biol. 2009, 144 (2): 99-104. 10.1016/j.ejogrb.2009.01.012.CrossRefPubMed
2.
Zurück zum Zitat Reddy UM, Goldenberg R, Silver R, Smith GC, Pauli RM, Wapner RJ, Gardosi J, Pinar H, Grafe M, Kupferminc M, et al: Stillbirth classification–developing an international consensus for research: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2009, 114 (4): 901-914. 10.1097/AOG.0b013e3181b8f6e4.CrossRefPubMedPubMedCentral Reddy UM, Goldenberg R, Silver R, Smith GC, Pauli RM, Wapner RJ, Gardosi J, Pinar H, Grafe M, Kupferminc M, et al: Stillbirth classification–developing an international consensus for research: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2009, 114 (4): 901-914. 10.1097/AOG.0b013e3181b8f6e4.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Flenady V, Froen JF, Pinar H, Torabi R, Saastad E, Guyon G, Russell L, Charles A, Harrison C, Chauke L, et al: An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth. 2009, 9: 24-10.1186/1471-2393-9-24.CrossRefPubMedPubMedCentral Flenady V, Froen JF, Pinar H, Torabi R, Saastad E, Guyon G, Russell L, Charles A, Harrison C, Chauke L, et al: An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth. 2009, 9: 24-10.1186/1471-2393-9-24.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Flenady V, Middleton P, Smith GC, Duke W, Erwich JJ, Khong TY, Neilson J, Ezzati M, Koopmans L, Ellwood D, et al: Stillbirths: the way forward in high-income countries. Lancet. 2011, 377 (9778): 1703-1717. 10.1016/S0140-6736(11)60064-0.CrossRefPubMed Flenady V, Middleton P, Smith GC, Duke W, Erwich JJ, Khong TY, Neilson J, Ezzati M, Koopmans L, Ellwood D, et al: Stillbirths: the way forward in high-income countries. Lancet. 2011, 377 (9778): 1703-1717. 10.1016/S0140-6736(11)60064-0.CrossRefPubMed
5.
Zurück zum Zitat Gardosi J, Kady SM, McGeown P, Francis A, Tonks A: Classification of stillbirth by relevant condition at death (ReCoDe): population based cohort study. BMJ. 2005, 331 (7525): 1113-1117. 10.1136/bmj.38629.587639.7C.CrossRefPubMedPubMedCentral Gardosi J, Kady SM, McGeown P, Francis A, Tonks A: Classification of stillbirth by relevant condition at death (ReCoDe): population based cohort study. BMJ. 2005, 331 (7525): 1113-1117. 10.1136/bmj.38629.587639.7C.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Chan A, King JF, Flenady V, Haslam RH, Tudehope DI: Classification of perinatal deaths: development of the Australian and New Zealand classifications. J Paediatr Child Health. 2004, 40 (7): 340-347. 10.1111/j.1440-1754.2004.00398.x.CrossRefPubMed Chan A, King JF, Flenady V, Haslam RH, Tudehope DI: Classification of perinatal deaths: development of the Australian and New Zealand classifications. J Paediatr Child Health. 2004, 40 (7): 340-347. 10.1111/j.1440-1754.2004.00398.x.CrossRefPubMed
7.
Zurück zum Zitat Froen JF, Pinar H, Flenady V, Bahrin S, Charles A, Chauke L, Day K, Duke CW, Facchinetti F, Fretts RC, et al: Causes of death and associated conditions (Codac): a utilitarian approach to the classification of perinatal deaths. BMC Pregnancy Childbirth. 2009, 9: 22-10.1186/1471-2393-9-22.CrossRefPubMedPubMedCentral Froen JF, Pinar H, Flenady V, Bahrin S, Charles A, Chauke L, Day K, Duke CW, Facchinetti F, Fretts RC, et al: Causes of death and associated conditions (Codac): a utilitarian approach to the classification of perinatal deaths. BMC Pregnancy Childbirth. 2009, 9: 22-10.1186/1471-2393-9-22.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade GR, Varner MW, Pinar H, Coustan D, Bukowski R, Stoll B, et al: A new system for determining the causes of stillbirth. Obstet Gynecol. 2010, 116 (2): 254-260. 10.1097/AOG.0b013e3181e7d975.CrossRefPubMed Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade GR, Varner MW, Pinar H, Coustan D, Bukowski R, Stoll B, et al: A new system for determining the causes of stillbirth. Obstet Gynecol. 2010, 116 (2): 254-260. 10.1097/AOG.0b013e3181e7d975.CrossRefPubMed
9.
Zurück zum Zitat Gardosi J, Madurasinghe V, Williams M, Malik A, Francis A: Maternal and fetal risk factors for stillbirth: population based study. BMJ. 2013, 346: f108-10.1136/bmj.f108.CrossRefPubMedPubMedCentral Gardosi J, Madurasinghe V, Williams M, Malik A, Francis A: Maternal and fetal risk factors for stillbirth: population based study. BMJ. 2013, 346: f108-10.1136/bmj.f108.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B: Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand. 2004, 83 (9): 801-807.CrossRefPubMed Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B: Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand. 2004, 83 (9): 801-807.CrossRefPubMed
11.
Zurück zum Zitat Kidron D, Bernheim J, Aviram R: Placental findings contributing to fetal death, a study of 120 stillbirths between 23 and 40 weeks gestation. Placenta. 2009, 30 (8): 700-704. 10.1016/j.placenta.2009.05.009.CrossRefPubMed Kidron D, Bernheim J, Aviram R: Placental findings contributing to fetal death, a study of 120 stillbirths between 23 and 40 weeks gestation. Placenta. 2009, 30 (8): 700-704. 10.1016/j.placenta.2009.05.009.CrossRefPubMed
12.
Zurück zum Zitat Korteweg FJ, Gordijn SJ, Timmer A, Holm JP, Ravise JM, Erwich JJ: A placental cause of intra-uterine fetal death depends on the perinatal mortality classification system used. Placenta. 2008, 29 (1): 71-80. 10.1016/j.placenta.2007.07.003.CrossRefPubMed Korteweg FJ, Gordijn SJ, Timmer A, Holm JP, Ravise JM, Erwich JJ: A placental cause of intra-uterine fetal death depends on the perinatal mortality classification system used. Placenta. 2008, 29 (1): 71-80. 10.1016/j.placenta.2007.07.003.CrossRefPubMed
13.
Zurück zum Zitat Rey S, Hoffmann P, Arnould P, Jouk PS, Tronc C, Cans C: Tendances et caractéristiques de la mortinatalité dans trois départements alpins (l’Isère, la Savoie et la Haute-Savoie). Revue de médecine périnatale. 2009, 1 (4): 200-207.CrossRef Rey S, Hoffmann P, Arnould P, Jouk PS, Tronc C, Cans C: Tendances et caractéristiques de la mortinatalité dans trois départements alpins (l’Isère, la Savoie et la Haute-Savoie). Revue de médecine périnatale. 2009, 1 (4): 200-207.CrossRef
14.
Zurück zum Zitat WHO: International statistical classification of diseases and related health problems. Tenth Revision. 1993, Geneva, Switzerland: World Health Organization, 129-2 WHO: International statistical classification of diseases and related health problems. Tenth Revision. 1993, Geneva, Switzerland: World Health Organization, 129-2
15.
Zurück zum Zitat Gardosi J, Mongelli M, Wilcox M, Chang A: An adjustable fetal weight standard. Ultrasound Obstet Gynecol. 1995, 6 (3): 168-174. 10.1046/j.1469-0705.1995.06030168.x.CrossRefPubMed Gardosi J, Mongelli M, Wilcox M, Chang A: An adjustable fetal weight standard. Ultrasound Obstet Gynecol. 1995, 6 (3): 168-174. 10.1046/j.1469-0705.1995.06030168.x.CrossRefPubMed
16.
Zurück zum Zitat Ego A, Subtil D, Grange G, Thiebaugeorges O, Senat MV, Vayssiere C, Zeitlin J: Customized versus population-based birth weight standards for identifying growth restricted infants: a French multicenter study. Am J Obstet Gynecol. 2006, 194 (4): 1042-1049. 10.1016/j.ajog.2005.10.816.CrossRefPubMed Ego A, Subtil D, Grange G, Thiebaugeorges O, Senat MV, Vayssiere C, Zeitlin J: Customized versus population-based birth weight standards for identifying growth restricted infants: a French multicenter study. Am J Obstet Gynecol. 2006, 194 (4): 1042-1049. 10.1016/j.ajog.2005.10.816.CrossRefPubMed
17.
Zurück zum Zitat Blondel B, Norton J, du Mazaubrun C, Breart G: Development of the main indicators of perinatal health in metropolitan France between 1995 and 1998. Results of the national perinatal survey. Journal de gynecologie, obstetrique et biologie de la reproduction. 2001, 30 (6): 552-564.PubMed Blondel B, Norton J, du Mazaubrun C, Breart G: Development of the main indicators of perinatal health in metropolitan France between 1995 and 1998. Results of the national perinatal survey. Journal de gynecologie, obstetrique et biologie de la reproduction. 2001, 30 (6): 552-564.PubMed
18.
Zurück zum Zitat Hadlock FP, Harrist RB, Martinez-Poyer J: In utero analysis of fetal growth: a sonographic weight standard. Radiology. 1991, 181 (1): 129-133.CrossRefPubMed Hadlock FP, Harrist RB, Martinez-Poyer J: In utero analysis of fetal growth: a sonographic weight standard. Radiology. 1991, 181 (1): 129-133.CrossRefPubMed
19.
Zurück zum Zitat Vergani P, Cozzolino S, Pozzi E, Cuttin MS, Greco M, Ornaghi S, Lucchini V: Identifying the causes of stillbirth: a comparison of four classification systems. Am J Obstet Gynecol. 2008, 199 (3): e311-314.CrossRef Vergani P, Cozzolino S, Pozzi E, Cuttin MS, Greco M, Ornaghi S, Lucchini V: Identifying the causes of stillbirth: a comparison of four classification systems. Am J Obstet Gynecol. 2008, 199 (3): e311-314.CrossRef
20.
Zurück zum Zitat Cousens S, Blencowe H, Stanton C, Chou D, Ahmed S, Steinhardt L, Creanga AA, Tuncalp O, Balsara ZP, Gupta S, et al: National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Lancet. 2011, 377 (9774): 1319-1330. 10.1016/S0140-6736(10)62310-0.CrossRefPubMed Cousens S, Blencowe H, Stanton C, Chou D, Ahmed S, Steinhardt L, Creanga AA, Tuncalp O, Balsara ZP, Gupta S, et al: National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Lancet. 2011, 377 (9774): 1319-1330. 10.1016/S0140-6736(10)62310-0.CrossRefPubMed
21.
Zurück zum Zitat Winbo IG, Serenius FH, Dahlquist GG, Kallen BA: NICE, a new cause of death classification for stillbirths and neonatal deaths. Neonatal and Intrauterine Death Classification according to Etiology. Int J Epidemiol. 1998, 27 (3): 499-504. 10.1093/ije/27.3.499.CrossRefPubMed Winbo IG, Serenius FH, Dahlquist GG, Kallen BA: NICE, a new cause of death classification for stillbirths and neonatal deaths. Neonatal and Intrauterine Death Classification according to Etiology. Int J Epidemiol. 1998, 27 (3): 499-504. 10.1093/ije/27.3.499.CrossRefPubMed
22.
Zurück zum Zitat Froen JF, Gordijn SJ, Abdel-Aleem H, Bergsjo P, Betran A, Duke CW, Fauveau V, Flenady V, Hinderaker SG, Hofmeyr GJ, et al: Making stillbirths count, making numbers talk - issues in data collection for stillbirths. BMC Pregnancy Childbirth. 2009, 9: 58-10.1186/1471-2393-9-58.CrossRefPubMedPubMedCentral Froen JF, Gordijn SJ, Abdel-Aleem H, Bergsjo P, Betran A, Duke CW, Fauveau V, Flenady V, Hinderaker SG, Hofmeyr GJ, et al: Making stillbirths count, making numbers talk - issues in data collection for stillbirths. BMC Pregnancy Childbirth. 2009, 9: 58-10.1186/1471-2393-9-58.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Lawn JE, Blencowe H, Pattinson R, Cousens S, Kumar R, Ibiebele I, Gardosi J, Day LT, Stanton C: S: Where? When? Why? How to make the data count?. Lancet. 2011, 377 (9775): 1448-1463. 10.1016/S0140-6736(10)62187-3.CrossRefPubMed Lawn JE, Blencowe H, Pattinson R, Cousens S, Kumar R, Ibiebele I, Gardosi J, Day LT, Stanton C: S: Where? When? Why? How to make the data count?. Lancet. 2011, 377 (9775): 1448-1463. 10.1016/S0140-6736(10)62187-3.CrossRefPubMed
24.
Zurück zum Zitat Gardosi J, Figueras F, Clausson B, Francis A: The customised growth potential: an international research tool to study the epidemiology of fetal growth. Paediatr Perinat Epidemiol. 2011, 25 (1): 2-10. 10.1111/j.1365-3016.2010.01166.x.CrossRefPubMed Gardosi J, Figueras F, Clausson B, Francis A: The customised growth potential: an international research tool to study the epidemiology of fetal growth. Paediatr Perinat Epidemiol. 2011, 25 (1): 2-10. 10.1111/j.1365-3016.2010.01166.x.CrossRefPubMed
25.
Zurück zum Zitat Cole SK, Hey EN, Thomson AM: Classifying perinatal death: an obstetric approach. Br J Obstet Gynaecol. 1986, 93 (12): 1204-1212. 10.1111/j.1471-0528.1986.tb07853.x.CrossRefPubMed Cole SK, Hey EN, Thomson AM: Classifying perinatal death: an obstetric approach. Br J Obstet Gynaecol. 1986, 93 (12): 1204-1212. 10.1111/j.1471-0528.1986.tb07853.x.CrossRefPubMed
26.
Zurück zum Zitat Korteweg FJ, Gordijn SJ, Timmer A, Erwich JJ, Bergman KA, Bouman K, Ravise JM, Heringa MP, Holm JP: The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. Bjog. 2006, 113 (4): 393-401. 10.1111/j.1471-0528.2006.00881.x.CrossRefPubMed Korteweg FJ, Gordijn SJ, Timmer A, Erwich JJ, Bergman KA, Bouman K, Ravise JM, Heringa MP, Holm JP: The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. Bjog. 2006, 113 (4): 393-401. 10.1111/j.1471-0528.2006.00881.x.CrossRefPubMed
27.
Zurück zum Zitat Wigglesworth JS: Monitoring perinatal mortality. A pathophysiological approach. Lancet. 1980, 2 (8196): 684-686.CrossRefPubMed Wigglesworth JS: Monitoring perinatal mortality. A pathophysiological approach. Lancet. 1980, 2 (8196): 684-686.CrossRefPubMed
28.
Zurück zum Zitat Gordon A, Jeffery HE: Classification and description of stillbirths in New South Wales, 2002–2004. Med J Aust. 2008, 188 (11): 645-648.PubMed Gordon A, Jeffery HE: Classification and description of stillbirths in New South Wales, 2002–2004. Med J Aust. 2008, 188 (11): 645-648.PubMed
29.
Zurück zum Zitat Froen JF, Arnestad M, Frey K, Vege A, Saugstad OD, Stray-Pedersen B: Risk factors for sudden intrauterine unexplained death: epidemiologic characteristics of singleton cases in Oslo, Norway, 1986–1995. Am J Obstet Gynecol. 2001, 184 (4): 694-702. 10.1067/mob.2001.110697.CrossRefPubMed Froen JF, Arnestad M, Frey K, Vege A, Saugstad OD, Stray-Pedersen B: Risk factors for sudden intrauterine unexplained death: epidemiologic characteristics of singleton cases in Oslo, Norway, 1986–1995. Am J Obstet Gynecol. 2001, 184 (4): 694-702. 10.1067/mob.2001.110697.CrossRefPubMed
30.
Zurück zum Zitat Huang DY, Usher RH, Kramer MS, Yang H, Morin L, Fretts RC: Determinants of unexplained antepartum fetal deaths. Obstet Gynecol. 2000, 95 (2): 215-221. 10.1016/S0029-7844(99)00536-0.PubMed Huang DY, Usher RH, Kramer MS, Yang H, Morin L, Fretts RC: Determinants of unexplained antepartum fetal deaths. Obstet Gynecol. 2000, 95 (2): 215-221. 10.1016/S0029-7844(99)00536-0.PubMed
31.
Zurück zum Zitat Gardosi J: Systematic reviews: insufficient evidence on which to base medicine. Br J Obstet Gynaecol. 1998, 105 (1): 1-5. 10.1111/j.1471-0528.1998.tb09339.x.CrossRefPubMed Gardosi J: Systematic reviews: insufficient evidence on which to base medicine. Br J Obstet Gynaecol. 1998, 105 (1): 1-5. 10.1111/j.1471-0528.1998.tb09339.x.CrossRefPubMed
Metadaten
Titel
Stillbirth classification in population-based data and role of fetal growth restriction: the example of RECODE
verfasst von
Anne Ego
Jennifer Zeitlin
Pierre Batailler
Séverine Cornec
Anne Fondeur
Marion Baran-Marszak
Pierre-Simon Jouk
Thierry Debillon
Christine Cans
Publikationsdatum
01.12.2013
Verlag
BioMed Central
Erschienen in
BMC Pregnancy and Childbirth / Ausgabe 1/2013
Elektronische ISSN: 1471-2393
DOI
https://doi.org/10.1186/1471-2393-13-182

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