Background
Effective HIV antiretroviral therapy (ART) controls viral replication, enhances or maintains immune function and decreases morbidity and mortality, allowing people living with HIV (PLWH) to have a life expectancy comparable to general population and helps prevent new infections [
1‐
3]. Several studies have demonstrated the effect of antiretroviral drugs in preventing HIV transmission by suppressing HIV RNA replication in people living with HIV (PLWH) to undetectable levels (treatment as prevention [TasP]), a strategy which has led to the ‘Undetectable equals Untransmittable’ (or ‘U=U’) campaign aimed at advocating for early access to HIV testing and treatment and motivate patients in the need to become virally suppressed through constant follow-up care [
4]. Since it has been demonstrated that sexual transmission of HIV does not occur if undetectable blood plasma HIV RNA is maintained [
5,
6], treatment for HIV also presents a great opportunity to reduce stigma and transform PLWH’s sexual relationships [
7]. However, despite ART’s success, patient attrition and loss to follow-up (LTFU) remain legitimate threats to the long-term success of ART scale up.
The ambitious but achievable 90–90-90 UNAIDS target proposes that by 2020 90% of all PLWH know their HIV status, 90% of all people diagnosed HIV infection receive sustained antiretroviral therapy, and 90% of all people on ART maintain viral suppression (VS )[
8]. In this sense, the main barriers in achieving this target in high income countries are patients lost during any of these three steps. Results from a multicentre study analysing 31 countries form Europe has shown that LTFU (defined as 12 months of HIV care disengagement) was 22%, and were mostly men, young, people who inject drugs and patients with high viral loads [
9]. In another UK study, LTFU reached 28.1% of disengagement during nine consecutive months, and further analysis of these patients showed that 26% were found as transferred to clinics outside the UK [
10]. In Spain, cohort studies reported 15% of LTFU (disengaged during a minimum of 12 months) and was linked to intravenous drug use, unemployment, more sporadic sex partners, being born in another country, and not having initiated ART [
11]. In Catalonia and Balearic islands, the PISCIS cohort [
12] has shown that 85% of HIV-diagnosed patients were retained (defined as 1 or more visits per year) [
13] and a more recent study estimated that 89% of the PLWH were diagnosed, of these 78% were under treatment and 73% are virally suppressed [
14]. Also in Catalonia, men who have sex with men (MSM) with a migration background experienced greater losses throughout the three steps of the 90–90-90 cascade: retention in care (74% vs. 55%), antiretroviral treatment (70% vs. 50%) and virally suppressed (65% vs. 46%), respectively [
15].
In a step forward, USAID extended their target strategy to 95–95-95 by 2030 [
16], which implies not only a need to increase retention in care, improve ART adherence and VS but also proactively reengage lost patients by hiring case managers to locate and give these patients the support they need to attend their clinical visits [
17]. However, previous studies aimed at identifying the best measures to increase linkage, retention and reengagement to HIV care found no evidence-based interventions addressing reengagement [
18] and described as major difficulties LTFU tracing, updating whereabouts data, lack of clinical records and time-gaps between HIV laboratory testing and initiating treatment [
19]. The description and analysis of previous experiences will allow us to design, prepare and deploy a new evidence-based reengagement strategy directed at LTFU HIV positive patients in Catalonia and Balearic Islands, nested and piloted within a population-based cohort (PISCIS cohort), in order to help reduce the risk of untreated and disengaged HIV positive patients. The objective of this scoping review is to evaluate the current knowledge on LTFU patient reengagement, describe procedures used to re-link LTFU patients into treatment, and determine which factors play a role in the implementation of these strategies.
Methods
Following scoping review methods described by Arksey H & O’Malley and the corresponding guidance developed by Peters et al. and Joanna Briggs Institute [
20], we divided our review strategy into the following steps [
21]:
This review was guided by the question: “What is known about those interventions used to reengage patients in HIV treatment and reduce lost to follow-up?”
Two types of documents were searched for: peer-review articles and grey literature. In the first case, searches were performed through PubMed, Scopus, Web of Science, Cochrane, PsycInfo EBSCO (see Additional file
1 for the search strategy). In the second case, grey literature was searched in Google. Initially, searches were performed using the following keywords in titles and abstracts, “reengagement/re-engagement”, “reengaged/re-engage”, “relink/re-link”, “HIV”, and “AIDS”; and then the medical subject headings (MeSH) were also used. All searchers where restricted to the last 15 years, (from January 2006 to May 2021) and were assessed by an independent librarian who checked the sources of data and the strategy used. In addition, bibliographies of chosen articles were further scanned for additional articles.
Studies were selected if they fulfilled the following criteria: 1) defined, analysed, developed, or used HIV patient care reengagement strategies, 2) provided details on the type of strategies used, 3) showed details on the outcomes of its implementation, and 4) were carried out in high-income countries according to the classification of the World Bank [
22]. Documents not published in English were excluded. Although, processes of search, selection and data charting were performed only by one person, one librarian specialist in health sciences research was consulted to assist and approve all these strategies.
Documents that met the inclusion criteria were registered in an Excel file specifying its title, author, abstract, intervention developed/used to reengage LTFU, type of study or design used, outcomes used to analyse the impact of the strategy, and key findings (see Additional file
2 for the final documents included in the review). Once chosen and entered into the study database, publications were revised again to confirm that they met inclusion criteria and complete missing information. In addition, the Preferred Reporting Items for Systematic Reviews - extension checklist for Scoping Reviews (PRISMA-ScR) was used (20] (see Additional file
3). Although the implementation protocol for this review was not registered, its objectives are encompassed within a broader project aimed at the study of LTFU in a cohort of PLWH in Spain.
Discussion
Retention in care and ART adherence constitute key strategies in HIV management and are essential for PLWH in order to stay healthy, live longer and prevent HIV transmission to others. Although few publications fulfilled the inclusion criteria for this scoping review, the selected studies provide useful and well organized information on how to identify LTFU patients, how to implement successful strategies to motivate and reengage patients into HIV care, and how to determine the impact of such strategies. During the identification of LTFU patients, electronic databases and other data sources are useful to obtain information on probable patients, and phone calls were the most used strategy in contacting these patients, combined with mailed letters, emails, home visits. The reengagement process itself is performed mainly by finding and reducing the barriers that make patients disengage and enhancing their motivation to return to HIV care, while preventing new losses.
Most of the selected studies were published in the United States and only one study was European (Ireland), evidencing a lack of knowledge in this field in different contexts. Analysing reengagement strategies under different HIV-care, social, and economic factors is still pending, and this would imply adapting the different strategies to local circumstances, testing which of them would work well, and measuring their impact on the reengagement of LTFU patients. Additionally, the fact that most of the studies were published after the year 2015 shows a growing need in reaching this group of PLWH, that despite their particular circumstances, could easily return to treatment and improve their health, with a relatively low effort and few resources invested. The dynamism of the HIV epidemic and the increased interest in LTFU patient reengagement are aligned with the treatment and care objectives (90–90-90 and 95–95-95), which not only focus in maintaining low viral loads and well controlled patients, but also in reducing diagnostic and treatment gaps.
Defining who is a LTFU patient is crucial, and the most used classification found is having no contact with HIV care professionals for over 12 months. However, why this is or other time-periods were chosen is only described in one of the reviewed articles, referring to specific clinical guidelines [
36]. Selecting 12 months or longer periods was described as more challenging due to the difficulties in acquiring patients’ contact information the longer they’ve been out-of-care [
37]. Shorter periods, such as 6 months, were selected due to clinical reasons [
34], because patients that were out-of-care during this period of time showed reduced chances of reengagement, which according to the authors may be explained by treatment regimen fatigue, and decreased motivation and adhere to medication as prescribed [
23]. In contrast, longer periods of time to be considered as out-of-care were also reported, such as 14 months, because authors tried to minimize the number of patients falsely identified as being out of care due to delays in data reporting, maximizing the specificity of the classification strategy [
46]. Standard definitions of retention in care in the United States are two clinical visits separated by ≥90 days during a 12-months measurement period or at least 1 visit in each 6-months period during a 24-months measurement period, with ≥60-d between visits in adjacent 6-mo periods [
52]. This might have implications for the organization, provision of HIV care and the need to follow patients frequently and avoiding losing them for even 6 months.
The most common way to find LTFU patients was to look for them in the clinical records, with some authors reporting the use of multiple data bases, as well as using external or secondary sources of information. As the majority of the studies were published with data from United States, where patients can be registered with different healthcare or buy-in providers [
23], combining different sources of information was common in order to locate patients. However, in certain European countries, where healthcare systems have less access barriers by having integrated and connected health records, tracking LTFU patients and reengaging them into HIV care could take less time and resources.
Tracking activities consisted mainly in making phone calls and sending letters/emails, with some publications also referring home visits to the patient’s last known address, but few details on how confidentiality was ensured during home visits was described. Phone calls were reported to be successful in reengaging patients, even when used alone, and authors mentioned the potential benefit of using this method in other countries/settings given its relatively low-cost and little time needed [
24]. The type, quantity, and time spent in reengagement procedures was also quite diverse among the reviewed literature, and there was no common trend since each study presented specific circumstances. However, one publication mentioned that the length of the intervention period was probably the reason of unsuccessful results [
38] and another study modified an intervention to include more sessions and offered linkage to other healthcare services [
26].
There was a considerable number of PLWH that, despite multiple efforts, could not be reached and reengaged. In the Irish study, where 81% of the contacts were reported to be unsuccessful, authors, along with others, explained that out-of-service phone numbers might explain for this high proportion and highlighted the need to maintain updated demographic and contact information within each visit [
30]. To do this, a strong and multidisciplinary work-team needs to be built within each centre, or even between multiple centres, in order to manage and update contact information and keep patients’ registries as accurate as possible, avoiding wrong classifications of LTFU and optimizing the time needed to attend patients [
25‐
27,
30,
33]. Updated clinical records is crucial, and some studies pointed out that at least a third of the presumed LTFU patients might actually be in care, reinforcing the importance of having a strong system that keeps these patients as well tracked as possible [
32,
37]. Moreover, integrating different records, for instance clinic-based and administrative records could avoid losses and ease the implementation of reengagement activities [
31]. In fact, these strategies has been reported as an opportunity for improving clinical registries, allowing at the same time the proper follow-up of patients [
25]. In addition, the proper use and sharing clinical records might help avoid extra work in finding presumably lost patients, when they might have simply transferred to other clinics, which according to the reviewed literature, can be as much as 50% of all LTFU. The implementation of field/outreach programs aimed at identifying, tracing, following-up on, and reengaging LTFU patients can complement other clinic staff’s efforts to locate patients who are hard to reach or those whose present access and adherence to care barriers such as lack of transportation, unstable housing, poverty, mental health, substance use disorders, among others [
24,
28].
There is evidence on how some determinants interfere in the likelihood of being successfully reengaged in HIV care. The provision of evidence-based training to health professionals and the improvement of the communication skills would enhance the chance of reengagement, reducing also the risk of stigma, time limitations and other difficulties [
30,
41]. In addition, reengagement strategies should consider the fact that low socioeconomic status plays an important role, making reengage less likely [
28] which in turn increases the need for social workers to collaborate with HIV care and find better ways to coordinate the units staff [
24]. Clinical variables have also been associated with reengagement. High levels of CD4 cell counts and lower viral loads have been reported as determinants of higher likelihood of reengagement [
24]. When patients have returned to care and are followed over time (90 or 180 days), viral loads remain lower compared to those not reengaged and retained [
34]. Similarly, being diagnosed with either concurrent or nonconcurrent AIDS increases the likelihood of being retained in care after reengagement [
23].
Successful reengagement depends largely on the ability of the professional to involve and motivate patients to attend future appointments and working with them to solve the specific reasons why they may disengage. Additionally, the number and length of these strategies, and the efforts made to achieve success, might depend on the professionals’ ability to tailor and modify these strategies according to each particular circumstance [
26]. Strength and motivational-based strategies are common among the revised studies, and basically consist in finding out and collaborating with the patient in order to find the best options in dealing with each particular engagement barrier. The role of the healthcare professionals is very important, especially in motivating LTFU patients, so professionals should be trained on increasing their ability to meet the patients’ needs, listening and working together to find solutions and overcoming the barriers that kept them out of care [
41]. Although the professionals’ work should be as holistic as possible, some LTFU patients could have needs which are difficult to meet. However, there is a basic group of LTFU needs that can ensure reengagement, which include: prioritization of urgent needs, dividing needs into short and long term, relying on partner organizations to provide support services, and having priority status to be included in programs like addiction units or social work assistance [
37].
A limitation of our review is the fact that only articles published in English were searched, missing possibly relevant information in other languages. In addition, although searches were performed to include different types of documents, the vast majority of the results were related to peer-reviewed articles and almost no reports or conference proceedings were found.
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