Successful Healthcare Provider Strategies to Overcome Psychological Insulin Resistance in Japanese Patients with Type 2 Diabetes

The global incidence of diabetes has been steadily increasing over the past few decades [1]. In Japan, the increasing prevalence of diabetes, particularly type 2 diabetes mellitus (T2D), is a major health concern [2]. Additionally, the prevalence of diabetes in Japan is predicted to further increase over the next decades, mainly due to an aging population [2].

Poorly controlled diabetes may lead to a number of serious health complications [1]. Globally, treatment guidelines for T2D (World Health Organization, American Diabetes Association, and European Association for the Study of Diabetes) recommend a patient-centered and stepwise approach to managing glycemic control [1, 3]. A focus on lifestyle management and diabetes self-management education and support are recommended, alongside metformin, oral antidiabetic and/or injectable medications, and/or basal insulin, as well as consultation with a healthcare provider (HCP) [3]. Similarly, guidelines for Japanese patients with diabetes recommend patient education regarding diet and exercise, followed by basal insulin therapy for those with inadequate glycemic control despite therapy with oral glucose-lowering medications [4]. This treatment strategy, however, should vary depending on the disease condition, age, metabolic abnormality, and status of diabetes complications of each patient [4].

While treatment with insulin is associated with higher rates of achieving adequate glycemic control [1, 3], initiation of insulin therapy is often delayed due to a variety of physician- and patient-related factors [5]. Reluctance to initiate insulin treatment, known as ‘psychological insulin resistance’ (PIR), is common among adults with diabetes, with a recent study reporting 29.9% of insulin-naïve adults with T2D declined insulin treatment after it was recommended by their HCP [6]. Recent studies revealed a high reluctance in the use of injectable therapies among injection-naïve Japanese patients with T2D, with less than 2% of study participants initially willing to take injectable medicines [7, 8].

Numerous studies have examined psychological barriers preventing the initiation of insulin therapy in adults [5, 9‐11]. PIR encompasses patient-related concerns, including injection anxiety, misconceptions about insulin, concerns about hypoglycemia, and societal attitudes [5, 10, 12, 13]. Several studies have documented recommendations to address PIR [14‐17]; however, there is little research regarding factors or effective strategies that help reluctant patients begin insulin treatment. In addition, although there are reports describing PIR among Japanese diabetic patients [18‐20], the evidence is limited.

To further understand the factors associated with reluctant patients initiating insulin, a multinational, noninterventional study (EMOTION) surveyed current insulin-using adults with T2D who were initially reluctant to begin insulin treatment. The EMOTION (AccEpting Insulin TreatMent for Reluctant PeOple with Type 2 DIabetes Mellitus—a GlObal Study to IdeNtify Effective Strategies) study was conducted in 3 phases: qualitative interviews (phase 1) with participants and HCPs in 6 countries (Brazil, Canada, Germany, Spain, the United Kingdom, and the United States), quantitative surveys (phase 2), and follow-up interviews (phase 3) with participants in the same 6 countries plus Japan. Phase 2 of EMOTION identified a number of HCP actions and life events (actions/events) that were rated as being the most helpful amongst the total population [21]. These included efforts to address injection concerns by demonstrating the insulin injection process, explaining the benefits of insulin, and adopting a collaborative communication style. The perceived helpfulness of these actions were, in turn, linked with earlier insulin initiation and greater insulin persistence over time [21].

We report a Japanese population subanalysis of EMOTION (phase 2). We aim to identify HCP actions/events that may help reluctant insulin users with T2D decide to initiate insulin therapy.

The data used in this study were derived from the EMOTION study. EMOTION was conducted in 7 countries: Brazil, Canada, Japan, Germany, Spain, the United Kingdom, and the United States. The study protocol was approved by the Western Institutional Review Board (IRB), Puyallup, Washington, USA, as well as the Nagoya University IRB, Nagoya, Japan. All procedures performed in this study involving human participants were in accordance with the ethical standards of the Western IRB, Puyallup, Washington, USA, and the Nagoya University IRB, Nagoya, Japan, and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. Participants were compensated for their time. The study design has been previously described [21]. Briefly, qualitative interviews with a total of 29 insulin-using adults with T2D and 29 HCPs across 6 countries (Brazil, Canada, Germany, Spain, the United Kingdom, and the United States) were conducted to inform survey content and design. Phase 2 involved a 30-min quantitative survey, derived from the qualitative interviews, with participants with T2D from these same nations plus Japan. This report focuses on the findings of the quantitative survey in Japanese participants with T2D.

Participants were selected from the market research panels of Survey Sampling International (SSI) and their local partners in Japan. Surveys were translated for Japanese participants by professional linguists from TransPerfect with knowledge of the language, the subject area, and the target audience. Survey participants were compensated for their time.

Eligible participants were adults (≥ 21 years old) with T2D who reported that they were initially not willing to start insulin treatment (i.e., chose “not willing” among the options “not willing,” “slightly willing,” “moderately willing,” or “very willing”). Participants had been diagnosed with T2D at least 1 year before starting basal insulin (self-reported), started basal insulin between 30 days and 3 years before the survey, and had used any insulin regularly for the 30 days before the survey. Subjects were ineligible if they had been diagnosed with any other type of diabetes, had experience with insulin therapy before the initiation of basal insulin therapy, or if they had initiated insulin using a premix product or basal bolus therapy.

Quantitative surveys were administered to eligible participants between December 2016 and August 2017. Participants were given the survey via an online platform. Participants were asked to survey 45 actions and statements that assisted in insulin initiation and to denote whether each action occurred. Actions/events that occurred were then rated for helpfulness on a 4-point Likert scale: 1 = it didn’t help at all, 2 = it helped a little, 3 = it helped moderately, 4 = it helped a lot. Other questions in the following key areas were included: participant demographics; disease history; time from initial HCP consult to initiation of insulin; reasons for insulin reluctance; transformative point/person involved in initiation of insulin; role of HCP in initiating insulin; experiences post-insulin initiation satisfaction with treatment; and attitude regarding insulin use. Completed surveys were screened to identify and omit those that were problematic (e.g., surveys which were completed in < 10 min or had the same responses to all survey items pertaining to HCP messages and actions).

Findings were presented using descriptive summary statistics, which included the number and percentage of participants with specific responses to categorical questions, the means and standard deviations for continuous variables (including age and years since first diabetes diagnosis), and actions/events with Likert-scale responses. The mean level of helpfulness of each item was calculated and rated from the most to the least helpful. Outcomes related to experiences post-insulin initiation were also summarized, including adherence to insulin therapy, experiences related to weight, energy, mood, and hypoglycemia, treatment satisfaction with insulin therapy, and attitude about insulin following insulin initiation.

Possible consequences of delayed insulin use for patients with T2D include serious health complications such as heart disease, stroke, kidney failure, vision loss, and nerve damage [1]. It is therefore imperative that HCPs understand psychological insulin resistance in patients so that adequate measures can be taken to reduce the delay in insulin initiation.

We report a Japanese subpopulation analysis of EMOTION, a multinational survey of current insulin-using adults with T2D. Approximately 40% of all Japanese participants reported being moderately or very surprised with the recommendation to commence insulin, with approximately 42% being moderately or very upset. Despite an initial unwillingness to initiate insulin therapy, approximately 80% of Japanese participants initiated insulin treatment immediately. Notably, the majority of the participants continued to use insulin once they initiated it. This high uptake rate may reflect Japanese participants’ trust in their HCPs, a trait associated with increased insulin adherence and reduced diabetes-related stress [22].

Psychosocial factors affecting insulin usage appear to be common among diabetic patients worldwide [13], and educational programs related to insulin initiation differ between Japanese and non-Japanese physicians [23]. Our results indicate that HCP actions are significantly associated with a patient’s decision to initiate insulin. We identify a number of HCP actions/events deemed to be the most and least helpful for initiating insulin among reluctant Japanese adults with T2D. Namely, HCP actions that provided practical demonstrations on how to use insulin were the most helpful. Reassurance concerning pain of injection, explanations regarding blood glucose numbers and future health, encouragement to make contact in case of any problems, and occurrence of a positive life event were also rated highly by Japanese participants as being helpful in deciding to start insulin treatment. In addition, some actions occurred less frequently but were considered very useful by Japanese participants. In particular, ‘HCP gave an injection while patient was in the office’ was not an action performed by many HCPs (25.3%), but was rated as helping moderately or a lot by 72.0% of participants. Similarly, ‘Patient talked with someone who was taking insulin and realized it might not be as bad as patient thought’ did not occur often (16.2%), but when it did occur, 62.5% of participants found this helped moderately or a lot.

HCP actions and life events rated as least helpful were those that referred the patient elsewhere, including HCP referral to educational classes and meeting other patients. Additionally, communication style may be important for Japanese patients. For example, ‘HCP warned patient that he/she was likely to develop complications if the patient didn’t get started with insulin to control his/her diabetes’ was only helpful for approximately half of participants (49.2%). Similarly, ‘HCP warned patient that he/she could not be responsible for what might happen if he/she did not start insulin soon’ was only helpful to 39.1% of Japanese participants.

Recent studies have examined reluctance to initiate insulin treatment in various populations. It has been documented that patients who were nonadherent to insulin regimens frequently felt that their HCP did not adequately explain the benefits and risks of insulin treatment [12]. Perceived physician inattention and lack of engagement as well as diabetes-related distress affect insulin adherence and glycemic control [24]. Many factors, including information, adequate counseling, and positive role models, have been found to influence PIR [25]. A multinational study that included Japan examined experiences during and after insulin initiation and discovered that patients who were classified as treatment ‘interrupters’ or ‘discontinuers’ were more likely to have concerns and challenges during the initiation process [26]. These patients were also less likely to exhibit improvements in glycemic control compared to patients classified as treatment ‘continuers’ [26]. In addition, a recent multicenter Japanese study concluded that educating patients about the benefits of insulin therapy may help reluctant insulin users to initiate therapy, and that practical support may assist current insulin users in maintaining therapy [20]. Indeed, our results relating to the helpfulness of HCP actions support these findings and highlight the important role that HCPs play in preventing and/or overcoming PIR amongst patients with T2D.

The Diabetes Attitudes, Wishes and Needs (DAWN2) survey was a global initiative aimed at assessing diabetes care and management among people with diabetes, as well as their HCPs and family members. DAWN2 was conducted in 17 countries, including Japan [23, 27]. In all countries surveyed, DAWN2 revealed that diabetes is a significant physical and psychological burden for many individuals with diabetes [23]. Specifically, DAWN2 reported depression (13.8%), diabetes-related distress (44.6%), poor or very poor quality of life (12.2%), a negative impact on relationships (20.5%) and physical health (62.2%), and medication interference in daily life (approximately 40%) [23]. Many factors may have influenced the findings from DAWN2, such as socioeconomic and cultural factors as well as differences in healthcare systems between countries. Indeed, in our analysis, there are notable differences between Japanese and Caucasian participants from the global EMOTION analysis. For example, differences in the level of full-time employment (51.5% Japan vs 35.0% US) and education (participants who completed high school: 42.4% Japan vs 18.3% US) were observed. Primary care physicians in Japan were more likely to be involved in assisting patients with initiating insulin compared to the overall EMOTION population (76.8% Japan vs 37.4% overall population), for whom this task was also likely to be performed by endocrinologists (12.6%) and diabetes nurse specialists (14.0%). Hence, country-specific analyses are warranted.

Diabetes-related distress, known as the emotional burden of and reaction to managing a chronic illness, is associated with a higher rate of diabetes-related complications [23, 28, 29]. A positive educational experience and support from HCPs at the time of insulin recommendation may be pivotal to maintaining adequate glycemic control and the long-term health of patients with T2D. In fact, a large retrospective cohort study found that a substantial proportion of people continue with poor glycemic control for several years before initiating intensification with oral antidiabetic medications and insulin [30]. Diabetes health-coaching consisting of goal-setting, education, and individualized and follow-up care have also been effective strategies to improve glycemic control, as demonstrated in a recent meta-analysis which concluded that diabetes health-coaching resulted in a statistically significant reduction in HbA1c levels (0.32%) [31]. Physician empathy is also noted as contributing to improved HbA1c outcomes [32], and practical strategies that HCPs can utilize to assist their patients to overcome emotional barriers may be warranted (e.g., the use of mnemonics) [33]. Practical diabetes health-coaching, along with routine diabetes care, supports our findings amongst Japanese participants, and may be a valuable tool to help motivate T2D patients to initiate and maintain insulin treatment.

This study provides valuable data regarding the experiences of Japanese participants diagnosed with T2D. We identify HCP actions and life events that were helpful in initiating insulin treatment. Our results agree with recently described results of a stepwise approach to diabetes and insulin education [17], which encompassed problem-solving, patient education, and physician enquiries about patient feelings and fears.

The strength in our analysis lies in the description of helpful (and less helpful) HCP actions rated by Japanese participants with T2D; data which are, at present, limited in this population. Limitations relating to the study design, however, should be noted. Firstly, the majority of survey respondents were recruited from online panels of individuals who had volunteered to participate in studies. These participants, therefore, may be more involved in their own diabetes management in comparison with typical patients. Perceptions regarding helpful PIR actions in these volunteers may not be indicative of the perceptions of the broader population. Secondly, the majority of Japanese survey participants were male and responses may vary with increased female participation. Thirdly, survey responses may be due to recall bias, with participants having initiated insulin between 2015 and 2017. Finally, the retrospective nature of the study should raise some caution: self-reported data may not be accurate and could potentially be subject to bias.

Further studies amongst this patient population are warranted and may further assist HCPs in providing optimal care for Japanese patients with T2D. Other factors that may affect PIR in Japanese patients, such as age, socioeconomic status, and mental health, also warrant further investigation.

Our findings suggest that a tailored approach in which HCPs explain the insulin injection process from patients’ perspectives is beneficial for reluctant Japanese insulin users. This study provides important information on actions that can be used by HCPs to assist Japanese adults with T2D who are reluctant insulin users in overcoming PIR. More generally, the findings from this survey of Japanese adults with T2D, who were initially reluctant to begin insulin treatment, suggest potentially useful clinical interventions for helping patients overcome PIR, a critical step towards designing comprehensive clinical recommendations for HCPs.