Skip to main content
Erschienen in: Drugs & Aging 5/2008

01.05.2008 | Review Article

Surgical Site Infections in Older Adults

Epidemiology and Management Strategies

verfasst von: Michael H. Young, Laraine Washer, Dr Preeti N. Malani

Erschienen in: Drugs & Aging | Ausgabe 5/2008

Einloggen, um Zugang zu erhalten

Abstract

Surgical site infections (SSIs) represent a major source of morbidity and mortality among older adults. In this review we discuss the epidemiology and risk factors for SSIs among older adults. We also offer an overview of current treatment and management strategies for several common SSIs. Our comments focus on the following areas in order to illustrate issues of clinical importance in the older patient: (i) cardiac surgery; (ii) vascular grafts; (iii) total joint arthroplasty; (iv) breast surgery; and (v) spinal surgeries. Besides being common and relatively specific to older adults, several of these surgical procedures require the use of prosthetic materials or devices, which present unique treatment challenges in the context of infection. When an older adult does develop an SSI, it is critical for clinicians to establish an overall treatment goal for each patient. In the majority of patients, this will be either complete cure or remission followed by suppressive therapy. However, clinicians caring for older adults must consider not only the possibility of microbiological cure, but also balance the need to preserve functional status and overall quality of life. Infections associated with devices and prosthetic material can present unique treatment challenges. Treatment of significant infections often requires prolonged courses of parenteral and/or oral antimicrobial therapy, which can raise issues related to the safety and tolerability of antimicrobial agents, including higher rates of nephrotoxicity. Issues concerning overall functional status, nutritional reserve and medical co-morbidities must be taken into consideration when approaching SSIs in an older adult.
Literatur
1.
Zurück zum Zitat Bacchetta MD, Ko W, Girardi LN, et al. Outcomes of cardiac surgery in nonagenarians: a 10-year experience. Ann Thorac Surg 2003; 75(4): 1215–20PubMedCrossRef Bacchetta MD, Ko W, Girardi LN, et al. Outcomes of cardiac surgery in nonagenarians: a 10-year experience. Ann Thorac Surg 2003; 75(4): 1215–20PubMedCrossRef
2.
Zurück zum Zitat Chukwuemeka A, Borger MA, Ivanov J, et al. Valve surgery in octogenarians: a safe option with good medium-term results. J Heart Valve Dis 2006; 15(2): 191–6; discussion 196PubMed Chukwuemeka A, Borger MA, Ivanov J, et al. Valve surgery in octogenarians: a safe option with good medium-term results. J Heart Valve Dis 2006; 15(2): 191–6; discussion 196PubMed
3.
Zurück zum Zitat Collart F, Feier H, Kerbaul F, et al. Primary valvular surgery in octogenarians: perioperative outcome. J Heart Valve Dis 2005; 14(2): 238–42; discussion 242PubMed Collart F, Feier H, Kerbaul F, et al. Primary valvular surgery in octogenarians: perioperative outcome. J Heart Valve Dis 2005; 14(2): 238–42; discussion 242PubMed
4.
Zurück zum Zitat Fowler Jr VG, O’Brien SM, Muhlbaier LH, et al. Clinical predictors of major infections after cardiac surgery. Circulation 2005; 112(9 Suppl.): 1358–65 Fowler Jr VG, O’Brien SM, Muhlbaier LH, et al. Clinical predictors of major infections after cardiac surgery. Circulation 2005; 112(9 Suppl.): 1358–65
5.
Zurück zum Zitat National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32(8): 470–85 National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32(8): 470–85
6.
Zurück zum Zitat Paletta CE, Huang DB, Fiore AC, et al. Major leg wound complications after saphenous vein harvest for coronary revascularization. Ann Thorac Surg 2000; 70(2): 492–7PubMedCrossRef Paletta CE, Huang DB, Fiore AC, et al. Major leg wound complications after saphenous vein harvest for coronary revascularization. Ann Thorac Surg 2000; 70(2): 492–7PubMedCrossRef
7.
Zurück zum Zitat Rupp M. Mediastinitis. In: Mandell G, Douglass R, Dolin R, editors. Principles and practice of infectious diseases. 6th ed. Philadelphia (PA): Churchill-Livingstone, 2005: 1070–8 Rupp M. Mediastinitis. In: Mandell G, Douglass R, Dolin R, editors. Principles and practice of infectious diseases. 6th ed. Philadelphia (PA): Churchill-Livingstone, 2005: 1070–8
8.
Zurück zum Zitat Mayhall C. Hospital epidemiology and infection control. In: Lew P, Pittet D, Walvogel F, editors. Infections that complicate the insertion of prosthetic devices. 3rd ed. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 287–310 Mayhall C. Hospital epidemiology and infection control. In: Lew P, Pittet D, Walvogel F, editors. Infections that complicate the insertion of prosthetic devices. 3rd ed. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 287–310
9.
Zurück zum Zitat Trouillet JL, Vuagnat A, Combes A, et al. Acute poststernotomy mediastinitis managed with debridement and closed-drainage aspiration: factors associated with death in the intensive care unit. J Thorac Cardiovasc Surg 2005; 129(3): 518–24PubMedCrossRef Trouillet JL, Vuagnat A, Combes A, et al. Acute poststernotomy mediastinitis managed with debridement and closed-drainage aspiration: factors associated with death in the intensive care unit. J Thorac Cardiovasc Surg 2005; 129(3): 518–24PubMedCrossRef
10.
Zurück zum Zitat Marggraf G, Splittgerber FH, Knox M, et al. Mediastinitis after cardiac surgery: epidemiology and current treatment. Eur J Surg Suppl 1999; (584): 12–6 Marggraf G, Splittgerber FH, Knox M, et al. Mediastinitis after cardiac surgery: epidemiology and current treatment. Eur J Surg Suppl 1999; (584): 12–6
11.
Zurück zum Zitat Tang AT, Ohri SK, Haw MP. Novel application of vacuum assisted closure technique to the treatment of sternotomy wound infection. Eur J Cardiothorac Surg 2000; 17(4): 482–4PubMedCrossRef Tang AT, Ohri SK, Haw MP. Novel application of vacuum assisted closure technique to the treatment of sternotomy wound infection. Eur J Cardiothorac Surg 2000; 17(4): 482–4PubMedCrossRef
12.
Zurück zum Zitat Culver DH, Horan TC, Gaynes RP, et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index: National Nosocomial Infections Surveillance system. Am J Med 1991; 91(3B): 152S–7SPubMedCrossRef Culver DH, Horan TC, Gaynes RP, et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index: National Nosocomial Infections Surveillance system. Am J Med 1991; 91(3B): 152S–7SPubMedCrossRef
13.
Zurück zum Zitat Borger MA, Rao V, Weisel RD, et al. Deep sternal wound infection: risk factors and outcomes. Ann Thorac Surg 1998; 65(4): 1050–6PubMedCrossRef Borger MA, Rao V, Weisel RD, et al. Deep sternal wound infection: risk factors and outcomes. Ann Thorac Surg 1998; 65(4): 1050–6PubMedCrossRef
14.
Zurück zum Zitat Harrington G, Russo P, Spelman D, et al. Surgical-site infection rates and risk factor analysis in coronary artery bypass graft surgery. Infect Control Hosp Epidemiol 2004; 25(6): 472–6PubMedCrossRef Harrington G, Russo P, Spelman D, et al. Surgical-site infection rates and risk factor analysis in coronary artery bypass graft surgery. Infect Control Hosp Epidemiol 2004; 25(6): 472–6PubMedCrossRef
15.
Zurück zum Zitat Bitkover CY, Gardlund B. Mediastinitis after cardiovascular operations: a case-control study of risk factors. Ann Thorac Surg 1998; 65(1): 36–40PubMedCrossRef Bitkover CY, Gardlund B. Mediastinitis after cardiovascular operations: a case-control study of risk factors. Ann Thorac Surg 1998; 65(1): 36–40PubMedCrossRef
16.
Zurück zum Zitat Lepelletier D, Perron S, Bizouarn P, et al. Surgical-site infection after cardiac surgery: incidence, microbiology, and risk factors. Infect Control Hosp Epidemiol 2005; 26(5): 466–72PubMedCrossRef Lepelletier D, Perron S, Bizouarn P, et al. Surgical-site infection after cardiac surgery: incidence, microbiology, and risk factors. Infect Control Hosp Epidemiol 2005; 26(5): 466–72PubMedCrossRef
17.
Zurück zum Zitat Garey KW, Kumar N, Dao T, et al. Risk factors for postoperative chest wound infections due to gram-negative bacteria in cardiac surgery patients. J Chemother 2006; 18(4): 402–8PubMed Garey KW, Kumar N, Dao T, et al. Risk factors for postoperative chest wound infections due to gram-negative bacteria in cardiac surgery patients. J Chemother 2006; 18(4): 402–8PubMed
18.
Zurück zum Zitat Wong E. Surgical site infections. In: Mayhall C, editor. Hospital epidemiology and infection control. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 287–310 Wong E. Surgical site infections. In: Mayhall C, editor. Hospital epidemiology and infection control. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 287–310
19.
Zurück zum Zitat Banbury MK, Brizzio ME, Rajeswaran J, et al. Transfusion increases the risk of postoperative infection after cardiovascular surgery. J Am Coll Surg 2006; 202(1): 131–8PubMedCrossRef Banbury MK, Brizzio ME, Rajeswaran J, et al. Transfusion increases the risk of postoperative infection after cardiovascular surgery. J Am Coll Surg 2006; 202(1): 131–8PubMedCrossRef
20.
Zurück zum Zitat Torres S, Kuo YH, Morris K, et al. Intravenous iron following cardiac surgery does not increase the infection rate. Surg Infect (Larchmt) 2006; 7(4): 361–6CrossRef Torres S, Kuo YH, Morris K, et al. Intravenous iron following cardiac surgery does not increase the infection rate. Surg Infect (Larchmt) 2006; 7(4): 361–6CrossRef
21.
Zurück zum Zitat Basaran M, Selimoglu O, Ozcan H, et al. Being an elderly woman: is it a risk factor for morbidity after coronary artery bypass surgery? Eur J Cardiothorac Surg 2007; 32(1): 58–64PubMedCrossRef Basaran M, Selimoglu O, Ozcan H, et al. Being an elderly woman: is it a risk factor for morbidity after coronary artery bypass surgery? Eur J Cardiothorac Surg 2007; 32(1): 58–64PubMedCrossRef
22.
Zurück zum Zitat Paul M, Raz A, Leibovici L, et al. Sternal wound infection after coronary artery bypass graft surgery: validation of existing risk scores. J Thorac Cardiovasc Surg 2007; 133(2): 397–403PubMedCrossRef Paul M, Raz A, Leibovici L, et al. Sternal wound infection after coronary artery bypass graft surgery: validation of existing risk scores. J Thorac Cardiovasc Surg 2007; 133(2): 397–403PubMedCrossRef
23.
Zurück zum Zitat Kaye KS, Schmader KE, Sawyer R. Surgical site infection in the elderly population. Clin Infect Dis 2004; 39(12): 1835–41PubMedCrossRef Kaye KS, Schmader KE, Sawyer R. Surgical site infection in the elderly population. Clin Infect Dis 2004; 39(12): 1835–41PubMedCrossRef
24.
Zurück zum Zitat Olsen MA, Lock-Buckley P, Hopkins D, et al. The risk factors for deep and superficial chest surgical-site infections after coronary artery bypass graft surgery are different. J Thorac Cardiovasc Surg 2002; 124(1): 136–45PubMedCrossRef Olsen MA, Lock-Buckley P, Hopkins D, et al. The risk factors for deep and superficial chest surgical-site infections after coronary artery bypass graft surgery are different. J Thorac Cardiovasc Surg 2002; 124(1): 136–45PubMedCrossRef
25.
Zurück zum Zitat Mishriki SF, Law DJ, Jeffery PJ. Factors affecting the incidence of postoperative wound infection. J Hosp Infect 1990; 16(3): 223–30PubMedCrossRef Mishriki SF, Law DJ, Jeffery PJ. Factors affecting the incidence of postoperative wound infection. J Hosp Infect 1990; 16(3): 223–30PubMedCrossRef
26.
Zurück zum Zitat Edwards FH, Engelman RM, Houck P, et al. The Society of Thoracic Surgeons practice guideline series: antibiotic prophylaxis in cardiac surgery. Part I: duration. Ann Thorac Surg 2006; 81: 397–404CrossRef Edwards FH, Engelman RM, Houck P, et al. The Society of Thoracic Surgeons practice guideline series: antibiotic prophylaxis in cardiac surgery. Part I: duration. Ann Thorac Surg 2006; 81: 397–404CrossRef
27.
Zurück zum Zitat Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 2004; 38(12): 1706–15PubMedCrossRef Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 2004; 38(12): 1706–15PubMedCrossRef
28.
Zurück zum Zitat Latham R, Lancaster AD, Covington JF, et al. The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 2001; 22(10): 607–12PubMedCrossRef Latham R, Lancaster AD, Covington JF, et al. The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 2001; 22(10): 607–12PubMedCrossRef
29.
Zurück zum Zitat Furnary AP, Zerr KJ, Grunkemeier GL, et al. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999; 67(2): 352–60; discussion 360–2PubMedCrossRef Furnary AP, Zerr KJ, Grunkemeier GL, et al. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999; 67(2): 352–60; discussion 360–2PubMedCrossRef
30.
Zurück zum Zitat Segers P, Speekenbrink RG, Ubbink DT, et al. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. JAMA 2006; 296(20): 2460–6PubMedCrossRef Segers P, Speekenbrink RG, Ubbink DT, et al. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. JAMA 2006; 296(20): 2460–6PubMedCrossRef
31.
Zurück zum Zitat Kluytmans JA, Mouton JW, VandenBergh MF, et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol 1996; 17(12): 780–5PubMedCrossRef Kluytmans JA, Mouton JW, VandenBergh MF, et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol 1996; 17(12): 780–5PubMedCrossRef
32.
Zurück zum Zitat Trautmann MJ, Stecher W, Hemmer K, et al. Intranasal mupirocin prophylaxis in elective surgery: a review of published studies. Chemotherapy 2008; 54: 9–16PubMedCrossRef Trautmann MJ, Stecher W, Hemmer K, et al. Intranasal mupirocin prophylaxis in elective surgery: a review of published studies. Chemotherapy 2008; 54: 9–16PubMedCrossRef
33.
Zurück zum Zitat Cimochowski GE, Harostock MD, Brown R, et al. Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics. Ann Thorac Surg 2001; 71: 1572–8PubMedCrossRef Cimochowski GE, Harostock MD, Brown R, et al. Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics. Ann Thorac Surg 2001; 71: 1572–8PubMedCrossRef
34.
Zurück zum Zitat Usry GH, Johnson L, Weems JJ, et al. Process improvement plan for the reduction of sternal surgical site infections among patients undergoing artery bypass graft surgery. Am J Infect Control 2002; 30: 434–6PubMedCrossRef Usry GH, Johnson L, Weems JJ, et al. Process improvement plan for the reduction of sternal surgical site infections among patients undergoing artery bypass graft surgery. Am J Infect Control 2002; 30: 434–6PubMedCrossRef
35.
Zurück zum Zitat Nicholson MR, Huesman LA. Controlling usage of intranasal mupirocin does impact the rate of Staphylococcus aureus deep sternal wound infections in cardiac surgery patients. Am J Infect Control 2006; 34: 44–8PubMedCrossRef Nicholson MR, Huesman LA. Controlling usage of intranasal mupirocin does impact the rate of Staphylococcus aureus deep sternal wound infections in cardiac surgery patients. Am J Infect Control 2006; 34: 44–8PubMedCrossRef
36.
Zurück zum Zitat Konvalinka A, Errett L, Fong IW. Impact of treating Staphylococcus aureus nasal carriers on wound infections in cardiac surgery. J Hosp Infect 2006; 64(2): 162–8PubMedCrossRef Konvalinka A, Errett L, Fong IW. Impact of treating Staphylococcus aureus nasal carriers on wound infections in cardiac surgery. J Hosp Infect 2006; 64(2): 162–8PubMedCrossRef
37.
Zurück zum Zitat Perl TM, Cullen JJ, Wenzel RP, et al. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 2002; 346(24): 1871–7PubMedCrossRef Perl TM, Cullen JJ, Wenzel RP, et al. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 2002; 346(24): 1871–7PubMedCrossRef
38.
Zurück zum Zitat Baddour LM, Wilson WR. Chapter 75: infections of prosthetic valves and other cardiovascular devices. In: Mandell G, Douglass R, Dolin R, editors. Principles and practice of infectious diseases. 6th ed. Philadelphia (PA): Churchill-Livingstone, 2005: 1038–9 Baddour LM, Wilson WR. Chapter 75: infections of prosthetic valves and other cardiovascular devices. In: Mandell G, Douglass R, Dolin R, editors. Principles and practice of infectious diseases. 6th ed. Philadelphia (PA): Churchill-Livingstone, 2005: 1038–9
39.
Zurück zum Zitat Chang JK, Calligaro KD, Ryan S, et al. Risk factors associated with infection of lower extremity revascularization: analysis of 365 procedures performed at a teaching hospital. Ann Vasc Surg 2003; 17(1): 91–6PubMedCrossRef Chang JK, Calligaro KD, Ryan S, et al. Risk factors associated with infection of lower extremity revascularization: analysis of 365 procedures performed at a teaching hospital. Ann Vasc Surg 2003; 17(1): 91–6PubMedCrossRef
40.
Zurück zum Zitat Ryan SV, Calligaro KD, Scharff J, et al. Management of infected prosthetic dialysis arteriovenous grafts. J Vasc Surg 2004; 39(1): 73–8PubMedCrossRef Ryan SV, Calligaro KD, Scharff J, et al. Management of infected prosthetic dialysis arteriovenous grafts. J Vasc Surg 2004; 39(1): 73–8PubMedCrossRef
41.
Zurück zum Zitat Calligaro KD, Veith FJ, Schwartz ML, et al. Selective preservation of infected prosthetic arterial grafts: analysis of a 20-year experience with 120 extracavitary-infected grafts. Ann Surg 1994; 220(4): 461–9; discussion 469–71PubMedCrossRef Calligaro KD, Veith FJ, Schwartz ML, et al. Selective preservation of infected prosthetic arterial grafts: analysis of a 20-year experience with 120 extracavitary-infected grafts. Ann Surg 1994; 220(4): 461–9; discussion 469–71PubMedCrossRef
42.
Zurück zum Zitat Edwards Jr WH, Martin 3rd RS, Jenkins JM, et al. Primary graft infections. J Vasc Surg 1987; 6(3): 235–9PubMed Edwards Jr WH, Martin 3rd RS, Jenkins JM, et al. Primary graft infections. J Vasc Surg 1987; 6(3): 235–9PubMed
43.
Zurück zum Zitat Jensen LJ, Kimose HH. Prosthetic graft infections: a review of 720 arterial prosthetic reconstructions. Thorac Cardiovasc Surg 1985; 33(6): 389–91PubMedCrossRef Jensen LJ, Kimose HH. Prosthetic graft infections: a review of 720 arterial prosthetic reconstructions. Thorac Cardiovasc Surg 1985; 33(6): 389–91PubMedCrossRef
44.
Zurück zum Zitat Mertens RA, O’Hara PJ, Hertzer NR, et al. Surgical management of infrainguinal arterial prosthetic graft infections: review of a thirty-five-year experience. J Vasc Surg 1995; 21(5): 782–90; discussion 790–1PubMedCrossRef Mertens RA, O’Hara PJ, Hertzer NR, et al. Surgical management of infrainguinal arterial prosthetic graft infections: review of a thirty-five-year experience. J Vasc Surg 1995; 21(5): 782–90; discussion 790–1PubMedCrossRef
45.
Zurück zum Zitat Taylor MD, Napolitano LM. Methicillin-resistant Staphylococcus aureus infections in vascular surgery: increasing prevalence. Surg Infect (Larchmt) 2004; 5(2): 180–7 Taylor MD, Napolitano LM. Methicillin-resistant Staphylococcus aureus infections in vascular surgery: increasing prevalence. Surg Infect (Larchmt) 2004; 5(2): 180–7
46.
Zurück zum Zitat Calligaro KD, Syrek JR, Dougherty MJ, et al. Use of arm and lesser saphenous vein compared with prosthetic grafts for infrapopliteal arterial bypass: are they worth the effort? J Vasc Surg 1997; 26(6): 919–24; discussion 925–7PubMedCrossRef Calligaro KD, Syrek JR, Dougherty MJ, et al. Use of arm and lesser saphenous vein compared with prosthetic grafts for infrapopliteal arterial bypass: are they worth the effort? J Vasc Surg 1997; 26(6): 919–24; discussion 925–7PubMedCrossRef
47.
Zurück zum Zitat Lee ES, Santilli SM, Olson MM, et al. Wound infection after infrainguinal bypass operations: multivariate analysis of putative risk factors. Surg Infect (Larchmt) 2000; 1(4): 257–63CrossRef Lee ES, Santilli SM, Olson MM, et al. Wound infection after infrainguinal bypass operations: multivariate analysis of putative risk factors. Surg Infect (Larchmt) 2000; 1(4): 257–63CrossRef
48.
Zurück zum Zitat Pedersen G, Laxdal E, Hagala M, et al. Local infections after above-knee prosthetic femoropopliteal bypass for intermittent claudication. Surg Infect (Larchmt) 2004; 5(2): 174–9CrossRef Pedersen G, Laxdal E, Hagala M, et al. Local infections after above-knee prosthetic femoropopliteal bypass for intermittent claudication. Surg Infect (Larchmt) 2004; 5(2): 174–9CrossRef
49.
Zurück zum Zitat Antonios VS, Noel AA, Steckelberg JM, et al. Prosthetic vascular graft infection: a risk factor analysis using a case-control study. J Infect 2006; 53(1): 49–55PubMedCrossRef Antonios VS, Noel AA, Steckelberg JM, et al. Prosthetic vascular graft infection: a risk factor analysis using a case-control study. J Infect 2006; 53(1): 49–55PubMedCrossRef
50.
Zurück zum Zitat Fiorani P, Speziale F, Calisti A, et al. Endovascular graft infection: preliminary results of an international enquiry. J Endovasc Ther 2003; 10(5): 919–27PubMedCrossRef Fiorani P, Speziale F, Calisti A, et al. Endovascular graft infection: preliminary results of an international enquiry. J Endovasc Ther 2003; 10(5): 919–27PubMedCrossRef
51.
Zurück zum Zitat Vriesendorp TM, Morelis QJ, Devries JH, et al. Early postoperative glucose levels are an independent risk factor for infection after peripheral vascular surgery: a retrospective study. Eur J Vasc Endovasc Surg 2004; 28(5): 520–5PubMedCrossRef Vriesendorp TM, Morelis QJ, Devries JH, et al. Early postoperative glucose levels are an independent risk factor for infection after peripheral vascular surgery: a retrospective study. Eur J Vasc Endovasc Surg 2004; 28(5): 520–5PubMedCrossRef
52.
Zurück zum Zitat Calligaro KD, Veith FJ, Schwartz ML, et al. Recommendations for initial antibiotic treatment of extracavitary arterial graft infections. Am J Surg 1995; 170(2): 123–5PubMedCrossRef Calligaro KD, Veith FJ, Schwartz ML, et al. Recommendations for initial antibiotic treatment of extracavitary arterial graft infections. Am J Surg 1995; 170(2): 123–5PubMedCrossRef
53.
Zurück zum Zitat Collazos J, Mayo J, Martinez E, et al. Prosthetic vascular graft infection due to Aspergillus species: case report and literature review. Eur J Clin Microbiol Infect Dis 2001; 20(6): 414–7PubMed Collazos J, Mayo J, Martinez E, et al. Prosthetic vascular graft infection due to Aspergillus species: case report and literature review. Eur J Clin Microbiol Infect Dis 2001; 20(6): 414–7PubMed
54.
Zurück zum Zitat Lephart P, Ferrieri P, van Burik JA. Reservoir of Candida albicans infection in a vascular bypass graft demonstrates a stable karyotype over six months. Med Mycol 2004; 42(3): 255–60PubMedCrossRef Lephart P, Ferrieri P, van Burik JA. Reservoir of Candida albicans infection in a vascular bypass graft demonstrates a stable karyotype over six months. Med Mycol 2004; 42(3): 255–60PubMedCrossRef
55.
Zurück zum Zitat Matthay RA, Levin DC, Wicks AB, et al. Disseminated histoplasmosis involving an aortofemoral prosthetic graft. JAMA 1976; 235(14): 1478–9PubMedCrossRef Matthay RA, Levin DC, Wicks AB, et al. Disseminated histoplasmosis involving an aortofemoral prosthetic graft. JAMA 1976; 235(14): 1478–9PubMedCrossRef
56.
Zurück zum Zitat Raffetto JD, Bernardo J, Menzoian JO. Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agents. J Vasc Surg 2004; 40(4): 826–9PubMedCrossRef Raffetto JD, Bernardo J, Menzoian JO. Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agents. J Vasc Surg 2004; 40(4): 826–9PubMedCrossRef
57.
Zurück zum Zitat Nasim A, Thompson MM, Naylor AR, et al. The impact of MRSA on vascular surgery. Eur J Vasc Endovasc Surg 2001; 22(3): 211–4PubMedCrossRef Nasim A, Thompson MM, Naylor AR, et al. The impact of MRSA on vascular surgery. Eur J Vasc Endovasc Surg 2001; 22(3): 211–4PubMedCrossRef
58.
Zurück zum Zitat FitzGerald SF, Kelly C, Humphreys H. Diagnosis and treatment of prosthetic aortic graft infections: confusion and inconsistency in the absence of evidence or consensus. J Antimicrob Chemother 2005; 56(6): 996–9PubMedCrossRef FitzGerald SF, Kelly C, Humphreys H. Diagnosis and treatment of prosthetic aortic graft infections: confusion and inconsistency in the absence of evidence or consensus. J Antimicrob Chemother 2005; 56(6): 996–9PubMedCrossRef
59.
Zurück zum Zitat Rossi P, Arata FM, Salvatori FM, et al. Prosthetic graft infection: diagnostic and therapeutic role of interventional radiology. J Vasc Interv Radiol 1997; 8(2): 271–7PubMedCrossRef Rossi P, Arata FM, Salvatori FM, et al. Prosthetic graft infection: diagnostic and therapeutic role of interventional radiology. J Vasc Interv Radiol 1997; 8(2): 271–7PubMedCrossRef
60.
Zurück zum Zitat Thomas P, Forstrom L. In-111 labeled purified granulocytes in the diagnosis of synthetic vascular graft infections. Clin Nucl Med 1994; 19(12): 1075–8PubMedCrossRef Thomas P, Forstrom L. In-111 labeled purified granulocytes in the diagnosis of synthetic vascular graft infections. Clin Nucl Med 1994; 19(12): 1075–8PubMedCrossRef
61.
Zurück zum Zitat Seify H, Moyer HR, Jones GE, et al. The role of muscle flaps in wound salvage after vascular graft infections: the Emory experience. Plast Reconstr Surg 2006; 117(4): 1325–33PubMedCrossRef Seify H, Moyer HR, Jones GE, et al. The role of muscle flaps in wound salvage after vascular graft infections: the Emory experience. Plast Reconstr Surg 2006; 117(4): 1325–33PubMedCrossRef
62.
Zurück zum Zitat Calligaro KD, Veith FJ, Schwartz ML, et al. Differences in early versus late extracavitary arterial graft infections. J Vasc Surg 1995; 22(6): 680–5; discussion 685–8PubMedCrossRef Calligaro KD, Veith FJ, Schwartz ML, et al. Differences in early versus late extracavitary arterial graft infections. J Vasc Surg 1995; 22(6): 680–5; discussion 685–8PubMedCrossRef
63.
Zurück zum Zitat O’Connor S, Andrew P, Batt M, et al. A systematic review and meta-analysis of treatments for aortic graft infection. J Vasc Surg 2006; 44(1): 38–45PubMedCrossRef O’Connor S, Andrew P, Batt M, et al. A systematic review and meta-analysis of treatments for aortic graft infection. J Vasc Surg 2006; 44(1): 38–45PubMedCrossRef
64.
Zurück zum Zitat Young RM, Cherry Jr KJ, Davis PM, et al. The results of in situ prosthetic replacement for infected aortic grafts. Am J Surg 1999; 178(2): 136–40PubMedCrossRef Young RM, Cherry Jr KJ, Davis PM, et al. The results of in situ prosthetic replacement for infected aortic grafts. Am J Surg 1999; 178(2): 136–40PubMedCrossRef
65.
Zurück zum Zitat Kurtz S, Mowat F, Ong K, et al. Prevalence of primary and revision total hip and knee arthroplasty in the United States from 1990 through 2002. J Bone Joint Surg Am 2005; 87(7): 1487–97PubMedCrossRef Kurtz S, Mowat F, Ong K, et al. Prevalence of primary and revision total hip and knee arthroplasty in the United States from 1990 through 2002. J Bone Joint Surg Am 2005; 87(7): 1487–97PubMedCrossRef
66.
Zurück zum Zitat Lentino JR. Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis 2003; 36(9): 1157–61PubMedCrossRef Lentino JR. Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis 2003; 36(9): 1157–61PubMedCrossRef
67.
Zurück zum Zitat Sia IG, Berbari EF, Karchmer AW. Prosthetic joint infections. Infect Dis Clin North Am 2005; 19(4): 885–914PubMedCrossRef Sia IG, Berbari EF, Karchmer AW. Prosthetic joint infections. Infect Dis Clin North Am 2005; 19(4): 885–914PubMedCrossRef
68.
Zurück zum Zitat Tsukayama DT, Estrada R, Gustilo RB. Infection after total hip arthroplasty: a study of the treatment of one hundred and six infections. J Bone Joint Surg Am 1996; 78(4): 512–23PubMed Tsukayama DT, Estrada R, Gustilo RB. Infection after total hip arthroplasty: a study of the treatment of one hundred and six infections. J Bone Joint Surg Am 1996; 78(4): 512–23PubMed
69.
Zurück zum Zitat Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med 2004; 351(16): 1645–54PubMedCrossRef Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med 2004; 351(16): 1645–54PubMedCrossRef
70.
Zurück zum Zitat Murdoch DR, Roberts SA, Fowler Jr VG, et al. Infection of orthopedic prostheses after Staphylococcus aureus bacteremia. Clin Infect Dis 2001; 32(4): 647–9PubMedCrossRef Murdoch DR, Roberts SA, Fowler Jr VG, et al. Infection of orthopedic prostheses after Staphylococcus aureus bacteremia. Clin Infect Dis 2001; 32(4): 647–9PubMedCrossRef
71.
Zurück zum Zitat Marculescu CE, Berbari EF, Cockerill 3rd FR, et al. Fungi, mycobacteria, zoonotic and other organisms in prosthetic joint infection. Clin Orthop Relat Res 2006; 451: 64–72PubMedCrossRef Marculescu CE, Berbari EF, Cockerill 3rd FR, et al. Fungi, mycobacteria, zoonotic and other organisms in prosthetic joint infection. Clin Orthop Relat Res 2006; 451: 64–72PubMedCrossRef
72.
Zurück zum Zitat Marculescu CE, Berbari EF, Cockerill 3rd FR, et al. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections. Clin Orthop Relat Res 2006; 451: 55–63PubMedCrossRef Marculescu CE, Berbari EF, Cockerill 3rd FR, et al. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections. Clin Orthop Relat Res 2006; 451: 55–63PubMedCrossRef
73.
Zurück zum Zitat Atkins BL, Athanasou N, Deeks JJ, et al. Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty: the OSIRIS Collaborative Study Group. J Clin Microbiol 1998; 36(10): 2932–9PubMed Atkins BL, Athanasou N, Deeks JJ, et al. Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty: the OSIRIS Collaborative Study Group. J Clin Microbiol 1998; 36(10): 2932–9PubMed
74.
Zurück zum Zitat Powers KA, Terpenning MS, Voice RA, et al. Prosthetic joint infections in the elderly. Am J Med 1990; 88(5N): 9N–13NPubMed Powers KA, Terpenning MS, Voice RA, et al. Prosthetic joint infections in the elderly. Am J Med 1990; 88(5N): 9N–13NPubMed
75.
Zurück zum Zitat Bare J, MacDonald SJ, Bourne RB. Preoperative evaluations in revision total knee arthroplasty. Clin Orthop Relat Res 2006; 446: 40–4PubMedCrossRef Bare J, MacDonald SJ, Bourne RB. Preoperative evaluations in revision total knee arthroplasty. Clin Orthop Relat Res 2006; 446: 40–4PubMedCrossRef
76.
Zurück zum Zitat Teller RE, Christie MJ, Martin W, et al. Sequential indium-labeled leukocyte and bone scans to diagnose prosthetic joint infection. Clin Orthop Relat Res 2000; 373: 241–7PubMedCrossRef Teller RE, Christie MJ, Martin W, et al. Sequential indium-labeled leukocyte and bone scans to diagnose prosthetic joint infection. Clin Orthop Relat Res 2000; 373: 241–7PubMedCrossRef
77.
Zurück zum Zitat Trampuz A, Hanssen AD, Osmon DR, et al. Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med 2004; 117(8): 556–62PubMedCrossRef Trampuz A, Hanssen AD, Osmon DR, et al. Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med 2004; 117(8): 556–62PubMedCrossRef
78.
Zurück zum Zitat Cyteval C, Hamm V, Sarrabere MP, et al. Painful infection at the site of hip prosthesis: CT imaging. Radiology 2002; 224(2): 477–83PubMedCrossRef Cyteval C, Hamm V, Sarrabere MP, et al. Painful infection at the site of hip prosthesis: CT imaging. Radiology 2002; 224(2): 477–83PubMedCrossRef
79.
Zurück zum Zitat Palestro CJ, Swyer AJ, Kim CK, et al. Infected knee prosthesis: diagnosis with In-111 leukocyte, Tc-99m sulfur colloid, and Tc-99m MDP imaging. Radiology 1991; 179(3): 645–8PubMed Palestro CJ, Swyer AJ, Kim CK, et al. Infected knee prosthesis: diagnosis with In-111 leukocyte, Tc-99m sulfur colloid, and Tc-99m MDP imaging. Radiology 1991; 179(3): 645–8PubMed
80.
Zurück zum Zitat Delank KS, Schmidt M, Michael JW, et al. The implications of 18F-FDG PET for the diagnosis of endoprosthetic loosening and infection in hip and knee arthroplasty: results from a prospective, blinded study. BMC Musculoskelet Disord 2006; 7: 20PubMedCrossRef Delank KS, Schmidt M, Michael JW, et al. The implications of 18F-FDG PET for the diagnosis of endoprosthetic loosening and infection in hip and knee arthroplasty: results from a prospective, blinded study. BMC Musculoskelet Disord 2006; 7: 20PubMedCrossRef
81.
Zurück zum Zitat Love C, Marwin SE, Tomas MB, et al. Diagnosing infection in the failed joint replacement: a comparison of coincidence detection 18F-FDG and 111 In-labeled leukocyte/99mTc-sul-fur colloid marrow imaging. J Nucl Med 2004; 45(11): 1864–71PubMed Love C, Marwin SE, Tomas MB, et al. Diagnosing infection in the failed joint replacement: a comparison of coincidence detection 18F-FDG and 111 In-labeled leukocyte/99mTc-sul-fur colloid marrow imaging. J Nucl Med 2004; 45(11): 1864–71PubMed
82.
Zurück zum Zitat Mumme T, Reinartz P, Alfer J, et al. Diagnostic values of positron emission tomography versus triple-phase bone scan in hip arthroplasty loosening. Arch Orthop Trauma Surg 2005; 125(5): 322–9PubMedCrossRef Mumme T, Reinartz P, Alfer J, et al. Diagnostic values of positron emission tomography versus triple-phase bone scan in hip arthroplasty loosening. Arch Orthop Trauma Surg 2005; 125(5): 322–9PubMedCrossRef
83.
Zurück zum Zitat Stumpe KD, Notzli HP, Zanetti M, et al. FDG PET for differentiation of infection and aseptic loosening in total hip replacements: comparison with conventional radiography and three-phase bone scintigraphy. Radiology 2004; 231(2): 333–41PubMedCrossRef Stumpe KD, Notzli HP, Zanetti M, et al. FDG PET for differentiation of infection and aseptic loosening in total hip replacements: comparison with conventional radiography and three-phase bone scintigraphy. Radiology 2004; 231(2): 333–41PubMedCrossRef
84.
Zurück zum Zitat Stumpe KD, Romero J, Ziegler O, et al. The value of FDG-PET in patients with painful total knee arthroplasty. Eur J Nucl Med Mol Imaging 2006; 33(10): 1218–25PubMedCrossRef Stumpe KD, Romero J, Ziegler O, et al. The value of FDG-PET in patients with painful total knee arthroplasty. Eur J Nucl Med Mol Imaging 2006; 33(10): 1218–25PubMedCrossRef
85.
Zurück zum Zitat Athanasou NA, Pandey R, de Steiger R, et al. Diagnosis of infection by frozen section during revision arthroplasty. J Bone Joint Surg Br 1995; 77(1): 28–33PubMed Athanasou NA, Pandey R, de Steiger R, et al. Diagnosis of infection by frozen section during revision arthroplasty. J Bone Joint Surg Br 1995; 77(1): 28–33PubMed
86.
Zurück zum Zitat Chimento GF, Finger S, Barrack RL. Gram stain detection of infection during revision arthroplasty. J Bone Joint Surg Br 1996; 78(5): 838–9PubMed Chimento GF, Finger S, Barrack RL. Gram stain detection of infection during revision arthroplasty. J Bone Joint Surg Br 1996; 78(5): 838–9PubMed
87.
Zurück zum Zitat Chuard C, Lucet JC, Rohner P, et al. Resistance of Staphylococcus aureus recovered from infected foreign body in vivo to killing by antimicrobials. J Infect Dis 1991; 163(6): 1369–73PubMedCrossRef Chuard C, Lucet JC, Rohner P, et al. Resistance of Staphylococcus aureus recovered from infected foreign body in vivo to killing by antimicrobials. J Infect Dis 1991; 163(6): 1369–73PubMedCrossRef
88.
Zurück zum Zitat Everts RJ, Chambers ST, Murdoch DR, et al. Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints. ANZ J Surg 2004; 74(4): 210–4PubMedCrossRef Everts RJ, Chambers ST, Murdoch DR, et al. Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints. ANZ J Surg 2004; 74(4): 210–4PubMedCrossRef
89.
Zurück zum Zitat Marculescu CE, Berbari EF, Hanssen AD, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis 2006; 42(4): 471–8PubMedCrossRef Marculescu CE, Berbari EF, Hanssen AD, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis 2006; 42(4): 471–8PubMedCrossRef
90.
Zurück zum Zitat Meehan AM, Osmon DR, Duffy MC, et al. Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis. Clin Infect Dis 2003; 36(7): 845–9PubMedCrossRef Meehan AM, Osmon DR, Duffy MC, et al. Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis. Clin Infect Dis 2003; 36(7): 845–9PubMedCrossRef
91.
Zurück zum Zitat Pavoni GL, Giannella M, Falcone M, et al. Conservative medical therapy of prosthetic joint infections: retrospective analysis of an 8-year experience. Clin Microbiol Infect 2004; 10(9): 831–7PubMedCrossRef Pavoni GL, Giannella M, Falcone M, et al. Conservative medical therapy of prosthetic joint infections: retrospective analysis of an 8-year experience. Clin Microbiol Infect 2004; 10(9): 831–7PubMedCrossRef
92.
Zurück zum Zitat Burger RR, Basch T, Hopson CN. Implant salvage in infected total knee arthroplasty. Clin Orthop Relat Res 1991; 273: 105–12PubMed Burger RR, Basch T, Hopson CN. Implant salvage in infected total knee arthroplasty. Clin Orthop Relat Res 1991; 273: 105–12PubMed
93.
Zurück zum Zitat Langlais F. Can we improve the results of revision arthroplasty for infected total hip replacement? J Bone Joint Surg Br 2003; 85(5): 637–40PubMed Langlais F. Can we improve the results of revision arthroplasty for infected total hip replacement? J Bone Joint Surg Br 2003; 85(5): 637–40PubMed
94.
Zurück zum Zitat Brandt CM, Sistrunk WW, Duffy MC, et al. Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clin Infect Dis 1997; 24(5): 914–9PubMedCrossRef Brandt CM, Sistrunk WW, Duffy MC, et al. Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clin Infect Dis 1997; 24(5): 914–9PubMedCrossRef
95.
Zurück zum Zitat Lieberman JR, Callaway GH, Salvati EA, et al. Treatment of the infected total hip arthroplasty with a two-stage reimplantation protocol. Clin Orthop Relat Res 1994; 301: 205–12PubMed Lieberman JR, Callaway GH, Salvati EA, et al. Treatment of the infected total hip arthroplasty with a two-stage reimplantation protocol. Clin Orthop Relat Res 1994; 301: 205–12PubMed
96.
Zurück zum Zitat Segreti J, Nelson JA, Trenholme GM. Prolonged suppressive antibiotic therapy for infected orthopedic prostheses. Clin Infect Dis 1998; 27(4): 711–3PubMedCrossRef Segreti J, Nelson JA, Trenholme GM. Prolonged suppressive antibiotic therapy for infected orthopedic prostheses. Clin Infect Dis 1998; 27(4): 711–3PubMedCrossRef
97.
Zurück zum Zitat Trampuz A, Zimmerli W. Prosthetic joint infections: update in diagnosis and treatment. Swiss Med Wkly 2005; 135(17–18): 243–51PubMed Trampuz A, Zimmerli W. Prosthetic joint infections: update in diagnosis and treatment. Swiss Med Wkly 2005; 135(17–18): 243–51PubMed
98.
Zurück zum Zitat Monzon M, Oteiza C, Leiva J, et al. Biofilm testing of Staphylococcus epidermidis clinical isolates: low performance of vancomycin in relation to other antibiotics. Diagn Microbiol Infect Dis 2002; 44(4): 319–24PubMedCrossRef Monzon M, Oteiza C, Leiva J, et al. Biofilm testing of Staphylococcus epidermidis clinical isolates: low performance of vancomycin in relation to other antibiotics. Diagn Microbiol Infect Dis 2002; 44(4): 319–24PubMedCrossRef
99.
Zurück zum Zitat Stewart PS. Mechanisms of antibiotic resistance in bacterial biofilms. Int J Med Microbiol 2002; 292(2): 107–13PubMedCrossRef Stewart PS. Mechanisms of antibiotic resistance in bacterial biofilms. Int J Med Microbiol 2002; 292(2): 107–13PubMedCrossRef
100.
Zurück zum Zitat Widmer AF, Frei R, Rajacic Z, et al. Correlation between in vivo and in vitro efficacy of antimicrobial agents against foreign body infections. J Infect Dis 1990; 162(1): 96–102PubMedCrossRef Widmer AF, Frei R, Rajacic Z, et al. Correlation between in vivo and in vitro efficacy of antimicrobial agents against foreign body infections. J Infect Dis 1990; 162(1): 96–102PubMedCrossRef
101.
Zurück zum Zitat Widmer AF, Wiestner A, Frei R, et al. Killing of nongrowing and adherent Escherichia coli determines drug efficacy in device-related infections. Antimicrob Agents Chemother 1991; 35(4): 741–6PubMedCrossRef Widmer AF, Wiestner A, Frei R, et al. Killing of nongrowing and adherent Escherichia coli determines drug efficacy in device-related infections. Antimicrob Agents Chemother 1991; 35(4): 741–6PubMedCrossRef
102.
Zurück zum Zitat Drancourt M, Stein A, Argenson JN, et al. Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants. Antimicrob Agents Chemother 1993; 37(6): 1214–8PubMedCrossRef Drancourt M, Stein A, Argenson JN, et al. Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants. Antimicrob Agents Chemother 1993; 37(6): 1214–8PubMedCrossRef
103.
Zurück zum Zitat Konig DP, Schierholz JM, Munnich U, et al. Treatment of staphylococcal implant infection with rifampicin-ciprofloxacin in stable implants. Arch Orthop Trauma Surg 2001; 121(5): 297–9PubMedCrossRef Konig DP, Schierholz JM, Munnich U, et al. Treatment of staphylococcal implant infection with rifampicin-ciprofloxacin in stable implants. Arch Orthop Trauma Surg 2001; 121(5): 297–9PubMedCrossRef
104.
Zurück zum Zitat Zimmerli W, Widmer AF, Blatter M, et al. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. JAMA 1998; 279(19): 1537–41PubMedCrossRef Zimmerli W, Widmer AF, Blatter M, et al. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. JAMA 1998; 279(19): 1537–41PubMedCrossRef
105.
Zurück zum Zitat Chuard C, Herrmann M, Vaudaux P, et al. Successful therapy of experimental chronic foreign-body infection due to methicillin-resistant Staphylococcus aureus by antimicrobial combinations. Antimicrob Agents Chemother 1991; 35(12): 2611–6PubMedCrossRef Chuard C, Herrmann M, Vaudaux P, et al. Successful therapy of experimental chronic foreign-body infection due to methicillin-resistant Staphylococcus aureus by antimicrobial combinations. Antimicrob Agents Chemother 1991; 35(12): 2611–6PubMedCrossRef
106.
Zurück zum Zitat Lucet JC, Herrmann M, Rohner P, et al. Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1990; 34(12): 2312–7PubMedCrossRef Lucet JC, Herrmann M, Rohner P, et al. Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1990; 34(12): 2312–7PubMedCrossRef
107.
Zurück zum Zitat Brause BD. Infected total knee replacement: diagnostic, therapeutic, and prophylactic considerations. Orthop Clin North Am 1982; 13(1): 245–9PubMed Brause BD. Infected total knee replacement: diagnostic, therapeutic, and prophylactic considerations. Orthop Clin North Am 1982; 13(1): 245–9PubMed
109.
Zurück zum Zitat Iglehart D, Kaelin C. Diseases of the breast. In: Townsend C, editor. Sabiston textbook of surgery. Philadelphia (PA): Saunders, 2004 Iglehart D, Kaelin C. Diseases of the breast. In: Townsend C, editor. Sabiston textbook of surgery. Philadelphia (PA): Saunders, 2004
110.
Zurück zum Zitat Alderman AK, Wilkins EG, Kim HM, et al. Complications in postmastectomy breast reconstruction: two-year results of the Michigan Breast Reconstruction Outcome Study. Plast Reconstr Surg 2002; 109(7): 2265–74PubMedCrossRef Alderman AK, Wilkins EG, Kim HM, et al. Complications in postmastectomy breast reconstruction: two-year results of the Michigan Breast Reconstruction Outcome Study. Plast Reconstr Surg 2002; 109(7): 2265–74PubMedCrossRef
111.
Zurück zum Zitat Armstrong RW, Berkowitz RL, Bolding F. Infection following breast reconstruction. Ann Plast Surg 1989; 23(4): 284–8PubMedCrossRef Armstrong RW, Berkowitz RL, Bolding F. Infection following breast reconstruction. Ann Plast Surg 1989; 23(4): 284–8PubMedCrossRef
112.
Zurück zum Zitat Nahabedian MY, Tsangaris T, Momen B, et al. Infectious complications following breast reconstruction with expanders and implants. Plast Reconstr Surg 2003; 112(2): 467–76PubMedCrossRef Nahabedian MY, Tsangaris T, Momen B, et al. Infectious complications following breast reconstruction with expanders and implants. Plast Reconstr Surg 2003; 112(2): 467–76PubMedCrossRef
113.
Zurück zum Zitat Lew D, Pittet D, Waldvogel F. Infections that complicate the insertion of prosthetic devices. In: Mayhall C, editor. Hospital epidemiology and infection control. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 1181–205 Lew D, Pittet D, Waldvogel F. Infections that complicate the insertion of prosthetic devices. In: Mayhall C, editor. Hospital epidemiology and infection control. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 1181–205
114.
Zurück zum Zitat Vilar-Compte D, Roldan-Marin R, Robles-Vidal C, et al. Surgical site infection (SSI) rates among patients who underwent mastectomy after the introduction of SSI prevention policies. Infect Control Hosp Epidemiol 2006; 27(8): 829–34PubMedCrossRef Vilar-Compte D, Roldan-Marin R, Robles-Vidal C, et al. Surgical site infection (SSI) rates among patients who underwent mastectomy after the introduction of SSI prevention policies. Infect Control Hosp Epidemiol 2006; 27(8): 829–34PubMedCrossRef
115.
Zurück zum Zitat Beatty JD, Robinson GV, Zaia JA, et al. A prospective analysis of nosocomial wound infection after mastectomy. Arch Surg 1983; 118(12): 1421–4PubMedCrossRef Beatty JD, Robinson GV, Zaia JA, et al. A prospective analysis of nosocomial wound infection after mastectomy. Arch Surg 1983; 118(12): 1421–4PubMedCrossRef
116.
Zurück zum Zitat Cordeiro PG, McCarthy CM. A single surgeon’s 12-year experience with tissue expander/implant breast reconstruction: part I. A prospective analysis of early complications. Plast Reconstr Surg 2006; 118(4): 825–31PubMedCrossRef Cordeiro PG, McCarthy CM. A single surgeon’s 12-year experience with tissue expander/implant breast reconstruction: part I. A prospective analysis of early complications. Plast Reconstr Surg 2006; 118(4): 825–31PubMedCrossRef
117.
Zurück zum Zitat Spear SL, Majidian A. Immediate breast reconstruction in two stages using textured, integrated-valve tissue expanders and breast implants: a retrospective review of 171 consecutive breast reconstructions from 1989 to 1996. Plast Reconstr Surg 1998; 101(1): 53–63PubMedCrossRef Spear SL, Majidian A. Immediate breast reconstruction in two stages using textured, integrated-valve tissue expanders and breast implants: a retrospective review of 171 consecutive breast reconstructions from 1989 to 1996. Plast Reconstr Surg 1998; 101(1): 53–63PubMedCrossRef
118.
Zurück zum Zitat Holm C, Muhlbauer W. Toxic shock syndrome in plastic surgery patients: case report and review of the literature. Aesthetic Plast Surg 1998; 22(3): 180–4PubMedCrossRef Holm C, Muhlbauer W. Toxic shock syndrome in plastic surgery patients: case report and review of the literature. Aesthetic Plast Surg 1998; 22(3): 180–4PubMedCrossRef
119.
Zurück zum Zitat Tejirian T, DiFronzo LA, Haigh PI. Antibiotic prophylaxis for preventing wound infection after breast surgery: a systematic review and metaanalysis. J Am Coll Surg 2006; 203(5): 729–34PubMedCrossRef Tejirian T, DiFronzo LA, Haigh PI. Antibiotic prophylaxis for preventing wound infection after breast surgery: a systematic review and metaanalysis. J Am Coll Surg 2006; 203(5): 729–34PubMedCrossRef
120.
Zurück zum Zitat Cunningham M, Bunn F, Handscomb K. Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery. Cochrane Database Syst Rev 2006; (2): CD005360 Cunningham M, Bunn F, Handscomb K. Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery. Cochrane Database Syst Rev 2006; (2): CD005360
121.
Zurück zum Zitat Fang A, Hu SS, Endres N, et al. Risk factors for infection after spinal surgery. Spine 2005; 30(12): 1460–5PubMedCrossRef Fang A, Hu SS, Endres N, et al. Risk factors for infection after spinal surgery. Spine 2005; 30(12): 1460–5PubMedCrossRef
122.
Zurück zum Zitat Pappou IP, Papadopoulos EC, Sama AA, et al. Postoperative infections in interbody fusion for degenerative spinal disease. Clin Orthop Relat Res 2006; 444: 120–8PubMedCrossRef Pappou IP, Papadopoulos EC, Sama AA, et al. Postoperative infections in interbody fusion for degenerative spinal disease. Clin Orthop Relat Res 2006; 444: 120–8PubMedCrossRef
123.
Zurück zum Zitat McHenry MC, Easley KA, Locker GA. Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis 2002; 34(10): 1342–50PubMedCrossRef McHenry MC, Easley KA, Locker GA. Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis 2002; 34(10): 1342–50PubMedCrossRef
124.
Zurück zum Zitat Labler L, Keel M, Trentz O, et al. Wound conditioning by vacuum assisted closure (VAC) in postoperative infections after dorsal spine surgery. Eur Spine J 2006; 15(9): 1388–96PubMedCrossRef Labler L, Keel M, Trentz O, et al. Wound conditioning by vacuum assisted closure (VAC) in postoperative infections after dorsal spine surgery. Eur Spine J 2006; 15(9): 1388–96PubMedCrossRef
125.
Zurück zum Zitat Kowalski TJ, Berbari EF, Huddleston PM, et al. The management and outcome of spinal implant infections: contemporary retrospective cohort study. Clin Infect Dis 2007; 44(7): 913–20PubMedCrossRef Kowalski TJ, Berbari EF, Huddleston PM, et al. The management and outcome of spinal implant infections: contemporary retrospective cohort study. Clin Infect Dis 2007; 44(7): 913–20PubMedCrossRef
126.
Zurück zum Zitat An HS, Seldomridge JA. Spinal infections: diagnostic tests and imaging studies. Clin Orthop Relat Res 2006; 444: 27–33PubMedCrossRef An HS, Seldomridge JA. Spinal infections: diagnostic tests and imaging studies. Clin Orthop Relat Res 2006; 444: 27–33PubMedCrossRef
127.
Zurück zum Zitat Dumanian GA, Ondra SL, Liu J, et al. Muscle flap salvage of spine wounds with soft tissue defects or infection. Spine 2003; 28(11): 1203–11PubMed Dumanian GA, Ondra SL, Liu J, et al. Muscle flap salvage of spine wounds with soft tissue defects or infection. Spine 2003; 28(11): 1203–11PubMed
128.
Zurück zum Zitat Kowalski TJ, Berbari EF, Huddleston PM, et al. Do follow-up imaging examinations provide useful prognostic information in patients with spine infection? Clin Infect Dis 2006; 43(2): 172–9PubMedCrossRef Kowalski TJ, Berbari EF, Huddleston PM, et al. Do follow-up imaging examinations provide useful prognostic information in patients with spine infection? Clin Infect Dis 2006; 43(2): 172–9PubMedCrossRef
129.
Zurück zum Zitat Cox AM, Malani PN, Wiseman SW, et al. Home intravenous antimicrobial infusion therapy: a viable option in older adults. J Am Geriatr Soc 2007; 55: 645–50PubMedCrossRef Cox AM, Malani PN, Wiseman SW, et al. Home intravenous antimicrobial infusion therapy: a viable option in older adults. J Am Geriatr Soc 2007; 55: 645–50PubMedCrossRef
130.
Zurück zum Zitat High KP. Outpatient parenteral antimicrobial therapy: a long overdue option for older adults. J Am Geriatr Soc 2007; 55: 792–3PubMedCrossRef High KP. Outpatient parenteral antimicrobial therapy: a long overdue option for older adults. J Am Geriatr Soc 2007; 55: 792–3PubMedCrossRef
Metadaten
Titel
Surgical Site Infections in Older Adults
Epidemiology and Management Strategies
verfasst von
Michael H. Young
Laraine Washer
Dr Preeti N. Malani
Publikationsdatum
01.05.2008
Verlag
Springer International Publishing
Erschienen in
Drugs & Aging / Ausgabe 5/2008
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI
https://doi.org/10.2165/00002512-200825050-00004

Weitere Artikel der Ausgabe 5/2008

Drugs & Aging 5/2008 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.