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Endocrine

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01.11.2014 | Original Article

Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year

verfasst von: Huiling Guo, Xiu Liu, Chenyang Li, Yushu Li, Miao Sang, Zhongyan Shan, Weiping Teng, Haixia Guan

Erschienen in: Endocrine | Ausgabe 2/2014

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Abstract

The purpose of the study is to explore the roles of leptin and interleukin-6 (IL-6) during the first postpartum year in the occurrence and development of postpartum thyroiditis (PPT). We retrospectively collected serum samples from 57 PPT patients consisting of 34 overt PPT (O-PPT) and 23 subclinical PPT (S-PPT) in addition to 37 healthy postpartum women at four postpartum time points, i.e., 3-day and 3, 6, 12-month postpartum. Serum leptin and IL-6 levels were measured by radioimmunoassay and ELISA assay, respectively. Leptin level and leptin/BMI (LEP/BMI) ratio were higher in PPT patients than in control during the first postpartum year, but were not significantly different between O-PPT and S-PPT. However, a similar trend but did not reach significant difference in IL-6 level was observed during the postpartum period in PPT patients and control women. We conclude that a sustained high level of serum leptin after delivery may be involved in the pathogenesis of PPT. IL-6 does not contribute to the development of PPT.

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Titel: Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year
verfasst von: Huiling Guo
Xiu Liu
Chenyang Li
Yushu Li
Miao Sang
Zhongyan Shan
Weiping Teng
Haixia Guan
Publikationsdatum: 01.11.2014
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2014
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-014-0176-3

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