nach oben

Clinical Oral Investigations

Erschienen in:

08.05.2020 | Review

Taste disorder’s management: a systematic review

verfasst von: Adeline Braud, Yves Boucher

Erschienen in: Clinical Oral Investigations | Ausgabe 6/2020

Einloggen, um Zugang zu erhalten

Abstract

Background

Taste disorder is a frequent drug-induced or disease-related oral trouble. Various pharmacological, surgical, or physical treatments have previously been proposed for taste function recovery.

Objectives

The aim of the present systematic review was to assess the effects of palliative and curative interventions on taste recovery in light of recent literature.

Materials and methods

In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search of the literature published up to June 2019 was conducted using MEDLINE via PubMed, EMBASE, and The US National Institutes of Health Trials Register (PROSPERO registration reference: CRD 42019139315). The methodological quality of the included trials was rated with the “Delphi list For Quality Assessment of Randomized Clinical Trials” and the Newcastle-Ottawa scale.

Results

From the 1842 titles first identified, 28 articles met the inclusion criteria. Interventions included zinc (aspartate, sulfate, gluconate, acetate, picolinate, and Polaprezinc®), esomeprazole, l-thyroxin, bethanechol, oral glutamine, delta-9-tetrahydrocannabinol, alpha-lipoic acid, Ginkgo biloba, artificial saliva, pilocarpine, local anesthesia, and improved oral hygiene. The quality of evidence ranged from poor to high.

Conclusion

Improving oral hygiene may promote taste ability. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy.

Clinical relevance

The systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects.

Nur mit Berechtigung zugänglich

Tournier C, Sumont-Rosse C, Guichard E (2007) Flavour perception: aroma, taste and texture interactions. Food 1:246–257

Roper SD (2007) Signal transduction and information processing in mammalian taste buds. Pflugers Arch 454:759–776PubMedPubMedCentralCrossRef

Welge-Lüssen A, Dörig P, Wolfensberger M, Krone F, Hummel T (2011) A study about the frequency of taste disorders. J Neurol 258:386–392PubMedCrossRef

Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, Kimmelman CP, Brightman VJ, Snow JB Jr (1991) Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 117:519–528PubMedCrossRef

Boucher Y, Berteretche MV, Farhang F, Arvy MP, Azérad J, Faurion A (2006) Taste deficits related to dental deafferentation: an electrogustometric study in humans. Eur J Oral Sci 114:456–464PubMedCrossRef

Soter A, Kim J, Jackman A, Tourbier I, Kaul A, Doty RL (2008) Accuracy of self-report in detecting taste dysfunction. Laryngoscope 118:611–617PubMedCrossRef

Rolls ET (2006) Brain mechanisms underlying flavour and appetite. Philos Trans R Soc Lond Ser B Biol Sci 361:1123–1136CrossRef

Rawal S, Hoffman HJ, Bainbridge KE, Huedo-Medina TB, Duffy VB (2016) Prevalence and risk factors of self-reported smell and taste alterations: results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES). Chem Senses 41:69–76PubMedCrossRef

Doty RL, Shah M, Bromley SM (2008) Drug-induced taste disorders. Drug Saf 31:199–215PubMedCrossRef

10.

Sato K, Endo S, Tomita H (2002) Sensitivity of three loci on the tongue and soft palate to four basic tastes in smokers and non-smokers. Acta Otolaryngol Suppl 546:74–82CrossRef

11.

Wrobel E, Skrok-Wolska D, Ziolkowski M, Korkosz A, Habrat B, Woronowicz B, Kukwa A, Kostowski W, Bienkowski P, Scinska A (2005) Taste responses to monosodium glutamate after alcohol exposure. Alcohol Alcohol 40:106–111PubMedCrossRef

12.

Naik BS, Shetty N, Maben EV (2010) Drug-induced taste disorders. Eur J Intern Med 21:240–243PubMedCrossRef

13.

Barnhart MK, Robinson RA, Simms VA, Ward EC, Cartmill B, Chandler SJ, Smee RI (2018) Treatment toxicities and their impact on oral intake following non-surgical management for head and neck cancer: a 3-year longitudinal study. Support Care Cancer 26:2341–2351PubMedCrossRef

14.

van der Werf A, Rovithi M, Langius JAE, de van der Schueren MAE, Verheul HMW (2017) Insight in taste alterations during treatment with protein kinase inhibitors. Eur J Cancer 86:125–134PubMedCrossRef

15.

Pellegrino R, Walliczek-Dworschak U, Winter G, Hull D, Hummel T (2017) Investigation of chemosensitivity during and after an acute cold. Int Forum Allergy Rhinol 7:185–191PubMedCrossRef

16.

Wolf A, Renner B, Tomazic PV, Mueller CA (2018) Gustatory function in patients with chronic rhinosinusitis. Ann Otol Rhinol Laryngol 127:229–234CrossRef

17.

Heald AE, Pieper CF, Schiffman SS (1998) Taste and smell complaints in HIV-infected patients. AIDS 12:1667–1674PubMedCrossRef

18.

Raja JV, Rai P, Khan M, Banu A, Bhuthaiah S (2013) Evaluation of gustatory function in HIV-infected subjects with and without HAART. J Oral Pathol Med 42:216–221PubMedCrossRef

19.

Musialik J, Suchecka W, Klimacka-Nawrot E, Petelenz M, Hartman M, Błońska-Fajfrowska B (2012) Taste and appetite disorders of chronic hepatitis C patients. Eur J Gastroenterol Hepatol 24:1400–1405PubMedCrossRef

20.

Mantani N, Ito K, Kogure T, Hoshino A, Kawada E, Sakamoto H, Fujita K, Tamura J (2005) A decade-long sour-taste sensation successfully treated with a proton-pump inhibitor. J Oral Rehabil 32:776–778PubMedCrossRef

21.

Lynch KE, Lynch R, Curhan GC, Brunelli SM (2013) Altered taste perception and nutritional status among hemodialysis patients. J Ren Nutr 23:288–295PubMedCrossRef

22.

Onoda K, Ikeda M, Sekine H, Ogawa H (2012) Clinical study of central taste disorders and discussion of the central gustatory pathway. J Neurol 259:261–266PubMedCrossRef

23.

Yanagisawa K, Bartoshuk LM, Catalanotto FA, Karrer TA, Kveton JF (1998) Anesthesia of the chorda tympani nerve and taste phantoms. Physiol Behav 63:329–335PubMedCrossRef

24.

McManus LJ, Stringer MD, Dawes PJ (2012) Iatrogenic injury of the chorda tympani: a systematic review. J Laryngol Otol 126:8–14PubMedCrossRef

25.

Suh KI, Lee JY, Chung JW, Kim YK, Kho HS (2007) Relationship between salivary flow rate and clinical symptoms and behaviours in patients with dry mouth. J Oral Rehabil 34:739–744PubMedCrossRef

26.

Nalcaci R, Baran I (2008) Factors associated with self-reported halitosis (SRH) and perceived taste disturbance (PTD) in elderly. Arch Gerontol Geriatr 46:307–316PubMedCrossRef

27.

Kameyama A, Ishii K, Tomita S, Tatsuta C, Sugiyama T, Ishizuka Y, Takahashi T, Tsunoda M (2015) Correlations between perceived oral malodor levels and self-reported oral complaints. Int J Dent 2015:343527PubMedPubMedCentralCrossRef

28.

Grushka M (1987) Clinical features of burning mouth syndrome. Oral Surg Oral Med Oral Pathol 63:30–36PubMedCrossRef

29.

Obrez A, Grussing PG (1999) Opinions and feelings on eating with complete dentures: a qualitative inquiry. Spec Care Dentist 19:225–229PubMedCrossRef

30.

Grushka M, Sessle B (1988) Taste dysfunction in burning mouth syndrome. Gerodontics 4:256–258PubMed

31.

Ikebe K, Nokubi T, Ettinger RL, Namba H, Tanioka N, Iwase K, Ono T (2002) Dental status and satisfaction with oral function in a sample of community-dwelling elderly people in Japan. Spec Care Dentist 22:33–40PubMedCrossRef

32.

Yoshinaka M, Yoshinaka MF, Ikebe K, Shimanuki Y, Nokubi T (2007) Factors associated with taste dissatisfaction in the elderly. J Oral Rehabil 34:497–502PubMedCrossRef

33.

Lindley C, McCune JS, Thomason TE, Lauder D, Sauls A, Adkins S, Sawyer WT (1999) Perception of chemotherapy side effects cancer versus noncancer patients. Cancer Pract 7:59–65PubMedCrossRef

34.

Ponticelli E, Clari M, Frigerio S, De Clemente A, Bergese I, Scavino E, Bernardini A, Sacerdote C (2017) Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: a cross-sectional study. Eur J Cancer Care (Engl) 2:e12633CrossRef

35.

Bernhardson BM, Tishelman C, Rutqvist LE (2007) Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. J Pain Symptom Manag 34:403–412CrossRef

36.

de Vries YC, Boesveldt S, Kelfkens CS, Posthuma EE, van den Berg MMGA, de Kruif JTCM, Haringhuizen A, Sommeijer DW, Buist N, Grosfeld S, de Graaf C, van Laarhoven HWM, Kampman E, Winkels RM (2018) Taste and smell perception and quality of life during and after systemic therapy for breast cancer. Breast Cancer Res Treat 170:27–34PubMedPubMedCentralCrossRef

37.

Merkonidis C, Grosse F, Ninh T, Hummel C, Haehner A, Hummel T (2015) Characteristics of chemosensory disorders--results from a survey. Eur Arch Otorhinolaryngol 272:1403–1416PubMedCrossRef

38.

Kershaw JC, Mattes RD (2018) Nutrition and taste and smell dysfunction. World J Otorhinolaryngol Head Neck Surg 4:3–10PubMedPubMedCentralCrossRef

39.

Mattes RD, Cowart BJ (1994) Dietary assessment of patients with chemosensory disorders. J Am Diet Assoc 94:50–56PubMedCrossRef

40.

Solemdal K, Møinichen-Berstad C, Mowe M, Hummel T, Sandvik L (2014) Impaired taste and increased mortality in acutely hospitalized older people. Chem Senses 39:263–269PubMedCrossRef

41.

Henkin RI, Potolicchio SJ Jr, Levy LM (2011) Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation. Am J Otolaryngol 32:38–46PubMedCrossRef

42.

Robinson PP, Smith KG (1996) A study on the efficacy of late lingual nerve repair. Br J Oral Maxillofac Surg 34:96–103PubMedCrossRef

43.

Russ JE, DeWys WD (1978) Correction of taste abnormality of malignancy with intravenous hyperalimentation. Arch Intern Med 138:799–800PubMedCrossRef

44.

Makler V, Litofsky NS (2015) Successful treatment of dysgeusia after middle-ear surgery with amitriptyline: case report. Am J Otolaryngol 36:456–459PubMedCrossRef

45.

Barker KE, Batstone MD, Savage NW (2009) Comparison of treatment modalities in burning mouth syndrome. Aust Dent J 54:300–305CrossRefPubMed

46.

Henkin RI, Levy LM, Lin CS (2000) Taste and smell phantoms revealed by brain functional MRI (fMRI). J Comput Assist Tomogr 24:106–123PubMedCrossRef

47.

Heckmann SM, Heckmann JG, Ungethum A, Hujoel P, Hummel T (2006) Gabapentin has little or no effect in the treatment of burning mouth syndrome - results of an open-label pilot study. Eur J Neurol 13:e6–e7PubMedCrossRef

48.

Henkin RI, Schecter PJ, Friedewald WT, Demets DL, Raff M (1976) A double-blind study of the effects of zinc sulfate on taste and smell dysfunction. Am J Med Sci 272:285–299PubMedCrossRef

49.

Nagao Y, Matsuoka H, Kawaguchi T, Sata M (2010) Aminofeel improves the sensitivity to taste in patients with HCV-infected liver disease. Med Sci Monit 16:PI7–P12PubMed

50.

Mattes RD, Pawlik MK (2004) Effects of Ginkgo biloba on alertness and chemosensory function in healthy adults. Hum Psychopharmacol 19:81–90PubMedCrossRef

51.

Femiano F, Scully C, Gombos F (2002) Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy. Int J Oral Maxillofac Surg 31:625–628PubMedCrossRef

52.

Henkin RI, Schultz M, Minnick-Poppe L (2012) Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Arch Otolaryngol Head Neck Surg 138:1064–1070PubMedCrossRef

53.

Deniz F, Ay SA, Salihoglu M, Kurt O, Baskoy K, Altundag A, Tekeli H, Yonem A, Hummel T (2016) Thyroid hormone replacement therapy improves olfaction and taste sensitivity in primary hypothyroid patients: a prospective randomised clinical trial. Exp Clin Endocrinol Diabetes 124:562–567PubMedCrossRef

54.

Epstein JB, Emerton S, Le ND, Stevenson-Moore P (1999) A double-blind crossover trial of Oral Balance gel and Biotene toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncol 35:132–137PubMedCrossRef

55.

Aframian DJ, Helcer M, Livni D, Robinson SD, Markitziu A, Nadler C (2007) Pilocarpine treatment in a mixed cohort of xerostomic patients. Oral Dis 13:88–92PubMedCrossRef

56.

Brisbois TD, de Kock IH, Watanabe SM, Mirhosseini M, Lamoureux DC, Chasen M, MacDonald N, Baracos VE, Wismer WV (2011) Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial. Ann Oncol 22:2086–2093PubMedCrossRef

57.

Heman-Ackah S, Pensak MA (2005) Incidental finding of dysgeusia relieved by injections of botulinum toxin a. Laryngoscope 115:844–845PubMedCrossRef

58.

Greenway FL, Ingram DK, Ravussin E, Hausmann M, Smith SR, Cox L, Tomayko K, Treadwell BV (2011) Loss of taste responds to high-dose biotin treatment. J Am Coll Nutr 30:178–181PubMedPubMedCentralCrossRef

59.

Wilken MK, Satiroff BA (2012) Pilot study of “miracle fruit” to improve food palatability for patients receiving chemotherapy. Clin J Oncol Nurs 16:E173–E177PubMedCrossRef

60.

Strasser F, Demmer R, Böhme C, Schmitz SF, Thuerlimann B, Cerny T, Gillessen S (2008) Prevention of docetaxel- or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study. Oncologist 13:337–346PubMedCrossRef

61.

Sasano T, Satoh-Kuriwada S, Shoji N, Sekine-Hayakawa Y, Kawai M, Uneyama H (2010) Application of umami taste stimulation to remedy hypogeusia based on reflex salivation. Biol Pharm Bull 33:1791–1795PubMedCrossRef

62.

Langan MJ, Yearick ES (1976) The effects of improved oral hygiene on taste perception and nutrition of the elderly. J Gerontol 31:413–418PubMedCrossRef

63.

Formaker BK, Mott AE, Frank ME (1998) The effects of topical anesthesia on oral burning in burning mouth syndrome. Ann N Y Acad Sci 855:776–780PubMedCrossRef

64.

Okada N, Hanafusa T, Abe S, Sato C, Nakamura T, Teraoka K, Abe M, Kawazoe K, Ishizawa K (2016) Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention. Support Care Cancer 24:3979–3985PubMedCrossRef

65.

Fujiyama R, Ishitobi S, Honda K, Okada Y, Oi K, Toda K (2010) Ice cube stimulation helps to improve dysgeusia. Odontology 98:82–84PubMedCrossRef

66.

Zhang WP, Ishida T (2006) An ageusia and dysosmia patient treated by acupuncture. Chin J Integr Med 12:66–67PubMedCrossRef

67.

Kumbargere Nagraj S, George RP, Shetty N, Levenson D, Ferraiolo DM, Shrestha A (2017) Interventions for managing taste disturbances. Cochrane Database Syst Rev 12:CD010470PubMed

68.

Henkin RI, Knöppel AB, Abdelmeguid M, Stateman WA, Hosein S (2017) Theophylline increases saliva sonic hedgehog and improves taste dysfunction. Arch Oral Biol 82:263–270PubMedCrossRef

69.

Suzuki M, Yokota M, Matsumoto T, Nakayama M, Takemura M, Kanemitsu Y, Niimi A, Nakamura Y, Murakami S (2019) Proton pump inhibitor ameliorates taste disturbance among patients with laryngopharyngeal reflux: a randomized controlled study. Tohoku J Exp Med 247:19–25PubMedCrossRef

70.

Wang A, Duncan SE, Lesser GJ, Ray WK, Dietrich AM (2018) Effect of lactoferrin on taste and smell abnormalities induced by chemotherapy: a proteome analysis. Food Funct 9:4948–4958PubMedCrossRef

71.

Mobadder ME, Farhat F, Mobadder WE, Nammour S. (2018) Photobiomodulation therapy in the treatment of oral mucositis, dysgeusia and oral dryness as side-effects of head and neck radiotherapy in a cancer patient: a case report. Dent J (Basel) 6. pii: E64

72.

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097PubMedPubMedCentralCrossRef

73.

Altman DG (1991) Practical statistics for medical research. Chapmann and Hall, London, 611pp

74.

Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, Knipschild PG (1998) The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 51:1235–1241PubMedCrossRef

75.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P. (2012) The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. http://wwwohrica/programs/clinical_epidemiology/oxfordasp

76.

Dahl H, Nørskov K, Peitersen E, Hilden J (1984) Zinc therapy of acetazolamide-induced side-effects. Acta Ophthalmol 62:739–745CrossRef

77.

Halyard MY, Jatoi A, Sloan JA, Bearden JD 3rd, Vora SA, Atherton PJ, Perez EA, Soori G, Zalduendo AC, Zhu A, Stella PJ, Loprinzi CL (2007) Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys 67:1318–1322PubMedCrossRef

78.

Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, Hummel T (2005) Zinc gluconate in the treatment of dysgeusia – a randomized clinical trial. J Dent Res 84:35–38PubMedCrossRef

79.

Jham BC, Chen H, Carvalho AL, Freire AR (2009) A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy: a secondary analysis. J Oral Sci 51:565–572PubMedCrossRef

80.

Khan AH, Safdar J, Siddiqui SU (2019) Efficacy of zinc sulfate on concurrent chemoradiotherapy induced taste alterations in oral cancer patients: a double blind randomized controlled trial. Pak J Med Sci 35:624–629PubMedPubMedCentral

81.

Lyckholm L, Heddinger SP, Parker G, Coyne PJ, Ramakrishnan V, Smith TJ, Henkin RI (2012) A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. J Pain Palliat Care Pharmacother 26:111–114PubMedPubMedCentralCrossRef

82.

Mahajan SK, Prasad AS, Lambujon J, Abbasi AA, Briggs WA, McDonald FD (1979) Improvement of uremic hypogeusia by zinc. Trans Am Soc Artif Intern Organs 25:443–448PubMedCrossRef

83.

Najafizade N, Hemati S, Gookizade A, Berjis N, Hashemi M, Vejdani S, Ghannadi A, Shahsanaee A, Arbab N (2013) Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: a randomized placebo-controlled trial. J Res Med Sci 18:123–126PubMedPubMedCentral

84.

Ohno T, Uematsu H, Nozaki S, Sugimoto K (2003) Improvement of taste sensitivity of the nursed elderly by oral care. J Med Dental Sci 50:101–107

85.

Quirynen M, Avontroodt P, Soers C, Zhao H, Pauwels M, van Steenberghe D (2004) Impact of tongue cleansers on microbial load and taste. J Clin Periodontol 31:506–510PubMedCrossRef

86.

Ripamonti C, Zecca E, Brunelli C, Fulfaro F, Villa S, Balzarini A, Bombardieri E, De Conno F (1998) A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation. Cancer 82:1938–1945PubMedCrossRef

87.

Sakagami M, Ikeda M, Tomita H, Ikui A, Aiba T, Takeda N, Inokuchi A, Kurono Y, Nakashima M, Shibasaki Y, Yotsuya O (2008) A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo controlled, multi-center study. Acta Otolaryngol 26:1–6

88.

Sakai F, Yoshida S, Endo S, Tomita H (2002) Double-blind, placebo-controlled trial of zinc picolinate for taste disorders. Acta Otolaryngol Suppl 546:129–133CrossRef

89.

Schuller DE, Stevens P, Clausen KP, Olsen J, Gahbauer R, Martin M (1989) Treatment of radiation side effects with oral pilocarpine. J Surg Oncol 42:272–276PubMedCrossRef

90.

Sprenger KB, Bundschu D, Lewis K, Spohn B, Schmitz J, Franz HE (1983) Improvement of uremic neuropathy and hypogeusia by dialysate zinc supplementation: a doubleblind study. Kidney Int Suppl 24:S315–S318CrossRef

91.

Stewart-Knox BJ, Simpson EE, Parr H, Rae G, Polito A, Intorre F et al (2008) Taste acuity in response to zinc supplementation in older Europeans. Br J Nutr 99:129–136PubMedCrossRef

92.

Treldal C, Jacobsen CB, Mogensen S, Rasmussen M, Jacobsen J, Petersen J, Lynge Pedersen AM, Andersen O (2016) Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome. Oral Dis 22:123–131PubMedCrossRef

93.

Yamagata T, Nakamura Y, Yamagata Y, Nakanishi M, Matsunaga K, Nakanishi H, Nishimoto T, Minakata Y, Mune M, Yukawa S (2003) The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer. J Exp Clin Cancer Res 22:557–563PubMed

94.

Fark T, Hummel C, Hähner A, Nin T, Hummel T (2013) Characteristics of taste disorders. Eur Arch Otorhinolaryngol 270:1855–1860PubMedCrossRef

95.

Yamanaka T, Hosoi H, Murai T, Kobayashi T, Inada Y, Nakamura T (2014) Regeneration of the nerves in the aerial cavity with an artificial nerve conduit --reconstruction of chorda tympani nerve gaps. PLoS One 9:e92258PubMedPubMedCentralCrossRef

96.

Hillerup S, Stoltze K (2007) Lingual nerve injury II. Observations on sensory recovery after micro-neurosurgical reconstruction. Int J Oral Maxillofac Surg 36:1139–1145PubMedCrossRef

97.

Leung YY, Cheung LK (2016) Longitudinal treatment outcomes of microsurgical treatment of neurosensory deficit after lower third molar surgery: a prospective case series. PLoS One 11:e0150149PubMedPubMedCentralCrossRef

98.

Chéruel F, Jarlier M, Sancho-Garnier H (2017) Effect of cigarette smoke on gustatory sensitivity, evaluation of the deficit and of the recovery time-course after smoking cessation. Tob Induc Dis 15:15PubMedPubMedCentralCrossRef

99.

Kabadi A, Saadi M, Schey R, Parkman HP (2017) Taste and smell disturbances in patients with gastroparesis and gastroesophageal reflux disease. J Neurogastroenterol Motil 23:370–377PubMedPubMedCentralCrossRef

100.

McConnell RJ, Menendez CE, Smith FR, Henkin RI, Rivlin RS (1975) Defects of taste and smell in patients with hypothyroidism. Am J Med 59:354–364PubMedCrossRef

101.

Clark AA, Dotson CD, Elson AE, Voigt A, Boehm U, Meyerhof W et al (2015) TAS2R bitter taste receptors regulate thyroid function. FASEB J 29:164–172PubMedCrossRef

102.

Baskoy K, Ay SA, Altundag A, Kurt O, Salihoglu M, Deniz F, Tekeli H, Yonem A, Hummel T (2016) Is there any effect on smell and taste functions with levothyroxine treatment in subclinical hypothyroidism? PLoS One 11:e0149979PubMedPubMedCentralCrossRef

103.

Markitziu A, Aframian D (1996) Side effects of omeprazole. Scand J Gastroenterol 31:624PubMedCrossRef

104.

Tomita H (1990) Zinc in taste and smell disorders. In: Tomita H (ed) Trace elements in clinical medicine. Springer - Verlag, Tokyo, pp 15–37CrossRef

105.

Ikeda M, Hirai R, Shigihara S, Ikui A (2008) Taste disorders and zinc deficiency. Int J Oral Med Sci 6:105–111CrossRef

106.

Takaoka T, Sarukura N, Ueda C, Kitamura Y, Kalubi B, Toda N, Abe K, Yamamoto S, Takeda N (2010) Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment. Auris Nasus Larynx 37:190–194PubMedCrossRef

107.

Yanagisawa H, Kawashima T, Miyazawa M, Ohshiro T (2016) Validity of the copper/zinc ratio as a diagnostic marker for taste disorders associated with zinc deficiency. J Trace Elem Med Biol 36:80–83PubMedCrossRef

108.

Henkin RI, Martin BM, Agarwal RP (1999) Efficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiency. Am J Med Sci 318:392–405PubMedCrossRef

109.

Lus G, Cantello R, Danni MC, Rini A, Sarchielli P, Tassinari T, Signoriello E (2018) Palatability and oral cavity tolerability of THC:CBD oromucosal spray and possible improvement measures in multiple sclerosis patients with resistant spasticity: a pilot study. Neurodegener Dis Manag 8:105–113PubMedCrossRef

110.

Temmel AF, Quint C, Schickinger-Fischer B, Hummel T (2005) Taste function in xerostomia before and after treatment with a saliva substitute containing carboxymethylcellulose. J Otolaryngol 34:116–120PubMedCrossRef

111.

Hannig C, Hannig M, Kensche A, Carpenter G (2017) The mucosal pellicle - an underestimated factor in oral physiology. Arch Oral Biol 80:144–152PubMedCrossRef

112.

Feng Y, Licandro H, Martin C, Septier C, Zhao M, Neyraud E, Morzel M (2018) The associations between biochemical and microbiological variables and taste differ in whole saliva and in the film lining the tongue. Biomed Res Int 2018:2838052PubMedPubMedCentral

113.

Neyraud E, Morzel M (2019) Biological films adhering to the oral soft tissues: structure, composition, and potential impact on taste perception. J Texture Stud 50:19–26PubMedCrossRef

114.

Koshimune S, Awano S, Gohara K, Kurihara E, Ansai T, Takehara T (2003) Low salivary flow and volatile sulfur compounds in mouth air. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:38–41PubMedCrossRef

Titel: Taste disorder’s management: a systematic review
verfasst von: Adeline Braud
Yves Boucher
Publikationsdatum: 08.05.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 6/2020
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03299-0

Neu im Fachgebiet Zahnmedizin

19.04.2024 | Vorhofflimmern | Nachrichten

Newsletter bestellen

Springer Medizin

Taste disorder’s management: a systematic review

Abstract

Background

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

Newsletter

Springer Medizin

Abstract

Background

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2020

Clinical significance of the G8 screening tool in elderly patients with oral squamous cell carcinoma

Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats

Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials

The precision of case difficulty and referral decisions: an innovative automated approach

Oro-facial manifestations in lepromatous leprosy patients in Central India: clinical findings from a cross-sectional study

Network meta-analysis of the desensitizing effects of lasers in patients with dentine hypersensitivity

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

Newsletter