Erschienen in:
01.12.2010 | Correspondence
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies
verfasst von:
H. Bea Kuiperij, Wilson F. Abdo, Baziel G. van Engelen, H. Jurgen Schelhaas, Marcel M. Verbeek
Erschienen in:
Acta Neuropathologica
|
Ausgabe 6/2010
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Excerpt
Sporadic inclusion body myositis (sIBM) is a progressive myopathy, clinically characterized by muscle weakness and atrophy, usually beginning after 50 years of age; sIBM belongs to a group of inflammatory myopathies, also including polymyositis (PM) and dermatomyositis (DM). Differentiating between these inflammatory myopathies can be difficult due to an overlap in clinical symptoms. Recently, the TAR DNA-binding protein-43 (TDP-43) was identified as a component of inclusions in sIBM muscle fibers [
7]. We examined if the TDP-43 protein could be identified in the plasma of sIBM patients, and could, as such, differentiate sIBM patients from patients with other inflammatory myopathies, in which TDP-43-positive inclusions are not, or only rarely, identified. …