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Erschienen in: Diabetologia 4/2020

02.01.2020 | Review

The changing face of paediatric diabetes

verfasst von: Amy S. Shah, Kristen J. Nadeau

Erschienen in: Diabetologia | Ausgabe 4/2020

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Abstract

The purpose of this review is to provide an update on the changing face of paediatric type 1 diabetes and type 2 diabetes. Paediatric diabetes is on the rise, with extensive research dedicated to understanding its pathophysiology, comorbidities and complications. As obesity continues to increase among all youth, differentiating between type 1 diabetes and type 2 diabetes has become increasingly difficult but remains important for optimising treatment, anticipating complications and predicting disease risk. Novel treatments are emerging, with the ultimate goal being to achieve glycaemic control, limit weight gain, improve quality of life and reduce comorbidities. In this review, we focus on updates regarding the epidemiology, clinical presentation, comorbidities and complications of paediatric type 1 diabetes and type 2 diabetes and conclude with current and emerging treatments.
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Literatur
3.
Zurück zum Zitat Copeland KC, Zeitler P, Geffner M et al (2011) Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 96:159–167CrossRefPubMed Copeland KC, Zeitler P, Geffner M et al (2011) Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 96:159–167CrossRefPubMed
5.
Zurück zum Zitat Dabelea D, Mayer-Davis EJ, Saydah S et al (2014) Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 311:1778–1786CrossRefPubMedPubMedCentral Dabelea D, Mayer-Davis EJ, Saydah S et al (2014) Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 311:1778–1786CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Stanescu DE, Lord K, Lipman TH (2012) The epidemiology of type 1 diabetes in children. Endocrinol Metab Clin N Am 41:679–694CrossRef Stanescu DE, Lord K, Lipman TH (2012) The epidemiology of type 1 diabetes in children. Endocrinol Metab Clin N Am 41:679–694CrossRef
7.
Zurück zum Zitat Harjutsalo V, Sund R, Knip M, Groop PH (2013) Incidence of type 1 diabetes in Finland. JAMA 310:427–428CrossRefPubMed Harjutsalo V, Sund R, Knip M, Groop PH (2013) Incidence of type 1 diabetes in Finland. JAMA 310:427–428CrossRefPubMed
8.
Zurück zum Zitat Harjutsalo V, Sjoberg L, Tuomilehto J (2008) Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 371:1777–1782CrossRefPubMed Harjutsalo V, Sjoberg L, Tuomilehto J (2008) Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 371:1777–1782CrossRefPubMed
9.
Zurück zum Zitat Silink M (2002) Childhood diabetes: a global perspective. Horm Res 57(Suppl 1):1–5PubMed Silink M (2002) Childhood diabetes: a global perspective. Horm Res 57(Suppl 1):1–5PubMed
10.
Zurück zum Zitat Mayer-Davis EJ, Lawrence JM, Dabelea D et al (2017) Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med 376:1419–1429CrossRefPubMedPubMedCentral Mayer-Davis EJ, Lawrence JM, Dabelea D et al (2017) Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med 376:1419–1429CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Urakami T, Suzuki J, Mugishima H et al (2012) Screening and treatment of childhood type 1 and type 2 diabetes mellitus in Japan. Pediatr Endocrinol Rev 10(Suppl 1):51–61PubMed Urakami T, Suzuki J, Mugishima H et al (2012) Screening and treatment of childhood type 1 and type 2 diabetes mellitus in Japan. Pediatr Endocrinol Rev 10(Suppl 1):51–61PubMed
16.
Zurück zum Zitat Quinn M, Fleischman A, Rosner B, Nigrin DJ, Wolfsdorf JI (2006) Characteristics at diagnosis of type 1 diabetes in children younger than 6 years. J Pediatr 148:366–371CrossRefPubMed Quinn M, Fleischman A, Rosner B, Nigrin DJ, Wolfsdorf JI (2006) Characteristics at diagnosis of type 1 diabetes in children younger than 6 years. J Pediatr 148:366–371CrossRefPubMed
22.
Zurück zum Zitat DuBose SN, Hermann JM, Tamborlane WV et al (2015) Obesity in youth with type 1 diabetes in Germany, Austria, and the United States. J Pediatr 167:627–632.e621-e624CrossRefPubMed DuBose SN, Hermann JM, Tamborlane WV et al (2015) Obesity in youth with type 1 diabetes in Germany, Austria, and the United States. J Pediatr 167:627–632.e621-e624CrossRefPubMed
23.
Zurück zum Zitat Bjornstad P, Maahs DM, Duca LM et al (2016) Estimated insulin sensitivity predicts incident micro- and macrovascular complications in adults with type 1 diabetes over 6 years: the coronary artery calcification in type 1 diabetes study. J Diabetes Complicat 30:586–590CrossRef Bjornstad P, Maahs DM, Duca LM et al (2016) Estimated insulin sensitivity predicts incident micro- and macrovascular complications in adults with type 1 diabetes over 6 years: the coronary artery calcification in type 1 diabetes study. J Diabetes Complicat 30:586–590CrossRef
24.
Zurück zum Zitat Specht BJ, Wadwa RP, Snell-Bergeon JK, Nadeau KJ, Bishop FK, Maahs DM (2013) Estimated insulin sensitivity and cardiovascular disease risk factors in adolescents with and without type 1 diabetes. J Pediatr 162:297–301CrossRefPubMed Specht BJ, Wadwa RP, Snell-Bergeon JK, Nadeau KJ, Bishop FK, Maahs DM (2013) Estimated insulin sensitivity and cardiovascular disease risk factors in adolescents with and without type 1 diabetes. J Pediatr 162:297–301CrossRefPubMed
25.
Zurück zum Zitat Cree-Green M, Wiromrat P, Stuppy J et al (2019) Youth with Type 2 diabetes have hepatic, peripheral and adipose insulin resistance. AJP Endo 316:E186–E195 Cree-Green M, Wiromrat P, Stuppy J et al (2019) Youth with Type 2 diabetes have hepatic, peripheral and adipose insulin resistance. AJP Endo 316:E186–E195
26.
Zurück zum Zitat Zeitler P, Arslanian S, Fu J et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: type 2 diabetes mellitus in youth. Pediatr Diabetes 19(Suppl 27):28–46 Zeitler P, Arslanian S, Fu J et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: type 2 diabetes mellitus in youth. Pediatr Diabetes 19(Suppl 27):28–46
27.
Zurück zum Zitat Arslanian S, Bacha F, Grey M, Marcus MD, White NH, Zeitler P (2018) Evaluation and management of youth-onset type 2 diabetes: a position statement by the American Diabetes Association. Diabetes Care 41(12):2648–2668. https://doi.org/10.2337/dci18-0052 Arslanian S, Bacha F, Grey M, Marcus MD, White NH, Zeitler P (2018) Evaluation and management of youth-onset type 2 diabetes: a position statement by the American Diabetes Association. Diabetes Care 41(12):2648–2668. https://​doi.​org/​10.​2337/​dci18-0052
30.
Zurück zum Zitat Couper JJ, Haller MJ, Greenbaum CJ et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: stages of type 1 diabetes in children and adolescents. Pediatr Diabetes 19(Suppl 27):20–27CrossRefPubMed Couper JJ, Haller MJ, Greenbaum CJ et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: stages of type 1 diabetes in children and adolescents. Pediatr Diabetes 19(Suppl 27):20–27CrossRefPubMed
33.
Zurück zum Zitat The RISE Consortium (2018) Impact of insulin and metformin versus metformin alone on beta-cell function in youth with impaired glucose tolerance or recently diagnosed type 2 diabetes. Diabetes Care 41: 1717–1725 The RISE Consortium (2018) Impact of insulin and metformin versus metformin alone on beta-cell function in youth with impaired glucose tolerance or recently diagnosed type 2 diabetes. Diabetes Care 41: 1717–1725
34.
Zurück zum Zitat RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: II. Observations using the oral glucose tolerance test. Diabetes Care 41:1707–1716CrossRef RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: II. Observations using the oral glucose tolerance test. Diabetes Care 41:1707–1716CrossRef
35.
Zurück zum Zitat RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: I. Observations using the hyperglycemic clamp. Diabetes Care 41:1696–1706CrossRef RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: I. Observations using the hyperglycemic clamp. Diabetes Care 41:1696–1706CrossRef
36.
Zurück zum Zitat RISE Consortium (2019) Effects of treatment of impaired glucose tolerance or recently diagnosed type 2 diabetes with metformin alone or in combination with insulin glargine on β-cell function: comparison of responses in youth and adults. Diabetes 68:1670–1680CrossRef RISE Consortium (2019) Effects of treatment of impaired glucose tolerance or recently diagnosed type 2 diabetes with metformin alone or in combination with insulin glargine on β-cell function: comparison of responses in youth and adults. Diabetes 68:1670–1680CrossRef
42.
Zurück zum Zitat Sànchez-Santos R, Sabench Pereferrer F, Estèvez Fernandez S et al (2013) Is the morbid obesity surgery profitable in times of crisis? A cost-benefit analysis of bariatric surgery. Cir Esp 91:476–484 [article in Spanish]CrossRefPubMed Sànchez-Santos R, Sabench Pereferrer F, Estèvez Fernandez S et al (2013) Is the morbid obesity surgery profitable in times of crisis? A cost-benefit analysis of bariatric surgery. Cir Esp 91:476–484 [article in Spanish]CrossRefPubMed
44.
Zurück zum Zitat Kavey RE, Allada V, Daniels SR et al (2007) Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research. J Cardiovasc Nurs 22(3):218–253. https://doi.org/10.1097/01.JCN.0000267827.50320.85 CrossRefPubMed Kavey RE, Allada V, Daniels SR et al (2007) Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research. J Cardiovasc Nurs 22(3):218–253. https://​doi.​org/​10.​1097/​01.​JCN.​0000267827.​50320.​85 CrossRefPubMed
45.
Zurück zum Zitat Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents (2011) Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 128(Suppl 5): S213-S256 Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents (2011) Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 128(Suppl 5): S213-S256
48.
Zurück zum Zitat Snell-Bergeon JK, Nadeau K (2012) Cardiovascular disease risk in young people with type 1 diabetes. J Cardiovasc Transl Res 5:446–462CrossRefPubMed Snell-Bergeon JK, Nadeau K (2012) Cardiovascular disease risk in young people with type 1 diabetes. J Cardiovasc Transl Res 5:446–462CrossRefPubMed
49.
Zurück zum Zitat Nadeau KJ, Reusch JE (2011) Cardiovascular function/dysfunction in adolescents with type 1 diabetes. Curr Diab Rep 11:185–192CrossRefPubMed Nadeau KJ, Reusch JE (2011) Cardiovascular function/dysfunction in adolescents with type 1 diabetes. Curr Diab Rep 11:185–192CrossRefPubMed
50.
Zurück zum Zitat Bjornstad P, Truong U, Pyle L et al (2016) Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: a RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complicat 30(6):1103–1110. https://doi.org/10.1016/j.jdiacomp.2016.04.008 Bjornstad P, Truong U, Pyle L et al (2016) Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: a RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complicat 30(6):1103–1110. https://​doi.​org/​10.​1016/​j.​jdiacomp.​2016.​04.​008
53.
Zurück zum Zitat Cree-Green M, Bergman BC, Cengiz E et al (2019) Metformin improves peripheral insulin sensitivity in youth with type 1 diabetes. J Clin Endocrinol Metab 104:3265–3278CrossRefPubMedPubMedCentral Cree-Green M, Bergman BC, Cengiz E et al (2019) Metformin improves peripheral insulin sensitivity in youth with type 1 diabetes. J Clin Endocrinol Metab 104:3265–3278CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Nadeau KJ, Zeitler PS, Bauer TA et al (2009) Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab 94:3687–3695CrossRefPubMedPubMedCentral Nadeau KJ, Zeitler PS, Bauer TA et al (2009) Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab 94:3687–3695CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Shah AS, El Ghormli L, Gidding SS et al (2018) Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: relationships to glycemic control and other risk factors. J Diabetes Complicat 32:740–745 Shah AS, El Ghormli L, Gidding SS et al (2018) Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: relationships to glycemic control and other risk factors. J Diabetes Complicat 32:740–745
56.
Zurück zum Zitat Bjornstad P, Truong U, Dorosz JL et al (2016) Cardiopulmonary dysfunction and adiponectin in adolescents with type 2 diabetes. J Am Heart Assoc 5:e002804CrossRefPubMedPubMedCentral Bjornstad P, Truong U, Dorosz JL et al (2016) Cardiopulmonary dysfunction and adiponectin in adolescents with type 2 diabetes. J Am Heart Assoc 5:e002804CrossRefPubMedPubMedCentral
57.
Zurück zum Zitat Bacha F, Gidding SS, Pyle L et al (2016) Relationship of cardiac structure and function to cardiorespiratory fitness and lean body mass in adolescents and young adults with type 2 diabetes. J Pediatr 177:159–166 e151CrossRefPubMedPubMedCentral Bacha F, Gidding SS, Pyle L et al (2016) Relationship of cardiac structure and function to cardiorespiratory fitness and lean body mass in adolescents and young adults with type 2 diabetes. J Pediatr 177:159–166 e151CrossRefPubMedPubMedCentral
58.
Zurück zum Zitat Levitt Katz L, Gidding SS, Bacha F et al (2015) Alterations in left ventricular, left atrial, and right ventricular structure and function to cardiovascular risk factors in adolescents with type 2 diabetes participating in the TODAY clinical trial. Pediatr Diabetes 16(1):39–47. https://doi.org/10.1111/pedi.12119 CrossRefPubMed Levitt Katz L, Gidding SS, Bacha F et al (2015) Alterations in left ventricular, left atrial, and right ventricular structure and function to cardiovascular risk factors in adolescents with type 2 diabetes participating in the TODAY clinical trial. Pediatr Diabetes 16(1):39–47. https://​doi.​org/​10.​1111/​pedi.​12119 CrossRefPubMed
60.
Zurück zum Zitat Nadeau KJ, Klingensmith G, Zeitler P (2005) Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr 41:94–98CrossRefPubMed Nadeau KJ, Klingensmith G, Zeitler P (2005) Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr 41:94–98CrossRefPubMed
61.
Zurück zum Zitat Newton KP, Hou J, Crimmins NA et al (2016) Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease. JAMA Pediatr 170:e161971CrossRefPubMedPubMedCentral Newton KP, Hou J, Crimmins NA et al (2016) Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease. JAMA Pediatr 170:e161971CrossRefPubMedPubMedCentral
63.
Zurück zum Zitat Tancredi M, Rosengren A, Svensson AM et al (2015) Excess mortality among persons with type 2 diabetes. N Engl J Med 373:1720–1732CrossRefPubMed Tancredi M, Rosengren A, Svensson AM et al (2015) Excess mortality among persons with type 2 diabetes. N Engl J Med 373:1720–1732CrossRefPubMed
68.
Zurück zum Zitat Barr CC (2001) Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy, by The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N. Engl. J. Med 342:381-9, 2000. Surv Ophthalmol 45: 459–460, 5, https://doi.org/10.1016/s0039-6257(01)00187-4 Barr CC (2001) Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy, by The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N. Engl. J. Med 342:381-9, 2000. Surv Ophthalmol 45: 459–460, 5, https://​doi.​org/​10.​1016/​s0039-6257(01)00187-4
69.
Zurück zum Zitat UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:854–865CrossRef UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:854–865CrossRef
71.
Zurück zum Zitat DiMeglio LA, Acerini CL, Codner E et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes. Pediatr Diabetes 19(Suppl 27):105–114 DiMeglio LA, Acerini CL, Codner E et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes. Pediatr Diabetes 19(Suppl 27):105–114
72.
Zurück zum Zitat Rege NK, Phillips NFB, Weiss MA (2017) Development of glucose-responsive ‘smart’ insulin systems. Curr Opin Endocrinol Diabetes Obes 24:267–278 Rege NK, Phillips NFB, Weiss MA (2017) Development of glucose-responsive ‘smart’ insulin systems. Curr Opin Endocrinol Diabetes Obes 24:267–278
75.
Zurück zum Zitat De Ridder F, den Brinker M, De Block C (2019) The road from intermittently scanned glucose monitoring to hybrid closed-loop systems: Part A. Keys to success: subject profiles, choice of systems, education. Ther Adv Endocrinol Metab 10:2042018819865399PubMedPubMedCentral De Ridder F, den Brinker M, De Block C (2019) The road from intermittently scanned glucose monitoring to hybrid closed-loop systems: Part A. Keys to success: subject profiles, choice of systems, education. Ther Adv Endocrinol Metab 10:2042018819865399PubMedPubMedCentral
77.
Zurück zum Zitat Meng H, Zhang A, Liang Y, Hao J, Zhang X, Lu J (2018) Effect of metformin on glycaemic control in patients with type 1 diabetes: a meta-analysis of randomized controlled trials. Diabetes Metab Res Rev 34:e2983 Meng H, Zhang A, Liang Y, Hao J, Zhang X, Lu J (2018) Effect of metformin on glycaemic control in patients with type 1 diabetes: a meta-analysis of randomized controlled trials. Diabetes Metab Res Rev 34:e2983
78.
Zurück zum Zitat Libman IM, Miller KM, DiMeglio LA et al (2015) Effect of metformin added to insulin on glycemic control among overweight/obese adolescents with type 1 diabetes: a Randomized Clinical Trial. JAMA 314:2241–2250 Libman IM, Miller KM, DiMeglio LA et al (2015) Effect of metformin added to insulin on glycemic control among overweight/obese adolescents with type 1 diabetes: a Randomized Clinical Trial. JAMA 314:2241–2250
80.
85.
Zurück zum Zitat Hummel S, Pfluger M, Hummel M, Bonifacio E, Ziegler AG (2011) Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 34:1301–1305CrossRefPubMedPubMedCentral Hummel S, Pfluger M, Hummel M, Bonifacio E, Ziegler AG (2011) Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 34:1301–1305CrossRefPubMedPubMedCentral
91.
Zurück zum Zitat Wittmeier KD, Wicklow BA, Sellers EA, Griffith AT, Dean HJ, McGavock JM (2012) Success with lifestyle monotherapy in youth with new-onset type 2 diabetes. Paediatr Child Health 17:129–132CrossRefPubMedPubMedCentral Wittmeier KD, Wicklow BA, Sellers EA, Griffith AT, Dean HJ, McGavock JM (2012) Success with lifestyle monotherapy in youth with new-onset type 2 diabetes. Paediatr Child Health 17:129–132CrossRefPubMedPubMedCentral
92.
93.
Zurück zum Zitat Zeitler P, Fu J, Tandon N et al (2014) ISPAD Clinical Practice Consensus Guidelines 2014. Type 2 diabetes in the child and adolescent. Pediatr Diabetes 15(Suppl 20):26–46CrossRefPubMed Zeitler P, Fu J, Tandon N et al (2014) ISPAD Clinical Practice Consensus Guidelines 2014. Type 2 diabetes in the child and adolescent. Pediatr Diabetes 15(Suppl 20):26–46CrossRefPubMed
94.
Zurück zum Zitat Han E, Shin E, Kim G et al (2018) Combining SGLT2 inhibition with a thiazolidinedione additively attenuate the very early phase of diabetic nephropathy progression in type 2 diabetes mellitus. Front Endocrinol 9:412CrossRef Han E, Shin E, Kim G et al (2018) Combining SGLT2 inhibition with a thiazolidinedione additively attenuate the very early phase of diabetic nephropathy progression in type 2 diabetes mellitus. Front Endocrinol 9:412CrossRef
98.
Zurück zum Zitat de Wit HM, Te Groen M, Rovers MM, Tack CJ (2016) The placebo response of injectable GLP-1 receptor agonists vs. oral DPP-4 inhibitors and SGLT-2 inhibitors: a systematic review and meta-analysis. Br J Clin Pharmacol 82:301–314CrossRefPubMedPubMedCentral de Wit HM, Te Groen M, Rovers MM, Tack CJ (2016) The placebo response of injectable GLP-1 receptor agonists vs. oral DPP-4 inhibitors and SGLT-2 inhibitors: a systematic review and meta-analysis. Br J Clin Pharmacol 82:301–314CrossRefPubMedPubMedCentral
102.
Zurück zum Zitat Pratt JS, Lenders CM, Dionne EA et al (2009) Best practice updates for pediatric/adolescent weight loss surgery. Obesity 17:901–910CrossRefPubMed Pratt JS, Lenders CM, Dionne EA et al (2009) Best practice updates for pediatric/adolescent weight loss surgery. Obesity 17:901–910CrossRefPubMed
106.
Zurück zum Zitat Inge TH, Laffel LM, Jenkins TM et al (2018) Comparison of surgical and medical therapy for type 2 diabetes in severely obese adolescents. JAMA Pediatr 172:452–460CrossRefPubMedPubMedCentral Inge TH, Laffel LM, Jenkins TM et al (2018) Comparison of surgical and medical therapy for type 2 diabetes in severely obese adolescents. JAMA Pediatr 172:452–460CrossRefPubMedPubMedCentral
108.
Zurück zum Zitat Chuang J, Zeller MH, Inge T, Crimmins N (2013) Bariatric surgery for severe obesity in two adolescents with type 1 diabetes. Pediatrics 132:e1031–e1034CrossRefPubMedPubMedCentral Chuang J, Zeller MH, Inge T, Crimmins N (2013) Bariatric surgery for severe obesity in two adolescents with type 1 diabetes. Pediatrics 132:e1031–e1034CrossRefPubMedPubMedCentral
Metadaten
Titel
The changing face of paediatric diabetes
verfasst von
Amy S. Shah
Kristen J. Nadeau
Publikationsdatum
02.01.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Diabetologia / Ausgabe 4/2020
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-019-05075-6

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