Background
Subjects and methods
Study population and collection of data
Results
Patient characteristics and renal function of study cohort
Characteristics | All Cirrhotics | CTP A | CTP B | CTP C | Controls |
---|---|---|---|---|---|
[N=50] | [N=18 (36%)] | [N=18 (36%)] | [N=14 (28%)] | [N=24] | |
Males/Females | 39/11 | 13/5 ¥
| 15/3 &
| 11/9 | 6/18¥
&
|
Age (yrs) | 50 ± 9 (24–68) | 47 ± 10 (24–67) | 51 ± 8 (35–68) | 54 ± 8 (36–65) | 51 ± 11 (24–66) |
BMI (kg/m2) | 26 ± 5 (17–40) | 25 ± 4 (20–32) | 27 ± 6 (17–41) | 27 ± 3 (21–34) | 25 ± 5 (18–37) |
MELD Score | 13 ± 5 (7–33) | 9 ± 2 (7–13) #
| 12 ± 2 (8–18) § | 19 ± 6 (12–33) # §
| n.a. |
- MELD < 15 | 38 (76%) | 18 (100%) | 17 (94%) | 3 (21%) | |
- MELD > 15 | 12 (24%) | 0 (0%) | 1 (6%) | 11 (79%) | |
Etiology | n.a. | ||||
- Alcohol | 36 (72%) | 10 (56%) | 13 (72%) | 13 (93%) | |
- Hepatitis B | 1 (2%) | 1 (6%) | - | | - | |
- Hemochromatosis | 1 (2%) | 1 (6%) | - | I - | |
- PSC | 4 (8%) | 3 (17%) | 1 (6%) | | - | |
- Unknown | 1 (2%) | - | 1 (6%) | | - | |
- AIH | 1 (2%) | 1 (6%) | - | 1 - | |
- Hepatitis C | 4 (8%) | 1 (6%) | 2 (11%) | 1 (7%) | |
- Wilson's disease | 2 (4%) | 1 (6%) | 1 (6%) | | - | |
Ascites | n.a. | ||||
- None | 24 (48%) | 17 (94%) % #
| 6 (33%) %
| 1 (7%) #
| |
- Mild | 11 (22%) | 1 (6%) %
| 8 (44%) %
| 2 (14%) | |
- Moderate | 15 (30%) | - | 4 (22%) §
| 11 (79%) §
| |
Hepatic Encephalopathy | n.a. | ||||
- None | 43 (86%) | 18 (100%) | 17 (94%) §
| 8 (57%) §
| |
- Stage I-II | 6 (12%) | - | 1 (6%) | 5 (36%) | |
- Stage III-IV | 1 (2%) | - | - | 1 (7%) | |
Portal Hypertension | 46/50 (92%) | 14/18 (78%) | 18/18 (100%) | 14/14 (100%) | n.a. |
Total Bilirubin (mg/dL) | 3.4 ± 6.1 (0.4-36.5)* | 1.1 ± 0.6 (0.5-2.6) #
| 1.9 ± 1.3 (0.4-6.4) §
| 8.4 ± 10.1 (2.2-36.5) # §$
| 0.5 ± 0.2 (0.2-1.5) * $
|
Albumin (g/dL) | 3.6 ± 0.7 (2.3-5.2)* | 4.4 ± 0.3 (4.0-5.2)% #
| 3.4 ± 0.5 (2.8-4.5) % &
| 3.1 ± 0.5 (2.3-3.8)#$
| 4.5 ± 0.4 (3.7-5.2) * &$
|
Prothrombin Time (%) | 62 ±18 (32–104)* | 77 ± 14 (52–104)% #
¥
| 61 ± 13 (42–88) % §&
| 45 ± 12(32–73)# §$
| 99 ± 10 (72–114) * ¥
& $
|
CRP (mg/dL) | 9 ± 12 (3–70)* | 3 ± 3 (3–11) #
| 9 ± 8 (6–27) | 19 ±19(3–70)# $
| 2 ± 2 (3–9) * $
|
Cr (mg/dL) | 0.8 ± 0.5-1.6) | 0.8 ± 0.2 (0.6-1.4) | 0.7 ± 0;2 (0;5–1;1) | 0.9 ± 0.3 (0.5-1.6) | 0.8: ± 0. 1(0.6–1.0) |
CysC (mg/dL) | 1.1 ±0.5 (0.6-3.9)* | 1.0 ± 0.4 (0.6-2.4) | 0.9 ± 0.3 (0.7-1.7) | 1.5 ± 0.8 (0.5-3.9) $
| 0.7 ± 0.1 (0.5-1.0)* $
|
Performance | CG | MDRD | CKD-EPI-Cr | Hoek | Larsson | CKD-EPI CysC | CKD-EPI-Cr-CysC |
---|---|---|---|---|---|---|---|
All Cirrhotics [N = 50] mGFR 89.6 ± 27.5 | |||||||
eGFR | 130.4 ± 41.0 | 101.1 ± 26.5 | 99.0 ± 18.5 | 78.0 ± 25.8 | 81.0 ± 31.3 | 80.9 ± 29.0 | 89.0 ± 24.8 |
Bias | −40.8 ± 29.2 | −11.5 ± 22.0 | −9.4 ± 20.7 | 11.1 ± 15.8 | 8.1 ± 17.7 | 8.2 ± 17.7 | 0.1 ± 16.3 |
Accuracy 10 % | 4 %* | 36 % | 38 % | 39 % | 41 % | 41 % | 49 % |
Accuracy 30 % | 36 %* | 74 % | 78 % | 84 % | 82 % | 84 % | 84 % |
CC (Pearson) (95 % CI) | 0.703 (0.52–0.82) | 0.688 (0.50–0.81) | 0.658 (0.46–0.79) | 0.862 (0.77–0.92) | 0.826 (0.71–0.89) | 0.805 (0.68–0.88) | 0.812 (0.69–0.89) |
CCC (95 % CI) | 0.383* (0.25–0.52) | 0.611* (0.45–0.77) | 0.563* (0.40–0.72) | 0.757 (0.64–0.87) | 0.789 (0.68–0.89) | 0.771 (0.66–0.88) | 0.807 (0.70–0.90) |
CTP A [N = 18] mGFR 97.2 ± 24.1 | |||||||
eGFR | 126.6 ± 37.9 | 100.0 ± 26.1 | 99.7 ± 19.2 | 83.8 ± 25.2 | 88.0 ± 31.0 | 88.1 ± 27.6 | 93.8 ± 24.6 |
Bias | −29.4 ± 21.6 | −2.8 ± 16.1 | −2.5 ± 15.4 | 13.3 ± 12.3 | 9.2 ± 15.3 | 9.1 ± 12.6 | 3.4 ± 11.1 |
Accuracy 10 % | 6 % | 61 % | 50 % | 39 % | 44 % | 39 % | 67 % |
Accuracy 30 % | 56 % | 89 % | 94 % | 89 % | 89 % | 94 % | 94 % |
CC (Pearson) (95 % CI) | 0.851 (0.64–0.94) | 0.798 (0.53–0.80) | 0.771 (0.48–0.91) | 0.877 (0.69–0.95) | 0.875 (0.69–0.95) | 0.889 (0.72–0.96) | 0.896 (0.74–0.96) |
CCC (95 % CI) | 0.529* (0.32–0.74) | 0.790 (0.61–0.97) | 0.746 (0.54–0.95) | 0.785 (0.58–0.93) | 0.801 (0.65–0.95) | 0.827 (0.69–0.97) | 0.887 (0.78–0.99) |
CTP B [N = 18] mGFR 89.1 ± 25.2 | |||||||
eGFR | 142.7 ± 45.1 | 106.3 ± 22.7 | 102.9 ± 13.4 | 83.2 ± 20.4 | 86.7 ± 24.7 | 88.3 ± 25.3 | 95.4 ± 20.2 |
Bias | −53.7 ± 31.9 | −17.2 ± 23.3 | −13.8 ± 20.6 | 5.9 ± 20.1 | 2.3 ± 21.7 | 0.8 ± 21.7 | −6.3 ± 19.1 |
Accuracy 10 % | 0 % | 22 % | 33 % | 44 % | 44 % | 44 % | 39 % |
Accuracy 30 % | 28 % | 67 % | 78 % | 83 % | 78 % | 78 % | 78 % |
CC (Pearson) (95 % CI) | 0.725 (0.39–0.89) | 0.534 (0.09–0.80) | 0.581 (0.16–0.82) | 0.628 (0.23–0.85) | 0.623 (0.22–0.84) | 0.632 (0.23–0.85) | 0.667 (0.29–0.87) |
CCC (95 % CI) | 0.288 (0.10–0.48) | 0.417 (0.10–0.74) | 0.387 (0.11–0.66) | 0.594 (0.30–0.89) | 0.620 (0.32–0.92) | 0.631 (0.34–0.93) | 0.625 (0.35–0.90) |
CTP C [N = 14] mGFR 80.4 ± 32.8 | |||||||
eGFR | 119.2 ± 37.9 | 95.8 ± 31.9 | 93.1 ± 22.7 | 62.9 ± 32.8 | 63.2 ± 35.2 | 60.5 ± 27.5 | 73.3 ± 25.6 |
Bias | −38.8 ± 29.4 | −15.4 ± 24.8 | −12.7 ± 25.4 | 15.1 ± 12.2 | 14.7 ± 12.5 | 17.4 ± 13.5 | 4.6 ± 16.3 |
Accuracy 10 % | 7 % | 21 % | 29 % | 31 % | 31 % | 38 % | 38 % |
Accuracy 30 % | 21 % | 64 % | 57 % | 77 % | 77 % | 77 % | 77 % |
CC (Pearson) (95 % CI) | 0.663 (0.20–0.88) | 0.706 (0.28–0.90) | 0.635 (0.16–0.87) | 0.930 (0.79–0.98) | 0.934 (0.80–0.98) | 0.915 (0.75–0.97) | 0.872 (0.64–0.96) |
CCC (95 % CI) | 0.399 (0.10–0.69) | 0.629 (0.32–0.94) | 0.535 (0.20–0.87) | 0.816 (0.66–0.98) | 0.846 (0.70–0.99) | 0.764 (0.57–0.96) | 0.835 (0.67–0.99) |
Controls [N = 24] mGF: 97.5 ± 15.1 | |||||||
eGFR | 98.7 ± 21.9 | 85.4 ± 12.9 | 93.5 ± 12.2 | 108.4 ± 17.9 | 118.9 ± 24.1 | 107.7 ± 13.6 | 102.1 ± 12.1 |
Bias | −1.2 ± 19.8 | 12.1 ± 12.3 | 4.1 ± 10.6 | −10.9 ± 19.5 | −21.4 ± 24.2 | −10.2 ± 12.1 | −4.5 ± 9.5 |
Accuracy 10 % | 21 %* | 16 %* | 54.% | 17 %* | 37 % | 54 % | 71 % |
Accuracy 30 % | 92 % | 100 % | 100 % | 83 % | 62 %* | 87 % | 91 % |
CC (Pearson) (95 % CI) | 0.481 (0.09–0.74) | 0.622 (0.29–0.82) | 0.718 (0.44–0.87) | 0.314* (−0.10–0.64) | 0.303* (−0.11–0.62) | 0.649 (0.33–0.83) | 0.778 (0.54–0.89) |
CCC (95 % CI) | 0.449 (0.14–0.80) | 0.443 (0.19–0.68) | 0.671 (0.46–0.88) | 0.252* (−0.06–0.57) | 0.171* (−0.06–0.40) | 0.510 (0.26–0.76) | 0.718 (0.53–0.90) |