Background
Methods
Sample
Outcome measures
Analyses
Ethics
Results
Demographics and baseline characteristics
All patients
|
ADAS-Cog
|
ADAS-Cog
|
ADAS-Cog
| |
---|---|---|---|---|
(n = 95)
|
improved
|
no change
|
worsened
| |
(n = 19)
|
(n = 53)
|
(n = 23)
| ||
Baseline characteristics
| ||||
Females, n (%) | 68 (72) | 15 (79) | 36 (68) | 17 (74) |
Age, mean years (sd) | 75.8 (7.7) | 79.8 (8.2) | 75.5 (6.3) | 73.3 (8.9) |
Education, mean years (sd) | 11.1 (3.2) | 10.5 (3.2) | 11.0 (3.2) | 11.6 (3.2) |
Duration of illness, mean years (sd) | 1.3 (1.5) | 1.0 (1.0) | 1.3 (1.7) | 1.5 (1.6) |
CDR = mild, n (%) | 73 (77) | 14 (74) | 44 (83) | 15 (65) |
Baseline outcomes
| ||||
CIBIS+, mean (sd) | 3.7 (0.8) | 3.7 (0.8) | 3.6 (0.7) | 3.9 (0.7) |
MMSE, mean (sd) | 19.9 (5.3) | 20.0 (4.7) | 20.6 (5.3) | 18.3 (5.4) |
ADAS-Cog, mean (sd) | 24.6 (9.9) | 26.4 (10.6) | 23.2 (9.3) | 26.3 (10.4) |
PSMS, mean (sd) | 8.8 (2.5) | 9.3 (2.1) | 8.8 (2.7) | 8.3 (2.2) |
IADL, mean (sd) | 19.9 (5.4) | 20.5 (4.6) | 20.1 (5.4) | 18.9 (6.1) |
CSD, mean (sd) | 5.7 (5.4) | 6.4 (5.5) | 5.5 (5.1) | 5.9 (6.2) |
Treatment goals set at baseline
| ||||
PGAS-total, mean (sd) | 8.6 (3.3) | 8.2 (2.7) | 8.7 (3.3) | 8.6 (3.8) |
PGAS-cognition, mean (sd)1
| 1.2 (0.8) | 1.1 (0.7) | 1.2 (0.8) | 1.2 (0.7) |
CGAS-total, mean (sd) | 3.4 (1.3) | 3.1 (0.8) | 3.5 (1.4) | 3.3 (1.2) |
CGAS-cognition, mean (sd)2
| 2.1 (1.8) | 2.5 (2.3) | 2.2 (1.7) | 1.8 (1.4) |
ADAS-Cog response at 6 months
Comparison of ADAS-Cog response with other outcomes at 6 months
ADAS-Cog
|
ADAS-Cog
|
ADAS-Cog
| |||||
---|---|---|---|---|---|---|---|
improved
|
no change
|
worsened
|
ADAS-Cog
|
CIBIC-Plus
|
PGAS*
|
CGAS*
| |
(n = 19)
|
(n = 53)
|
(n = 23)
|
(n = 95)
|
(n = 95)
|
(n = 95)
|
(n = 95)
| |
CIBIC-Plus | -0.15 | 0.15 | 0.38 | 0.27 | 1.00 | ||
PGAS* | 0.40 | -0.32 | -0.15 | -0.09 | -0.59 | 1.00 | |
Cognition* | 0.58 | -0.50 | -0.32 | -0.22 | -0.60 | 0.81 | 0.58 |
Function* | 0.23 | -0.25 | -0.07 | -0.03 | -0.27 | 0.69 | 0.22 |
Behaviour* | -0.33 | 0.17 | -0.17 | -0.06 | -0.12 | 0.47 | 0.18 |
Leisure* | 0.44 | -0.32 | -0.15 | -0.11 | -0.50 | 0.87 | 0.36 |
Social* | 0.73 | -0.32 | -0.50 | -0.04 | -0.52 | 0.72 | 0.39 |
CGAS* | 0.33 | -0.09 | -0.32 | -0.22 | -0.77 | 0.52 | 1.00 |
Cognition* | 0.41 | -0.12 | -0.27 | -0.21 | -0.69 | 0.51 | 0.84 |
Function* | 0.36 | -0.29 | 0.20 | -0.14 | -0.60 | 0.51 | 0.77 |
Behaviour* | 0.20 | 0.35 | -0.43 | -0.30 | -0.72 | 0.41 | 0.89 |
Leisure* | -1.00 | 0.11 | 0.29 | 0.12 | -0.25 | 0.32 | 0.63 |
Social* | 0.15 | -0.31 | 0.21 | 0.01 | -0.76 | 0.48 | 0.86 |
MMSE* | 0.59 | -0.18 | -0.24 | -0.35 | -0.29 | 0.24 | 0.32 |
PSMS | -0.28 | 0.00 | 0.37 | 0.21 | 0.51 | -0.36 | -0.53 |
IADL | -0.29 | 0.16 | -0.15 | 0.11 | 0.37 | -0.27 | -0.46 |
CSD | 0.24 | -0.03 | 0.39 | 0.25 | 0.40 | -0.15 | -0.53 |