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01.12.2020 | Original Article

The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism

verfasst von: Sema Hepsen, Pinar Akhanli, Davut Sakiz, Muhammed Erkam Sencar, Bekir Ucan, Ilknur Ozturk Unsal, Erman Cakal, Mustafa Ozbek

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2020

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Abstract

Summary

This study aims to evaluate factors affecting the quality of life (QOL) of hypoparathyroidism. While QOL is reduced in post-surgical and non-surgical groups, mental health seems to be less affected in non-surgical patients. Having an additional disease affects QOL negatively but having thyroid cancer may not change the QOL results.

Purpose

Hypoparathyroidism (HypoPT) is an orphan disease, which causes physical, emotional, and cognitive problems. We aimed to estimate the factors affecting the quality of life (QOL) of HypoPT patients.

Methods

Basal characteristics, treatments, and laboratory results of the participants were recorded. QOL of the patients and controls were evaluated via the Short Form-36 (SF-36) survey.

Results

One hundred sixty HypoPT patients were compared with 148 controls. Patients had lower scores in all SF-36 domains than controls. Non-surgical patients had better scores in vitality and mental health compared with post-surgical ones. Males had higher scores in mental and physical health domains than females. Non-surgical patients had higher scores in mental health compared with post-surgical ones when calcium levels were between 8 and 8.9 mg/dL. When we compared the patients with the pathological results, QOL scores of post-surgical patients with thyroid cancer were not different from the patients with thyroid nodular hyperplasia. HypoPT patients having an additional disease presented lower scores in physical functions and general health. Disease duration was found out positively correlated with vitality in non-surgical patients.

Conclusion

While QOL is reduced in both post-surgical and non-surgical HypoPT groups, mental health seems to be less affected in non-surgical patients. Non-surgical patients might be tolerating hypocalcemia symptoms, lower calcium levels, and longer disease duration better than post-surgical ones. Having an additional disease affects the QOL negatively but having thyroid cancer may not change the QOL results of post-surgical patients.

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Titel: The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism
verfasst von: Sema Hepsen
Pinar Akhanli
Davut Sakiz
Muhammed Erkam Sencar
Bekir Ucan
Ilknur Ozturk Unsal
Erman Cakal
Mustafa Ozbek
Publikationsdatum: 01.12.2020
Verlag: Springer London
Erschienen in: Archives of Osteoporosis / Ausgabe 1/2020
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-020-00759-8

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The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism