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28.07.2023 | Review

The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis

verfasst von: Hossein Bahari, Hossein Rafiei, Kian Goudarzi, Kosar Omidian, Omid Asbaghi, Kosar Sadat Hosseini Kolbadi, Moslem Naderian, Ali Hosseini

Erschienen in: Inflammopharmacology | Ausgabe 5/2023

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Abstract

Background

Several studies have shown the effects of pomegranate on oxidative stress and inflammation biomarkers, while some studies showed no effects of pomegranate on these biomarkers. Therefore, we aimed to evaluate the effects of pomegranate consumption on C-reactive protein (CRP), interlukin-6 (IL-6), tumor necrosis factor α (TNF-α), total antioxidant capacity (TAC), and malondialdehyde (MDA) in adults.

Methods

A systematic literature search was performed using databases, including PubMed, Web of Science, and Scopus, up to May 2023 to identify eligible randomized controlled trials (RCTs). Heterogeneity tests of the included trials were performed using the I² statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval.

Results

Of 3811 records, 33 eligible RCTs were included in the current study. Our meta-analysis of the pooled findings showed that pomegranate consumption significantly reduced CRP (WMD: −0.50 mg/l; 95% CI −0.79 to −0.20; p = 0.001), IL-6 (WMD: −1.24 ng/L 95% CI −1.95 to −0.54; p = 0.001), TNF-α (WMD: −1.96 pg/ml 95%CI −2.75 to −1.18; p < 0.001), and MDA (WMD: −0.34 nmol/ml 95%CI −0.42 to −0.25; p < 0.001). Pooled analysis of 13 trials revealed that pomegranate consumption led to a significant increase in TAC (WMD: 0.26 mmol/L 95%CI 0.03 to 0.49; p = 0.025).

Conclusion

Overall, the results demonstrated that pomegranate consumption has beneficial effects on oxidative stress and inflammatory biomarkers in adults. Therefore, pomegranate can be consumed as an effective dietary approach to attenuate oxidative stress and inflammation in patients with cardiovascular diseases.

PROSPERO registration code

CRD42023406684

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Titel: The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis
verfasst von: Hossein Bahari
Hossein Rafiei
Kian Goudarzi
Kosar Omidian
Omid Asbaghi
Kosar Sadat Hosseini Kolbadi
Moslem Naderian
Ali Hosseini
Publikationsdatum: 28.07.2023
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 5/2023
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-023-01294-x

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

PROSPERO registration code

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

PROSPERO registration code

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